Results 41 to 50 of about 484,847 (189)

PERK in POMC neurons connects celastrol with metabolism. [PDF]

JCI Insight, 2021
ER stress and activation of the unfolded protein response in the periphery as well as the central nervous system have been linked to various metabolic abnormalities. Chemically lowering protein kinase R–like ER kinase (PERK) activity within the hypothalamus leads to decreased food intake and body weight.
He Z, Lieu L, Dong Y, Afrin S, Chau D, Kabahizi A, Wallace B, Cao J, Hwang ES, Yao T, Huang Y, Okolo J, Cheng B, Gao Y, Hu L, Williams KW.   +15 more
europepmc   +5 more sources

POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons. [PDF]

Elife
Abstract Inactivating mutations in the melanocortin 4 receptor (MC4R) gene cause monogenic obesity. Interestingly, female patients also display various degrees of reproductive disorders, in line with the subfertile phenotype of MC4RKO female mice. However, the cellular mechanisms by which MC4R regulates reproduction are unknown.
Talbi R, Stincic TL, Ferrari K, Ji Hae C, Walec K, Medve E, Gerutshang A, Leon S, McCarthy EA, Rønnekleiv OK, Kelly MJ, Navarro VM.   +11 more
europepmc   +5 more sources

Deciphering molecular inputs to CRH neurons from POMC neurons. [PDF]

Fundam Res
Junaid M, Bae Y, Choe HK, Kondoh K, Lee EJ, Lim SB.   +5 more
europepmc   +2 more sources

TLR4 in POMC neurons regulates thermogenesis in a sex-dependent manner. [PDF]

J Lipid Res, 2023
The rising prevalence of obesity has become a worldwide health concern. Obesity usually occurs when there is an imbalance between energy intake and energy expenditure. However, energy expenditure consists of several components, including metabolism, physical activity, and thermogenesis. Toll-like receptor 4 (TLR4) is a transmembrane pattern recognition
Li Y, Zhu S, Du D, Li Q, Xie K, Chen L, Feng X, Wu X, Sun Z, Zhou J, Yang J, Shu G, Wang S, Gao P, Zhu C, Jiang Q, Wang L.   +16 more
europepmc   +4 more sources

Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency

Molecular Metabolism, 2021
Objective: Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus are essential regulators of energy balance. Selective loss of POMC production in these cells results in extreme obesity and metabolic comorbidities.
Surbhi, Gábor Wittmann, Malcolm J. Low, Ronald M. Lechan   +3 more
doaj   +1 more source

Relative number and distribution of murine hypothalamic proopiomelanocortin neurons innervating distinct target sites. [PDF]

PLoS ONE, 2011
Proopiomelanocortin (POMC) neurons send projections widely throughout the brain consistent with their role in regulating numerous homeostatic processes and mediating analgesia and reward.
Connie M King, Shane T Hentges
doaj   +1 more source

Nicotine, Food Intake, and Activation of POMC Neurons [PDF]

Neuropsychopharmacology, 2012
The effect of smoking on appetite is well known to smokers. Individuals who quit smoking gain on average 11–15 pounds in the first 2 years of abstinence, and adolescent girls, in particular, may smoke to control their weight (Stice and Shaw, 2003). As we know well from warnings of public health organizations, there is also a growing obesity epidemic in
Marina R, Picciotto, Yann S, Mineur
openaire   +2 more sources

NMDA Receptors in POMC Neurons Connect Exercise With Insulin Sensitivity. [PDF]

Diabetes
Increased arcuate proopiomelanocortin (POMC) neuron activity improves glucose metabolism and reduces appetite, facilitating weight loss. We recently showed that arcuate POMC neurons are activated by exercise. However, the role of excitatory glutamatergic input in these neurons and the metabolic outcomes of exercise
Portillo B, Hwang E, Ajwani J, Grose K, Lieu L, Wallace B, Kabahizi A, Elmquist JK, Williams KW.   +8 more
europepmc   +3 more sources

mTOR Signaling Fades POMC Neurons during Aging [PDF]

Neuron, 2012
Hypothalamic POMC neurons contribute to the regulation of energy homeostasis and glucose metabolism. In this issue of Neuron, Yang et al. (2012) show that the mTOR pathway has a pivotal role in deterioration of POMC neurons during age-dependent obesity.
Kim, Jae Geun, Horvath, Tamas L.
openaire   +2 more sources

The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight

Molecular Metabolism, 2020
Objective: Regulation of food intake and energy balance depends on a group of hypothalamic neurons that release anorexigenic melanocortins encoded by the Pomc gene.
Clara E. Hael, Daniela Rojo, Daniela P. Orquera, Malcolm J. Low, Marcelo Rubinstein   +4 more
doaj   +1 more source