Results 21 to 30 of about 10,743 (219)
Molecular Metabolism, 2021 Objective: Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus are essential regulators of energy balance. Selective loss of POMC production in these cells results in extreme obesity and metabolic comorbidities.
Surbhi +3 more
doaj +1 more source
Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances [PDF]
, 2007 The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two of the five melanocortin receptors, MC3R and MC4R are involved in hypothalamic control of energy homeostasis, with the MC4R having the major influence. It is
Hisadome, Kazunari +11 more
core +1 more source
Fetal Alcohol Spectrum Disorders and their Transmission through Genetic and Epigenetic Mechanisms
Frontiers in Genetics, 2014 Fetal alcohol spectrum disorders (FASD) are a group of related conditions that arise from prenatal exposure to maternal consumption of the teratogen, ethanol.
Edward A Mead, Dipak eSarkar
doaj +1 more source
Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress
Cell Reports, 2017 The relationship between loss of hypothalamic function and onset of diabetes mellitus remains elusive. Therefore, we generated a targeted oxidative-stress murine model utilizing conditional knockout (KO) of selenocysteine-tRNA (Trsp) using rat-insulin ...
Yoko Yagishita +9 more
doaj +1 more source
Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy
Nature Communications, 2021 Proopiomelanocortin is an anti-nociceptive peptide. Here the authors show in a mouse model of diabetes, that this peptide is downregulated, which may contribute to the neuropathic pain like behaviour in these models.
Divija Deshpande +7 more
doaj +1 more source
Frontiers in Physiology, 2023 The present review considers the putative hormonal opioid peptides in birds. In birds and all other vertebrates, there are four opioid related genes encoding a series of peptides.
Krystyna Pierzchała-Koziec +1 more
doaj +1 more source
Frontiers in Endocrinology, 2013 The regulated secretory pathway provides critical control of peptide, growth factor, and hormone release from neuroendocrine and endocrine cells, and neurons, maintaining physiological homeostasis.
Stephen eSalton +2 more
doaj +1 more source
Hypothalamic Proopiomelanocortin Is Necessary for Normal Glucose Homeostasis in Female Mice
Frontiers in Endocrinology, 2018 The arcuate nucleus of the hypothalamus is a key regulator of energy balance and glucose homeostasis. In particular, arcuate proopiomelanocortin (POMC) neurons inhibit food intake, stimulate energy expenditure and increase glucose tolerance.
Ramiro Alsina +3 more
doaj +1 more source
Increase of proopiomelanocortin-related peptides during subjective menopausal flushes
, 1984 The present study reports the plasma levels of gonadotropins (luteinizing hormone, follicle-stimulating hormone), proopiomelanocortin-related peptides (adrenocorticotropic hormone, β-endorphin, and β-lipotropin), and cortisol in eight menopausal women ...
Facchini, V. +11 more
core +2 more sources
Selected hormonal and neurotransmitter mechanisms regulating feed intake in sheep
Animal, 2010 Appetite control is a major issue in normal growth and in suboptimal growth performance settings. A number of hormones, in particular leptin, activate or inhibit orexigenic or anorexigenic neurotransmitters within the arcuate nucleus of the hypothalamus,
J.L. Sartin +3 more
doaj +1 more source