Results 21 to 30 of about 11,890 (215)

Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances [PDF]

, 2007
The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two of the five melanocortin receptors, MC3R and MC4R are involved in hypothalamic control of energy homeostasis, with the MC4R having the major influence. It is
Hisadome, Kazunari, Michael L. J. Ashford, Smith, Mark A., Helen Heffron, Mark A. Smith, Al-Qassab, Hind, Kazunari Hisadome, Withers, Dominic J., Hind Al‐Qassab, Dominic J. Withers, Ashford, Michael L. J.; id_orcid, Heffron, Helen   +11 more
core   +1 more source

Fetal Alcohol Spectrum Disorders and their Transmission through Genetic and Epigenetic Mechanisms

Frontiers in Genetics, 2014
Fetal alcohol spectrum disorders (FASD) are a group of related conditions that arise from prenatal exposure to maternal consumption of the teratogen, ethanol.
Edward A Mead, Dipak eSarkar
doaj   +1 more source

The Cell Adhesion Activity of the Joining Peptide of Proopiomelanocortin

Molecules, 2023
Proopiomelanocortin (POMC) is a precursor protein of several peptide hormones, such as ACTH and β-endorphin. Almost all of the peptide hormones in POMC have been drastically investigated in terms of their biological activities.
Kyona Hiroshima, Nana Sakata, Tadafumi Konogami, Shigeru Shimamoto, Yuji Hidaka   +4 more
doaj   +1 more source

A Patient with Proopiomelanocortin Deficiency: An Increasingly Important Diagnosis to Make [PDF]

, 2018
Proopiomelanocortin (POMC) deficiency is a rare monogenic disorder with early-onset obesity. Investigation of this entity have increased our insight into the important role of the leptin-melanocortin pathway in energy balance. Here, we present a patient
Guran, T, Kurnaz, E, Keskin, M, Cetinkaya, S, Achermann, JC, Sagsak, E, Aycan, Z, Buonocore, F, Suntharalingham, JP, Erdeve, SS   +9 more
core   +3 more sources

Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress

Cell Reports, 2017
The relationship between loss of hypothalamic function and onset of diabetes mellitus remains elusive. Therefore, we generated a targeted oxidative-stress murine model utilizing conditional knockout (KO) of selenocysteine-tRNA (Trsp) using rat-insulin ...
Yoko Yagishita, Akira Uruno, Toshiaki Fukutomi, Ritsumi Saito, Daisuke Saigusa, Jingbo Pi, Akiyoshi Fukamizu, Fumihiro Sugiyama, Satoru Takahashi, Masayuki Yamamoto   +9 more
doaj   +1 more source

Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy

Nature Communications, 2021
Proopiomelanocortin is an anti-nociceptive peptide. Here the authors show in a mouse model of diabetes, that this peptide is downregulated, which may contribute to the neuropathic pain like behaviour in these models.
Divija Deshpande, Nitin Agarwal, Thomas Fleming, Claire Gaveriaux-Ruff, Christoph S. N. Klose, Anke Tappe-Theodor, Rohini Kuner, Peter Nawroth   +7 more
doaj   +1 more source

Avian opioid peptides: evolutionary considerations, functional roles and a challenge to address critical questions

Frontiers in Physiology, 2023
The present review considers the putative hormonal opioid peptides in birds. In birds and all other vertebrates, there are four opioid related genes encoding a series of peptides.
Krystyna Pierzchała-Koziec, Colin G. Scanes   +1 more
doaj   +1 more source

The regulated secretory pathway and human disease: insights from gene variants and single nucleotide polymorphisms

Frontiers in Endocrinology, 2013
The regulated secretory pathway provides critical control of peptide, growth factor, and hormone release from neuroendocrine and endocrine cells, and neurons, maintaining physiological homeostasis.
Stephen eSalton, Stephen eSalton, Wei Jye Lin   +2 more
doaj   +1 more source

Hypothalamic Proopiomelanocortin Is Necessary for Normal Glucose Homeostasis in Female Mice

Frontiers in Endocrinology, 2018
The arcuate nucleus of the hypothalamus is a key regulator of energy balance and glucose homeostasis. In particular, arcuate proopiomelanocortin (POMC) neurons inhibit food intake, stimulate energy expenditure and increase glucose tolerance.
Ramiro Alsina, Milagros Trotta, Viviana Florencia Bumaschny, Viviana Florencia Bumaschny   +3 more
doaj   +1 more source

Erythropoietin Non-hematopoietic Tissue Response and Regulation of Metabolism During Diet Induced Obesity

Frontiers in Pharmacology, 2021
Erythropoietin (EPO) receptor (EPOR) determines EPO response. High level EPOR on erythroid progenitor cells gives rise to EPO regulated production of red blood cells. Animal models provide evidence for EPO activity in non-hematopoietic tissue mediated by
Soumyadeep Dey, Jeeyoung Lee, Constance T. Noguchi   +2 more
doaj   +1 more source