Results 41 to 50 of about 41,053 (237)

The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight

Molecular Metabolism, 2020
Objective: Regulation of food intake and energy balance depends on a group of hypothalamic neurons that release anorexigenic melanocortins encoded by the Pomc gene.
Clara E. Hael, Daniela Rojo, Daniela P. Orquera, Malcolm J. Low, Marcelo Rubinstein   +4 more
doaj   +1 more source

Behavioral/Cognitive Acute and Long-Term Suppression of Feeding Behavior by POMC Neurons in the Brainstem and Hypothalamus, Respectively [PDF]

, 2013
POMC-derived melanocortins inhibit food intake. In the adult rodent brain, POMC-expressing neurons are located in the arcuate nucleus (ARC) and the nucleus tractus solitarius (NTS), but it remains unclear how POMC neurons in these two brain nuclei ...
Bao, Junhong, Feng, Qiru, Lin, Shuailiang, Luo, Minmin, Wu, Ping, Zhan, Cheng, Zhang, Ju-en, Zhou, Jingfeng   +7 more
core   +1 more source

Nicotine Decreases Food Intake Through Activation of POMC Neurons [PDF]

Science, 2011
Nicotine decreases weight gain by targeting a brain pathway involved in the regulation of energy balance and food intake.
Mineur, Yann S, Abizaid, Alfonso, Rao, Yan, Salas, Ramiro, DiLeone, Ralph J, Gündisch, Daniela, Diano, Sabrina, De Biasi, Mariella, Horvath, Tamas L, Gao, Xiao-Bing, Picciotto, Marina R   +10 more
openaire   +3 more sources

Whole-brain Mapping of the Direct Inputs and Axonal Projections of Pro-opiomelanocortin(POMC) and Agouti-related peptide(AgRP) Neurons

Frontiers in Neuroanatomy, 2015
Pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) of the hypothalamus and nucleus tractus solitarius (NTS) of the brainstem play important roles in suppressing food intake and maintaining energy homeostasis.
Daqing ewang, Daqing ewang, Xiaobing eHe, Xiaobing eHe, Zhe ezhao, Qiru eFeng, Rui eLin, Yue eSun, Ting eDing, Fuqiang eXu, Fuqiang eXu, Fuqiang eXu, Minmin eLuo, Minmin eLuo, Cheng eZhan   +14 more
doaj   +1 more source

Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo

Molecular Metabolism, 2021
Objective: Long-acting glucagon-like peptide-1 receptor agonists (GLP-1RAs), like liraglutide and semaglutide, are viable treatments for diabetes and obesity. Liraglutide directly activates hypothalamic proopiomelanocortin (POMC) neurons while indirectly
Yanbin Dong, Jamie Carty, Nitsan Goldstein, Zhenyan He, Eunsang Hwang, Dominic Chau, Briana Wallace, Anita Kabahizi, Linh Lieu, Yunqian Peng, Yong Gao, Ling Hu, J. Nicholas Betley, Kevin W. Williams   +13 more
doaj   +1 more source

Selective Restoration ofPomcExpression in Glutamatergic POMC Neurons: Evidence for a Dynamic Hypothalamic Neurotransmitter Network [PDF]

eneuro, 2019
AbstractHypothalamic POMC deficiency leads to obesity and metabolic deficiencies, largely due to the loss of melanocortin peptides. However, POMC neurons in the arcuate nucleus (ARC) are comprised of glutamatergic and GABAergic subpopulations. The developmental program, relative proportion and function of these two subpopulations are unresolved.
Graham L. Jones, Gábor Wittmann, Eva B. Yokosawa, Hui Yu, Aaron J. Mercer, Ronald M. Lechan, Malcolm J. Low   +6 more
openalex   +3 more sources

Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing [PDF]

, 2013
It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity.
Cakir, Isin, Cyr, Nicole E., Litvinov, Bogdan Patedakis, Nillni, Eduardo A., Perello, Mario, Romero, Amparo, Stuart, Ronald C.   +6 more
core   +1 more source

Hormone and glucose signalling in POMC and AgRP neurons

The Journal of Physiology, 2009
In the wake of the obesity pandemic, increased research efforts are under way to define how peripheral hormones and metabolites regulate energy homeostasis. The melanocortin system, comprising anorexigenic proopiomelanocortin (POMC) expressing neurons and orexigenic agouti‐related protein (AgRP)/neuropeptide Y (NPY) coexpressing neurons in the arcuate ...
Bengt‐Frederik Belgardt, Tomoo Okamura, Jens C. Brüning   +2 more
openalex   +5 more sources

Unraveling the central proopiomelanocortin neural circuits

Frontiers in Neuroscience, 2013
Central proopiomelanocortin (POMC) neurons form a potent anorexigenic network, but our understanding of the integration of this hypothalamic circuit throughout the central nervous system (CNS) remains incomplete. POMC neurons extend projections along the
Aaron J. Mercer, Shane T. Hentges, Charles K. Meshul, Charles K. Meshul, Malcolm J. Low, Malcolm J. Low   +5 more
doaj   +1 more source

Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression

iScience, 2023
Summary: Hypothalamic pro-opiomelanocortin (POMC) neuron development is considered to play an essential role in the development of obesity. However, the underlying mechanisms remain unclear.
Chenyang Lu, Jinglin Zhang, Bingjie Wang, Qiao Gao, Kezhe Ma, Shaona Pei, Juxue Li, Sheng Cui   +7 more
doaj   +1 more source