Results 51 to 60 of about 23,715 (250)

Sex-specific differences in mediobasal hypothalamus in response to nutritional states

Nature Communications
The arcuate nucleus of the hypothalamus plays a central role in sensing and integrating nutritional, hormonal, and neural signals that regulate feeding, energy homeostasis, growth, and reproduction, all of which show pronounced sex differences.
Jonathan C. Bean, Jinjing Jian, Tzu-Chiao Lu, Hailan Liu, Kristine Conde, Darah A. Threat, Sanika V. Jossy, Megan E. Burt, Jingjing Cheng, Yue Deng, Xing Fang, Xiaoyu Geng, Junying Han, Yongxiang Li, Hesong Liu, Qingzhuo Liu, Yutian Liu, Yuhan Shi, Longlong Tu, Mengjie Wang, Xu Xu, Yuxue Yang, Meng Yu, Xinming Liu, Meixin Sun, Fuhui Wang, Olivia Z. Ginnard, Yongjie Yang, Yang He, Chunmei Wang, Yanyan Qi, Hongjie Li, Yong Xu   +32 more
doaj   +1 more source

Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress

Cell Reports, 2018
Summary: Compelling evidence has shown that, besides its putative effect on the regulation of the gonadal axis, estradiol (E2) exerts a dichotomic effect on the hypothalamus to regulate food intake and energy expenditure.
Ismael González-García, Cristina Contreras, Ánxela Estévez-Salguero, Francisco Ruíz-Pino, Benoit Colsh, Iván Pensado, Laura Liñares-Pose, Eva Rial-Pensado, Pablo B. Martínez de Morentin, Johan Fernø, Carlos Diéguez, Rubén Nogueiras, Hervé Le Stunff, Christophe Magnan, Manuel Tena-Sempere, Miguel López   +15 more
doaj   +1 more source

Hypothalamic Perineuronal Nets Are Regulated by Sex and Dietary Interventions

Frontiers in Physiology, 2021
Perineuronal nets (PNNs) are widely present in the hypothalamus, and are thought to provide physical protection and ion buffering for neurons and regulate their synaptic plasticity and intracellular signaling.
Nan Zhang, Nan Zhang, Nan Zhang, Zili Yan, Hailan Liu, Meng Yu, Yang He, Hesong Liu, Chen Liang, Longlong Tu, Lina Wang, Na Yin, Junying Han, Nikolas Scarcelli, Yongjie Yang, Chunmei Wang, Tianshu Zeng, Tianshu Zeng, Lu-Lu Chen, Lu-Lu Chen, Yong Xu, Yong Xu   +21 more
doaj   +1 more source

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source

The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system

, 2008
INTRODUCTION: Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation. The cannabinoid receptor type 1 (CB1)
Judith Harvey-White, Francesca Lolli, Farkas, I., Amin, F., Mirjam Christ-Crain, Kola, Blerina, Fekete, Csaba, George Kunos, Kola, B., Faisal Amin, A. B. Grossman, M. Korbonits, Blerina Kola, Liposits, Zsolt, G. Kunos, Ashley B Grossman, B. Kola, Amin, F, Gábor Wittmann, Kunos, George, Christ-Crain, M, Farkas, Imre, Lolli, F, Zsolt Liposits, Lolli, F., F. Amin, Farkas, I, Christ-Crain, M., Korbonits, M., I. Farkas, Grossman, AB, C. Fekete, Kola, B, Harvey-White, J., Wittmann, Gábor, Korbonits, Márta, G. Wittmann, Harvey-White, J, Fekete, C, Harvey-White, Judith, Márta Korbonits, Imre Farkas, Liposits, Z, Z. Liposits, Grossman, Ashley B., Ashley B. Grossman, Wittmann, G., Christ-Crain, Mirjam, Amin, Faisal, Lolli, Francesca, Liposits, Z., M. Christ Crain, J. Harvey White, Fekete, C., Korbonits, M, Kunos, G., Csaba Fekete, Grossman, A. B., Kunos, G, Wittmann, G   +59 more
core   +1 more source

Hypomorphic Expression of Pitx3 Disrupts Circadian Clocks and Prevents Metabolic Entrainment of Energy Expenditure

Cell Reports, 2019
Summary: Daily adaptation of metabolic activity to light-dark cycles to maintain homeostasis is controlled by hypothalamic nuclei receiving information from the retina and from nutritional inputs that vary according to feeding cycles.
Almudena del Río-Martín, Iara Pérez-Taboada, Antonio Fernández-Pérez, Rosario Moratalla, Pedro de la Villa, Mario Vallejo   +5 more
doaj   +1 more source

Melanocortin 4 Receptor and Dopamine D2 Receptor Expression in Brain Areas Involved in Food Intake [PDF]

Endocrinology and Metabolism, 2015
BackgroundThe melanocortin 4 receptor (MC4R) is involved in the regulation of homeostatic energy balance by the hypothalamus. Recent reports showed that MC4R can also control the motivation for food in association with a brain reward system, such as ...
Ye Ran Yoon, Ja-Hyun Baik
doaj   +1 more source

Syncing Health Timing: Exploring the Interplay of Circadian Rhythms, Obesity, and Cardiovascular Diseases

Food Safety and Health, EarlyView.
Circadian rhythm disruption impairs metabolic regulation, appetite control, and vascular function, promoting obesity and cardiovascular diseases. Evidence highlights a bidirectional relationship where metabolic disorders further disturb circadian timing.
Ghizal Fatima, István Dalmadi, Anna Jánosi, Krisztina Takács, Eszter Halmy   +4 more
wiley   +1 more source

Regulation of Feeding Behavior and Body Weight by Orexigenic Neurons in the Arcuate Nucleus

Journal of Obesity & Metabolic Syndrome
The arcuate nucleus of the hypothalamus is arguably the most important nucleus for regulating energy homeostasis and metabolism. Since its initial description in the human brain, its function in metabolic regulation has been studied extensively.
Yu Fu
doaj   +1 more source

Arcuate Nucleus-Dependent Regulation of Metabolism—Pathways to Obesity and Diabetes Mellitus

Endocrine reviews, 2021
The central nervous system (CNS) receives information from afferent neurons, circulating hormones, and absorbed nutrients and integrates this information to orchestrate the actions of the neuroendocrine and autonomic nervous systems in maintaining ...
A. Jais, J. Brüning
semanticscholar   +1 more source