Structure of the rat pro‐opiomelanocortin (POMC) gene [PDF]
FEBS Letters, 1985 The gene encoding pro‐opiomelanocortin (POMC) presents unique regulatory features. In particular, glucocorticoids inhibit transcription of the POMC gene in the anterior pituitary, but not in the intermediate pituitary. In order to study the mechanism leading to transcriptional inhibition of POMC by glucocorticoid and the interaction of the ...
Jean Charron +2 more
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PGC-1α expression in murine AgRP neurons regulates food intake and energy balance [PDF]
Molecular Metabolism, 2016 Objective: Food intake and whole-body energy homeostasis are controlled by agouti-related protein (AgRP) and pro-opiomelanocortin (POMC) neurons located in the arcuate nucleus of the hypothalamus.
Jonathan F. Gill +3 more
doaj +5 more sources
Profiles of pro-opiomelanocortin and encoded peptides, and their processing enzymes in equine pituitary pars intermedia dysfunction. [PDF]
PLoS ONE, 2018 Equine pituitary pars intermedia dysfunction (PPID) is characterized by hyperplasia of the pars intermedia (PI) melanotrophs of the pituitary gland (PG), and increased production of proopiomelanocortin (POMC).
James L Carmalt +4 more
doaj +2 more sources
ACTH in invertebrates: a molecule for all seasons [PDF]
Invertebrate Survival Journal, 2016 In vertebrate and invertebrate models, adrenocorticotropic hormone (ACTH) belongs to the melanocortin group of related peptides, which share a common precursor, pro-opiomelanocortin (POMC).
D Malagoli, E Ottaviani
doaj +3 more sources
Insulin and leptin excite anorexigenic pro-opiomelanocortin neurones via activation of TRPC5 channels. [PDF]
J Neuroendocrinol, 2018 Qiu J +3 more
europepmc +2 more sources
60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides. [PDF]
J Mol Endocrinol, 2016 Cawley NX, Li Z, Loh YP.
europepmc +2 more sources
Regulation of BAT thermogenesis via TRPA1-expressing hypothalamic POMC neurons [PDF]
Animal Cells and SystemsPro-opiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) play a pivotal role in regulating brown adipose tissue (BAT) thermogenesis via the sympathetic nervous system.
Arbi Bahtiar Boedi Iman Halanobis +10 more
doaj +2 more sources
Irradiation Decreases the Neuroendocrine Biomarker Pro-Opiomelanocortin in Small Cell Lung Cancer Cells In Vitro and In Vivo. [PDF]
PLoS ONE, 2016 BACKGROUND:Small cell lung cancer (SCLC) is an extremely aggressive disease, commonly displaying therapy-resistant relapse. We have previously identified neuroendocrine and epithelial phenotypes in SCLC tumours and the neuroendocrine marker, pro ...
Suzanne L Meredith +6 more
doaj +2 more sources
Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus
Diabetes, 1997 Randy J Seeley, Denis G Baskin
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