Results 1 to 10 of about 40,983 (192)

GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity [PDF]

Molecular Metabolism, 2023
Objective: G-protein-signaling modulator 1 (GPSM1) has been proved the potential role in brain tissues, however, whether GPSM1 in hypothalamic nuclei, especially in POMC neurons is essential for the proper regulation of whole-body energy balance remains ...
Mengyang Tang, Yi Zhang, Rong Zhang, Yuemei Zhang, Jiangfei Zheng, Daixi Wang, Xinyu Wang, Jing Yan, Cheng Hu   +8 more
doaj   +3 more sources

Lactate activates hypothalamic POMC neurons by intercellular signaling [PDF]

Scientific Reports, 2021
Previous studies indicate that the activity of hypothalamic POMC neurons can be regulated by glucose via intracellular mechanisms, but its regulation by lactate is poorly understood. In addition to its energetic role, lactate acts as a signaling molecule.
P. Órdenes, P. S. Villar, E. Tarifeño-Saldivia, M. Salgado, R. Elizondo-Vega, Ricardo C. Araneda, María A. García-Robles   +6 more
doaj   +4 more sources

IL-17A produced by POMC neurons regulates diet-induced obesity [PDF]

iScience
Summary: Overeating leads to obesity, a low-grade inflammatory condition involving interleukin-17A (IL-17A). While pro-opiomelanocortin (POMC) neurons regulate feeding, their connection with IL-17A is not well understood.
Rosa Gallo, Ana Teijeiro, Mariana Angulo-Aguado, Nabil Djouder   +3 more
doaj   +3 more sources

SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis [PDF]

Cell & Bioscience, 2022
Background Pro-opiomelanocortin (POMC) neurons play a sexually dimorphic role in body weight and glucose balance. However, the mechanisms for the sex differences in POMC neuron functions are not fully understood.
Meng Yu, Jonathan C. Bean, Hailan Liu, Yang He, Yongjie Yang, Xing Cai, Kaifan Yu, Zhou Pei, Hesong Liu, Longlong Tu, Kristine M. Conde, Mengjie Wang, Yongxiang Li, Na Yin, Nan Zhang, Junying Han, Nikolas A. Scarcelli, Pingwen Xu, Yanlin He, Yong Xu, Chunmei Wang   +20 more
doaj   +2 more sources

Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes [PDF]

eLife, 2022
Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus are essential to regulate food intake and energy balance. However, the ontogenetic transcriptional programs that specify the identity and functioning of these neurons are poorly ...
Hui Yu, Marcelo Rubinstein, Malcolm J Low   +2 more
doaj   +2 more sources

The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice [PDF]

Molecular Metabolism
Objective: Proopiomelanocortin (POMC) neurons release potent anorexigenic neuropeptides, which suppress food intake and enhance energy expenditure via melanocortin receptors.
Hui Yu, Angelika Chiang, Marcelo Rubinstein, Malcolm J. Low   +3 more
doaj   +2 more sources

Cellular and synaptic reorganization of arcuate NPY/AgRP and POMC neurons after exercise

Molecular Metabolism, 2018
Objective: Hypothalamic Pro-opiomelanocortin (POMC) and Neuropeptide Y/Agouti-Related Peptide (NPY/AgRP) neurons are critical nodes of a circuit within the brain that sense key metabolic cues as well as regulate metabolism.
Zhenyan He, Yong Gao, Amber L. Alhadeff, Carlos M. Castorena, Yiru Huang, Linh Lieu, Sadia Afrin, Jia Sun, J. Nicholas Betley, Hongbo Guo, Kevin W. Williams   +10 more
doaj   +2 more sources

The small GTPase Rap1 in POMC neurons regulates leptin actions and glucose metabolism [PDF]

Molecular Metabolism
The hypothalamic leptin-proopiomelanocortin (POMC) pathway is critical for regulating metabolism. POMC neurons in the arcuate nucleus respond to leptin and play a pivotal role in mediating energy and glucose balance. However, during diet-induced obesity (
Kentaro Kaneko, Weisheng Lu, Yong Xu, Alexei Morozov, Makoto Fukuda   +4 more
doaj   +2 more sources

Regulation of BAT thermogenesis via TRPA1-expressing hypothalamic POMC neurons [PDF]

Animal Cells and Systems
Pro-opiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) play a pivotal role in regulating brown adipose tissue (BAT) thermogenesis via the sympathetic nervous system.
Arbi Bahtiar Boedi Iman Halanobis, Ju Hwan Yang, Eun-Hye Byeon, Sang Won Park, Hyun Joon Kim, Dawon Kang, Deok-Ryong Kim, Jinsung Yang, Wanil Kim, Dong-Hee Kim, Dong Kun Lee   +10 more
doaj   +2 more sources

Fatty Acid Synthase regulates glucose and energy homeostasis via POMC neurons and adrenergic signals [PDF]

Molecular Metabolism
Objectives: Hypothalamic Fatty Acid Synthase (FASN) plays a critical role in regulating energy balance by influencing food intake and body weight. This study aimed to investigate the neuronal mechanisms by which FASN impacts metabolism, focusing on its ...
Luis Leon-Mercado, Yanbin Dong, Bandy Chen, Arely Tinajero, Caleb C. Lord, Syann Lee, Chen Liu, Guosheng Liang, Jay D. Horton, Kevin W. Williams, Joel K. Elmquist   +10 more
doaj   +2 more sources