Results 31 to 40 of about 1,457,386 (196)
The Tissue‐Specific Processing of Pro‐Opiomelanocortin [PDF]
Journal of Neuroendocrinology, 2008 It is just over 30 years since the definitive identification of the adrenocorticotrophin (ACTH) precursor, pro‐opiomelanocotin (POMC). Although first characterised in the anterior and intermediate lobes of the pituitary, POMC is also expressed in a number of both central and peripheral tissues including the skin, central nervous tissue and placenta ...
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Effect of calcium ions on the processing of pro‐opiomelanocortin by bovine intermediate lobe pro‐opiomelanocortin‐converting enzyme [PDF]
European Journal of Biochemistry, 1991 The effect of Ca2+ on the extent and pattern of processing of pro‐opiomelanocortin and an N‐terminal fragment by a purified pituitary secretory vesicle, soluble aspartic endoprotease, was studied. Ca2+ stimulated the first cleavage of pro‐opiomelanocortin by pro‐opiomelanocortin‐converting enzyme to yield 21–23 kDa adrenocorticotropin and β‐lipotropin,
N P, Birch +3 more
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Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities
Frontiers in Physiology, 2021 Melanocortin peptides, melanocortin receptors, melanocortin receptor accessory proteins, and endogenous antagonists of melanocortin receptors are the key components constituting the melanocortin hormone system, one of the most complex and important ...
Mingyang Chang +4 more
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Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis
Nature Communications, 2019 Neurons expressing pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here the authors show that Steroid Receptor Coactivator-1 (SRC-1) regulates the function of Pomc expressing neurons, and that rare heterozygous variants found in obese ...
Yongjie Yang +26 more
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Role of Reactive Oxygen Species in Hypothalamic Regulation of Energy Metabolism [PDF]
Endocrinology and Metabolism, 2013 To understand the etiology of metabolic disorders, including obesity and type II diabetes, it is essential to gain better insight into how stored and available energy sources are monitored by the central nervous system.
Sabrina Diano
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, 1989 Expression of the RNA coding for the ACTH-beta-lipotrophin precursor, pro-opiomelanocortin (POMC), has been demonstrated in five human small-cell lung cancer (SCLC) cell lines.
Lavender, P M +7 more
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Developmental programming of hypothalamic neuronal circuits: impact on energy balance control
Frontiers in Neuroscience, 2015 The prevalence of obesity in adults and children has increased globally at an alarming rate. Mounting evidence from both epidemiological studies and animal models indicates that adult obesity and associated metabolic disorders can be programmed by ...
Thanuja eGali Ramamoorthy +3 more
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TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis
Nature Communications, 2018 Sexual dimorphism exists in a number of physiological processes, including energy homeostasis. Here, the authors show that pro-opiomelanocortin neurons in female mice fire more rapidly than males, and that deletion of the transcription TAp63 leads to a ...
Chunmei Wang +17 more
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STAR Protocols, 2023 Summary: Here, we present a protocol for tanycyte-neuron paired whole-cell patch-clamp recording in living mouse brain slices. We describe steps for mice generation, solution preparation, and dissection.
Tori Lhomme, Vincent Prévot
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Pro-opiomelanocortin mRNA and peptide co-expression in the developing rat pituitary [PDF]
, 1991 Pro-opiomelanocortin (POMC) is synthesized in both the pituitary gland and the brain. Various peptide products of this precursor, namely beta-endorphin, ACTH and alpha-MSH are co-localized in the anterior lobe corticotrophs, all intermediate lobe cells ...
Schafer, Martin K.-H. +3 more
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