Pro-opiomelanocortin and ACTH–cortisol dissociation during pediatric cardiac surgery [PDF]
Endocrine ConnectionsIn critically ill adults, high plasma cortisol in the face of low ACTH coincides with high pro-opiomelanocortin (POMC) levels. Glucocorticoids further lower ACTH without affecting POMC.
Arno Téblick +9 more
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PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons [PDF]
Stem Cell Reports, 2017 We recently developed a technique for generating hypothalamic neurons from human pluripotent stem cells. Here, as proof of principle, we examine the use of these cells in modeling of a monogenic form of severe obesity: PCSK1 deficiency.
Liheng Wang +10 more
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Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression [PDF]
iScience, 2023 Summary: Hypothalamic pro-opiomelanocortin (POMC) neuron development is considered to play an essential role in the development of obesity. However, the underlying mechanisms remain unclear.
Chenyang Lu +7 more
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Pro-Opiomelanocortin and Melanocortin Receptor 3 and 4 Mutations in Genetic Obesity [PDF]
BiomoleculesGenetic obesity results from loss-of-function mutations, including those affecting the leptin–melanocortin system, which regulates body weight. Pro-opiomelanocortin (POMC)-derived neurohormones act as ligands for melanocortin receptors (MCRs), regulating
Tulin Yanik, Seyda Tugce Durhan
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Ethanol consumption activates a subset of arcuate nucleus pro‐opiomelanocortin (POMC)‐producing neurons: a c‐fos immunohistochemistry study [PDF]
Physiological Reports, 2022 Ethanol activates various opioid peptide‐containing circuits within the brain that may underlie its motivational and rewarding effects. One component of this circuitry consists of neurons located in the arcuate nucleus (ArcN) of the hypothalamus which ...
Lauren E. Hood +3 more
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17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior. [PDF]
Aging Cell, 2018 Weight loss is an effective intervention for diminishing disease burden in obese older adults. Pharmacological interventions that reduce food intake and thereby promote weight loss may offer effective strategies to reduce age‐related disease.
Steyn FJ +10 more
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Regulation of Agouti-Related Protein and Pro-Opiomelanocortin Gene Expression in the Avian Arcuate Nucleus. [PDF]
Front Endocrinol (Lausanne), 2017 The arcuate nucleus is generally conserved across vertebrate taxa in its neuroanatomy and neuropeptide expression. Gene expression of agouti-related protein (AGRP), neuropeptide Y (NPY), pro-opiomelanocortin (POMC), and cocaine- and amphetamine-regulated
Boswell T, Dunn IC.
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Long-term effects of pro-opiomelanocortin methylation induced in food-restricted dams on metabolic phenotypes in male rat offspring [PDF]
Obstetrics & Gynecology Science, 2020 ObjectiveMaternal malnutrition affects the growth and metabolic health of the offspring. Little is known about the long-term effect on metabolic indices of epigenetic changes in the brain caused by maternal diet.
Sangmi Lee +5 more
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The multiplicity of post-translational modifications in pro-opiomelanocortin-derived peptides [PDF]
Frontiers in Endocrinology, 2013 The precursor protein, pro-opiomelanocortin (POMC) undergoes extensive post-translational processing in a tissue-specific manner to yield various biologically active peptides involved in diverse cellular functions.
Akikazu eYasuda +2 more
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The Role of Pro-Opiomelanocortin Derivatives in the Development of Type 2 Diabetes-Associated Myocardial Infarction: Possible Links with Prediabetes [PDF]
BiomedicinesMyocardial infarction is a major contributor to CVD-related mortality. T2DM is a risk factor for MI. Stress activates the HPA axis, SNS, and endogenous OPS.
Nompumelelo Anna-Cletta Gumede +1 more
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