AZGP1 in POMC neurons modulates energy homeostasis and metabolism through leptin-mediated STAT3 phosphorylation [PDF]
Nature CommunicationsZinc-alpha2-glycoprotein (AZGP1) has been implicated in peripheral metabolism; however, its role in regulating energy metabolism in the brain, particularly in POMC neurons, remains unknown. Here, we show that AZGP1 in POMC neurons plays a crucial role in
Sheng Qiu +9 more
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Molecular Metabolism, 2020 Objective: Although the hypothalamus is crucial for peripheral metabolism control, the signals in specific neurons involved remain poorly understood.
Feixiang Yuan +10 more
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Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost’ subtypes with atypical identity in a mouse model of obesity [PDF]
Nature CommunicationsThe hypothalamus contains a remarkable diversity of neurons that orchestrate behavioural and metabolic outputs in a highly plastic manner. Neuronal diversity is key to enabling hypothalamic functions and, according to the neuroscience dogma, it is ...
Stéphane Leon +23 more
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PERK in POMC neurons connects celastrol with metabolism. [PDF]
JCI Insight, 2021 ER stress and activation of the unfolded protein response in the periphery as well as the central nervous system have been linked to various metabolic abnormalities. Chemically lowering protein kinase R-like ER kinase (PERK) activity within the hypothalamus leads to decreased food intake and body weight.
He Z +15 more
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UCP2-dependent redox sensing in POMC neurons regulates feeding. [PDF]
Cell Rep, 2022 Paradoxically, glucose, the primary driver of satiety, activates a small population of anorexigenic pro-opiomelanocortin (POMC) neurons. Here, we show that lactate levels in the circulation and in the cerebrospinal fluid are elevated in the fed state and the addition of lactate to glucose activates the majority of POMC neurons while increasing ...
Yoon NA +7 more
europepmc +4 more sources
Increased intrinsic and synaptic excitability of hypothalamic POMC neurons underlies chronic stress-induced behavioral deficits. [PDF]
Mol Psychiatry, 2023 Fang X +10 more
europepmc +3 more sources
Agrp-negative arcuate NPY neurons drive feeding under positive energy balance via altering leptin responsiveness in POMC neurons [PDF]
Cell Metabolism, 2023 Yue Qi +6 more
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TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons [PDF]
Cell Reports, 2017 The molecular mechanisms underlying acute leptin and serotonin 2C receptor-induced hypophagia remain unclear. Here, we show that neuronal and pro-opiomelanocortin (Pomc)-specific loss of transient receptor potential cation 5 (TrpC5) subunits is sufficient to decrease energy expenditure and increase food intake resulting in elevated body weight ...
Yong Gao +15 more
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Functional heterogeneity of POMC neurons relies on mTORC1 signaling [PDF]
Cell Reports, 2021 Hypothalamic pro-opiomelanocortin (POMC) neurons are known to trigger satiety. However, these neuronal cells encompass heterogeneous subpopulations that release γ-aminobutyric acid (GABA), glutamate, or both neurotransmitters, whose functions are poorly defined. Using conditional mutagenesis and chemogenetics, we show that blockade of the energy sensor
Saucisse, Nicolas +23 more
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Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance
Cell, 2013 Marc Schneeberger +15 more
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