Results 71 to 80 of about 1,067,103 (202)

Stimulation of pro-opiomelanocortin gene expression by glucocorticoids in the denervated rat intermediate pituitary gland

, 1988
The effect of frontal deafferentation of the medial basal hypothalamus on pro-opiomelanocortin (POMC) gene expression was studied in the intermediate lobe (IL) and anterior lobe (AL) of the pituitary gland in the absence and presence of corticosterone ...
Kiss, Jozsef Zoltan, Burbach, J P, de Kloet, E R, van Eekelen, J A, Seger, M A   +4 more
core   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, Volume 13, Issue 29, 22 May 2026.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

How does type 2 diabetes modify the risk of Alzheimer's disease?

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract Type 2 diabetes (T2D) and Alzheimer's disease (AD) are both increasing exponentially worldwide. T2D has also been identified as one of 14 modifiable risk factors for dementia, but the mechanism is unknown. T2D could promote dementia via vascular or AD neuropathological changes, and mechanistic hypotheses include central insulin resistance and ...
G. T. Sutherland, A. Chen, H‐T. Nguyen‐Hao, H. Mundell, E. Aladyeva, M. J. Hofer, O. Harari, S. M. Twigg   +7 more
wiley   +1 more source

Use of Naltrexone–Bupropion in Persons With Overweight/Obesity and Symptoms of Depression: A Pooled Analysis

Obesity, Volume 34, Issue 5, Page 1010-1019, May 2026.
ABSTRACT Objective The present study examined the safety and efficacy of the fixed‐dose, extended‐release combination of naltrexone and bupropion (NB‐ER) in individuals with overweight/obesity and mild to moderate symptoms of depression. Methods Data were pooled from four double‐blind, placebo‐controlled trials.
Jena Shaw Tronieri, Robert F. Kushner, Caroline M. Apovian, Angela Fitch, Christopher Still, Thomas A. Wadden   +5 more
wiley   +1 more source

The Regulation of Leptin, Leptin Receptor and Pro-opiomelanocortin Expression by N-3 PUFAs in Diet-Induced Obese Mice Is Not Related to the Methylation of Their Promoters

Nutrition & Metabolism, 2011
Background The expression of leptin is increased in obesity and inhibited by n-3 polyunsaturated fatty acids (n-3 PUFAs), but the underlying molecular mechanisms have not been firmly established.
Qi Kemin, Deckelbaum Richard J, Shen Wenwen, Liu Xinli, Fan Chaonan   +4 more
doaj   +1 more source

Methodological Challenges for Ablation of BMPR1A in Hypothalamic Tanycytes—A Cautionary Tale

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
Two strategies were used to target BMPR1A in adult hypothalamic tanycytes: (1) inducible Rax‐CreERT2 and (2) AAV‐Dio2‐iCre–mediated recombination. Although robust expression of reporter fluorescence and recombination gel analysis confirmed Cre activity in both models, BMPR1A expression was not reduced in targeted tanycytes.
Tianyi Tao, Noelle Leon‐Palmer, Sabrina DiPietro, Kristy L. Townsend   +3 more
wiley   +1 more source

Stimulation of the Hippocampal POMC/MC4R Circuit Alleviates Synaptic Plasticity Impairment in an Alzheimer’s Disease Model

Cell Reports, 2016
Hippocampal synaptic plasticity is modulated by neuropeptides, the disruption of which might contribute to cognitive deficits observed in Alzheimer’s disease (AD).
Yang Shen, Min Tian, Yuqiong Zheng, Fei Gong, Amy K.Y. Fu, Nancy Y. Ip   +5 more
doaj   +1 more source

Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos, Ana Margarida Araújo, Isabel M. P. L. V. O. Ferreira, Miguel A. Faria   +3 more
wiley   +1 more source

Pro-Opiomelanocortin-Derived Peptides Induce 11-1 0 Production in Human Monocytes

, 1996
Bhardwaj R, Schwarz A, Becher E, et al. Pro-Opiomelanocortin-Derived Peptides Induce 11-1 0 Production in Human Monocytes. The Journal of Immunology.
Mahnke, Karsten, Bhardwaj, Ranjit, Becher, Eva ; https://orcid.org/, Schwarz, Thomas, Luger, Thomas, Schwarz, Agatha, Aragane, Yoshi   +6 more
core  

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver

, 2010
Mice lacking 5-HT 2C receptors (5-HT(2C)Rs) displayed hepatic insulin resistance, a phenotype normalized by re-expression of 5-HT(2C)Rs only in pro-opiomelanocortin (POMC) neurons.
Eric D Berglund, Elmquist, Joel K., Juli E Jones, Sohn, Jong-Woo, Fukuda, Makoto, Philipp E Scherer, Scherer, Philipp E., Joel K Elmquist, Chuang, Jen-Chieh, Bradford B Lowell, Williams, W., Jari Rossi, Jeffrey M Zigman, Yong Xu, Jen-Chieh Chuang, Xu, Yong, Lowell, Bradford B., Zigman, Jeffrey M., Rossi, Jari, Makoto Fukuda, William L Holland, Jones, Juli E., Kevin W Williams, Berglund, Eric D., Jong-Woo Sohn, Holland, William L.   +25 more
core   +1 more source