Results 31 to 40 of about 1,067,103 (202)

The Tissue‐Specific Processing of Pro‐Opiomelanocortin [PDF]

Journal of Neuroendocrinology, 2008
It is just over 30 years since the definitive identification of the adrenocorticotrophin (ACTH) precursor, pro‐opiomelanocotin (POMC). Although first characterised in the anterior and intermediate lobes of the pituitary, POMC is also expressed in a number of both central and peripheral tissues including the skin, central nervous tissue and placenta ...
openaire   +2 more sources

Effect of calcium ions on the processing of pro‐opiomelanocortin by bovine intermediate lobe pro‐opiomelanocortin‐converting enzyme [PDF]

European Journal of Biochemistry, 1991
The effect of Ca2+ on the extent and pattern of processing of pro‐opiomelanocortin and an N‐terminal fragment by a purified pituitary secretory vesicle, soluble aspartic endoprotease, was studied. Ca2+ stimulated the first cleavage of pro‐opiomelanocortin by pro‐opiomelanocortin‐converting enzyme to yield 21–23 kDa adrenocorticotropin and β‐lipotropin,
N P, Birch, H P, Bennett, F E, Estivariz, Y P, Loh   +3 more
openaire   +2 more sources

Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities

Frontiers in Physiology, 2021
Melanocortin peptides, melanocortin receptors, melanocortin receptor accessory proteins, and endogenous antagonists of melanocortin receptors are the key components constituting the melanocortin hormone system, one of the most complex and important ...
Mingyang Chang, Bohan Chen, James Shaffner, Lance D. Dworkin, Rujun Gong   +4 more
doaj   +1 more source

Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis

Nature Communications, 2019
Neurons expressing pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here the authors show that Steroid Receptor Coactivator-1 (SRC-1) regulates the function of Pomc expressing neurons, and that rare heterozygous variants found in obese ...
Yongjie Yang, Agatha A. van der Klaauw, Liangru Zhu, Tessa M. Cacciottolo, Yanlin He, Lukas K. J. Stadler, Chunmei Wang, Pingwen Xu, Kenji Saito, Antentor Hinton, Xiaofeng Yan, Julia M. Keogh, Elana Henning, Matthew C. Banton, Audrey E. Hendricks, Elena G. Bochukova, Vanisha Mistry, Katherine L. Lawler, Lan Liao, Jianming Xu, Stephen O’Rahilly, Qingchun Tong, UK10K Consortium, Inês Barroso, Bert W. O’Malley, I. Sadaf Farooqi, Yong Xu   +26 more
doaj   +1 more source

Role of Reactive Oxygen Species in Hypothalamic Regulation of Energy Metabolism [PDF]

Endocrinology and Metabolism, 2013
To understand the etiology of metabolic disorders, including obesity and type II diabetes, it is essential to gain better insight into how stored and available energy sources are monitored by the central nervous system.
Sabrina Diano
doaj   +1 more source

TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis

Nature Communications, 2018
Sexual dimorphism exists in a number of physiological processes, including energy homeostasis. Here, the authors show that pro-opiomelanocortin neurons in female mice fire more rapidly than males, and that deletion of the transcription TAp63 leads to a ...
Chunmei Wang, Yanlin He, Pingwen Xu, Yongjie Yang, Kenji Saito, Yan Xia, Xiaofeng Yan, Antentor Hinton Jr, Chunling Yan, Hongfang Ding, Likai Yu, Gang Shu, Rajat Gupta, Qi Wu, Qingchun Tong, William R. Lagor, Elsa R. Flores, Yong Xu   +17 more
doaj   +1 more source

Developmental programming of hypothalamic neuronal circuits: impact on energy balance control

Frontiers in Neuroscience, 2015
The prevalence of obesity in adults and children has increased globally at an alarming rate. Mounting evidence from both epidemiological studies and animal models indicates that adult obesity and associated metabolic disorders can be programmed by ...
Thanuja eGali Ramamoorthy, Ghazala eBegum, Erika eHarno, Anne eWhite   +3 more
doaj   +1 more source

Protocol for simultaneous patch-clamp recording from tanycytes and neurons in living mouse brain slices

STAR Protocols, 2023
Summary: Here, we present a protocol for tanycyte-neuron paired whole-cell patch-clamp recording in living mouse brain slices. We describe steps for mice generation, solution preparation, and dissection.
Tori Lhomme, Vincent Prévot
doaj   +1 more source

Alpha-MSH and pro-opiomelanocortin in Rab3a KO melanotrophs.

, 2013
Representative confocal microscopy micrographs from immunocytochemistry of γ-MSH/ pro-opiomelanocortin (POMC) (top) and α-MSH (bottom) in WT and Rab3a KO pituitary slices. Arrow indicates the intermediate lobe (PI).
Maša Skelin Klemen (474643), Oliver M. Schlüter (474644), Marjan Slak Rupnik (276794), Simon Sedej (474642)   +3 more
core   +1 more source

Development of the Hypothalamic Melanocortin System

Frontiers in Endocrinology, 2013
The melanocortin system is a critical component of the forebrain and hindbrain regulatory systems involved in energy balance. This system is composed of pro-opiomelanocortin (POMC) neurons that act, in part, through the melanocortin-4 receptor (MC4R ...
Berengere eCoupe, Sebastien G Bouret
doaj   +1 more source