Results 41 to 50 of about 27,832 (229)

Hyperandrogenism induces proportional changes in the expression of Kiss-1, Tac2, and DynA in hypothalamic KNDy neurons

Reproductive Biology and Endocrinology, 2022
Background Kisspeptin released from Kiss-1 neurons in the hypothalamus plays an essential role in the control of the hypothalamic–pituitary–gonadal axis by regulating the release of gonadotropin-releasing hormone (GnRH).
Hiroe Okada, Haruhiko Kanasaki, Tuvshintugs Tumurbaatar, Zolzaya Tumurgan, Aki Oride, Satoru Kyo   +5 more
doaj   +1 more source

Exercise Restores Hypothalamic Health in Obesity by Reshaping the Inflammatory Network

Antioxidants, 2023
Obesity and overnutrition induce inflammation, leptin-, and insulin resistance in the hypothalamus. The mediobasal hypothalamus responds to exercise enabling critical adaptions at molecular and cellular level that positively impact local inflammation ...
Lucio Della Guardia, Roberto Codella
doaj   +1 more source

Effect of hyperthyroidism on circulating prolactin and hypothalamic expression of tyrosine hydroxylase, prolactin signaling cascade members and estrogen and progesterone receptors during late pregnancy and lactation in the rat [PDF]

, 2017
Hyperthyroidism (HyperT) compromises pregnancy and lactation, hindering suckling-induced PRL release. We studied the effect of HyperT on hypothalamic mRNA (RT-qPCR) and protein (Western blot) expression of tyrosine hydroxylase (TH), PRL receptor (PRLR ...
Jahn, Graciela Alma, Neira, Flavia Judith, Pennacchio, Gisela Erika, Soaje, Marta, Valdez, Susana Ruth   +4 more
core   +1 more source

Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat.

, 2006
Intracerebroventricular (ICV) administration of the hypothalamic neuropeptide neuromedin U (NMU) or the adipostat hormone leptin increases plasma ACTH and corticosterone.
Abbott, CR, Bloom, SR, Darch, SJ, Ghatei, MA, Jethwa, PH, Murphy, KG, Patel, SR, Semjonous, NM, Seth, A, Small, CJ, Smith, KL, Todd, JF   +11 more
core   +1 more source

Identification of sex hormone-binding globulin in the human hypothalamus [PDF]

, 2005
Gonadal steroids are known to influence hypothalamic functions through both genomic and non-genomic pathways. Sex hormone-binding globulin ( SHBG) may act by a non-genomic mechanism independent of classical steroid receptors.
Becchis M, Caldwell JD, Caldwell JD, Caldwell JD, Caldwell JD, Christian Melle, Englebienne P, Fassler R, Feldman M, Ferdinand von Eggeling, Forunati N, Gao G, Gustav F. Jirikowski, Hammond GL, Hans-Gert Bernstein, Herbert Z, Hoskins EK, Hryb DJ, Jack D. Caldwell, Jirikowski GF, John Lewis, Joseph DR, Khan MS, Krupenko SA, Lewis JG, Melle C, Paoletti AM, Pardridge WM, Remington SG, Reventos J, Rosner W, Selva DM, Susanne Göthe, Vigh Teichmann I, Wang YM, Zsófia Herbert   +35 more
core   +1 more source

Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity

Disease Models & Mechanisms, 2013
SUMMARY The ventral hypothalamus acts to integrate visceral and systemic information to control energy balance. The basic helix-loop-helix transcription factor neurogenin-3 (Ngn3) is required for pancreatic β-cell development and has been implicated in ...
Neal Anthwal, Michelle Pelling, Suzanne Claxton, Georg Mellitzer, Caitlin Collin, Nicoletta Kessaris, William D. Richardson, Gérard Gradwohl, Siew-Lan Ang   +8 more
doaj   +1 more source

Identification of Sox2 and NeuN Double-Positive Cells in the Mouse Hypothalamic Arcuate Nucleus and Their Reduction in Number With Aging

Frontiers in Aging Neuroscience, 2021
The hypothalamus plays a central role in homeostasis and aging. The hypothalamic arcuate nucleus (ARC) controls homeostasis of food intake and energy expenditure and retains adult neural stem cells (NSCs)/progenitor cells.
Ayumu Sugiura, Tatsuhiro Shimizu, Takeshi Kameyama, Tomohiko Maruo, Shin Kedashiro, Muneaki Miyata, Kiyohito Mizutani, Yoshimi Takai   +7 more
doaj   +1 more source

The melanocortin receptors and their accessory proteins. [PDF]

, 2013
The five melanocortin receptors (MCRs) named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behavior as well as exocrine function.
Chan, LF, Clark, AJ, Gorrigan, RJ, Ramachandrappa, S   +3 more
core   +2 more sources

Effect of Early Calf-Hood Nutrition on the Transcriptional Regulation of the Hypothalamic-Pituitary-Testicular axis in Holstein-Friesian Bull Calves

Scientific Reports, 2018
The aim of this study was to investigate the effect of early calf-hood nutrition on the transcriptomic profile of the arcuate nucleus of the hypothalamus, anterior pituitary and testes in Holstein-Friesian bulls. Holstein-Friesian bull calves with a mean
A. M. English, C. J. Byrne, P Cormican, S. M. Waters, S. Fair, D. A. Kenny   +5 more
doaj   +1 more source

Hypothalamic Perineuronal Nets Are Regulated by Sex and Dietary Interventions

Frontiers in Physiology, 2021
Perineuronal nets (PNNs) are widely present in the hypothalamus, and are thought to provide physical protection and ion buffering for neurons and regulate their synaptic plasticity and intracellular signaling.
Nan Zhang, Nan Zhang, Nan Zhang, Zili Yan, Hailan Liu, Meng Yu, Yang He, Hesong Liu, Chen Liang, Longlong Tu, Lina Wang, Na Yin, Junying Han, Nikolas Scarcelli, Yongjie Yang, Chunmei Wang, Tianshu Zeng, Tianshu Zeng, Lu-Lu Chen, Lu-Lu Chen, Yong Xu, Yong Xu   +21 more
doaj   +1 more source