The Arcuate Nucleus of the Hypothalamus and Metabolic Regulation: An Emerging Role for Renin–Angiotensin Pathways [PDF]
International Journal of Molecular Sciences, 2021 Obesity is a chronic state of energy imbalance that represents a major public health problem and greatly increases the risk for developing hypertension, hyperglycemia, and a multitude of related pathologies that encompass the metabolic syndrome. The underlying mechanisms and optimal treatment strategies for obesity, however, are still not fully ...
Darren Mehay +2 more
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Arcuate Nucleus of the Hypothalamus: Anatomy, Physiology, and Diseases
Experimental Neurobiology, 2023 The hypothalamus is part of the diencephalon and has several nuclei, one of which is the arcuate nucleus. The arcuate nucleus of hypothalamus (ARH) consists of neuroendocrine neurons and centrally-projecting neurons. The ARH is the center where the homeostasis of nutrition/metabolism and reproduction are maintained.
Song, Juhyun, Choi, Seok-Yong
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Journal of Education, Health and Sport, 2019 It has been proved that arterial hypertension is not associated exclusively with an increase in vascular tone but also with a complex of pathological processes that results in cardiovascular pathology and lesions of the target organs.
S. V. Tishchenko
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Amylin Selectively Signals Onto POMC Neurons in the Arcuate Nucleus of the Hypothalamus [PDF]
Diabetes, 2018 Amylin phosphorylates ERK (p-ERK) in the area postrema to reduce eating and synergizes with leptin to phosphorylate STAT3 in the arcuate (ARC) and ventromedial (VMN) hypothalamic nuclei to reduce food intake and body weight. The current studies assessed potential amylin and amylin-leptin ARC/VMN interactions on ERK signaling and their roles in ...
Lutz, Thomas A +7 more
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Involvement of the Arcuate Nucleus of the Hypothalamus in Interleukin-1-Induced Anorexia [PDF]
The Journal of Neuroscience, 2002 Cytokine-mediated anorexia is a component of "sickness behavior" and presents a significant obstacle in the treatment of chronic illnesses. We hypothesized an involvement of the hypothalamic arcuate nucleus (ARH) in mediating the anorexic effects of a systemic interleukin-1 (IL-1) challenge based on its content of peptidergic neurons involved in ...
Teresa M, Reyes, Paul E, Sawchenko
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Frontiers in Cell and Developmental Biology, 2021 Through the past decade of research, the pathogenic mechanisms underlying metabolic syndrome have been suggested to involve not only the peripheral tissues, but also central metabolic regulation imbalances.
Yinqiong Huang +3 more
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Relative number and distribution of murine hypothalamic proopiomelanocortin neurons innervating distinct target sites. [PDF]
PLoS ONE, 2011 Proopiomelanocortin (POMC) neurons send projections widely throughout the brain consistent with their role in regulating numerous homeostatic processes and mediating analgesia and reward.
Connie M King, Shane T Hentges
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Fetal alcohol exposure alters proopiomelanocortin gene expression and hypothalamic-pituitary-adrenal axis function via increasing MeCP2 expression in the hypothalamus. [PDF]
PLoS ONE, 2014 Proopiomelanocortin (POMC) is a precursor gene of the neuropeptide β-endorphin in the hypothalamus and is known to regulate various physiological functions including stress response.
Omkaram Gangisetty +3 more
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ProSAAS-derived peptides are colocalized with neuropeptide Y and function as neuropeptides in the regulation of food intake. [PDF]
PLoS ONE, 2011 ProSAAS is the precursor of a number of peptides that have been proposed to function as neuropeptides. Because proSAAS mRNA is highly expressed in the arcuate nucleus of the hypothalamus, we examined the cellular localization of several proSAAS-derived ...
Jonathan H Wardman +4 more
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QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior. [PDF]
PLoS ONE, 2016 How the hypothalamus transmits hunger information to other brain regions to govern whole brain function to orchestrate feeding behavior has remained largely unknown.
Kitaro Okamoto +13 more
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