Structure of the rat pro‐opiomelanocortin (POMC) gene [PDF]
FEBS Letters, 1985 The gene encoding pro‐opiomelanocortin (POMC) presents unique regulatory features. In particular, glucocorticoids inhibit transcription of the POMC gene in the anterior pituitary, but not in the intermediate pituitary. In order to study the mechanism leading to transcriptional inhibition of POMC by glucocorticoid and the interaction of the ...
J Drouin +2 more
exaly +4 more sources
Long-term effects of pro-opiomelanocortin methylation induced in food-restricted dams on metabolic phenotypes in male rat offspring [PDF]
Obstetrics & Gynecology Science, 2020 ObjectiveMaternal malnutrition affects the growth and metabolic health of the offspring. Little is known about the long-term effect on metabolic indices of epigenetic changes in the brain caused by maternal diet.
Sangmi Lee +5 more
doaj +2 more sources
Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons [PDF]
eLife, 2017 POMC neurons integrate metabolic signals from the periphery. Here, we show in mice that food deprivation induces a linear current-voltage relationship of AMPAR-mediated excitatory postsynaptic currents (EPSCs) in POMC neurons.
Shigetomo Suyama +9 more
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Hypothalamic Expression of Neuropeptide Y (NPY) and Pro-OpioMelanoCortin (POMC) in Adult Male Mice Is Affected by Chronic Exposure to Endocrine Disruptors [PDF]
Metabolites, 2021 In the arcuate nucleus, neuropeptide Y (NPY) neurons, increase food intake and decrease energy expenditure, and control the activity of pro-opiomelanocortin (POMC) neurons, that decrease food intake and increase energy expenditure.
Marilena Marraudino +8 more
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The multiplicity of post-translational modifications in pro-opiomelanocortin-derived peptides [PDF]
Frontiers in Endocrinology, 2013 The precursor protein, pro-opiomelanocortin (POMC) undergoes extensive post-translational processing in a tissue-specific manner to yield various biologically active peptides involved in diverse cellular functions.
Akikazu eYasuda +2 more
doaj +2 more sources
Activation of Brainstem Pro-opiomelanocortin Neurons Produces Opioidergic Analgesia, Bradycardia and Bradypnoea. [PDF]
PLoS ONE, 2016 Opioids are widely used medicinally as analgesics and abused for hedonic effects, actions that are each complicated by substantial risks such as cardiorespiratory depression.
Serena Cerritelli +4 more
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The Role of Pro-Opiomelanocortin Derivatives in the Development of Type 2 Diabetes-Associated Myocardial Infarction: Possible Links with Prediabetes [PDF]
BiomedicinesMyocardial infarction is a major contributor to CVD-related mortality. T2DM is a risk factor for MI. Stress activates the HPA axis, SNS, and endogenous OPS.
Nompumelelo Anna-Cletta Gumede +1 more
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Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing [PDF]
Molecular Metabolism, 2017 Objective: Arcuate proopiomelanocortin (POMC) neurons are critical nodes in the control of body weight. Often characterized simply as direct targets for leptin, recent data suggest a more complex architecture.
Brian Y.H. Lam +14 more
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Characterization of two Pro-opiomelanocortin gene variants and their effects on carcass traits in beef cattle [PDF]
BMC Genetics, 2011 Background Carcass quantity (lean meat yield) and quality (degree of marbling) in beef cattle determines much of their economic value. Consequently, it is important to study genes that are part of the appetite pathway and that may ultimately affect ...
Deobald Heather M, Buchanan Fiona C
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PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons [PDF]
Stem Cell Reports, 2017 We recently developed a technique for generating hypothalamic neurons from human pluripotent stem cells. Here, as proof of principle, we examine the use of these cells in modeling of a monogenic form of severe obesity: PCSK1 deficiency.
Liheng Wang +10 more
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