Results 71 to 80 of about 23,715 (250)
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
Leptin Signaling in the Hypothalamus: Cellular Insights and Therapeutic Perspectives in Obesity
EndocrinesLeptin, an adipocyte-derived hormone, plays a central role in the regulation of energy homeostasis by acting on distinct hypothalamic nuclei. This review explores recent advances in our understanding of leptin’s region-specific actions within the arcuate
Milen Hristov
doaj +1 more source
Glial Glucokinase Expression in Adult and Post-Natal Development of the Hypothalamic Region
ASN Neuro, 2010 It has recently been proposed that hypothalamic glial cells sense glucose levels and release lactate as a signal to activate adjacent neurons. GK (glucokinase), the hexokinase involved in glucose sensing in pancreatic β-cells, is also expressed in the ...
Carola Millán +10 more
doaj +1 more source
Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleus
Molecular Metabolism, 2017 Objectives: Phytocannabinoids, such as THC and endocannabinoids, are well known to promote feeding behavior and to control energy metabolism through cannabinoid type 1 receptors (CB1R).
Yury M. Morozov +3 more
doaj +1 more source
Amylin analogues as a novel perspective in anti‐obesity therapy
British Journal of Pharmacology, EarlyView.Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus +7 more
wiley +1 more source
Integrating Neural Circuits Controlling Female Sexual Behavior
Frontiers in Systems Neuroscience, 2017 The hypothalamus is most often associated with innate behaviors such as is hunger, thirst and sex. While the expression of these behaviors important for survival of the individual or the species is nested within the hypothalamus, the desire (i.e ...
Paul E. Micevych +2 more
doaj +1 more source
Alterações na ingestão de alimento após a injeção de 8-OH-DPAT e MM-77 no núcleo arqueado do hipotálamo [PDF]
, 2012 Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em NeurociênciasEstudos em nosso laboratório mostraram que 8-hidroxi-2-(di-npropilamino)-tetralina (8-OH-DPAT) injetado no Núcleo ...
Felício, Daniela
core
Role of Flial Cells in the Arcuate Nucleus of the Hypothalamus in High-Fat Diet Consuming Mice
, 2022 Obesity is a complex condition involving the progressive excess of body fat that increases the risk of further health concerns. Consumption of high-fat diet leads to spontaneous and persistent activation of AgRP neurons in the arcuate nucleus of the ...
Samuel, Hunter
core
Immunization against active ghrelin using virus-like particles for obesity treatment. [PDF]
, 2013 Ghrelin is a gut hormone that stimulates food intake. In physiological conditions, ghrelin plasma levels rise with fasting and decrease after meals. Obese individuals have low fasting ghrelin levels that rise after food restriction, which is pointed out ...
Carreira, Marcos +6 more
core +1 more source