Results 91 to 100 of about 1,051,322 (230)

Joint TOS/OMA/OAC Expert Guidance Statement on the Pharmacological Management of United States Adults With Overweight or Obesity Using the GRADE Approach

Obesity, Volume 34, Issue 4, Page 851-870, April 2026.
Guidance recommendations by TOS/OMA/OAC for the use of obesity medications to treat obesity and its complications. ABSTRACT Background Obesity affects over 40% of US adults, with severe obesity on the rise. Despite recognition of obesity as a chronic disease, it remains underdiagnosed and undertreated.
Lydia Alexander, Jonathan Q. Purnell, Karlijn Burridge, Marc‐André Cornier, Angela Golden, Deborah Bade Horn, Michelle Look, Joe Nadglowski, Camila Ávila‐Oliver, Francisco Novillo, Ana María Rojas‐Gómez, Brad Hussey, Ximena Ramos Salas   +12 more
wiley   +1 more source

Growth and hormonal profiling in children with congenital melanocytic naevi [PDF]

, 2015
BACKGROUND: Multiple congenital melanocytic naevi (CMN) is a rare mosaic RASopathy, caused by post-zygotic activating mutations in NRAS. Growth and hormonal disturbances are described in germline RASopathies.
Cole, T, Dattani, M, Healy, E, Hindmarsh, P, Kennedy, H, Khan, S, Kinsler, V, Martinez, A, Moore, G, Sebire, N, Semple, R, Waelchi, R, White, A, Williams, J   +13 more
core   +1 more source

Targeting Multiple Gut‐Brain Pathways in Obesity: Rationale for Combination Pharmacotherapy

Obesity Science &Practice, Volume 12, Issue 2, April 2026.
ABSTRACT Background As a disease of energy dysregulation, obesity involves metabolic, hormonal, and neural factors, the interconnection of which is referred to as the “gut‐brain axis.” Objective This review aimed to provide an overview of the clinical evidence of physiological and objective or subjective changes in eating behavior with gut hormone ...
Alexander D. Miras, Muzamil Hussain
wiley   +1 more source

Characterization of two Pro-opiomelanocortin gene variants and their effects on carcass traits in beef cattle

BMC Genetics, 2011
Background Carcass quantity (lean meat yield) and quality (degree of marbling) in beef cattle determines much of their economic value. Consequently, it is important to study genes that are part of the appetite pathway and that may ultimately affect ...
Deobald Heather M, Buchanan Fiona C
doaj   +1 more source

Uninephrectomy in rats on a fixed food intake potentiates both anorexia and circulating cytokine subsets in response to LPS [PDF]

, 2015
Recent human studies have suggested that mild reduction in kidney function can alter immune response and increase susceptibility to infection. The role of mild reduction in kidney function in altering susceptibility to bacterial lipopolysaccharide (LPS ...
Arsenijevic, Denis, Montani, Jean-Pierre
core   +1 more source

Obesity and Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD): A Literature Review on Pathophysiology and Treatment

Diabetes, Obesity and Metabolism, Volume 28, Issue S2, Page 19-30, April 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) represents a key hepatic manifestation of obesity and systemic metabolic dysfunction and is a leading cause of chronic liver disease worldwide. Obesity‐driven mechanisms, including adipose tissue dysfunction, insulin resistance and increased free fatty acid flux to the liver ...
Michael Romanos, Juan M. Garcia Cordova, Jose Villamarin, Juan D. Pazmino Zurita, Andres Acosta   +4 more
wiley   +1 more source

Orexigenic Gene Expression in Late Gestation Ovine Foetal Hypothalamus is Sensitive to Maternal Undernutrition and Realimentation [PDF]

, 2015
Acknowledgements Research was funded by the Scottish Government's Rural and Environment Science and Analytical Services Division (RESAS), including the Strategic Partnership for Animal Science Excellence (SPASE). The authors have no conflicts of interest
Adam, C. L., Aitken, R. P., Milne, J. S., Wallace, J. M., Williams, P. A.   +4 more
core   +1 more source

Noradrenergic inhibition of definitive POMC neurons through direct and indirect mechanisms

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Norepinephrine and the α2‐adrenoceptor agonist UK 14,304 robustly inhibit definitive arcuate POMC neurons. Direct inhibition is mediated by ADRA2A‐dependent activation of potassium conductances, while additional indirect mechanisms also contribute. In vivo, inducible POMC‐specific Adra2a deletion minimally affects energy balance and modestly impairs ...
Olivier Lavoie, Audrey Turmel, Axelle Khouma, Moein Minbashi Moeini, Chen Liu, Natalie J. Michael, Alexandre Caron   +6 more
wiley   +1 more source

Hypothalamikus struktúrák glutamáterg innervációjának neurokémiai és funkcionális elemzése = Glutamatergic innervation of hypothalamic structures: neurochemical and functional analysis [PDF]

, 2007
A [3H]D-aszpartát szelektív felvételén és retrográd transzportján alapuló autoradiográfiás eljárással feltérképeztük a mediális preoptikus areába projiciáló glutamáterg idegsejtek lokalizációját.
Csáki, Ágnes, Halász, Béla, Kiss, József, Nagy M., György   +3 more
core  

Expression in the human brain of retinoic acid induced 1, a protein associated with neurobehavioural disorders [PDF]

, 2014
Acknowledgements Funding was provided by the Wellcome Trust and Tenovus Scotland. Prof Fragoso is the recipient of a Post Doctoral Science without Borders grant from the Brazilian National Council for Scientific and Technological Development (CNPq, 37450/
Fragoso, Yara Dadalti, McCaffery, Peter, Nanescu, Sonia E., Sementilli, Angelo, Sementilli, Pietro, Shearer, Kirsty D., Stoney, Patrick N.   +6 more
core   +2 more sources