Results 21 to 30 of about 484,847 (189)

Defining POMC Neurons Using Transgenic Reagents: Impact of Transient Pomc Expression in Diverse Immature Neuronal Populations [PDF]

Endocrinology, 2012
Melanocortin signaling plays a central role in the regulation of phenotypes related to body weight and energy homeostasis. To specifically target and study the function of proopiomelanocortin (POMC) neurons, Pomc promoter elements have been utilized to ...
Lori M. Zeltser, Daniel Reef, Stephanie L. Padilla   +2 more
core   +3 more sources

TNFα drives mitochondrial stress in POMC neurons in obesity. [PDF]

Nature Communications, 2017
Consuming a calorically dense diet stimulates microglial reactivity in the mediobasal hypothalamus (MBH) in association with decreased number of appetite-curbing pro-opiomelanocortin (POMC) neurons; whether the reduction in POMC neuronal function is ...
Bidlingmaier, Martin, Walter, M.C., Pitra, Soledad, Yuanqing Gao, Legutko, Beata, Bidlingmaier, M., Stefanie Kälin, Gao, Y., Kaelin, Stefanie, Stern, Javier E., Matthias H. Tschöp, Jastroch, M., Clarita Layritz, Layritz, Clarita, Soledad Pitra, Pitra, S., Woods, S.C., Beata Legutko, Tschöp, Matthias H., Kälin, S., Cristina García-Cáceres, Conzelmann, K.K., Woods, Stephen C., Legutko, B., Conzelmann, Karl-Klaus, Stephen C. Woods, Layritz, C., Bielohuby, M., Tschöp, M.H., Marc Walter, Martin Jastroch, Ghanem, A., Bielohuby, Maximilian, Javier E. Stern, Alexander Ghanem, Ghanem, Alexander, Jastroch, Martin, Yi, Chun-Xia, Chun-Xia Yi, García-Cáceres, C., Walter, Marc, Martin Bidlingmaier, Gao, Yuanqing, Yi, C.-X., Maximilian Bielohuby, Karl-Klaus Conzelmann, Stern, J.E., Yi, Chun-Xia;Walter, Marc;Gao, Yuanqing;Pitra, Soledad;Legutko, Beata;Kälin, Stefanie;Layritz, Clarita;García-Cáceres, Cristina;Bielohuby, Maximilian;Bidlingmaier, Martin;Woods, Stephen C.;Ghanem, Alexander;Conzelmann, Karl-Klaus;Stern, Javier E.;Jastroch, Martin;Tschöp, Matthias H., Garcia-Caceres, Cristina   +48 more
core   +8 more sources

Gabra5 plays a sexually dimorphic role in POMC neuron activity and glucose balance

Frontiers in Endocrinology, 2022
Pro-opiomelanocortin (POMC) neurons are important for the regulation of body weight and glucose balance. The inhibitory tone to POMC neurons is mediated primarily by the GABA receptors. However, the detailed mechanisms and functions of GABA receptors are
Zili Yan, Junying Han, Na Yin
exaly   +3 more sources

Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin. [PDF]

The Journal of Neuroscience, 2007
Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus (ARC) suppress appetite, and lack of POMC-derived peptides or electrical silencing of POMC neurons causes obesity.
Brüning, JC, Burdakov, D, Zubcevic, L, Ma, X, Ashcroft, Frances   +4 more
core   +3 more sources

Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice [PDF]

Molecular Metabolism, 2020
Objective: Hypothalamic arcuate proopiomelanocortin (Arc-POMC) neurons are involved in different physiological processes such as the regulation of energy balance, glucose homeostasis, and stress-induced analgesia.
Milagros Trotta, Estefanía Pilar Bello, Ramiro Alsina, María Belén Tavella, José Luis Ferrán, Marcelo Rubinstein, Viviana Florencia Bumaschny   +6 more
doaj   +2 more sources

Role of SOCS3 in POMC Neurons in metabolic and cardiovascular regulation. [PDF]

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2019
Suppressor of cytokine signaling 3 (SOCS3) is a negative regulator of leptin signaling. We previously showed that the chronic effects of leptin on blood pressure (BP) and glucose regulation are mediated by stimulation of pro-opiomelanocortin (POMC ...
da Silva, Alexandre A, Bailey, Kandice C, Wang, Zhen, Aberdein, Nicola, do Carmo, Jussara M, Hall, John E, Moak, Sydney P   +6 more
core   +5 more sources

GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity [PDF]

Molecular Metabolism
Objective: G-protein-signaling modulator 1 (GPSM1) has been proved the potential role in brain tissues, however, whether GPSM1 in hypothalamic nuclei, especially in POMC neurons is essential for the proper regulation of whole-body energy balance remains ...
Mengyang Tang, Yi Zhang, Rong Zhang, Yuemei Zhang, Jiangfei Zheng, Daixi Wang, Xinyu Wang, Jing Yan, Cheng Hu   +8 more
doaj   +2 more sources

Hypothalamic POMC neurons regulate intestinal glucose absorption via a gut–brain circuit [PDF]

Nature Communications
Hypothalamic proopiomelanocortin (POMC)-producing neurons are essential for maintaining energy balance and glucose homeostasis. We show that cAMP-dependent protein kinase A (PKA) signaling in these neurons is activated postprandially and upon the ...
Hyo Sun Lim, Se Hee Min, Hyo Jin Kim, Chae Beom Park, Seong Jun Kim, Mun Gyeom Kim, Ji Su Kim, Jun Young Byun, Se Eun Park, Myeong Ju Kim, So Yeon Jeong, Jin A. An, Seokbeom Seo, Joomi Park, Yeji Kim, Ji Ye Kim, Sang Ju Lee, Seog-Young Kim, Xin Yi Yeo, Edra London, Jong-Woo Sohn, Gil Myoung Kang, Sangyong Jung, Min-Seon Kim   +23 more
doaj   +2 more sources

Regulation of BAT thermogenesis via TRPA1-expressing hypothalamic POMC neurons [PDF]

Animal Cells and Systems
Pro-opiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) play a pivotal role in regulating brown adipose tissue (BAT) thermogenesis via the sympathetic nervous system.
Arbi Bahtiar Boedi Iman Halanobis, Ju Hwan Yang, Eun-Hye Byeon, Sang Won Park, Hyun Joon Kim, Dawon Kang, Deok-Ryong Kim, Jinsung Yang, Wanil Kim, Dong-Hee Kim, Dong Kun Lee   +10 more
doaj   +2 more sources

Fatty Acid Synthase regulates glucose and energy homeostasis via POMC neurons and adrenergic signals [PDF]

Molecular Metabolism
Objectives: Hypothalamic Fatty Acid Synthase (FASN) plays a critical role in regulating energy balance by influencing food intake and body weight. This study aimed to investigate the neuronal mechanisms by which FASN impacts metabolism, focusing on its ...
Luis Leon-Mercado, Yanbin Dong, Bandy Chen, Arely Tinajero, Caleb C. Lord, Syann Lee, Chen Liu, Guosheng Liang, Jay D. Horton, Kevin W. Williams, Joel K. Elmquist   +10 more
doaj   +2 more sources