Results 1 to 10 of about 484,847 (189)

Dopamine-inhibited POMCDrd2+ neurons in the ARC acutely regulate feeding and body temperature

JCI Insight, 2022
Dopamine acts on neurons in the arcuate nucleus (ARC) of the hypothalamus, which controls homeostatic feeding responses. Here we demonstrate a differential enrichment of dopamine receptor 1 (Drd1) expression in food intake–promoting agouti related ...
Isabella Gaziano, Svenja Corneliussen, Nasim Biglari, René Neuhaus, Linyan Shen, Tamara Sotelo-Hitschfeld, Paul Klemm, Lukas Steuernagel, Alain J. De Solis, Weiyi Chen, F. Thomas Wunderlich, Peter Kloppenburg, Jens C. Brüning   +12 more
doaj   +2 more sources

Central Dicer-miR-103/107 controls developmental switch of POMC progenitors into NPY neurons and impacts glucose homeostasis

eLife, 2018
Proopiomelanocortin (POMC) neurons are major negative regulators of energy balance. A distinct developmental property of POMC neurons is that they can adopt an orexigenic neuropeptide Y (NPY) phenotype.
Sophie Croizier, Soyoung Park, Julien Maillard, Sebastien G Bouret   +3 more
doaj   +2 more sources

Cellular and synaptic reorganization of arcuate NPY/AgRP and POMC neurons after exercise

Molecular Metabolism, 2018
Objective: Hypothalamic Pro-opiomelanocortin (POMC) and Neuropeptide Y/Agouti-Related Peptide (NPY/AgRP) neurons are critical nodes of a circuit within the brain that sense key metabolic cues as well as regulate metabolism.
Zhenyan He, Yong Gao, Amber L. Alhadeff, Carlos M. Castorena, Yiru Huang, Linh Lieu, Sadia Afrin, Jia Sun, J. Nicholas Betley, Hongbo Guo, Kevin W. Williams   +10 more
doaj   +2 more sources

Over-expression of leptin receptors in hypothalamic POMC neurons increases susceptibility to diet-induced obesity. [PDF]

PLoS ONE, 2012
Diet-induced obesity (DIO) in rodents is characterized by impaired activation of signal-transducer and activator of transcription 3 (STAT3) by leptin receptors (LepRb) within the hypothalamic arcuate nucleus.
Kevin M Gamber, Lihong Huo, Sangdeuk Ha, Joyce E Hairston, Sarah Greeley, Christian Bjørbæk   +5 more
doaj   +2 more sources

Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing

Molecular Metabolism, 2017
Objective: Arcuate proopiomelanocortin (POMC) neurons are critical nodes in the control of body weight. Often characterized simply as direct targets for leptin, recent data suggest a more complex architecture.
Brian Y.H. Lam, Irene Cimino, Joseph Polex-Wolf, Sara Nicole Kohnke, Debra Rimmington, Valentine Iyemere, Nicholas Heeley, Chiara Cossetti, Reiner Schulte, Luis R. Saraiva, Darren W. Logan, Clemence Blouet, Stephen O'Rahilly, Anthony P. Coll, Giles S.H. Yeo   +14 more
doaj   +1 more source

Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons

Cell Reports, 2018
Summary: Leptin acts on hypothalamic pro-opiomelanocortin (POMC) neurons to regulate glucose homeostasis, but the precise mechanisms remain unclear.
Mark A. Smith, Loukia Katsouri, Samuel Virtue, Agharul I. Choudhury, Antonio Vidal-Puig, Michael L.J. Ashford, Dominic J. Withers   +6 more
doaj   +1 more source

Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling

Molecular Metabolism, 2020
Objective: Sirt6 is an essential regulator of energy metabolism in multiple peripheral tissues. However, the direct role of Sirt6 in the hypothalamus, specifically pro-opiomelanocortin (POMC) neurons, controlling energy balance has not been established ...
Qin Tang, Yong Gao, Qinhui Liu, Xuping Yang, Tong Wu, Cuiyuan Huang, Ya Huang, Jinhang Zhang, Zijing Zhang, Rui Li, Shiyun Pu, Guorong Zhang, Yingnan Zhao, Jian Zhou, Hui Huang, Yanping Li, Wei Jiang, Yongsheng Chang, Jinhan He   +18 more
doaj   +1 more source

Trilogy Development of Proopiomelanocortin Neurons From Embryonic to Adult Stages in the Mice Retina

Frontiers in Cell and Developmental Biology, 2021
Proopiomelanocortin-positive amacrine cells (POMC ACs) were first discovered in adult mouse retinas in 2010; however, the development of POMC-ACs has not been studied.
Xuhong Zhang, Xiaoyu Wang, Xiaoyu Wang, Senjie Wang, Wei Peng, Rahim Ullah, Rahim Ullah, Junfen Fu, Yudong Zhou, Yudong Zhou, Ye Shen   +10 more
doaj   +1 more source

Glucose rapidly induces different forms of excitatory synaptic plasticity in hypothalamic POMC neurons. [PDF]

PLoS ONE, 2014
Hypothalamic POMC neurons are required for glucose and energy homeostasis. POMC neurons have a wide synaptic connection with neurons both within and outside the hypothalamus, and their activity is controlled by a balance between excitatory and inhibitory
Jun Hu, Lin Jiang, Malcolm J Low, Liangyou Rui   +3 more
doaj   +1 more source

TRPC1/5-CaV3 Complex Mediates Leptin-Induced Excitability in Hypothalamic Neurons

Frontiers in Neuroscience, 2021
Leptin regulates hypothalamic POMC+ (pro-opiomelanocortin) neurons by inducing TRPC (Transient Receptor Potential Cation) channel-mediate membrane depolarization.
Paula P. Perissinotti, Elizabeth Martínez-Hernández, Erika S. Piedras-Rentería   +2 more
doaj   +1 more source