Results 71 to 80 of about 484,847 (189)

Palmitic and Stearic Acids Inhibit Chaperone-Mediated Autophagy (CMA) in POMC-like Neurons In Vitro [PDF]

, 2022
The intake of food with high levels of saturated fatty acids (SatFAs) is associated with the development of obesity and insulin resistance. SatFAs, such as palmitic (PA) and stearic (SA) acids, have been shown to accumulate in the hypothalamus, causing ...
Gutierrez, Karla, Parra, Valentina, Criollo, Alfredo, Pablo Galaz-Davison, Espinosa Lemunao, Rodrigo, Burgos, Patricia V., Valentina Parra, César A. Ramírez-Sarmiento, Eugenia Morselli, Ramírez, César, Ríos Castillo, Javiera, Espinosa, Rodrigo, Budini, Mauricio, Parra Ortiz, Valentina, Karla Gutiérrez, Ormeno, Fernando, Burgos, Patricia, V, Galaz, Pablo, Rios, Javiera, Burgos, Patricia, Mauricio Budini, Ramírez Sarmiento, César, Iván E. Alfaro, Criollo Céspedes, Alfredo, Galaz Davison, Pablo, Rodrigo Espinosa, Liliana Yantén, Alfredo Criollo, Javiera Rios, Amelina Albornoz, Patricia V. Burgos, Alfaro, Iván, Ramirez-Sarmiento, Cesar A., Fernando Ormeño, Yanten, Liliana, Alfaro, Ivan E., Morselli, Eugenia, Galaz-Davison, Pablo, Albornoz, Amelina, Universidad San Sebastián   +39 more
core   +1 more source

Chromatin Accessibility Profiling of the Canine Brain Reveals Regulatory Programs Associated With Dog‐Wolf Divergence and Human Psychiatric Risk

Integrative Zoology, EarlyView.
The dog is a valuable model for studying social behavior and neuropsychiatric disease. We generated an ATAC‐seq atlas of 7 brain regions and pituitary from 4 beagles, identifying 251,492 CREs. Integrating dog‐wolf divergence revealed tissue‐specific CREs overlapping divergent loci, including neuronal and neuroendocrine genes.
Biao Deng, Junze Wu, Ye Liu, Xuan Li, Yuanfang Xu, Rongjie Duan, Yibo Tong, Jinsheng Xu, Mengyang Ni, Zijie Scott Zhang, Dan Xue, Bowen Zhou, Yanhu Liu, Rui Cheng, Yuedong Zhang, Ya‐Ping Zhang   +15 more
wiley   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

Rapamycin Ameliorates Age-Dependent Obesity Associated with Increased mTOR Signaling in Hypothalamic POMC Neurons [PDF]

, 2012
SummaryThe prevalence of obesity in older people is the leading cause of metabolic syndromes. Central neurons serving as homeostatic sensors for body-weight control include hypothalamic neurons that express pro-opiomelanocortin (POMC) or neuropeptide-Y ...
Boddupalli, Gayatri, Tien, An-Chi, Yang, Shi-Bing, Xu, Allison W, Yang, Shi Bing, Tien, An Chi, Xu, Allison W., Jan, Yuh Nung, Jan, Lily Yeh   +8 more
core   +1 more source

Ire1α in Pomc Neurons Is Required for Thermogenesis and Glycemia [PDF]

Diabetes, 2016
Whether neuronal inositol-requiring enzyme 1 (Ire1) is required for the proper regulation of energy balance and glucose homeostasis is unclear. We found that pro-opiomelanocortin (Pomc)–specific deficiency of Ire1α accelerated diet-induced obesity concomitant with a decrease in energy expenditure.
Ting, Yao, Zhuo, Deng, Yong, Gao, Jia, Sun, Xingxing, Kong, Yiru, Huang, Zhenyan, He, Yanchao, Xu, Yongsheng, Chang, Kai-Jiang, Yu, Brianna G, Findley, Eric D, Berglund, Rui-Tao, Wang, Hongbo, Guo, Hong, Chen, Xu, Li, Randal J, Kaufman, Jianqun, Yan, Tiemin, Liu, Kevin W, Williams   +19 more
openaire   +2 more sources

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Systematic profiling reveals broad G protein coupling and context‐dependent modulation of cyclic AMP by the orphan receptor GPR139

British Journal of Pharmacology, EarlyView.
Background and Purpose G protein‐coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear.
Boris Trapkov, Hans Bräuner, Alexander Sebastian Hauser   +2 more
wiley   +1 more source

Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal

Cell Reports, 2020
Summary: Mechanistic studies in rodents evidenced synaptic remodeling in neuronal circuits that control food intake. However, the physiological relevance of this process is not well defined.
Danaé Nuzzaci, Céline Cansell, Fabienne Liénard, Emmanuelle Nédélec, Selma Ben Fradj, Julien Castel, Ewout Foppen, Raphael Denis, Dominique Grouselle, Amélie Laderrière, Aleth Lemoine, Alexia Mathou, Virginie Tolle, Tony Heurtaux, Xavier Fioramonti, Etienne Audinat, Luc Pénicaud, Jean-Louis Nahon, Carole Rovère, Alexandre Benani   +19 more
doaj   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source