Results 41 to 50 of about 1,051,322 (230)

From obesity resistance to obesity prediction and prevention? [PDF]

, 2016
Comment on: Regulation of hypothalamic neuropeptides gene expression in diet induced obesity resistant rats: possible targets for obesity prediction?
Cassano, Tommaso, Gaetani, Silvana
core   +9 more sources

Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production

Nature Communications, 2020
Hypothalamic melanocortin neurons regulate systemic glucose homeostasis through incompletely understood pathways. Here, the authors show that a subset of pro-opiomelanocortin neurons innervate the liver via preganglionic parasympathetic cholinergic ...
Eunjin Kwon, Hye-Young Joung, Shun-Mei Liu, Streamson C. Chua, Gary J. Schwartz, Young-Hwan Jo   +5 more
doaj   +1 more source

Augmented Hypothalamic Corticotrophin-Releasing Hormone mRNA and Corticosterone Responses to Stress in Adult Rats Exposed to Perinatal Hypoxia [PDF]

, 2007
Stressful events before or just after parturition alter the subsequent phenotypical response to stress in a general process termed programming. Hypoxia during the period before and during parturition, and in the postnatal period, is one of the most ...
Cullinan, William E, Jacobson, Lauren, Raff, Hershel   +2 more
core   +2 more sources

A Neural basis for Octanoic acid regulation of energy balance

Molecular Metabolism, 2020
Objectives: Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain fatty acid species transported into the brain, their effects on energy balance, and the
Vanessa R. Haynes, Natalie J. Michael, Marco van den Top, Fei-Yue Zhao, Russell D. Brown, David De Souza, Garron T. Dodd, David Spanswick, Matthew J. Watt   +8 more
doaj   +1 more source

Metabolic effects of diets differing in glycaemic index depend on age and endogenous GIP [PDF]

, 2009
Aims/hypothesis High- vs low-glycaemic index (GI) diets unfavourably affect body fat mass and metabolic markers in rodents. Different effects of these diets could be age-dependent, as well as mediated, in part, by carbohydrate-induced stimulation of ...
A. Abdelrahman, A. F. Pfeiffer, AR Josse, AW Barclay, B. Thorens, C Yamada, C Zhang, Coon PJ, Rogus EM, Drinkwater D, Muller DC, Goldberg AP, DB Pawlak, DB Pawlak, DS Ludwig, DW Foster, EM Schothorst van, EO Diaz, F Isken, F Isken, F Preitner, F. Isken, J Brand-Miller, J Salmeron, J Salmeron, J Stevens, JA Marshall, JJ Holst, JJ Meier, K Miyawaki, KA Meyer, KB Scribner, KB Scribner, KH Ding, M Kabir, M Lerer-Metzger, M. H. Tschöp, M. Möhlig, M. O. Weickert, MB Schulze, MK Hellerstein, MO Weickert, R. Nogueiras, RM Dam van, S Liu, S. Klaus, SE Byrnes, SJ Gatenby, WM Kohrt, X Pi-Sunyer   +45 more
core   +1 more source

5-HT obesity medication efficacy via POMC activation is maintained during aging [PDF]

, 2014
Peer reviewedPublisher ...
Billups, Brian, Burdakov, Denis, Burke, Luke K, D'Agostino, Giuseppe, Doslikova, Barbora, Evans, Mark L, Farooq, Gala, Garfield, Alastair S, Heisler, Lora, Low, Malcolm, Rubinstein, Marcelo   +10 more
core   +3 more sources

Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures [PDF]

, 2019
Primary cilia dysfunction has been associated with hyperphagia and obesity in both ciliopathy patients and mouse models of cilia perturbation. Neurons throughout the brain possess these solitary cellular appendages, including in the feeding centers of ...
Antonellis, Patrick J., Bansal, Ruchi, Baucum, Anthony J., Berbari, Nicolas F., Cummins, Theodore R., Engle, Staci E., Reiter, Jeremy F., Whitehouse, Logan S.   +7 more
core   +1 more source

Distribution of cells responsive to 5-HT6 receptor antagonist-induced hypophagia [PDF]

, 2014
Open Access funded by Medical Research CouncilPeer reviewedPublisher ...
Alastair S. Garfield, Blevins, Fisas, Frassetto, Garfield, Grill, Heal, Heisler, Heisler, Heisler, Hirst, Holenz, Jill Shaw, Lam, Lam, Leibowitz, Li, Lora K. Heisler, Luke K. Burke, Mark L. Evans, Michaud, Monti, Roberts, Wesołowska, Woolley, Woolley, Xu, Xu, Yeo   +28 more
core   +1 more source

Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities

Frontiers in Physiology, 2021
Melanocortin peptides, melanocortin receptors, melanocortin receptor accessory proteins, and endogenous antagonists of melanocortin receptors are the key components constituting the melanocortin hormone system, one of the most complex and important ...
Mingyang Chang, Bohan Chen, James Shaffner, Lance D. Dworkin, Rujun Gong   +4 more
doaj   +1 more source

Considerations about rodent models of binge eating episodes [PDF]

, 2014
A binge eating episode is defined as an uncontrolled event of hyperphagia, in which people quickly eat a large amount of food while feeling a sense of loss of control over eating (Wolfe et al., 2009).
Garcia Romero, Guadalupe, Perello, Mario, Raingo, Jesica, Valdivia Torres, Lesly Spring   +3 more
core   +2 more sources