Results 81 to 90 of about 1,051,322 (230)

Methodological Challenges for Ablation of BMPR1A in Hypothalamic Tanycytes—A Cautionary Tale

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
Two strategies were used to target BMPR1A in adult hypothalamic tanycytes: (1) inducible Rax‐CreERT2 and (2) AAV‐Dio2‐iCre–mediated recombination. Although robust expression of reporter fluorescence and recombination gel analysis confirmed Cre activity in both models, BMPR1A expression was not reduced in targeted tanycytes.
Tianyi Tao, Noelle Leon‐Palmer, Sabrina DiPietro, Kristy L. Townsend   +3 more
wiley   +1 more source

MicroRNAs are involved in the hypothalamic leptin sensitivity

Epigenetics, 2018
The central nervous system monitors modifications in metabolic parameters or hormone levels (leptin) and elicits adaptive responses such as food intake and glucose homeostasis regulation. Particularly, within the hypothalamus, pro-opiomelanocortin (POMC)
Adel Derghal, Mehdi Djelloul, Myriam Azzarelli, Sébastien Degonon, Franck Tourniaire, Jean-François Landrier, Lourdes Mounien   +6 more
doaj   +1 more source

MicroRNA 375 Mediates the Signaling Pathway of Corticotropin-releasing Factor (CRF) Regulating Pro-opiomelanocortin (POMC) Expression by Targeting Mitogen-activated Protein Kinase 8*

Journal of Biological Chemistry, 2013
Background: MicroRNA 375 (miR-375) is expressed in the pituitary gland, but its functions and the related mechanisms have not been studied. Results: miR-375 mediates the signaling pathway of CRF regulating POMC expression by targeting MAP3K8. Conclusion:
N. Zhang, Junkai Lin, Juan Chen, Xiong Liu, Jiali Liu, Hao-shu Luo, Yueqin Li, S. Cui   +7 more
semanticscholar   +1 more source

Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos, Ana Margarida Araújo, Isabel M. P. L. V. O. Ferreira, Miguel A. Faria   +3 more
wiley   +1 more source

Gene expression and methylation profiles show the involvement of POMC in primary hyperparathyroidsm

Journal of Translational Medicine, 2022
Primary hyperparathyroidism (PHPT) is mainly caused by parathyroid adenoma, which produces excess parathyroid hormones. Its pathogenic mechanisms have not yet been fully understood.
Wen-Xuan Zhou, Shu Wang, Ting-Chao Wu, Ling-Chao Cheng, Yao Du, Wei Wu, Chen Lin, Xin-Ying Li, Zhong-Liang Hu   +8 more
doaj   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, Volume 183, Issue 9, Page 2139-2165, May 2026.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

Tissue-Specific Activity of the Pro-Opiomelanocortin Gene Promoter [PDF]

Molecular and Cellular Biology, 1987
The pro-opiomelanocortin (POMC) gene is specifically expressed in corticotroph cells of the anterior pituitary. To define the POMC promoter sequences responsible for tissue-specific expression, we assessed POMC promoter activity by gene transfer into POMC-expressing pituitary tumor cells (AtT-20) and fibroblast L cells.
L, Jeannotte, M A, Trifiro, R K, Plante, M, Chamberland, J, Drouin   +4 more
openaire   +2 more sources

Time‐Restricted Feeding Alters Behavior in a Sex‐Specific Manner in Mice With Neuropathic Pain

Molecular Nutrition &Food Research, Volume 70, Issue 8, 27 April 2026.
Time‐restricted feeding (TRF) alleviates anxiety‐like behavior in male mice with neuropathic pain (NP), but not in females. Upon nerve injury, TRF altered the diurnal expression of transcripts in the hypothalamus. These findings suggest that TRF should be explored as a new therapeutic approach to alleviate the comorbid anxiety in NP.
Manqing Wen, Wenjing Dai, Eija Kalso, Vinko Palada   +3 more
wiley   +1 more source

Cross-talk between metabolism and reproduction: The Role of POMC and SF-1 Neurons

Frontiers in Endocrinology, 2012
Energy homeostasis and reproduction need to be tightly coordinated. The mechanisms for this coordinated control are not fully understood. Two subsets of hypothalamic neurons, namely pro-opiomelanocortin (POMC) neurons in the arcuate nucleus and ...
Yong eXu, Latric eFaulkner, Jennifer Wootton Hill   +2 more
doaj   +1 more source

Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake

Cell & Bioscience, 2022
Background Central nervous system (CNS) control of metabolism plays a pivotal role in maintaining energy balance. In the brain, Glucagon-like peptide 1 (GLP-1), encoded by the proglucagon ‘Gcg’ gene, produced in a distinct population of neurons in the ...
Ishnoor Singh, Le Wang, Baijuan Xia, Ji Liu, Azeddine Tahiri, Abdelfattah El Ouaamari, Michael B. Wheeler, Zhiping P. Pang   +7 more
doaj   +1 more source