Results 11 to 20 of about 11,890 (215)

Posttranslational modifications of proopiomelanocortin in vertebrates and their biological significance [PDF]

Frontiers in Endocrinology, 2013
Proopiomelanocortin (POMC) is the precursor of several peptide hormones generated in the pituitary gland. After biosynthesis, POMC undergoes several posttranslational modifications, including proteolytic cleavage, acetylation, amidation, phosphorylation,
Akiyoshi eTakahashi, Kanta eMizusawa
doaj   +5 more sources

Proopiomelanocortin (POMC) and psychodermatology

Skin Health and Disease, 2023
Psychodermatology is the crossover discipline between Dermatology and Clinical Psychology and/or Psychiatry. It encompasses both Psychiatric diseases that present with cutaneous manifestations (such as delusional infestation) or more commonly, the ...
George W. M. Millington, Hannah E. Palmer   +1 more
doaj   +3 more sources

Evolution of proopiomelanocortin

, 2019
Proopiomelanocortin (POMC) belongs to the opioid/orphanin gene family whose peptide precursors include either opioid (YGGF) or the orphanin/nociceptin core sequences (FGGF). In addition to POMC the family includes the proenkephalin (PENK), prodynorphin (PDYN), and nociceptin/proorphanin (PNOC) precursors.
Rocha, Ana, Godino Gimeno, Alejandra, Cerdá-Reverter, José Miguel   +2 more
openaire   +4 more sources

One-month of high-intensity exercise did not change the food intake and the hypothalamic arcuate nucleus proopiomelanocortin and neuropeptide Y expression levels in male Wistar rats

Endocrine Regulations, 2019
Objective. The hypothalamic arcuate nucleus proopiomelanocortin (POMC) and neuropeptide Y (NPY) circuitries are involved in the inhibition and stimulation of the appetite, respectively.
Khajehnasiri Nazli, Khazali Homayoun, Sheikhzadeh Farzam, Ghowsi Mahnaz   +3 more
doaj   +2 more sources

Unraveling the central proopiomelanocortin neural circuits [PDF]

Frontiers in Neuroscience, 2013
Central proopiomelanocortin (POMC) neurons form a potent anorexigenic network, but our understanding of the integration of this hypothalamic circuit throughout the central nervous system (CNS) remains incomplete. POMC neurons extend projections along the
Aaron J. Mercer, Shane T. Hentges, Charles K. Meshul, Charles K. Meshul, Malcolm J. Low, Malcolm J. Low   +5 more
doaj   +3 more sources

Pituitary Proopiomelanocortin Peptides in Mental Disorders

, 1986
Publisher Summary Proopiomelanocortin (POMC) is a long-chain pituitary peptide (PP), the secretion of which is controlled by hypothalamic corticotropin-releasing factor (CRF). POMC is cleaved in the anterior pituitary (AP) into various fragments, including ACTH, β-lipotropin (β-LPH) and β-endorphin (β-E), which under physiological conditions are ...
F. Brambilla, F. Petraglia, FACCHINETTI, Fabio, M. Maggioni, A. R. Genazzani   +4 more
openaire   +8 more sources

Proopiomelanocortin Gene Product Regulation in Keratinocytes

Journal of Investigative Dermatology, 1996
Proopiomelanocortin (POMC) is the precursor for adrenocorticotropic hormone, melanocyte-stimulating hormones, beta-lipotropic hormone (beta LPH), and beta endorphin. These peptides can function as neurotransmitters, modulate immune responses, and affect melanogenesis. We investigated POMC expression and protein processing in normal human keratinocytes.
Wintzen, Marjolein, Yaar, Mina, Burbach, J. Peter H., Gilchrest, Barbara A.   +3 more
openaire   +3 more sources

Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]

, 2013
Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Nunez, Cristina, Edina Zelei, M Victoria Milanés, Polyák, Ágnes, Zelei, Edina, Agnes Polyák, Krisztina J Kovács, Kovács, Krisztina J., Cristina Núnez, Milanes, Victoria M., Pintér-Kübler, Bernadett, Ferenczi, Szilamér, Bernadett Pintér-Kübler, Szilamér Ferenczi   +13 more
core   +3 more sources

Proopiomelanocortin (POMC)–β‐Endorphin System in the Rat Colon: Expression, Up Regulation by Stress, and Correlation With Stress‐Induced Visceral Analgesia [PDF]

Neurogastroenterol Motil
This study identified a functional proopiomelanocortin–β‐endorphin system in the rat colon. Peripheral CRF and repeated water avoidance stress increased colonic POMC expression, which was associated with reduced visceral pain. These findings suggest that, outside the pituitary, a CRF‐ and stress‐sensitive enteric POMC–β‐endorphin system may help ...
Yuan P, Larauche M, Wu V, Taché Y.
europepmc   +2 more sources

Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency

Molecular Metabolism, 2021
Objective: Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus are essential regulators of energy balance. Selective loss of POMC production in these cells results in extreme obesity and metabolic comorbidities.
Surbhi, Gábor Wittmann, Malcolm J. Low, Ronald M. Lechan   +3 more
doaj   +1 more source