The role of pro-opiomelanocortin in the ACTH–cortisol dissociation of sepsis [PDF]
Critical Care, 2021 Background Sepsis is typically hallmarked by high plasma (free) cortisol and suppressed cortisol breakdown, while plasma adrenocorticotropic hormone (ACTH) is not increased, referred to as ‘ACTH–cortisol dissociation.’ We hypothesized that sepsis acutely
Arno Téblick +6 more
doaj +3 more sources
Knockout of inositol-requiring enzyme 1α in pro-opiomelanocortin neurons decreases fat mass via increasing energy expenditure [PDF]
Open Biology, 2016 Although numerous functions of inositol-requiring enzyme 1α (IRE1α) have been identified, a role of IRE1α in pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus is largely unknown.
Yuzhong Xiao, Tingting Xia, Junjie Yu
exaly +4 more sources
Neurochemical Characterization of Brainstem Pro-Opiomelanocortin Cells. [PDF]
Endocrinology, 2020 Genetic research has revealed pro-opiomelanocortin (POMC) to be a fundamental regulator of energy balance and body weight in mammals. Within the brain, POMC is primarily expressed in the arcuate nucleus of the hypothalamus (ARC), while a smaller ...
Georgescu T +11 more
europepmc +6 more sources
Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling [PDF]
Molecular Metabolism, 2020 Objective: Sirt6 is an essential regulator of energy metabolism in multiple peripheral tissues. However, the direct role of Sirt6 in the hypothalamus, specifically pro-opiomelanocortin (POMC) neurons, controlling energy balance has not been established ...
Qin Tang +18 more
doaj +3 more sources
Nuclear Receptors as Regulators of Pituitary Corticotroph Pro-Opiomelanocortin Transcription [PDF]
Cells, 2020 The hypothalamic–pituitary–adrenal (HPA) axis plays a critical role in adaptive stress responses and maintaining organism homeostasis. The pituitary corticotroph is the central player in the HPA axis and is regulated by a plethora of hormonal and stress ...
Dongyun Zhang, Anthony P. Heaney
doaj +3 more sources
Pro-opiomelanocortin (POMC) neuron translatome signatures underlying obesogenic gestational malprogramming in mice [PDF]
Molecular Metabolism, 2020 Objective: Maternal unbalanced nutritional habits during embryonic development and perinatal stages perturb hypothalamic neuronal programming of the offspring, thus increasing obesity-associated diabetes risk. However, the underlying molecular mechanisms
Roberta Haddad-Tóvolli +11 more
doaj +3 more sources
Hypothalamic Expression of Neuropeptide Y (NPY) and Pro-OpioMelanoCortin (POMC) in Adult Male Mice Is Affected by Chronic Exposure to Endocrine Disruptors [PDF]
Metabolites, 2021 In the arcuate nucleus, neuropeptide Y (NPY) neurons, increase food intake and decrease energy expenditure, and control the activity of pro-opiomelanocortin (POMC) neurons, that decrease food intake and increase energy expenditure.
Marilena Marraudino +8 more
doaj +3 more sources
Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons [PDF]
eLife, 2017 POMC neurons integrate metabolic signals from the periphery. Here, we show in mice that food deprivation induces a linear current-voltage relationship of AMPAR-mediated excitatory postsynaptic currents (EPSCs) in POMC neurons.
Shigetomo Suyama +9 more
doaj +3 more sources
Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing [PDF]
Molecular Metabolism, 2017 Objective: Arcuate proopiomelanocortin (POMC) neurons are critical nodes in the control of body weight. Often characterized simply as direct targets for leptin, recent data suggest a more complex architecture.
Brian Y.H. Lam +14 more
doaj +3 more sources
Activation of Brainstem Pro-opiomelanocortin Neurons Produces Opioidergic Analgesia, Bradycardia and Bradypnoea. [PDF]
PLoS ONE, 2016 Opioids are widely used medicinally as analgesics and abused for hedonic effects, actions that are each complicated by substantial risks such as cardiorespiratory depression.
Serena Cerritelli +4 more
doaj +3 more sources