Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing [PDF]
, 2013 It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity.
Cakir, Isin +6 more
core +1 more source
Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight [PDF]
, 2016 Despite clear associations between vitamin D deficiency and obesity and/or type 2 diabetes, a causal relationship is not established. Vitamin D receptors (VDRs) are found within multiple tissues, including the brain.
Arble, Deanna M. +9 more
core +4 more sources
GABA Release from Proopiomelanocortin Neurons [PDF]
The Journal of Neuroscience, 2004 Neural networks controlling food intake and energy homeostasis clearly involve proopiomelanocortin (POMC) neurons and their peptide transmitters. α-melanocyte-stimulating hormone from arcuate POMC neurons potently reduces food intake, whereas arcuate neuropeptide Y (NPY) neurons act in opposition to stimulate food intake.
Shane T, Hentges +5 more
openaire +2 more sources
Fetal Alcohol Spectrum Disorders and their Transmission through Genetic and Epigenetic Mechanisms
Frontiers in Genetics, 2014 Fetal alcohol spectrum disorders (FASD) are a group of related conditions that arise from prenatal exposure to maternal consumption of the teratogen, ethanol.
Edward A Mead, Dipak eSarkar
doaj +1 more source
Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress
Cell Reports, 2017 The relationship between loss of hypothalamic function and onset of diabetes mellitus remains elusive. Therefore, we generated a targeted oxidative-stress murine model utilizing conditional knockout (KO) of selenocysteine-tRNA (Trsp) using rat-insulin ...
Yoko Yagishita +9 more
doaj +1 more source
Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy
Nature Communications, 2021 Proopiomelanocortin is an anti-nociceptive peptide. Here the authors show in a mouse model of diabetes, that this peptide is downregulated, which may contribute to the neuropathic pain like behaviour in these models.
Divija Deshpande +7 more
doaj +1 more source
Frontiers in Physiology, 2023 The present review considers the putative hormonal opioid peptides in birds. In birds and all other vertebrates, there are four opioid related genes encoding a series of peptides.
Krystyna Pierzchała-Koziec +1 more
doaj +1 more source
A Patient with Proopiomelanocortin Deficiency: An Increasingly Important Diagnosis to Make [PDF]
, 2017 Proopiomelanocortin (POMC) deficiency is a rare monogenic disorder with early-onset obesity. Investigation of this entity have increased our insight into the important role of the leptin-melanocortin pathway in energy balance. Here, we present a patient
Achermann, JC +9 more
core +2 more sources
Frontiers in Endocrinology, 2013 The regulated secretory pathway provides critical control of peptide, growth factor, and hormone release from neuroendocrine and endocrine cells, and neurons, maintaining physiological homeostasis.
Stephen eSalton +2 more
doaj +1 more source
Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells - Redundancy or specificity of neuroimmunoendocrine modulators? [PDF]
, 2004 Objective: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Methods: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM.
Auernhammer, Christoph J. +9 more
core +1 more source