Results 101 to 110 of about 1,051,322 (230)

The urinary albumin‐to‐creatinine ratio can direct personalized prevention and treatment for cardiovascular and chronic kidney disease

Journal of Internal Medicine, Volume 299, Issue 4, Page 444-466, April 2026.
Abstract Increased urinary albumin excretion is a strong predictor for cardiovascular events in persons with and without decreased glomerular filtration rate and can be assessed with the urinary albumin‐to‐creatinine ratio (UACR), which is a selective, sensitive, and convenient method for patients.
Holly J. Kramer, George L. Bakris
wiley   +1 more source

The Regulation of Leptin, Leptin Receptor and Pro-opiomelanocortin Expression by N-3 PUFAs in Diet-Induced Obese Mice Is Not Related to the Methylation of Their Promoters

Nutrition & Metabolism, 2011
Background The expression of leptin is increased in obesity and inhibited by n-3 polyunsaturated fatty acids (n-3 PUFAs), but the underlying molecular mechanisms have not been firmly established.
Qi Kemin, Deckelbaum Richard J, Shen Wenwen, Liu Xinli, Fan Chaonan   +4 more
doaj   +1 more source

Mutationsanalyse des Pro-Opiomelanocortin-Gens bei extrem adipösen Kindern und Jugendlichen [PDF]

, 2003
Adipositas stellt in der heutigen Gesellschaft ein ernstzunehmendes gesundheitspolitisches Problem dar. Untersuchungen des ?National Center for Health Statistics?
Han, Weixin, Shen, Yi, Trentelman, Harry L., Wang, Zhenhua   +3 more
core   +2 more sources

Adipose tissue‐derived small extracellular vesicles and blood–brain barrier function in adults with overweight and obesity

Experimental Physiology, Volume 111, Issue 4, Page 1819-1830, 1 April 2026.
Abstract Obesity is associated with adverse changes in brain structure and function, in part, through crosstalk between adipose tissue (AT) and the brain. AT releases small extracellular vesicles (sEV) that can cross the blood–brain barrier (BBB) and modulate multiple pathophysiological pathways, including BBB function; however, this has never been ...
Shalini Mishra, Yixin Su, Sangeeta Singh, Ashish Kumar, Fang‐Chi Hsu, Gagan Deep, Tina E. Brinkley   +6 more
wiley   +1 more source

Stimulation of the Hippocampal POMC/MC4R Circuit Alleviates Synaptic Plasticity Impairment in an Alzheimer’s Disease Model

Cell Reports, 2016
Hippocampal synaptic plasticity is modulated by neuropeptides, the disruption of which might contribute to cognitive deficits observed in Alzheimer’s disease (AD).
Yang Shen, Min Tian, Yuqiong Zheng, Fei Gong, Amy K.Y. Fu, Nancy Y. Ip   +5 more
doaj   +1 more source

Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT(2C) receptor mediated appetite [PDF]

, 2016
Alternate splicing of serotonin (5-hydroxytryptamine; 5-HT) 2C receptor (5-HT2CR) pre-RNA is negatively regulated by the small nucleolar RNA, Snord115, loss of which is observed in nearly all individuals with Prader-Willi Syndrome (PWS), a multigenic ...
Burke, LK, Davies, JR, Furby, HV, Garfield, AS, Heisler, LK, Isles, AR, Wilkinson, LS   +6 more
core  

Serotonin mediated changes in corticotropin releasing factor mRNA expression and feeding behavior isolated to the hypothalamic paraventricular nuclei [PDF]

, 2011
Fenfluramine reduces hunger and promotes body weight loss by increasing central serotonin (5-HT) signaling. More recently, neuropeptides have been linked to the regulation of feeding behavior, metabolism and body weight.
Boisvert, Joanne P, Boschuetz, Tyler J., Choi, Sujean, Mueller, Christopher R, Resch, Jon M   +4 more
core   +2 more sources

Complete amino acid sequence of mouse pro-opiomelanocortin derived from the nucleotide sequence of pro-opiomelanocortin cDNA.

Journal of Biological Chemistry, 1983
Polyadenylated RNA was isolated from a mouse pituitary tumor cell line (AtT-20/D16v) which synthesizes and secretes adrenocorticotropic hormone and beta-endorphin. The RNA was used to construct a cDNA library by a double linker technique and the library was screened for pro-opiomelanocortin (POMC) sequences.
M, Uhler, E, Herbert
openaire   +2 more sources

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

CNS Control of Glucose Metabolism: Response to Environmental Challenges [PDF]

, 2013
Over the last 15 years, considerable work has accumulated to support the role of the CNS in regulating postprandial glucose levels. As discussed in the first section of this review, the CNS receives and integrates information from afferent neurons ...
Arble, Deanna M., Sandoval, Darleen A.
core   +1 more source