Results 21 to 30 of about 366,068 (244)

Relative number and distribution of murine hypothalamic proopiomelanocortin neurons innervating distinct target sites. [PDF]

PLoS ONE, 2011
Proopiomelanocortin (POMC) neurons send projections widely throughout the brain consistent with their role in regulating numerous homeostatic processes and mediating analgesia and reward.
Connie M King, Shane T Hentges
doaj   +1 more source

Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice

Nature Communications, 2023
Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It requires estrogen to restrain kisspeptin (KISS1)-neuron pulsatility in the arcuate hypothalamic nucleus, while also exerting a surge-
Jose M. Ramos-Pittol, Isabel Fernandes-Freitas, Alexandra Milona, Stephen M. Manchishi, Kara Rainbow, Brian Y. H. Lam, John A. Tadross, Anthony Beucher, William H. Colledge, Inês Cebola, Kevin G. Murphy, Irene Miguel-Aliaga, Giles S. H. Yeo, Waljit S. Dhillo, Bryn M. Owen   +14 more
doaj   +1 more source

Downregulation of GRK6 in arcuate nucleus promotes chronic visceral hypersensitivity via NF-κB upregulation in adult rats with neonatal maternal deprivation

Molecular Pain, 2020
Aims The arcuate nucleus is a vital brain region for coursing of pain command. G protein-coupled kinase 6 (GRK6) accommodates signaling through G protein-coupled receptors.
Xin Li, Yu-Cheng Xu, Yuan-Qin Tian, Ping-An Zhang, Shu-Fen Hu, Lin-Hui Wang, Xing-Hong Jiang, Guang-Yin Xu   +7 more
doaj   +1 more source

Oxytocin signaling in the posterior hypothalamus prevents hyperphagic obesity in mice

eLife, 2022
Decades of studies have revealed molecular and neural circuit bases for body weight homeostasis. Neural hormone oxytocin (Oxt) has received attention in this context because it is produced by neurons in the paraventricular hypothalamic nucleus (PVH), a ...
Kengo Inada, Kazoku Tsujimoto, Masahide Yoshida, Katsuhiko Nishimori, Kazunari Miyamichi   +4 more
doaj   +1 more source

Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances [PDF]

, 2007
The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two of the five melanocortin receptors, MC3R and MC4R are involved in hypothalamic control of energy homeostasis, with the MC4R having the major influence. It is
Hisadome, Kazunari, Michael L. J. Ashford, Smith, Mark A., Helen Heffron, Mark A. Smith, Al-Qassab, Hind, Kazunari Hisadome, Withers, Dominic J., Hind Al‐Qassab, Dominic J. Withers, Ashford, Michael L. J.; id_orcid, Heffron, Helen   +11 more
core   +1 more source

Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man. [PDF]

, 2012
Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in
Herczeg, László, Sipos, Máté T., Molnár, Csilla S., Vida, Barbara, Borsay, Beáta Á., Dhillo, Waljit S., Liposits, Zsolt, Hrabovszky, Erik, Rácz, Kálmán, Bloom, Stephen R., Ghatei, Mohammad A., Ciofi, Philippe   +11 more
core   +1 more source

The balance of pressor and depressor substances in the neurons of arcuate nucleus of hypothalamus in etiologically different arterial hypertension

Journal of Education, Health and Sport, 2019
It has been proved that arterial hypertension is not associated exclusively with an increase in vascular tone but also with a complex of pathological processes that results in cardiovascular pathology and lesions of the target organs.
S. V. Tishchenko
doaj   +3 more sources

Short photoperiod-induced decrease of histamine H3 receptors facilitates activation of hypothalamic neurons in the Siberian Hamster [PDF]

, 2009
Nonhibernating seasonal mammals have adapted to temporal changes in food availability through behavioral and physiological mechanisms to store food and energy during times of predictable plenty and conserve energy during predicted shortage.
Bartness, Timothy J., Barrett, Perry, van den Top, Marco, Spanswick, David C., Wilson, D., Mercer, Julian G., Morgan, Peter J., Song, C. K.   +7 more
core   +1 more source

Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis [PDF]

, 2018
Aims Glucokinase (GK) serves as a glucose sensor in several tissues including glucose‐sensitive neurons of the arcuate nucleus within the hypothalamus.
Ma, Yue, Marie-Sophie Nguyen-Tu, Holton, C, Gardiner, James, Schwappach, B, Sufyan Hussain, Errol Richardson, Gaelle Carrat, Guy A. Rutter, Nguyen-Tu, M-S, Ratnasabapathy, Risheka, Carrat, G, Norton, M, Izzi-Engbeaya, Chioma, Schwappach, Blanche, Risheka Ratnasabapathy, De, Backer I, Waljit S. Dhillo, Holton, Christopher, Carrat, Gaelle, Richardson, E, Rutter, G, Ratnasabapathy, R, Dhillo, W, Hussain, S; id_orcid, Hussain, S, De Backer, ivan, Dhillo, Waljit S., Hussain, Sufyan, Gardiner, JV, Nguyen-Tu, Marie-Sophie, James Gardiner, Rutter, Guy A., Norton, mariana, Blanche Schwappach, Chioma Izzi-Engbeaya, Yue Ma, Izzi-Engbeaya, CN, Richardson, errol, Ivan De Backer, Ma, Yua, Mariana Norton, Christopher Holton   +42 more
core   +1 more source

Glucokinase activity in the arcuate nucleus regulates glucose intake [PDF]

, 2014
The brain relies on a constant supply of glucose, its primary fuel, for optimal function. A taste-independent mechanism within the CNS that promotes glucose delivery to the brain has been postulated to maintain glucose homeostasis; however, evidence for ...
Niki Buckley, Ma, Yue, Holton, C, Buckley, N, Gardiner, James, Bewick, G, Errol Richardson, Hussain, Syed, Steve Bloom, Gardiner, J, Dhillo, Waljit, De Backer, I, Richardson, Errol, David Carling, Ma, Y, Holton, Christopher, Richardson, E, Bloom, Steve, Carling, D, Dhillo, W, Syed Hussain, Hussain, S, Zhang, S, Waljit Dhillo, Zhang, Shuai, James Gardiner, Buckley, Niki, Yue Ma, De Backer, Ivan, Shuai Zhang, Carling, David, Bloom, S, Ivan De Backer, Gavin Bewick, Bewick, Gavin; id_orcid, Christopher Holton   +35 more
core   +1 more source