Results 21 to 30 of about 1,457,386 (196)
Neurochemical Characterization of Brainstem Pro-Opiomelanocortin Cells. [PDF]
Endocrinology, 2020 Abstract Genetic research has revealed pro-opiomelanocortin (POMC) to be a fundamental regulator of energy balance and body weight in mammals. Within the brain, POMC is primarily expressed in the arcuate nucleus of the hypothalamus (ARC), while a smaller population exists in the brainstem nucleus of the solitary tract (POMCNTS).
Georgescu T +11 more
europepmc +5 more sources
Intracerebroventricular Injection of Metformin Induces Anorexia in Rats [PDF]
Diabetes & Metabolism Journal, 2012 BackgroundMetformin, an oral biguanide insulin-sensitizing agent, is well known to decrease appetite. Although there is evidence that metformin could affect the brain directly, the exact mechanism is not yet known.MethodsTo evaluate whether metformin ...
Chang Koo Lee +5 more
doaj +1 more source
The pituitary gland of the European eel reveals massive expression of genes involved in the melanocortin system. [PDF]
PLoS ONE, 2013 Hormones secreted from the pituitary gland regulate important processes such as development, growth and metabolism, reproduction, water balance, and body pigmentation.
Eirill Ager-Wick +10 more
doaj +1 more source
Nature Communications, 2022 The role of non-neuronal glial cells in the regulation of adipose tissue function are incompletely understood. Here the authors report that stimulation of mediobasal hypothalamic astrocytes promotes inguinal white adipose tissue lipolysis in mice ...
Dan Chen +3 more
doaj +1 more source
Nature Communications, 2020 Hypothalamic melanocortin neurons regulate systemic glucose homeostasis through incompletely understood pathways. Here, the authors show that a subset of pro-opiomelanocortin neurons innervate the liver via preganglionic parasympathetic cholinergic ...
Eunjin Kwon +5 more
doaj +1 more source
Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity. [PDF]
Autophagy, 2015 The autophagy-related proteins ATG12 and ATG5 form a covalent complex essential for autophagy. Here, we demonstrate that ATG12 has distinct functions from ATG5 in pro-opiomelanocortin (POMC)-expressing neurons.
Malhotra R +4 more
europepmc +2 more sources
A Neural basis for Octanoic acid regulation of energy balance
Molecular Metabolism, 2020 Objectives: Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain fatty acid species transported into the brain, their effects on energy balance, and the
Vanessa R. Haynes +8 more
doaj +1 more source
17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior. [PDF]
Aging Cell, 2018 Weight loss is an effective intervention for diminishing disease burden in obese older adults. Pharmacological interventions that reduce food intake and thereby promote weight loss may offer effective strategies to reduce age-related disease.
Steyn FJ +10 more
europepmc +2 more sources
Expression of pro-opiomelanocortin gene in human ovarian tissue.
Human reproduction (Oxford, England), 1995 The high concentration of pro-opiomelanocortin (POMC)-derived peptides in human follicular fluid, which is several times higher than in plasma, suggested a local expression of the POMC gene. This has previously been observed in the animal ovaries. Peripheral POMC-like mRNAs are not translated in POMC-derived peptides but recent evidence supports the ...
Gallinelli A +4 more
openaire +3 more sources
, 2014 Using an indirect immunoperoxidase technique, we studied the distribution of cell bodies and fibres containing non-opioid peptides (adrenocorticotropin hormone (ACTH), alpha-melanocyte-stimulating hormone) and opioid peptides (beta-endorphin (1–27 ...
Sánchez, M.L. +6 more
core +2 more sources