Nuclear Receptors as Regulators of Pituitary Corticotroph Pro-Opiomelanocortin Transcription [PDF]
Cells, 2020 The hypothalamic–pituitary–adrenal (HPA) axis plays a critical role in adaptive stress responses and maintaining organism homeostasis. The pituitary corticotroph is the central player in the HPA axis and is regulated by a plethora of hormonal and stress ...
Anthony Heaney +2 more
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Hypothalamic Expression of Neuropeptide Y (NPY) and Pro-OpioMelanoCortin (POMC) in Adult Male Mice Is Affected by Chronic Exposure to Endocrine Disruptors [PDF]
Metabolites, 2021 In the arcuate nucleus, neuropeptide Y (NPY) neurons, increase food intake and decrease energy expenditure, and control the activity of pro-opiomelanocortin (POMC) neurons, that decrease food intake and increase energy expenditure.
Marilena Marraudino +2 more
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Knockout of inositol-requiring enzyme 1α in pro-opiomelanocortin neurons decreases fat mass via increasing energy expenditure [PDF]
Open Biology, 2016 Although numerous functions of inositol-requiring enzyme 1α (IRE1α) have been identified, a role of IRE1α in pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus is largely unknown.
Feifan Guo, Feifan Guo, Yuzhong Xiao
exaly +3 more sources
Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression [PDF]
iScience, 2023 Summary: Hypothalamic pro-opiomelanocortin (POMC) neuron development is considered to play an essential role in the development of obesity. However, the underlying mechanisms remain unclear.
Chenyang Lu +7 more
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The role of pro-opiomelanocortin in the ACTH–cortisol dissociation of sepsis [PDF]
Critical Care, 2021 Background Sepsis is typically hallmarked by high plasma (free) cortisol and suppressed cortisol breakdown, while plasma adrenocorticotropic hormone (ACTH) is not increased, referred to as ‘ACTH–cortisol dissociation.’ We hypothesized that sepsis acutely
Arno Téblick +6 more
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Pro-Opiomelanocortin and Melanocortin Receptor 3 and 4 Mutations in Genetic Obesity [PDF]
BiomoleculesGenetic obesity results from loss-of-function mutations, including those affecting the leptin–melanocortin system, which regulates body weight. Pro-opiomelanocortin (POMC)-derived neurohormones act as ligands for melanocortin receptors (MCRs), regulating
Tulin Yanik, Seyda Tugce Durhan
doaj +2 more sources
Pro-opiomelanocortin and ACTH–cortisol dissociation during pediatric cardiac surgery [PDF]
Endocrine ConnectionsIn critically ill adults, high plasma cortisol in the face of low ACTH coincides with high pro-opiomelanocortin (POMC) levels. Glucocorticoids further lower ACTH without affecting POMC.
Arno Téblick +9 more
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Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling [PDF]
Molecular Metabolism, 2020 Objective: Sirt6 is an essential regulator of energy metabolism in multiple peripheral tissues. However, the direct role of Sirt6 in the hypothalamus, specifically pro-opiomelanocortin (POMC) neurons, controlling energy balance has not been established ...
Qin Tang +18 more
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Ethanol consumption activates a subset of arcuate nucleus pro‐opiomelanocortin (POMC)‐producing neurons: a c‐fos immunohistochemistry study [PDF]
Physiological Reports, 2022 Ethanol activates various opioid peptide‐containing circuits within the brain that may underlie its motivational and rewarding effects. One component of this circuitry consists of neurons located in the arcuate nucleus (ArcN) of the hypothalamus which ...
Lauren E. Hood +3 more
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Pro-opiomelanocortin (POMC) neuron translatome signatures underlying obesogenic gestational malprogramming in mice [PDF]
Molecular Metabolism, 2020 Objective: Maternal unbalanced nutritional habits during embryonic development and perinatal stages perturb hypothalamic neuronal programming of the offspring, thus increasing obesity-associated diabetes risk. However, the underlying molecular mechanisms
Roberta Haddad-Tóvolli +11 more
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