Results 51 to 60 of about 41,053 (237)

Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice [PDF]

, 2018
We thank AstraZeneca for providing AZ-4217, Mark Smith (Imperial College, London) and Yuchio Yanagawa (Gunma University, Maebashi) for VGlut2-GFP and GAD67-GFP tissue, respectively.
Allsop, David J. P., Ashford, Michael L. J., Bailey, Charlotte L. S., Cavellini, Daniella L., Dale, J. Kim, Heisler, Lora K., Irvine, Stuart W., Jalicy, Susan M., Liddell, Mary K., Liu, Yu-Ru, McCrimmon, Rory J., McGinley, Christopher, McNeilly, Alison D., Meakin, Paul J., Montagut, Gemma, Parmionova, Karolina   +15 more
core   +5 more sources

TNFα drives mitochondrial stress in POMC neurons in obesity [PDF]

Nature Communications, 2017
AbstractConsuming a calorically dense diet stimulates microglial reactivity in the mediobasal hypothalamus (MBH) in association with decreased number of appetite-curbing pro-opiomelanocortin (POMC) neurons; whether the reduction in POMC neuronal function is secondary to the microglial activation is unclear.
Chun-Xia Yi, Marc Walter, Yuanqing Gao, Soledad Pitra, Beata Legutko, Stefanie Kälin, Clarita Layritz, Cristina García-Cáceres, Maximilian Bielohuby, Martin Bidlingmaier, Stephen C. Woods, Alexander Ghanem, Karl-Klaus Conzelmann, Javier E. Stern, Martin Jastroch, Matthias H. Tschöp   +15 more
openaire   +7 more sources

Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight [PDF]

, 2016
Despite clear associations between vitamin D deficiency and obesity and/or type 2 diabetes, a causal relationship is not established. Vitamin D receptors (VDRs) are found within multiple tissues, including the brain.
Arble, Deanna M., Chambers, Adam P., Gardner, David, Gutierrez-Aguilar, Ruth, He, Yanlin, Moore, David D., Sandoval, Darleen A., Seeley, Randy J., Sisley, Stephanie R., Xu, Yong   +9 more
core   +4 more sources

Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures [PDF]

, 2019
Primary cilia dysfunction has been associated with hyperphagia and obesity in both ciliopathy patients and mouse models of cilia perturbation. Neurons throughout the brain possess these solitary cellular appendages, including in the feeding centers of ...
Antonellis, Patrick J., Bansal, Ruchi, Baucum, Anthony J., Berbari, Nicolas F., Cummins, Theodore R., Engle, Staci E., Reiter, Jeremy F., Whitehouse, Logan S.   +7 more
core   +1 more source

Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism. [PDF]

Nat Metab
De Solis AJ, Del Río-Martín A, Radermacher J, Chen W, Steuernagel L, Bauder CA, Eggersmann FR, Morgan DA, Cremer AL, Sué M, Germer M, Kukat C, Vollmar S, Backes H, Rahmouni K, Kloppenburg P, Brüning JC.   +16 more
europepmc   +2 more sources

Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity

Cell Reports, 2018
Summary: Mitochondrial oxidative phosphorylation (OXPHOS) and substrate utilization critically regulate the function of hypothalamic proopiomelanocortin (POMC)-expressing neurons.
Katharina Timper, Lars Paeger, Carmen Sánchez-Lasheras, Luis Varela, Alexander Jais, Hendrik Nolte, Merly C. Vogt, A. Christine Hausen, Christian Heilinger, Nadine Evers, J. Andrew Pospisilik, Josef M. Penninger, Eric B. Taylor, Tamas L. Horvath, Peter Kloppenburg, Jens Claus Brüning   +15 more
doaj   +1 more source

Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]

, 2013
Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Ferenczi, Szilamér, Kovács, Krisztina J., Milanes, Victoria M., Nunez, Cristina, Pintér-Kübler, Bernadett, Polyák, Ágnes, Zelei, Edina   +6 more
core   +2 more sources

Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function. [PDF]

, 2019
The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood.
Chen, Jihuan, Chen, Valerie, Hoang, Ivy, Kawamura, Tomoya, McBride, Ryan, Millhauser, Glenn L, Repunte-Canonigo, Vez, Sanna, Pietro Paolo, Wong, Ashley Tess, Yang, Yang   +9 more
core   +1 more source

Islet-1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood [PDF]

, 2015
Food intake and body weight regulation depend on proper expression of the proopiomelanocortin gene (Pomc) in a group of neurons located in the mediobasal hypothalamus of all vertebrates.
Gonzalez, Laura Elisabeth, Low, Malcolm J., Nasif, Sofia, Orquera, Daniela Paula, Rubinstein, Marcelo, Silva Junqueira de Souza, Flavio, Yamashita, Miho   +6 more
core   +2 more sources

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis [PDF]

EMBO reports, 2012
Autophagy degrades cytoplasmic contents to achieve cellular homeostasis. We show that selective loss of autophagy in hypothalamic proopiomelanocortin (POMC) neurons decreases α‐melanocyte‐stimulating hormone (MSH) levels, promoting adiposity, impairing lipolysis and altering glucose homeostasis.
Susmita, Kaushik, Esperanza, Arias, Hyokjoon, Kwon, Nuria Martinez, Lopez, Diana, Athonvarangkul, Srabani, Sahu, Gary J, Schwartz, Jeffrey E, Pessin, Rajat, Singh   +8 more
openaire   +2 more sources