Results 61 to 70 of about 1,457,386 (196)

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver

, 2010
Mice lacking 5-HT 2C receptors (5-HT(2C)Rs) displayed hepatic insulin resistance, a phenotype normalized by re-expression of 5-HT(2C)Rs only in pro-opiomelanocortin (POMC) neurons.
Eric D Berglund, Elmquist, Joel K., Juli E Jones, Sohn, Jong-Woo, Fukuda, Makoto, Philipp E Scherer, Scherer, Philipp E., Joel K Elmquist, Chuang, Jen-Chieh, Bradford B Lowell, Williams, W., Jari Rossi, Jeffrey M Zigman, Yong Xu, Jen-Chieh Chuang, Xu, Yong, Lowell, Bradford B., Zigman, Jeffrey M., Rossi, Jari, Makoto Fukuda, William L Holland, Jones, Juli E., Kevin W Williams, Berglund, Eric D., Jong-Woo Sohn, Holland, William L.   +25 more
core   +1 more source

Cushing syndrome in a child due to pro-opiomelanocortin (POMC) secretion from a yolk sac tumor [PDF]

, 2017
CONTEXT: Pituitary microadenomas and adrenal tumours are the most common causes for endogenous Cushing syndrome (CS) in children.CASE DESCRIPTION: We describe a two-year old girl with Cushing syndrome due to ectopic pro-opiomelanocortin (POMC) production
Slater, Olga, Sebire, NJ, Slater, O, Shah, P, White, Anne; id_orcid, White, A, Peters, C, Torpiano, John, Gevers, EF, Dattani, Mehul T, Torpiano, J, Dattani, MT, Meredith, Suzanne, Shah, Pratik, Sebire, Neil J, Meredith, S, Gevers, Evelien F, Peters, Catherine   +17 more
core   +1 more source

Gene expression and methylation profiles show the involvement of POMC in primary hyperparathyroidsm

Journal of Translational Medicine, 2022
Primary hyperparathyroidism (PHPT) is mainly caused by parathyroid adenoma, which produces excess parathyroid hormones. Its pathogenic mechanisms have not yet been fully understood.
Wen-Xuan Zhou, Shu Wang, Ting-Chao Wu, Ling-Chao Cheng, Yao Du, Wei Wu, Chen Lin, Xin-Ying Li, Zhong-Liang Hu   +8 more
doaj   +1 more source

Identifying Systemic Lupus Erythematosus From Serum Proteomic Profiles Using Machine Learning and Genetic Risk Stratification

Arthritis &Rheumatology, Volume 78, Issue 11, Page 2280-2291, November 2026.
Objective Proteome‐wide risk models for lupus remain underexplored. We developed classification models to identify lupus from serum proteomic profiles. Methods Patients with lupus and individuals with other autoimmune diseases in the UK Biobank were included.
Mehmet Hocaoǧlu, Jishnu Das, Amr H. Sawalha   +2 more
wiley   +1 more source

Characterization of pro-opiomelanocortin gene variants and their effect on carcass traits in beef cattle [PDF]

, 2009
Pro-opiomelanocortin is a prohormone that codes for many different peptides, some of which are involved in the appetite pathway. A single nucleotide polymorphism c.288C>T in pro-opiomelanocortin (POMC) was previously demonstrated to be associated with ...
Deobald, Heather Maureen
core  

Abnormal pro-opiomelanocortin processing in Alzheimer's disease. A case report.

, 1987
Several authors have reported reduced levels of pro-opiomelanocortin (POMC)-related peptides in the cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD), but the mechanisms regulating the CSF content of these substances are still debated ...
Storchi AR, GENAZZANI, ANDREA, Martignoni E, Facchinetti F, Pacchetti C   +4 more
core   +1 more source

Updates on intra‐articular corticosteroid administration in horses

Equine Veterinary Education, Volume 38, Issue 11, Page 600-610, November 2026.
Summary Intra‐articular (IA) corticosteroid administration in equine athletes has gained increased attention recently, particularly in racing. Despite widespread corticosteroid use in equine practice for decades, there are still a lack of equine‐specific studies to address key questions related to their use.
K. Tanner, L. Bass, C. Kawcak, L. V. Schnabel, K. L. Hallowell, L. M. Pezzanite   +5 more
wiley   +1 more source

Upregulation of the pro-opiomelanocortin gene in motoneurones after acrylamide administration in mice

, 2004
Immunocytochemistry was used to demonstrate the presence of beta-endorphin and alpha-MSH, and in situ hybridisation was used to study the presence of pro-opiomelanocortin (POMC) mRNA, in spinal motoneurones, up to 8 days following the administration of a
Simpson, MG, Hughes, Sharon, Child, T, Smith, Margaret   +3 more
core   +1 more source

Cross-talk between metabolism and reproduction: The Role of POMC and SF-1 Neurons

Frontiers in Endocrinology, 2012
Energy homeostasis and reproduction need to be tightly coordinated. The mechanisms for this coordinated control are not fully understood. Two subsets of hypothalamic neurons, namely pro-opiomelanocortin (POMC) neurons in the arcuate nucleus and ...
Yong eXu, Latric eFaulkner, Jennifer Wootton Hill   +2 more
doaj   +1 more source