Results 1 to 10 of about 7,418 (162)

The role of pro-opiomelanocortin in the ACTH–cortisol dissociation of sepsis [PDF]

Critical Care, 2021
Background Sepsis is typically hallmarked by high plasma (free) cortisol and suppressed cortisol breakdown, while plasma adrenocorticotropic hormone (ACTH) is not increased, referred to as ‘ACTH–cortisol dissociation.’ We hypothesized that sepsis acutely
Arno Téblick, Sarah Vander Perre, Lies Pauwels, Sarah Derde, Tim Van Oudenhove, Lies Langouche, Greet Van den Berghe   +6 more
doaj   +5 more sources

Knockout of inositol-requiring enzyme 1α in pro-opiomelanocortin neurons decreases fat mass via increasing energy expenditure [PDF]

Open Biology, 2016
Although numerous functions of inositol-requiring enzyme 1α (IRE1α) have been identified, a role of IRE1α in pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus is largely unknown.
Yuzhong Xiao, Tingting Xia, Junjie Yu, Yalan Deng, Hao Liu, Bin Liu, Shanghai Chen, Yong Liu, Feifan Guo   +8 more
doaj   +4 more sources

Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression [PDF]

iScience, 2023
Summary: Hypothalamic pro-opiomelanocortin (POMC) neuron development is considered to play an essential role in the development of obesity. However, the underlying mechanisms remain unclear.
Chenyang Lu, Jinglin Zhang, Bingjie Wang, Qiao Gao, Kezhe Ma, Shaona Pei, Juxue Li, Sheng Cui   +7 more
doaj   +2 more sources

Nuclear Receptors as Regulators of Pituitary Corticotroph Pro-Opiomelanocortin Transcription [PDF]

Cells, 2020
The hypothalamic–pituitary–adrenal (HPA) axis plays a critical role in adaptive stress responses and maintaining organism homeostasis. The pituitary corticotroph is the central player in the HPA axis and is regulated by a plethora of hormonal and stress ...
Dongyun Zhang, Anthony P. Heaney
doaj   +2 more sources

Pro-Opiomelanocortin and Melanocortin Receptor 3 and 4 Mutations in Genetic Obesity [PDF]

Biomolecules
Genetic obesity results from loss-of-function mutations, including those affecting the leptin–melanocortin system, which regulates body weight. Pro-opiomelanocortin (POMC)-derived neurohormones act as ligands for melanocortin receptors (MCRs), regulating
Tulin Yanik, Seyda Tugce Durhan
doaj   +2 more sources

Pro-opiomelanocortin and ACTH–cortisol dissociation during pediatric cardiac surgery [PDF]

Endocrine Connections
In critically ill adults, high plasma cortisol in the face of low ACTH coincides with high pro-opiomelanocortin (POMC) levels. Glucocorticoids further lower ACTH without affecting POMC.
Arno Téblick, Ilse Vanhorebeek, Inge Derese, An Jacobs, Renata Haghedooren, Sofie Maebe, Gerdien A Zeilmaker-Roest, Enno D Wildschut, Lies Langouche, Greet Van den Berghe   +9 more
doaj   +2 more sources

Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling [PDF]

Molecular Metabolism, 2020
Objective: Sirt6 is an essential regulator of energy metabolism in multiple peripheral tissues. However, the direct role of Sirt6 in the hypothalamus, specifically pro-opiomelanocortin (POMC) neurons, controlling energy balance has not been established ...
Qin Tang, Yong Gao, Qinhui Liu, Xuping Yang, Tong Wu, Cuiyuan Huang, Ya Huang, Jinhang Zhang, Zijing Zhang, Rui Li, Shiyun Pu, Guorong Zhang, Yingnan Zhao, Jian Zhou, Hui Huang, Yanping Li, Wei Jiang, Yongsheng Chang, Jinhan He   +18 more
doaj   +2 more sources

Neurochemical Characterization of Brainstem Pro-Opiomelanocortin Cells [PDF]

Endocrinology, 2020
Abstract Genetic research has revealed pro-opiomelanocortin (POMC) to be a fundamental regulator of energy balance and body weight in mammals. Within the brain, POMC is primarily expressed in the arcuate nucleus of the hypothalamus (ARC), while a smaller population exists in the brainstem nucleus of the solitary tract (POMCNTS).
Lora K Heisler, Alastair S Garfield, Justin J Rochford, Giles S H Yeo, Brian Y H Lam, Raffaella Chianese, Luke K Burke, Oliver Marston, Ana Paula Garcia, Barbora Doslikova, David Lyons, Teodora Georgescu   +11 more
openaire   +5 more sources

Ethanol consumption activates a subset of arcuate nucleus pro‐opiomelanocortin (POMC)‐producing neurons: a c‐fos immunohistochemistry study [PDF]

Physiological Reports, 2022
Ethanol activates various opioid peptide‐containing circuits within the brain that may underlie its motivational and rewarding effects. One component of this circuitry consists of neurons located in the arcuate nucleus (ArcN) of the hypothalamus which ...
Lauren E. Hood, Erin K. Nagy, Jonna M. Leyrer‐Jackson, M. Foster Olive   +3 more
doaj   +2 more sources

Pro-opiomelanocortin (POMC) neuron translatome signatures underlying obesogenic gestational malprogramming in mice [PDF]

Molecular Metabolism, 2020
Objective: Maternal unbalanced nutritional habits during embryonic development and perinatal stages perturb hypothalamic neuronal programming of the offspring, thus increasing obesity-associated diabetes risk. However, the underlying molecular mechanisms
Roberta Haddad-Tóvolli, Jordi Altirriba, Arnaud Obri, Elena Eyre Sánchez, Iñigo Chivite, Maria Milà-Guasch, Sara Ramírez, Alicia G. Gómez-Valadés, Macarena Pozo, Jasmine Burguet, Licio A. Velloso, Marc Claret   +11 more
doaj   +2 more sources