Results 1 to 10 of about 10,743 (219)

Differential expression of POMC-processing genes in corticotroph tumors [PDF]

Endocrine Oncology
Objective: Corticotroph tumors (CTs) derive from the TBX19 lineage and are functioning (FCTs) or nonfunctioning (NFCTs). In FCTs, the main pathogenic variants are found in USP8, enhancing proopiomelanocortin (POMC) transcription through epidermal growth ...
Elisa Lamback, Renan L Miranda, Laryssa Mendonça, Camila S de Figueiredo, Kaio C R Salum, Rômulo S Dezonne, Luiz Eduardo Wildemberg, Mônica R Gadelha   +7 more
doaj   +2 more sources

Genistein during Development Alters Differentially the Expression of POMC in Male and Female Rats

Metabolites, 2021
Phytoestrogens are considered beneficial for health, but some studies have shown that they may cause adverse effects. This study investigated the effects of genistein administration during the second week of life on energy metabolism and on the circuits ...
Jose Manuel Fernandez-Garcia, Beatriz Carrillo, Patricia Tezanos, Paloma Collado, Helena Pinos   +4 more
doaj   +1 more source

Non-Canonical Effects of ACTH: Insights Into Adrenal Insufficiency

Frontiers in Endocrinology, 2021
IntroductionAdrenocorticotropic hormone (ACTH) is produced from proopiomelanocortin, which is predominantly synthetized in the corticotroph and melanotroph cells of the anterior and intermediate lobes of the pituitary gland and the arcuate nucleus of the
Valeria Hasenmajer, Ilaria Bonaventura, Marianna Minnetti, Valentina Sada, Emilia Sbardella, Andrea M. Isidori   +5 more
doaj   +1 more source

Leukemia Inhibitory Factor Induces Proopiomelanocortin via CRH/CRHR Pathway in Mouse Trophoblast

Frontiers in Cell and Developmental Biology, 2021
We previously showed that maternal leukemia inhibitory factor (LIF) induces placental production of adrenocorticotropic hormone (ACTH), which stimulates fetal nucleated red blood cells to further secrete LIF and promote neurogenesis in rodent brains ...
He Wang, He Wang, Hiromi Sakata-Haga, Hiroko Masuta, Mitsuhiro Tomosugi, Tsuyoshi Tsukada, Hiroki Shimada, Daisuke Sakai, Hiroki Shoji, Toshihisa Hatta   +9 more
doaj   +1 more source

Hypothalamic CREB Regulates the Expression of Pomc-Processing Enzyme Pcsk2

Cells, 2022
Background: The hypothalamic proopiomelanocortin (Pomc) neurons act as first-order sensors of systemic energy stores, providing signals that regulate caloric intake and energy expenditure.
Ariane Maria Zanesco, Natalia F. Mendes, Daiane F. Engel, Rodrigo S. Gaspar, Davi Sidarta-Oliveira, José Donato, Licio A. Velloso   +6 more
doaj   +1 more source

Two Cases With an Early Presented Proopiomelanocortin Deficiency—A Long-Term Follow-Up and Systematic Literature Review

Frontiers in Endocrinology, 2021
Proopiomelanocortin (POMC) deficiency is an extremely rare inherited autosomal recessive disorder characterized by severe obesity, adrenal insufficiency, skin hypopigmentation, and red hair. It is caused by pathogenic variants in the POMC gene that codes
Nadan Gregoric, Nadan Gregoric, Urh Groselj, Urh Groselj, Natasa Bratina, Natasa Bratina, Marusa Debeljak, Marusa Debeljak, Mojca Zerjav Tansek, Mojca Zerjav Tansek, Jasna Suput Omladic, Jasna Suput Omladic, Jernej Kovac, Tadej Battelino, Tadej Battelino, Primoz Kotnik, Primoz Kotnik, Magdalena Avbelj Stefanija, Magdalena Avbelj Stefanija   +18 more
doaj   +1 more source

Anti-Obesity Effect of Pine Needle Extract on High-Fat Diet-Induced Obese Mice

Plants, 2021
Background: Obesity due to an excessive intake of nutrient disturbs the hypothalamus-mediated energy metabolism subsequently develops metabolic disorders.
Eun A. Kim, Ju-Hwan Yang, Eun-Hye Byeon, Woong Kim, Dawon Kang, Jaehee Han, Seong-Geun Hong, Deok-Ryong Kim, Sang-Je Park, Jae-Won Huh, Hyeonsook Cheong, Seung-Pil Yun, Dong-Kun Lee   +12 more
doaj   +1 more source

β‐endorphin differentially contributes to food anticipatory activity in male and female mice undergoing activity‐based anorexia

Physiological Reports, 2021
Anorexia nervosa (AN) has a lifetime prevalence of up to 4% and a high mortality rate (~5–10%), yet little is known regarding the etiology of this disease.
Caitlin M. Daimon, Shane T. Hentges
doaj   +1 more source

Effects of Dietary Calcium Propionate Supplementation on Hypothalamic Neuropeptide Messenger RNA Expression and Growth Performance in Finishing Rambouillet Lambs

Life, 2021
The objective of this experiment was to evaluate the effects of feeding different levels concentrations of dietary calcium propionate (CaPr) on lambs’ growth performance; ruminal fermentation parameters; glucose–insulin concentration; and hypothalamic ...
Oswaldo Cifuentes-Lopez, Héctor A. Lee-Rangel, German D. Mendoza, Pablo Delgado-Sanchez, Luz Guerrero-Gonzalez, Alfonso Chay-Canul, Juan Manuel Pinos-Rodriguez, Rogelio Flores-Ramírez, José Alejandro Roque-Jiménez, Alejandro E. Relling   +9 more
doaj   +1 more source

Ghrelin and the central regulation of feeding and energy balance

Indian Journal of Endocrinology and Metabolism, 2012
Ghrelin was discovered in 1999 as growth hormone secretagouge released from the gut. Soon after it was recognized that ghrelin is a fundamental driver of appetite in rodents and humans and that its mode of action requires alteration of hypothalamic ...
Alfonso Abizaid, Tamas L Horvath
doaj   +1 more source