Results 41 to 50 of about 23,715 (250)

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons [PDF]

, 2007
Hypothalamic AMP-activated protein kinase (AMPK) has been suggested to act as a key sensing mechanism, responding to hormones and nutrients in the regulation of energy homeostasis.
Carling, D., Choudhury, Agharul I., Smith, Mark A., Fryer, L.G.D., Speakman, J.R., Ashford, MLJ, Carling, D, Withers, DJ, Selman, Colin, Xu, Allison W., Al-Qassab, H, Fryer, Lee G.D., Vaulont, Sophie, Choudhury, AI, Fryer, LGD, Vaulont, S., Claret, Marc, Heffron, H, Speakman, John R., Heffron, H., Barsh, Gregory S., Clements, M, Choudhury, A.I., Vaulont, S, Heffron, Helen, Xu, A.W., Withers, D.J., Viollet, B, Smith, MA, Barsh, G.S., Clements, Melanie, Withers, Dominic J., Viollet, B., Ashford, Michael L. J.; id_orcid, Batterham, RL, Selman, C, Claret, M., Barsh, GS, Claret, M, Selman, C., Al-Qassab, H., Xu, AW, Al-Qassab, Hind, Viollet, Benoit, Smith, M.A., Ashford, M.L.J., Batterham, R.L., Batterham, Rachel L., Carling, David, Speakman, JR, Clements, M.   +50 more
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Hyperandrogenism induces proportional changes in the expression of Kiss-1, Tac2, and DynA in hypothalamic KNDy neurons

Reproductive Biology and Endocrinology, 2022
Background Kisspeptin released from Kiss-1 neurons in the hypothalamus plays an essential role in the control of the hypothalamic–pituitary–gonadal axis by regulating the release of gonadotropin-releasing hormone (GnRH).
Hiroe Okada, Haruhiko Kanasaki, Tuvshintugs Tumurbaatar, Zolzaya Tumurgan, Aki Oride, Satoru Kyo   +5 more
doaj   +1 more source

Exercise Restores Hypothalamic Health in Obesity by Reshaping the Inflammatory Network

Antioxidants, 2023
Obesity and overnutrition induce inflammation, leptin-, and insulin resistance in the hypothalamus. The mediobasal hypothalamus responds to exercise enabling critical adaptions at molecular and cellular level that positively impact local inflammation ...
Lucio Della Guardia, Roberto Codella
doaj   +1 more source

Glucokinase activity in the arcuate nucleus regulates glucose intake [PDF]

, 2014
The brain relies on a constant supply of glucose, its primary fuel, for optimal function. A taste-independent mechanism within the CNS that promotes glucose delivery to the brain has been postulated to maintain glucose homeostasis; however, evidence for ...
Niki Buckley, Ma, Yue, Holton, C, Buckley, N, Gardiner, James, Bewick, G, Errol Richardson, Hussain, Syed, Steve Bloom, Gardiner, J, Dhillo, Waljit, De Backer, I, Richardson, Errol, David Carling, Ma, Y, Holton, Christopher, Richardson, E, Bloom, Steve, Carling, D, Dhillo, W, Syed Hussain, Hussain, S, Zhang, S, Waljit Dhillo, Zhang, Shuai, James Gardiner, Buckley, Niki, Yue Ma, De Backer, Ivan, Shuai Zhang, Carling, David, Bloom, S, Ivan De Backer, Gavin Bewick, Bewick, Gavin; id_orcid, Christopher Holton   +35 more
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Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity

Disease Models & Mechanisms, 2013
SUMMARY The ventral hypothalamus acts to integrate visceral and systemic information to control energy balance. The basic helix-loop-helix transcription factor neurogenin-3 (Ngn3) is required for pancreatic β-cell development and has been implicated in ...
Neal Anthwal, Michelle Pelling, Suzanne Claxton, Georg Mellitzer, Caitlin Collin, Nicoletta Kessaris, William D. Richardson, Gérard Gradwohl, Siew-Lan Ang   +8 more
doaj   +1 more source

Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man.

, 2012
Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in
Herczeg, László, Sipos, Máté T., Molnár, Csilla S., Vida, Barbara, Borsay, Beáta Á., Dhillo, Waljit S., Liposits, Zsolt, Hrabovszky, Erik, Rácz, Kálmán, Bloom, Stephen R., Ghatei, Mohammad A., Ciofi, Philippe   +11 more
core   +1 more source

Effect of Early Calf-Hood Nutrition on the Transcriptional Regulation of the Hypothalamic-Pituitary-Testicular axis in Holstein-Friesian Bull Calves

Scientific Reports, 2018
The aim of this study was to investigate the effect of early calf-hood nutrition on the transcriptomic profile of the arcuate nucleus of the hypothalamus, anterior pituitary and testes in Holstein-Friesian bulls. Holstein-Friesian bull calves with a mean
A. M. English, C. J. Byrne, P Cormican, S. M. Waters, S. Fair, D. A. Kenny   +5 more
doaj   +1 more source

Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation

BMC Neuroscience, 2011
Background The arcuate nucleus of the hypothalamus regulates food intake. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) is expressed in neuropeptide Y and proopiomelanocortin (POMC) neurons in the arcuate nucleus, target neurons in the ...
Xia Zefeng, Fritze Danielle, Zhang Chao, Wu Xiaobin, Zhang Weizhen, Chai Biaoxin, Li Ji-Yao, Patterson Cam, Mulholland Michael W   +8 more
doaj   +1 more source

Identification of Sox2 and NeuN Double-Positive Cells in the Mouse Hypothalamic Arcuate Nucleus and Their Reduction in Number With Aging

Frontiers in Aging Neuroscience, 2021
The hypothalamus plays a central role in homeostasis and aging. The hypothalamic arcuate nucleus (ARC) controls homeostasis of food intake and energy expenditure and retains adult neural stem cells (NSCs)/progenitor cells.
Ayumu Sugiura, Tatsuhiro Shimizu, Takeshi Kameyama, Tomohiko Maruo, Shin Kedashiro, Muneaki Miyata, Kiyohito Mizutani, Yoshimi Takai   +7 more
doaj   +1 more source

Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis [PDF]

, 2018
Aims Glucokinase (GK) serves as a glucose sensor in several tissues including glucose‐sensitive neurons of the arcuate nucleus within the hypothalamus.
Ma, Yue, Marie-Sophie Nguyen-Tu, Holton, C, Gardiner, James, Schwappach, B, Sufyan Hussain, Errol Richardson, Gaelle Carrat, Guy A. Rutter, Nguyen-Tu, M-S, Ratnasabapathy, Risheka, Carrat, G, Norton, M, Izzi-Engbeaya, Chioma, Schwappach, Blanche, Risheka Ratnasabapathy, De, Backer I, Waljit S. Dhillo, Holton, Christopher, Carrat, Gaelle, Richardson, E, Rutter, G, Ratnasabapathy, R, Dhillo, W, Hussain, S; id_orcid, Hussain, S, De Backer, ivan, Dhillo, Waljit S., Hussain, Sufyan, Gardiner, JV, Nguyen-Tu, Marie-Sophie, James Gardiner, Rutter, Guy A., Norton, mariana, Blanche Schwappach, Chioma Izzi-Engbeaya, Yue Ma, Izzi-Engbeaya, CN, Richardson, errol, Ivan De Backer, Ma, Yua, Mariana Norton, Christopher Holton   +42 more
core   +1 more source