Results 71 to 80 of about 31,735 (160)

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

Energy imbalance alters Ca2+ handling and excitability of POMC neurons

eLife, 2017
Satiety-signaling, pro-opiomelanocortin (POMC)-expressing neurons in the arcuate nucleus of the hypothalamus play a pivotal role in the regulation of energy homeostasis. Recent studies reported altered mitochondrial dynamics and decreased mitochondria- endoplasmic reticulum contacts in POMC neurons during diet-induced obesity. Since mitochondria play a
Paeger, Lars, Pippow, Andreas, Hess, Simon, Paehler, Moritz, Klein, Andréas, Husch, Andreas, Pouzat, Christophe, Brüning, Jens, Kloppenburg, Peter   +8 more
openaire   +5 more sources

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons [PDF]

Neuron, 2011
Leptin acts in the brain to prevent obesity. The underlying neurocircuitry responsible for this is poorly understood, in part because of incomplete knowledge regarding first-order, leptin-responsive neurons. To address this, we and others have been removing leptin receptors from candidate first-order neurons.
Vong, Linh, Ye, Chianping, Yang, Zongfang, Choi, Brian, Chua, Streamson, Lowell, Bradford B.   +5 more
openaire   +2 more sources

Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons – Implications for energy balance and glucose control

Molecular Metabolism, 2019
Objective: The long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist, liraglutide, stimulates insulin secretion and efficiently suppresses food intake to reduce body weight.
Zhenyan He, Yong Gao, Linh Lieu, Sadia Afrin, Jianhong Cao, Natalie J. Michael, Yanbin Dong, Jia Sun, Hongbo Guo, Kevin W. Williams   +9 more
doaj   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Multidisciplinary Therapy to Target Obesity and Its Complications in Adult Population: A Narrative Review

Obesity Reviews, Volume 27, Issue 7, July 2026.
ABSTRACT Obesity as a chronic and multifactorial disease requires a multidisciplinary team acting together in a holistic multitarget intervention. Multidisciplinary therapy targeting obesity and its complications includes physical exercise, nutritional, and behavior counseling.
Ana Raimunda Dâmaso, Flávia Campos Corgosinho, Deborah Cristina Landi Masquio, Nayra Figueiredo, Fabiana Kattah, Cintia Cercato, Lian Tock, Raquel Munhoz da Silveira Campos   +7 more
wiley   +1 more source

Amylin Selectively Signals Onto POMC Neurons in the Arcuate Nucleus of the Hypothalamus [PDF]

Diabetes, 2018
Amylin phosphorylates ERK (p-ERK) in the area postrema to reduce eating and synergizes with leptin to phosphorylate STAT3 in the arcuate (ARC) and ventromedial (VMN) hypothalamic nuclei to reduce food intake and body weight. The current studies assessed potential amylin and amylin-leptin ARC/VMN interactions on ERK signaling and their roles in ...
Lutz, Thomas A, Coester, Bernd, Whiting, Lynda, Dunn-Meynell, Ambrose A, Boyle, Christina N, Bouret, Sebastien G, Levin, Barry E, Le Foll, Christelle   +7 more
openaire   +3 more sources

Development of a Brain‐Penetrant Nurr1 Agonist Tool

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Nuclear receptor‐related 1 (Nurr1) is a ligand‐activated transcription factor with neuroprotective properties, thought to hold therapeutic potential in neurodegeneration. Here, we developed a potent, brain‐penetrant Nurr1 agonist to study the effects of pharmacological Nurr1 activation in the CNS in vivo. The ligand‐sensing transcription factor nuclear
Jan Vietor, Tanja Stiller, Christian Gege, Wael Saeb, Úrsula López‐García, Hella Kohlhof, Daniel Vitt, Daniel Merk   +7 more
wiley   +1 more source

Increased body weight in mice with fragile X messenger ribonucleoprotein 1 (Fmr1) gene mutation is associated with hypothalamic dysfunction

Scientific Reports, 2023
Mutations in the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene are linked to Fragile X Syndrome, the most common monogenic cause of intellectual disability and autism. People affected with mutations in FMR1 have higher incidence of obesity, but the
Rebecca E. Ruggiero-Ruff, Pedro A. Villa, Sarah Abu Hijleh, Bryant Avalos, Nicholas V. DiPatrizio, Sachiko Haga-Yamanaka, Djurdjica Coss   +6 more
doaj   +1 more source

Hydroxy‐α‐Sanshools From Zanthoxylum bungeanum Maxim. Alleviate Obesity in Mice via the Regulation of Appetite and Gut Microbiota

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Hydroxy‐alpha‐sanshool could modulate the expression of appetite‐related factors and the composition of intestinal microbiota in mice fed with a high‐fat diet by regulating food intake and maintaining energy homeostasis, which is consistent with the involvement of the gut‐brain axis in this regulatory mechanism.
Tianting Luo, Yuping Zhu, Fangyan Xu, Jiao Xie, Huifang Chen, Likang Qin, Tingyuan Ren   +6 more
wiley   +1 more source