Results 61 to 70 of about 1,051,322 (230)

PTEN: A master regulator of neuronal structure, function, and plasticity. [PDF]

, 2014
PTEN (phosphatase and tensin homolog on chromosome ten) is a dual protein/lipid phosphatase that dephosphorylates PIP3, thereby inhibiting the AKT/mTOR pathway. This inhibition ultimately decreases protein translation, cell proliferation and cell growth.
Garcia-Junco-Clemente, Pablo, Golshani, Peyman   +1 more
core   +1 more source

Melatonin Receptor 1 Deficiency Affects Feeding Dynamics and Pro-Opiomelanocortin Expression in the Arcuate Nucleus and Pituitary of Mice

Neuroendocrinology, 2016
Background/Methods: Melatonin, the neurohormone for darkness, mediates photoperiod-dependent changes in physiology and behavior by targeting specific membrane-bound receptors (MT1 and MT2). In the present study, we investigated the impact of MT1 receptor
C. Fischer, T. Mueller, M. Pfeffer, H. Wicht, C. von Gall, H. Korf   +5 more
semanticscholar   +1 more source

The Tissue‐Specific Processing of Pro‐Opiomelanocortin [PDF]

Journal of Neuroendocrinology, 2008
It is just over 30 years since the definitive identification of the adrenocorticotrophin (ACTH) precursor, pro‐opiomelanocotin (POMC). Although first characterised in the anterior and intermediate lobes of the pituitary, POMC is also expressed in a number of both central and peripheral tissues including the skin, central nervous tissue and placenta ...
openaire   +2 more sources

Assessments at multiple levels of biological organization allow for an integrative determination of physiological tolerances to turbidity in an endangered fish species. [PDF]

, 2016
Turbidity can influence trophic levels by altering species composition and can potentially affect fish feeding strategies and predator-prey interactions.
Connon, Richard E, Fangue, Nann A, Geist, Juergen, Hasenbein, Matthias, Komoroske, Lisa M, McPherson, Rina, Truong, Jennifer   +6 more
core   +1 more source

Development of the Hypothalamic Melanocortin System

Frontiers in Endocrinology, 2013
The melanocortin system is a critical component of the forebrain and hindbrain regulatory systems involved in energy balance. This system is composed of pro-opiomelanocortin (POMC) neurons that act, in part, through the melanocortin-4 receptor (MC4R ...
Berengere eCoupe, Sebastien G Bouret
doaj   +1 more source

Identifying Systemic Lupus Erythematosus From Serum Proteomic Profiles Using Machine Learning and Genetic Risk Stratification

Arthritis &Rheumatology, EarlyView.
Objective Proteome‐wide risk models for lupus remain underexplored. We developed classification models to identify lupus from serum proteomic profiles. Methods Patients with lupus and individuals with other autoimmune diseases in the UK Biobank were included.
Mehmet Hocaoǧlu, Jishnu Das, Amr H. Sawalha   +2 more
wiley   +1 more source

Anesthetic drugs modulate feeding behavior and hypothalamic expression of the POMC polypeptide precursor and the NPY neuropeptide

BMC Anesthesiology, 2018
Background Several hypnotic drugs have been previously identified as modulators of food intake, but exact mechanisms remain unknown. Feeding behavior implicates several neuronal populations in the hypothalamic arcuate nucleus including orexigenic ...
E. Besnier, T. Clavier, M. C. Tonon, G. Pelletier, B. Dureuil, H. Castel, V. Compère   +6 more
doaj   +1 more source

Immune-Neuroendocrine Interactions: Evolution, Ecology, and Susceptibility to Illness [PDF]

, 2017
The integration between immune and neuroendocrine systems is crucial for maintaining homeostasis from invertebrates to humans. In the first, the phagocytic cell, i.e., the immunocyte, is the main actor, while in the latter, the principle player is the ...
Blom, Johanna M. C., Ottaviani, Enzo
core   +1 more source

Effect of calcium ions on the processing of pro‐opiomelanocortin by bovine intermediate lobe pro‐opiomelanocortin‐converting enzyme [PDF]

European Journal of Biochemistry, 1991
The effect of Ca2+ on the extent and pattern of processing of pro‐opiomelanocortin and an N‐terminal fragment by a purified pituitary secretory vesicle, soluble aspartic endoprotease, was studied. Ca2+ stimulated the first cleavage of pro‐opiomelanocortin by pro‐opiomelanocortin‐converting enzyme to yield 21–23 kDa adrenocorticotropin and β‐lipotropin,
N P, Birch, H P, Bennett, F E, Estivariz, Y P, Loh   +3 more
openaire   +2 more sources

Effectiveness and Safety of Setmelanotide in a Patient With a Heterozygous PCSK1 Deficiency

Obesity, EarlyView.
ABSTRACT Setmelanotide, a melanocortin 4 receptor (MC4R) agonist, is a promising pharmacological treatment option for people with rare monogenic obesity conditions affecting the leptin‐melanocortin signaling pathway, including proprotein convertase subtilisin/kexin type 1 (PCSK1) gene mutations.
Ellina Lytvyak, Arshdeep Rattol, Eduardo Grunvald   +2 more
wiley   +1 more source