Results 51 to 60 of about 1,051,322 (230)

Gel chromatographic characterization of immunoreactive adrenocorticotropin in patients with ACTH hypersecretion [PDF]

, 1989
We investigated the molecular size of circulating immunoreactive ACTH by gel chromatography in patients with ACTH hypersecretion due to various disorders of the hypothalamic-pituitary-adrenal axis.
A Chatelain, AC Hale, B Allolio, B. Allolio, H Imura, JL Doppmann, JW Findling, K Nakao, M Reincke, M Reincke, M Thoren, M. Reincke, PJ Fuller, RC Pedersen, RE Mains, RS Yalow, SJ Ratter, U. Deuß, W. Winkelmann, Y Yamada   +19 more
core   +1 more source

Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis

Nature Communications, 2019
Neurons expressing pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here the authors show that Steroid Receptor Coactivator-1 (SRC-1) regulates the function of Pomc expressing neurons, and that rare heterozygous variants found in obese ...
Yongjie Yang, Agatha A. van der Klaauw, Liangru Zhu, Tessa M. Cacciottolo, Yanlin He, Lukas K. J. Stadler, Chunmei Wang, Pingwen Xu, Kenji Saito, Antentor Hinton, Xiaofeng Yan, Julia M. Keogh, Elana Henning, Matthew C. Banton, Audrey E. Hendricks, Elena G. Bochukova, Vanisha Mistry, Katherine L. Lawler, Lan Liao, Jianming Xu, Stephen O’Rahilly, Qingchun Tong, UK10K Consortium, Inês Barroso, Bert W. O’Malley, I. Sadaf Farooqi, Yong Xu   +26 more
doaj   +1 more source

Role of Reactive Oxygen Species in Hypothalamic Regulation of Energy Metabolism [PDF]

Endocrinology and Metabolism, 2013
To understand the etiology of metabolic disorders, including obesity and type II diabetes, it is essential to gain better insight into how stored and available energy sources are monitored by the central nervous system.
Sabrina Diano
doaj   +1 more source

Circulating phagocytes: The ancient and conserved interface between immune and neuroendocrine function [PDF]

, 2017
Immune and neuroendocrine functions display significant overlap in highly divergent and evolutionarily distant models such as molluscs, crustaceans, insects and mammals.
MALAGOLI, Davide, MANDRIOLI, Mauro, OTTAVIANI, Enzo, TASCEDDA, Fabio   +3 more
core   +1 more source

Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing [PDF]

, 2013
It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity.
Cakir, Isin, Cyr, Nicole E., Litvinov, Bogdan Patedakis, Nillni, Eduardo A., Perello, Mario, Romero, Amparo, Stuart, Ronald C.   +6 more
core   +1 more source

TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis

Nature Communications, 2018
Sexual dimorphism exists in a number of physiological processes, including energy homeostasis. Here, the authors show that pro-opiomelanocortin neurons in female mice fire more rapidly than males, and that deletion of the transcription TAp63 leads to a ...
Chunmei Wang, Yanlin He, Pingwen Xu, Yongjie Yang, Kenji Saito, Yan Xia, Xiaofeng Yan, Antentor Hinton Jr, Chunling Yan, Hongfang Ding, Likai Yu, Gang Shu, Rajat Gupta, Qi Wu, Qingchun Tong, William R. Lagor, Elsa R. Flores, Yong Xu   +17 more
doaj   +1 more source

Seeing is Believing: Dynamic Evolution of Gene Families [PDF]

, 2015
Department of Integrative Biology, Center for Computational Biology, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712Supported by National Science Foundation Grants IOS- 0843712 and IOS-1354942 (to H.A.H.)
Harris, Rayna M., Hofmann, Hans A.
core   +1 more source

Arcuate nucleus homeostatic systems reflect blood leptin concentration but not feeding behaviour during scheduled feeding on a high-fat diet in mice [PDF]

, 2017
Acknowledgements T.B. was funded by a CASE studentship from the BBSRC and AstraZeneca. J.B. was a summer student from Bordeaux Sciences Agro and funded by student laboratory experience grant from the British Society of Neuroendocrinology. The authors are
Bake, T., Baron, J., Duncan, J. S., Mercer, J. G., Morgan, D. G. A.   +4 more
core   +1 more source

Developmental programming of hypothalamic neuronal circuits: impact on energy balance control

Frontiers in Neuroscience, 2015
The prevalence of obesity in adults and children has increased globally at an alarming rate. Mounting evidence from both epidemiological studies and animal models indicates that adult obesity and associated metabolic disorders can be programmed by ...
Thanuja eGali Ramamoorthy, Ghazala eBegum, Erika eHarno, Anne eWhite   +3 more
doaj   +1 more source

Protocol for simultaneous patch-clamp recording from tanycytes and neurons in living mouse brain slices

STAR Protocols, 2023
Summary: Here, we present a protocol for tanycyte-neuron paired whole-cell patch-clamp recording in living mouse brain slices. We describe steps for mice generation, solution preparation, and dissection.
Tori Lhomme, Vincent Prévot
doaj   +1 more source