Two Cases With an Early Presented Proopiomelanocortin Deficiency—A Long-Term Follow-Up and Systematic Literature Review [PDF]
Frontiers in Endocrinology, 2021 Proopiomelanocortin (POMC) deficiency is an extremely rare inherited autosomal recessive disorder characterized by severe obesity, adrenal insufficiency, skin hypopigmentation, and red hair. It is caused by pathogenic variants in the POMC gene that codes
Nadan Gregoric +18 more
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Molecular evolution of the proopiomelanocortin system in Barn owl species.
PLoS ONE, 2020 Examination of genetic polymorphisms in outbred wild-living species provides insights into the evolution of complex systems. In higher vertebrates, the proopiomelanocortin (POMC) precursor gives rise to α-, β-, and γ-melanocyte-stimulating hormones (MSH),
Karin Löw +8 more
doaj +3 more sources
The Cell Adhesion Activity of the Joining Peptide of Proopiomelanocortin [PDF]
Molecules, 2023 Proopiomelanocortin (POMC) is a precursor protein of several peptide hormones, such as ACTH and β-endorphin. Almost all of the peptide hormones in POMC have been drastically investigated in terms of their biological activities.
Kyona Hiroshima +4 more
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Unraveling the Central Proopiomelanocortin Neural Circuits
Frontiers in Neuroscience, 2013 Central proopiomelanocortin (POMC) neurons form a potent anorexigenic network, but our understanding of the integration of this hypothalamic circuit throughout the central nervous system (CNS) remains incomplete. POMC neurons extend projections along the
Aaron J Mercer +2 more
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ASSOCIATION BETWEEN PROOPIOMELANOCORTIN GENE VARIATION AND ALCOHOL DEPENDENCE IN JAPANESE [PDF]
Int J NeuropsychopharmacolShinya Kasai +3 more
europepmc +3 more sources
Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation [PDF]
BMC Neuroscience, 2011 Background The arcuate nucleus of the hypothalamus regulates food intake. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) is expressed in neuropeptide Y and proopiomelanocortin (POMC) neurons in the arcuate nucleus, target neurons in the ...
Xia Zefeng +8 more
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Genistein during Development Alters Differentially the Expression of POMC in Male and Female Rats
Metabolites, 2021 Phytoestrogens are considered beneficial for health, but some studies have shown that they may cause adverse effects. This study investigated the effects of genistein administration during the second week of life on energy metabolism and on the circuits ...
Jose Manuel Fernandez-Garcia +4 more
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Non-Canonical Effects of ACTH: Insights Into Adrenal Insufficiency
Frontiers in Endocrinology, 2021 IntroductionAdrenocorticotropic hormone (ACTH) is produced from proopiomelanocortin, which is predominantly synthetized in the corticotroph and melanotroph cells of the anterior and intermediate lobes of the pituitary gland and the arcuate nucleus of the
Valeria Hasenmajer +5 more
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Leukemia Inhibitory Factor Induces Proopiomelanocortin via CRH/CRHR Pathway in Mouse Trophoblast
Frontiers in Cell and Developmental Biology, 2021 We previously showed that maternal leukemia inhibitory factor (LIF) induces placental production of adrenocorticotropic hormone (ACTH), which stimulates fetal nucleated red blood cells to further secrete LIF and promote neurogenesis in rodent brains ...
He Wang +9 more
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Hypothalamic CREB Regulates the Expression of Pomc-Processing Enzyme Pcsk2
Cells, 2022 Background: The hypothalamic proopiomelanocortin (Pomc) neurons act as first-order sensors of systemic energy stores, providing signals that regulate caloric intake and energy expenditure.
Ariane Maria Zanesco +6 more
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