Results 71 to 80 of about 27,832 (229)

Novel hypophysiotropic AgRP2 neurons and pineal cells revealed by BAC transgenesis in zebrafish [PDF]

, 2017
The neuropeptide agouti-related protein (AgRP) is expressed in the arcuate nucleus of the mammalian hypothalamus and plays a key role in regulating food consumption and energy homeostasis.
Buchshtab, A, Cone, RD, Gothilf, Y, Hawkins, TA, Shainer, I, Wilson, SW   +5 more
core   +1 more source

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleus

Molecular Metabolism, 2017
Objectives: Phytocannabinoids, such as THC and endocannabinoids, are well known to promote feeding behavior and to control energy metabolism through cannabinoid type 1 receptors (CB1R).
Yury M. Morozov, Marco Koch, Pasko Rakic, Tamas L. Horvath   +3 more
doaj   +1 more source

Leptin Modulates the Intrinsic Excitability of AgRP/NPY Neurons in the Arcuate Nucleus of the Hypothalamus [PDF]

The Journal of Neuroscience, 2014
The hypothalamic arcuate nucleus (ARH) is a brain region critical for regulation of food intake and a primary area for the action of leptin in the CNS. In lean mice, the adipokine leptin inhibits neuropeptide Y (NPY) and agouti-related peptide (AgRP) neuronal activity, resulting in decreased food intake.
Scott B, Baver, Kevin, Hope, Shannon, Guyot, Christian, Bjørbaek, Catherine, Kaczorowski, Kristen M S, O'Connell   +5 more
openaire   +2 more sources

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Leptin Signaling in the Hypothalamus: Cellular Insights and Therapeutic Perspectives in Obesity

Endocrines
Leptin, an adipocyte-derived hormone, plays a central role in the regulation of energy homeostasis by acting on distinct hypothalamic nuclei. This review explores recent advances in our understanding of leptin’s region-specific actions within the arcuate
Milen Hristov
doaj   +1 more source

Glial Glucokinase Expression in Adult and Post-Natal Development of the Hypothalamic Region

ASN Neuro, 2010
It has recently been proposed that hypothalamic glial cells sense glucose levels and release lactate as a signal to activate adjacent neurons. GK (glucokinase), the hexokinase involved in glucose sensing in pancreatic β-cells, is also expressed in the ...
Carola Millán, Fernando Martínez, Christian Cortés-Campos, Isabel Lizama, Maria Jose Yañez, Paula Llanos, Karin Reinicke, Federico Rodríguez, Bruno Peruzzo, Francisco Nualart, Maria Angeles García   +10 more
doaj   +1 more source

Integrating Neural Circuits Controlling Female Sexual Behavior

Frontiers in Systems Neuroscience, 2017
The hypothalamus is most often associated with innate behaviors such as is hunger, thirst and sex. While the expression of these behaviors important for survival of the individual or the species is nested within the hypothalamus, the desire (i.e ...
Paul E. Micevych, Paul E. Micevych, Robert L. Meisel   +2 more
doaj   +1 more source

Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior [PDF]

, 2017
Glucokinase (GK), the hexokinase involved in glucosensing in pancreatic β-cells, is also expressed in arcuate nucleus (AN) neurons and hypothalamic tanycytes, the cells that surround the basal third ventricle (3V).
Barahona, María José, Elizondo Vega, Roberto, García Robles, María de los Ángeles, Martinez, Fernando, Millán, Carola, Ordenes, Patricio, Recabal, Antonia, Salgado, Magdiel, Sepúlveda, Fernando, Uranga, Romina Maria, Uribe, Elena   +10 more
core   +1 more source

FRI275 Glutamate Receptor Agonists Stimulate Kisspeptin Neurons In The Arcuate Nucleus Of The Hypothalamus

Journal of the Endocrine Society, 2023
Abstract Disclosure: R. Bearss: None. R. Piet: None. KNDy neurons co-express kisspeptin, neurokinin B (NKB), dynorphin A (Dyn A), and glutamate. These neurons, located in the arcuate nucleus of the hypothalamus, drive pulsatile gonadotropin releasing hormone (GnRH) secretion. This eventually promotes pulsatile gonadotropin
Bearss, Robin, Piet, Richard
openaire   +1 more source