Results 51 to 60 of about 24,202 (294)

Magel2 is required for leptin-mediated depolarization of POMC neurons in the hypothalamic arcuate nucleus in mice.

PLoS Genetics, 2013
Prader-Willi Syndrome is the most common syndromic form of human obesity and is caused by the loss of function of several genes, including MAGEL2. Mice lacking Magel2 display increased weight gain with excess adiposity and other defects suggestive of ...
Rebecca E Mercer, Sheldon D Michaelson, Melissa J S Chee, Tanya A Atallah, Rachel Wevrick, William F Colmers   +5 more
doaj   +1 more source

Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes

eLife, 2022
Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus are essential to regulate food intake and energy balance. However, the ontogenetic transcriptional programs that specify the identity and functioning of these neurons are poorly ...
Hui Yu, Marcelo Rubinstein, Malcolm J Low   +2 more
doaj   +1 more source

In Situ Micromechanical Study of Bimodal γ′–γ″ Precipitate Assemblies in Ni–Cr–Al–Nb Superalloy

Advanced Engineering Materials, EarlyView.
A Ni–Cr–Al–Nb superalloy with a bimodal γ′–γ″ precipitate distribution is developed. Composite precipitate assemblies form through heterogeneous nucleation, effectively impeding dislocation motion. Micropillar compression reveals high strength at room and elevated temperatures, governed by precipitate shearing, with coupled faulting mechanisms ...
Ujjval Bansal, Tae‐Hyeok Kang, Pyuck‐Pa Choi, Subin Lee, Christoph Kirchlechner   +4 more
wiley   +1 more source

Sex-specific differences in mediobasal hypothalamus in response to nutritional states

Nature Communications
The arcuate nucleus of the hypothalamus plays a central role in sensing and integrating nutritional, hormonal, and neural signals that regulate feeding, energy homeostasis, growth, and reproduction, all of which show pronounced sex differences.
Jonathan C. Bean, Jinjing Jian, Tzu-Chiao Lu, Hailan Liu, Kristine Conde, Darah A. Threat, Sanika V. Jossy, Megan E. Burt, Jingjing Cheng, Yue Deng, Xing Fang, Xiaoyu Geng, Junying Han, Yongxiang Li, Hesong Liu, Qingzhuo Liu, Yutian Liu, Yuhan Shi, Longlong Tu, Mengjie Wang, Xu Xu, Yuxue Yang, Meng Yu, Xinming Liu, Meixin Sun, Fuhui Wang, Olivia Z. Ginnard, Yongjie Yang, Yang He, Chunmei Wang, Yanyan Qi, Hongjie Li, Yong Xu   +32 more
doaj   +1 more source

Developmental Switch of Leptin Signaling in Arcuate Nucleus Neurons [PDF]

Journal of Neuroscience, 2014
Leptin is well known for its role in the regulation of energy homeostasis in adults, a mechanism that at least partially results from the inhibition of the activity of NPY/AgRP/GABA neurons (NAG) in the arcuate nucleus of the hypothalamus (ARH). During early postnatal development in the rodent, leptin promotes axonal outgrowth from ARH neurons, and ...
Arian F, Baquero, Alain J, de Solis, Sarah R, Lindsley, Melissa A, Kirigiti, M Susan, Smith, Michael A, Cowley, Lori M, Zeltser, Kevin L, Grove   +7 more
openaire   +2 more sources

Encyclopedia of 2D β′‐In2Se3 Growth Using Chemical Vapor Deposition: The Effects of Synthesis Parameters Onto Material Quality

Advanced Engineering Materials, EarlyView.
A distinct semi‐confined inner‐tube chemical vapor deposition geometry enables reproducible, large‐area growth of phase‐pure 2D β′‐In2Se3 from InI + Se precursors. Engineering local vapor transport and optimizing precursor delivery and temperature–time conditions yield uniform continuous films.
Dasun P. W. Guruge, P. Sanju S. Panawala, Joseph F. S. Fernando, Zhenhuan Chen, Chao Zhang, Dong‐Chen Qi, Liangzhi Kou, Konstantin L. Firestein, Dmitri V. Golberg   +8 more
wiley   +1 more source

MCT2 is expressed in arcuate nucleus neurons.

, 2013
(a–c) Low magnification analysis of the basal hypothalamic area using anti-vimentin (a, orange), anti-GFAP (b, red) anti-MCT2 (c, green) antibodies. TOPRO-3 was used as nuclear stain (blue).
Claudio Carril (407760), Christian Cortes-Campos (5654713), Roberto Elizondo (231547), Fernando Martínez (2485834), Katica Boric (407761), Maria Angeles Garcia-Robles (407762), Francisco Nualart (231550)   +6 more
core   +1 more source

Adverse effects of prenatal tobacco smoke exposure on biological parameters of the developing brainstem

Neurobiology of Disease, 2005
We aimed to study the consequences of chronic exposure to tobacco smoke in utero on the morphological and functional maturation of the brainstem by comparing stillbirths of smoker mothers versus nonsmoker mothers.
Anna Maria Lavezzi, Giulia Ottaviani, Luigi Matturri   +2 more
doaj   +1 more source

Role of the hypothalamic arcuate nucleus in cardiovascular regulation [PDF]

Autonomic Neuroscience, 2013
Recently the hypothalamic arcuate nucleus (Arc) has been implicated in cardiovascular regulation. Both pressor and depressor responses can be elicited by the chemical stimulation of the Arc. The direction of cardiovascular responses (increase or decrease) elicited from the Arc depends on the baseline blood pressure.
openaire   +2 more sources

Ultrasmall High‐Entropy Materials: Nanoscale Effects, Synthesis, and Mechanistic Insights

Advanced Functional Materials, EarlyView.
This review article focuses on sub‐10 nm high‐entropy materials that combine nanoscale design with complex compositions for next‐generation applications. ABSTRACT Ultrasmall high‐entropy nanomaterials (USHENMs, <10 nm) merge multicomponent chemistry with size‐dependent effects, forming a distinct class of materials with unprecedented properties.
Yueyue He, Wenbo Wang, Simon Schweidler, Yanjiao Ma, Ben Breitung, Torsten Brezesinski   +5 more
wiley   +1 more source