Results 61 to 70 of about 1,067,103 (202)
, 2017 A) Adult pituitary pro-opiomelanocortin (Pomc); n = 8 CL, 6 SL, and B) growth hormone (Gh) mRNA expression; n = 6 CL, 7 SL. Data are mean + SEM.
Ilvana Ziko (3436904) +2 more
core +1 more source
The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets
Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley +1 more source
Abnormal pro-opiomelanocortin processing in Alzheimer's disease. A case report.
, 1987 Several authors have reported reduced levels of pro-opiomelanocortin (POMC)-related peptides in the cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD), but the mechanisms regulating the CSF content of these substances are still debated ...
A. R. Storchi +4 more
core +1 more source
Cross-talk between metabolism and reproduction: The Role of POMC and SF-1 Neurons
Frontiers in Endocrinology, 2012 Energy homeostasis and reproduction need to be tightly coordinated. The mechanisms for this coordinated control are not fully understood. Two subsets of hypothalamic neurons, namely pro-opiomelanocortin (POMC) neurons in the arcuate nucleus and ...
Yong eXu +2 more
doaj +1 more source
Cell & Bioscience, 2022 Background Central nervous system (CNS) control of metabolism plays a pivotal role in maintaining energy balance. In the brain, Glucagon-like peptide 1 (GLP-1), encoded by the proglucagon ‘Gcg’ gene, produced in a distinct population of neurons in the ...
Ishnoor Singh +7 more
doaj +1 more source
Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.Abstract Disorders of gonadotropin pulsatility contribute to reproductive dysfunction in humans and are often associated with metabolic dysfunction. Hypogonadotropic hypogonadism is characterized by chronically insufficient gonadotropin hormone production, leading to reproductive and metabolic impairments, such as infertility and obesity.
Nimisha Nandankar +7 more
wiley +1 more source
Tissue-specific activity of the pro-opiomelanocortin (POMC) gene and repression by glucocorticoids
, 1989 The gene encoding pro-opiomelanocortin (POMC) is specifically expressed in two different cell types of the pituitary gland. We have defined the regulatory DNA sequences of the POMC gene that are responsible for this cell-specific expression. In addition,
Yu Lin Sun +7 more
core +1 more source
ACTH in invertebrates: a molecule for all seasons [PDF]
Invertebrate Survival Journal, 2016 In vertebrate and invertebrate models, adrenocorticotropic hormone (ACTH) belongs to the melanocortin group of related peptides, which share a common precursor, pro-opiomelanocortin (POMC).
D Malagoli, E Ottaviani
doaj +1 more source
PGC-1α expression in murine AgRP neurons regulates food intake and energy balance
Molecular Metabolism, 2016 Objective: Food intake and whole-body energy homeostasis are controlled by agouti-related protein (AgRP) and pro-opiomelanocortin (POMC) neurons located in the arcuate nucleus of the hypothalamus.
Jonathan F. Gill +3 more
doaj +1 more source
OPA1 in MC4R Neurons Regulates Dietary Fat Intake and Body Weight in Mice
The FASEB Journal, Volume 40, Issue 10, 31 May 2026.Soybean oil intake induces OPA1 expression in hypothalamic MC4R neurons, contributing to adaptive regulation of appetite. MC4R neuron‐specific OPA1 deficiency increases soybean oil consumption and leads to obesity, with a more pronounced effect in females.
Shigenobu Matsumura +10 more
wiley +1 more source