Results 21 to 30 of about 31,735 (160)

TLR4 in POMC neurons regulates thermogenesis in a sex-dependent manner. [PDF]

J Lipid Res, 2023
The rising prevalence of obesity has become a worldwide health concern. Obesity usually occurs when there is an imbalance between energy intake and energy expenditure. However, energy expenditure consists of several components, including metabolism, physical activity, and thermogenesis. Toll-like receptor 4 (TLR4) is a transmembrane pattern recognition
Li Y, Zhu S, Du D, Li Q, Xie K, Chen L, Feng X, Wu X, Sun Z, Zhou J, Yang J, Shu G, Wang S, Gao P, Zhu C, Jiang Q, Wang L.   +16 more
europepmc   +4 more sources

TRPV1-Mediated Sensing of Sodium and Osmotic Pressure in POMC Neurons in the Arcuate Nucleus of the Hypothalamus [PDF]

Nutrients, 2022
, Toshihiko Yada, Masanori Nakata
exaly   +2 more sources

Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency

Molecular Metabolism, 2021
Objective: Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus are essential regulators of energy balance. Selective loss of POMC production in these cells results in extreme obesity and metabolic comorbidities.
Surbhi, Gábor Wittmann, Malcolm J. Low, Ronald M. Lechan   +3 more
doaj   +1 more source

Gabra5 plays a sexually dimorphic role in POMC neuron activity and glucose balance

Frontiers in Endocrinology, 2022
Pro-opiomelanocortin (POMC) neurons are important for the regulation of body weight and glucose balance. The inhibitory tone to POMC neurons is mediated primarily by the GABA receptors. However, the detailed mechanisms and functions of GABA receptors are
Zhou Pei, Zhou Pei, Yang He, Jonathan C. Bean, Yongjie Yang, Hailan Liu, Meng Yu, Kaifan Yu, Ilirjana Hyseni, Xing Cai, Hesong Liu, Na Qu, Longlong Tu, Kristine M. Conde, Mengjie Wang, Yongxiang Li, Na Yin, Nan Zhang, Junying Han, Camille HS. Potts, Nikolas A. Scarcelli, Zili Yan, Pingwen Xu, Qi Wu, Yanlin He, Yong Xu, Yong Xu, Chunmei Wang   +27 more
doaj   +1 more source

Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice

Molecular Metabolism, 2020
Objective: Hypothalamic arcuate proopiomelanocortin (Arc-POMC) neurons are involved in different physiological processes such as the regulation of energy balance, glucose homeostasis, and stress-induced analgesia.
Milagros Trotta, Estefanía Pilar Bello, Ramiro Alsina, María Belén Tavella, José Luis Ferrán, Marcelo Rubinstein, Viviana Florencia Bumaschny   +6 more
doaj   +1 more source

Relative number and distribution of murine hypothalamic proopiomelanocortin neurons innervating distinct target sites. [PDF]

PLoS ONE, 2011
Proopiomelanocortin (POMC) neurons send projections widely throughout the brain consistent with their role in regulating numerous homeostatic processes and mediating analgesia and reward.
Connie M King, Shane T Hentges
doaj   +1 more source

Nicotine, Food Intake, and Activation of POMC Neurons [PDF]

Neuropsychopharmacology, 2012
The effect of smoking on appetite is well known to smokers. Individuals who quit smoking gain on average 11–15 pounds in the first 2 years of abstinence, and adolescent girls, in particular, may smoke to control their weight (Stice and Shaw, 2003). As we know well from warnings of public health organizations, there is also a growing obesity epidemic in
Marina R, Picciotto, Yann S, Mineur
openaire   +2 more sources

Defining POMC Neurons Using Transgenic Reagents: Impact of Transient Pomc Expression in Diverse Immature Neuronal Populations [PDF]

Endocrinology, 2012
Melanocortin signaling plays a central role in the regulation of phenotypes related to body weight and energy homeostasis. To specifically target and study the function of proopiomelanocortin (POMC) neurons, Pomc promoter elements have been utilized to generate reporter and Cre recombinase transgenic reagents.
Stephanie L, Padilla, Daniel, Reef, Lori M, Zeltser   +2 more
openaire   +2 more sources

Role of SOCS3 in POMC neurons in metabolic and cardiovascular regulation [PDF]

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2019
Suppressor of cytokine signaling 3 (SOCS3) is a negative regulator of leptin signaling. We previously showed that the chronic effects of leptin on blood pressure (BP) and glucose regulation are mediated by stimulation of proopiomelanocortin (POMC) neurons.
Wang, Zhen, do Carmo, Jussara M, da Silva, Alexandre A, Bailey, Kandice C, Aberdein, Nicola, Moak, Sydney P, Hall, John E   +6 more
openaire   +3 more sources

TNFα drives mitochondrial stress in POMC neurons in obesity [PDF]

Nature Communications, 2017
AbstractConsuming a calorically dense diet stimulates microglial reactivity in the mediobasal hypothalamus (MBH) in association with decreased number of appetite-curbing pro-opiomelanocortin (POMC) neurons; whether the reduction in POMC neuronal function is secondary to the microglial activation is unclear.
Chun-Xia Yi, Marc Walter, Yuanqing Gao, Soledad Pitra, Beata Legutko, Stefanie Kälin, Clarita Layritz, Cristina García-Cáceres, Maximilian Bielohuby, Martin Bidlingmaier, Stephen C. Woods, Alexander Ghanem, Karl-Klaus Conzelmann, Javier E. Stern, Martin Jastroch, Matthias H. Tschöp   +15 more
openaire   +6 more sources