Results 41 to 50 of about 1,457,386 (196)

Development of the Hypothalamic Melanocortin System

Frontiers in Endocrinology, 2013
The melanocortin system is a critical component of the forebrain and hindbrain regulatory systems involved in energy balance. This system is composed of pro-opiomelanocortin (POMC) neurons that act, in part, through the melanocortin-4 receptor (MC4R ...
Berengere eCoupe, Sebastien G Bouret
doaj   +1 more source

Alpha-MSH and pro-opiomelanocortin in Rab3a KO melanotrophs.

, 2013
Representative confocal microscopy micrographs from immunocytochemistry of γ-MSH/ pro-opiomelanocortin (POMC) (top) and α-MSH (bottom) in WT and Rab3a KO pituitary slices. Arrow indicates the intermediate lobe (PI).
Maša Skelin Klemen (474643), Oliver M. Schlüter (474644), Marjan Slak Rupnik (276794), Simon Sedej (474642)   +3 more
core   +1 more source

Biosynthesis of pro-opiomelanocortin is increased in the rat intermediate pituitary following denervation [PDF]

, 1987
In order to study the effect of pituitary intermediate lobe denervation on pro-opiomelanocortin (POMC) biosynthesis and processing, radioactive amino acids were incorporated in vitro into whole neurointermediate lobe (NIL) explants obtained from ...
Kiss, Jozsef Zoltan, Burbach, J P, Seger, M.A., Tol, H.H.M. van, Kiss, J.Z., Seger, M A, van Tol, H H, Burbach, J.P.H.   +7 more
core   +1 more source

Effects of neonatal overfeeding on pro-opiomelanocortin (Pomc) and Growth hormone (Gh) mRNA expression in the adult pituitary.

, 2017
A) Adult pituitary pro-opiomelanocortin (Pomc); n = 8 CL, 6 SL, and B) growth hormone (Gh) mRNA expression; n = 6 CL, 7 SL. Data are mean + SEM.
Ilvana Ziko (3436904), Sarah J. Spencer (193012), Luba Sominsky (386056)   +2 more
core   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Tissue-specific activity of the pro-opiomelanocortin (POMC) gene and repression by glucocorticoids

, 1989
The gene encoding pro-opiomelanocortin (POMC) is specifically expressed in two different cell types of the pituitary gland. We have defined the regulatory DNA sequences of the POMC gene that are responsible for this cell-specific expression. In addition,
Yu Lin Sun, Jacques Drouin, Lucie Jeannotte, Jean Charron, Marc Therrien, Yves Tremblay, Jean-Pierre Gagner, Mona Nemer   +7 more
core   +1 more source

Anesthetic drugs modulate feeding behavior and hypothalamic expression of the POMC polypeptide precursor and the NPY neuropeptide

BMC Anesthesiology, 2018
Background Several hypnotic drugs have been previously identified as modulators of food intake, but exact mechanisms remain unknown. Feeding behavior implicates several neuronal populations in the hypothalamic arcuate nucleus including orexigenic ...
E. Besnier, T. Clavier, M. C. Tonon, G. Pelletier, B. Dureuil, H. Castel, V. Compère   +6 more
doaj   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

GLP‐1 receptor activation attenuates chronic migraine‐like behaviour: Sex‐specific modulation of opioid‐ and endocannabinoid‐related pathways

British Journal of Pharmacology, EarlyView.
Background and Purpose Chronic migraine (CM) is a highly disabling condition that remains suboptimally treated. Metabolic disturbances may trigger migraine chronification, whereas impaired endogenous pain inhibition contributes to CM development. Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), used for type 2 diabetes and obesity, show efficacy ...
Katarina Sićović, Katarina Nastić, Miroslav Dinić, Emilija Brdarić, Uroš Pecikoza, Maja Tomić, Ana Micov   +6 more
wiley   +1 more source

Comparison of plasma separation techniques prior to freezing on equine immunoreactive adrenocorticotrophic hormone

Equine Veterinary Education, EarlyView.
Summary Background Pituitary pars intermedia dysfunction (PPID) is the most common endocrine disorder affecting older horses and is commonly diagnosed by measurement of basal plasma adrenocorticotrophic hormone (ACTH) concentration. Current guidelines advise that whole blood or gravity‐separated plasma samples must not be frozen prior to analysis ...
L. J. Hughes, A. E. Durham, C. A. Maile
wiley   +1 more source