Results 41 to 50 of about 31,735 (160)
Selective Restoration ofPomcExpression in Glutamatergic POMC Neurons: Evidence for a Dynamic Hypothalamic Neurotransmitter Network [PDF]
eneuro, 2019 AbstractHypothalamic POMC deficiency leads to obesity and metabolic deficiencies, largely due to the loss of melanocortin peptides. However, POMC neurons in the arcuate nucleus (ARC) are comprised of glutamatergic and GABAergic subpopulations. The developmental program, relative proportion and function of these two subpopulations are unresolved.
Graham L. Jones +6 more
openaire +2 more sources
Nicotine Decreases Food Intake Through Activation of POMC Neurons [PDF]
Science, 2011 Nicotine decreases weight gain by targeting a brain pathway involved in the regulation of energy balance and food intake.
Mineur, Yann S +10 more
openaire +3 more sources
Unveiling the transcriptome alteration of POMC neuron in diet-induced obesity [PDF]
Experimental Cell Research, 2019 Abstract Background: Loss of neuron homeostasis in the Arcuate nucleus (ARC) is suggested to be responsible for the development diet-induced-obesity (DIO). We previously reported that loss of Rb1 gene compromised the homeostasis of anorexigenic POMC neurons in ARC and induced obesity in mice.Method: To shed light on how DIO develops, we propose
Peng Lyu +7 more
openaire +2 more sources
POMC neuronal heterogeneity in energy balance and beyond: an integrated view
Nature Metabolism, 2021 Hypothalamic AgRP and POMC neurons are conventionally viewed as the yin and yang of the body's energy status, since they act in an opposite manner to modulate appetite and systemic energy metabolism. However, although AgRP neurons' functions are comparatively well understood, a unifying theory of how POMC neuronal cells operate has remained elusive ...
Carmelo Quarta +8 more
openaire +5 more sources
Molecular Metabolism, 2018 Objectives: The autonomic nervous system is critically involved in mediating the control by leptin of many physiological processes. Here, we examined the role of the leptin receptor (LepR) in proopiomelanocortin (POMC) and agouti-related peptide (AgRP ...
Balyssa B. Bell +4 more
doaj +1 more source
Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake. [PDF]
PLoS Biology, 2018 Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) respond to numerous hormonal and neural signals, resulting in changes in food intake.
Jae Hoon Jeong +5 more
doaj +1 more source
Molecular Metabolism, 2018 Objective: Nutrient availability modulates reactive oxygen species (ROS) production in the hypothalamus. In turn, ROS regulate hypothalamic neuronal activity and feeding behavior.
Magalie Haissaguerre +9 more
doaj +1 more source
Hypothalamic Proopiomelanocortin Is Necessary for Normal Glucose Homeostasis in Female Mice
Frontiers in Endocrinology, 2018 The arcuate nucleus of the hypothalamus is a key regulator of energy balance and glucose homeostasis. In particular, arcuate proopiomelanocortin (POMC) neurons inhibit food intake, stimulate energy expenditure and increase glucose tolerance.
Ramiro Alsina +3 more
doaj +1 more source
Molecular Metabolism, 2017 Objective: Arcuate proopiomelanocortin (POMC) neurons are critical nodes in the control of body weight. Often characterized simply as direct targets for leptin, recent data suggest a more complex architecture.
Brian Y.H. Lam +14 more
doaj +1 more source
Over-expression of leptin receptors in hypothalamic POMC neurons increases susceptibility to diet-induced obesity. [PDF]
PLoS ONE, 2012 Diet-induced obesity (DIO) in rodents is characterized by impaired activation of signal-transducer and activator of transcription 3 (STAT3) by leptin receptors (LepRb) within the hypothalamic arcuate nucleus.
Kevin M Gamber +5 more
doaj +1 more source