Results 21 to 30 of about 23,715 (250)

Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit [PDF]

Molecular and Cellular Endocrinology, 2010
Acute or long-term energy deficit in lean or obese rodents or humans stimulates food intake or appetite and reduces metabolic rate or energy expenditure. These changes contribute to weight regain in post-obese animals and humans. Some studies show that the reduction in metabolic rate with energy deficit in overweight people is transient.
Sainsbury, Amanda, Zhang, L
openaire   +5 more sources

Single-Cell Gene Expression Analysis of Cholinergic Neurons in the Arcuate Nucleus of the Hypothalamus

PLOS ONE, 2016
The cholinoceptive system in the hypothalamus, in particular in the arcuate nucleus (ARC), plays a role in regulating food intake. Neurons in the ARC contain multiple neuropeptides, amines, and neurotransmitters. To study molecular and neurochemical heterogeneity of ARC neurons, we combine single-cell qRT-PCR and single-cell whole transcriptome ...
Jae Hoon Jeong, Young Jae Woo, Streamson Chua, Young-Hwan Jo   +3 more
openaire   +5 more sources

Insulin in the arcuate nucleus of the hypothalamus reduces fat consumption in rats. [PDF]

Brain research, 1997
Data are accumulating that insulin acting in the central nervous system is a physiological regulator of food intake and body weight, presumably via its effect in the hypothalamus. The present study investigated whether infusion of a small dose of insulin into two major hypothalamic insulin-binding areas also has an effect on diet selection and behavior.
van Dijk, G, de Groote, C, Chavez, M, van der Werf, Y, Steffens, AB, Strubbe, JH   +5 more
openaire   +3 more sources

Substance p immunoreactivity exhibits frequent colocalization with kisspeptin and neurokinin B in the human infundibular region. [PDF]

, 2013
Neurons synthesizing neurokinin B (NKB) and kisspeptin (KP) in the hypothalamic arcuate nucleus represent important upstream regulators of pulsatile gonadotropin-releasing hormone (GnRH) neurosecretion.
Herczeg, László, László Herczeg, Hrabovszky, E, Bloom, SR, Borsay, Beáta Á., Kálmán Rácz, Hrabovszky, Erik, Borsay, BA, Borsay Beáta Á., Ghatei Mohammad A., Liposits Zsolt, Rácz Kálmán, Ciofi Philippe, Ciofi, Philippe, Beáta Á Borsay, Dhillo, WS, Liposits, Z, Herczeg László, Mohammad A Ghatei, Racz, K, Hrabovszky Erik, Dhillo, Waljit S., Ciofi, P, Philippe Ciofi, Ghatei, MA, Liposits, Zsolt, Erik Hrabovszky, Bloom Stephen R., Rácz, Kálmán, Bloom, Stephen R., Ghatei, Mohammad A., Waljit S Dhillo, Herczeg, L, Dhillo Waljit S., Stephen R Bloom, Zsolt Liposits   +35 more
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Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances [PDF]

, 2007
The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two of the five melanocortin receptors, MC3R and MC4R are involved in hypothalamic control of energy homeostasis, with the MC4R having the major influence. It is
Hisadome, Kazunari, Michael L. J. Ashford, Smith, Mark A., Helen Heffron, Mark A. Smith, Al-Qassab, Hind, Kazunari Hisadome, Withers, Dominic J., Hind Al‐Qassab, Dominic J. Withers, Ashford, Michael L. J.; id_orcid, Heffron, Helen   +11 more
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PVN pathways controlling energy homeostasis

Indian Journal of Endocrinology and Metabolism, 2012
Research into the control of energy balance has tended to focus on discrete brain regions, such as the brainstem, medulla, arcuate nucleus of the hypothalamus, and neocortex.
Jennifer W Hill
doaj   +1 more source

Short photoperiod-induced decrease of histamine H3 receptors facilitates activation of hypothalamic neurons in the Siberian Hamster [PDF]

, 2009
Nonhibernating seasonal mammals have adapted to temporal changes in food availability through behavioral and physiological mechanisms to store food and energy during times of predictable plenty and conserve energy during predicted shortage.
Bartness, Timothy J., Barrett, Perry, van den Top, Marco, Spanswick, David C., Wilson, D., Mercer, Julian G., Morgan, Peter J., Song, C. K.   +7 more
core   +1 more source

Identification of sex hormone-binding globulin in the human hypothalamus [PDF]

, 2005
Gonadal steroids are known to influence hypothalamic functions through both genomic and non-genomic pathways. Sex hormone-binding globulin ( SHBG) may act by a non-genomic mechanism independent of classical steroid receptors.
Caldwell, Jack D., Eggeling, Ferdinand von, Bernstein, Hans-Gert, Melle, Christian, Jirikowski, Gustav F., Lewis, John, Herbert, Zsófia, Göthe, Susanne   +7 more
core   +1 more source

Molecular and cellular characterization of nAChR subtypes in the arcuate nucleus of the mouse hypothalamus

European Journal of Neuroscience, 2018
Nicotine, acting through nicotinic acetylcholine receptors (nAChRs), increases the firing rate of both orexigenic agouti‐related peptide (AgRP) and anorexigenic pro‐opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC), yet ...
Cali A. Calarco, Zhiying Li, Seth R. Taylor, Somin Lee, Wenliang Zhou, J. Friedman, Y. Mineur, C. Gotti, M. Picciotto   +8 more
semanticscholar   +1 more source

Leptin mediates the increase in blood pressure associated with obesity [PDF]

, 2014
Obesity is associated with increased blood pressure (BP), which in turn increases the risk of cardiovascular diseases. We found that the increase in leptin levels seen in diet-induced obesity (DIO) drives an increase in BP in rodents, an effect that was ...
Cowley, Michael A., Ravussin, E., Cowley, M., Elmquist, Joel K., Myers, M., Enriori, P., Spanswick, D., O’Rahilly, S. (Stephen), Myers, Martin G., Henning, Elana, Licinio, Julio, Simonds, Stephanie E., Greenway, Frank L., Simonds, S., Farooqi, I., Brown, Russell D., Allen, A., Brown, R., Spanswick, David C., Dileone, R., Farooqi, I. Sadaf, Allen, Andrew M., Elmquist, J., Bassi, J., O’Rahilly, Stephen, Keogh, Julia M., Keogh, J., Sternson, S., Myer, Martin G., Greenway, F., Licinio, J., Enriori, Pablo J., Pryor, J., Pryor, Jack T., Dileone, Ralph, Grove, Kevin L., O’Rahilly, S., Henning, E., Ravussin, Eric, Bassi, Jaspreet, Sternson, Scott M., Grove, K.   +41 more
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