Results 11 to 20 of about 10,743 (219)

Posttranslational modifications of proopiomelanocortin in vertebrates and their biological significance [PDF]

Frontiers in Endocrinology, 2013
Proopiomelanocortin (POMC) is the precursor of several peptide hormones generated in the pituitary gland. After biosynthesis, POMC undergoes several posttranslational modifications, including proteolytic cleavage, acetylation, amidation, phosphorylation,
Akiyoshi eTakahashi, Kanta eMizusawa
doaj   +4 more sources

Proopiomelanocortin (POMC) and psychodermatology

Skin Health and Disease, 2023
Psychodermatology is the crossover discipline between Dermatology and Clinical Psychology and/or Psychiatry. It encompasses both Psychiatric diseases that present with cutaneous manifestations (such as delusional infestation) or more commonly, the ...
George W. M. Millington, Hannah E. Palmer   +1 more
doaj   +3 more sources

Evolution of proopiomelanocortin

, 2019
Proopiomelanocortin (POMC) belongs to the opioid/orphanin gene family whose peptide precursors include either opioid (YGGF) or the orphanin/nociceptin core sequences (FGGF). In addition to POMC the family includes the proenkephalin (PENK), prodynorphin (PDYN), and nociceptin/proorphanin (PNOC) precursors.
Rocha, Ana, Godino Gimeno, Alejandra, Cerdá-Reverter, José Miguel   +2 more
openaire   +4 more sources

Disregulation of proopiomelanocortin and contagious maladaptive behavior [PDF]

Regulatory Peptides, 2002
Self-injurious behavior (SIB) is an untreatable and often life-threatening problem among individuals with developmental disorders, especially those diagnosed with autism. Functioning, relationships and processing of the proopiomelanocortin (POMC) system are "uncoupled" in subgroups of self-injuring individuals resulting in different ratios of ACTH and ...
Sandman, Curt A, Touchette, Paul, Marion, Sarah, Lenjavi, Mohammed, Chicz-Demet, Aleksandra   +4 more
openaire   +6 more sources

Unraveling the central proopiomelanocortin neural circuits [PDF]

Frontiers in Neuroscience, 2013
Central proopiomelanocortin (POMC) neurons form a potent anorexigenic network, but our understanding of the integration of this hypothalamic circuit throughout the central nervous system (CNS) remains incomplete. POMC neurons extend projections along the
Aaron J. Mercer, Shane T. Hentges, Charles K. Meshul, Charles K. Meshul, Malcolm J. Low, Malcolm J. Low   +5 more
doaj   +3 more sources

The Cell Adhesion Activity of the Joining Peptide of Proopiomelanocortin

Molecules, 2023
Proopiomelanocortin (POMC) is a precursor protein of several peptide hormones, such as ACTH and β-endorphin. Almost all of the peptide hormones in POMC have been drastically investigated in terms of their biological activities.
Kyona Hiroshima, Nana Sakata, Tadafumi Konogami, Shigeru Shimamoto, Yuji Hidaka   +4 more
doaj   +2 more sources

Proopiomelanocortin Gene Product Regulation in Keratinocytes

Journal of Investigative Dermatology, 1996
Proopiomelanocortin (POMC) is the precursor for adrenocorticotropic hormone, melanocyte-stimulating hormones, beta-lipotropic hormone (beta LPH), and beta endorphin. These peptides can function as neurotransmitters, modulate immune responses, and affect melanogenesis. We investigated POMC expression and protein processing in normal human keratinocytes.
Wintzen, Marjolein, Yaar, Mina, Burbach, J. Peter H., Gilchrest, Barbara A.   +3 more
openaire   +3 more sources

One-month of high-intensity exercise did not change the food intake and the hypothalamic arcuate nucleus proopiomelanocortin and neuropeptide Y expression levels in male Wistar rats

Endocrine Regulations, 2019
Objective. The hypothalamic arcuate nucleus proopiomelanocortin (POMC) and neuropeptide Y (NPY) circuitries are involved in the inhibition and stimulation of the appetite, respectively.
Khajehnasiri Nazli, Khazali Homayoun, Sheikhzadeh Farzam, Ghowsi Mahnaz   +3 more
doaj   +2 more sources

Pituitary Proopiomelanocortin Peptides in Mental Disorders

, 1986
Publisher Summary Proopiomelanocortin (POMC) is a long-chain pituitary peptide (PP), the secretion of which is controlled by hypothalamic corticotropin-releasing factor (CRF). POMC is cleaved in the anterior pituitary (AP) into various fragments, including ACTH, β-lipotropin (β-LPH) and β-endorphin (β-E), which under physiological conditions are ...
F. Brambilla, F. Petraglia, FACCHINETTI, Fabio, M. Maggioni, A. R. Genazzani   +4 more
openaire   +8 more sources

The role of proopiomelanocortin (POMC) neurones in feeding behaviour [PDF]

Nutrition & Metabolism, 2007
The precursor protein, proopiomelanocortin (POMC), produces many biologically active peptides via a series of enzymatic steps in a tissue-specific manner, yielding the melanocyte-stimulating hormones (MSHs), corticotrophin (ACTH) and β-endorphin.
Millington George WM
doaj   +2 more sources