Results 1 to 10 of about 27,832 (229)

Sex-specific differences in mediobasal hypothalamus in response to nutritional states [PDF]

Nature Communications
The arcuate nucleus of the hypothalamus plays a central role in sensing and integrating nutritional, hormonal, and neural signals that regulate feeding, energy homeostasis, growth, and reproduction, all of which show pronounced sex differences.
Jonathan C. Bean, Jinjing Jian, Tzu-Chiao Lu, Hailan Liu, Kristine Conde, Darah A. Threat, Sanika V. Jossy, Megan E. Burt, Jingjing Cheng, Yue Deng, Xing Fang, Xiaoyu Geng, Junying Han, Yongxiang Li, Hesong Liu, Qingzhuo Liu, Yutian Liu, Yuhan Shi, Longlong Tu, Mengjie Wang, Xu Xu, Yuxue Yang, Meng Yu, Xinming Liu, Meixin Sun, Fuhui Wang, Olivia Z. Ginnard, Yongjie Yang, Yang He, Chunmei Wang, Yanyan Qi, Hongjie Li, Yong Xu   +32 more
doaj   +2 more sources

Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation [PDF]

BMC Neuroscience, 2011
Background The arcuate nucleus of the hypothalamus regulates food intake. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) is expressed in neuropeptide Y and proopiomelanocortin (POMC) neurons in the arcuate nucleus, target neurons in the ...
Xia Zefeng, Fritze Danielle, Zhang Chao, Wu Xiaobin, Zhang Weizhen, Chai Biaoxin, Li Ji-Yao, Patterson Cam, Mulholland Michael W   +8 more
doaj   +4 more sources

Single-Cell Gene Expression Analysis of Cholinergic Neurons in the Arcuate Nucleus of the Hypothalamus. [PDF]

PLoS ONE, 2016
The cholinoceptive system in the hypothalamus, in particular in the arcuate nucleus (ARC), plays a role in regulating food intake. Neurons in the ARC contain multiple neuropeptides, amines, and neurotransmitters.
Jae Hoon Jeong, Young Jae Woo, Streamson Chua, Young-Hwan Jo   +3 more
doaj   +4 more sources

Intra-accumbens baclofen, but not muscimol, increases second order instrumental responding for food reward in rats [PDF]

, 2011
Stimulation of either GABA(A) or GABA(B) receptors within the nucleus accumbens shell strongly enhances food intake in rats. However the effects of subtype-selective stimulation of GABA receptors on instrumental responses for food reward are less well ...
Clifton, Peter G, Pulman, Kim G T, Somerville, Elizabeth M   +2 more
core   +13 more sources

Arcuate Nucleus of the Hypothalamus: Anatomy, Physiology, and Diseases

Experimental Neurobiology, 2023
The hypothalamus is part of the diencephalon and has several nuclei, one of which is the arcuate nucleus. The arcuate nucleus of hypothalamus (ARH) consists of neuroendocrine neurons and centrally-projecting neurons. The ARH is the center where the homeostasis of nutrition/metabolism and reproduction are maintained.
Song, Juhyun, Choi, Seok-Yong
openaire   +2 more sources

Neuropeptide Y and Metabolism Syndrome: An Update on Perspectives of Clinical Therapeutic Intervention Strategies

Frontiers in Cell and Developmental Biology, 2021
Through the past decade of research, the pathogenic mechanisms underlying metabolic syndrome have been suggested to involve not only the peripheral tissues, but also central metabolic regulation imbalances.
Yinqiong Huang, Xiahong Lin, Shu Lin, Shu Lin   +3 more
doaj   +1 more source

Relative number and distribution of murine hypothalamic proopiomelanocortin neurons innervating distinct target sites. [PDF]

PLoS ONE, 2011
Proopiomelanocortin (POMC) neurons send projections widely throughout the brain consistent with their role in regulating numerous homeostatic processes and mediating analgesia and reward.
Connie M King, Shane T Hentges
doaj   +1 more source

Fetal alcohol exposure alters proopiomelanocortin gene expression and hypothalamic-pituitary-adrenal axis function via increasing MeCP2 expression in the hypothalamus. [PDF]

PLoS ONE, 2014
Proopiomelanocortin (POMC) is a precursor gene of the neuropeptide β-endorphin in the hypothalamus and is known to regulate various physiological functions including stress response.
Omkaram Gangisetty, Rola Bekdash, George Maglakelidze, Dipak K Sarkar   +3 more
doaj   +1 more source

The balance of pressor and depressor substances in the neurons of arcuate nucleus of hypothalamus in etiologically different arterial hypertension

Journal of Education, Health and Sport, 2019
It has been proved that arterial hypertension is not associated exclusively with an increase in vascular tone but also with a complex of pathological processes that results in cardiovascular pathology and lesions of the target organs.
S. V. Tishchenko
doaj   +3 more sources

Amylin Selectively Signals Onto POMC Neurons in the Arcuate Nucleus of the Hypothalamus [PDF]

Diabetes, 2018
Amylin phosphorylates ERK (p-ERK) in the area postrema to reduce eating and synergizes with leptin to phosphorylate STAT3 in the arcuate (ARC) and ventromedial (VMN) hypothalamic nuclei to reduce food intake and body weight. The current studies assessed potential amylin and amylin-leptin ARC/VMN interactions on ERK signaling and their roles in ...
Lutz, Thomas A, Coester, Bernd, Whiting, Lynda, Dunn-Meynell, Ambrose A, Boyle, Christina N, Bouret, Sebastien G, Levin, Barry E, Le Foll, Christelle   +7 more
openaire   +3 more sources