Results 21 to 30 of about 1,067,103 (202)

Profiles of pro-opiomelanocortin and encoded peptides, and their processing enzymes in equine pituitary pars intermedia dysfunction. [PDF]

PLoS ONE, 2018
Equine pituitary pars intermedia dysfunction (PPID) is characterized by hyperplasia of the pars intermedia (PI) melanotrophs of the pituitary gland (PG), and increased production of proopiomelanocortin (POMC).
James L Carmalt, Sima Mortazavi, Rebecca C McOnie, Andrew L Allen, Suraj Unniappan   +4 more
doaj   +2 more sources

Irradiation Decreases the Neuroendocrine Biomarker Pro-Opiomelanocortin in Small Cell Lung Cancer Cells In Vitro and In Vivo. [PDF]

PLoS ONE, 2016
BACKGROUND:Small cell lung cancer (SCLC) is an extremely aggressive disease, commonly displaying therapy-resistant relapse. We have previously identified neuroendocrine and epithelial phenotypes in SCLC tumours and the neuroendocrine marker, pro ...
Suzanne L Meredith, Jennifer L Bryant, Muhammad Babur, Philip W Riddell, Roya Behrouzi, Kaye J Williams, Anne White   +6 more
doaj   +2 more sources

Regulation of BAT thermogenesis via TRPA1-expressing hypothalamic POMC neurons [PDF]

Animal Cells and Systems
Pro-opiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) play a pivotal role in regulating brown adipose tissue (BAT) thermogenesis via the sympathetic nervous system.
Arbi Bahtiar Boedi Iman Halanobis, Ju Hwan Yang, Eun-Hye Byeon, Sang Won Park, Hyun Joon Kim, Dawon Kang, Deok-Ryong Kim, Jinsung Yang, Wanil Kim, Dong-Hee Kim, Dong Kun Lee   +10 more
doaj   +2 more sources

Intracerebroventricular Injection of Metformin Induces Anorexia in Rats [PDF]

Diabetes & Metabolism Journal, 2012
BackgroundMetformin, an oral biguanide insulin-sensitizing agent, is well known to decrease appetite. Although there is evidence that metformin could affect the brain directly, the exact mechanism is not yet known.MethodsTo evaluate whether metformin ...
Chang Koo Lee, Yoon Jung Choi, So Young Park, Jong Yeon Kim, Kyu Chang Won, Yong Woon Kim   +5 more
doaj   +1 more source

The pituitary gland of the European eel reveals massive expression of genes involved in the melanocortin system. [PDF]

PLoS ONE, 2013
Hormones secreted from the pituitary gland regulate important processes such as development, growth and metabolism, reproduction, water balance, and body pigmentation.
Eirill Ager-Wick, Ron P Dirks, Erik Burgerhout, Rasoul Nourizadeh-Lillabadi, Daniëlle L de Wijze, Herman P Spaink, Guido E E J M van den Thillart, Katsumi Tsukamoto, Sylvie Dufour, Finn-Arne Weltzien, Christiaan V Henkel   +10 more
doaj   +1 more source

Deconstruction of a hypothalamic astrocyte-white adipocyte sympathetic axis that regulates lipolysis in mice

Nature Communications, 2022
The role of non-neuronal glial cells in the regulation of adipose tissue function are incompletely understood. Here the authors report that stimulation of mediobasal hypothalamic astrocytes promotes inguinal white adipose tissue lipolysis in mice ...
Dan Chen, Yong Qi, Jia Zhang, Yunlei Yang   +3 more
doaj   +1 more source

Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity. [PDF]

Autophagy, 2015
The autophagy-related proteins ATG12 and ATG5 form a covalent complex essential for autophagy. Here, we demonstrate that ATG12 has distinct functions from ATG5 in pro-opiomelanocortin (POMC)-expressing neurons.
Malhotra R, Warne JP, Salas E, Xu AW, Debnath J.   +4 more
europepmc   +2 more sources

Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production

Nature Communications, 2020
Hypothalamic melanocortin neurons regulate systemic glucose homeostasis through incompletely understood pathways. Here, the authors show that a subset of pro-opiomelanocortin neurons innervate the liver via preganglionic parasympathetic cholinergic ...
Eunjin Kwon, Hye-Young Joung, Shun-Mei Liu, Streamson C. Chua, Gary J. Schwartz, Young-Hwan Jo   +5 more
doaj   +1 more source

A Neural basis for Octanoic acid regulation of energy balance

Molecular Metabolism, 2020
Objectives: Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain fatty acid species transported into the brain, their effects on energy balance, and the
Vanessa R. Haynes, Natalie J. Michael, Marco van den Top, Fei-Yue Zhao, Russell D. Brown, David De Souza, Garron T. Dodd, David Spanswick, Matthew J. Watt   +8 more
doaj   +1 more source

Immunohistochemical mapping of pro-opiomelanocortin- and pro-dynorphin-derived peptides in the alpaca (Lama pacos) diencephalon

, 2014
Using an indirect immunoperoxidase technique, we studied the distribution of cell bodies and fibres containing non-opioid peptides (adrenocorticotropin hormone (ACTH), alpha-melanocyte-stimulating hormone) and opioid peptides (beta-endorphin (1–27 ...
Sánchez, M.L., Aguilar, L.A., Manso, B., Narváez, J.A., Coveñas, R., Medina, L.E., Díaz-Cabiale, Z.   +6 more
core   +2 more sources