Results 91 to 100 of about 31,735 (160)

Exploring the Potential of Calebin‐A in Targeting Obesity‐Related Genes and Pathways

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Obesity is a global health crisis affecting millions, associated with metabolic disorders such as type 2 diabetes and cardiovascular disease. Calebin‐A, a bioactive compound derived from Curcuma species, has shown promise in managing obesity and its complications.
Ali Mahmoudi, Ali Saeedi‐Boroujeni, Sercan Karav, Prashant Kesharwani, Amirhossein Sahebkar   +4 more
wiley   +1 more source

KNDy kisspeptin is required for metabolic homeostasis in female mice in an ovarian hormone‐independent manner

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Disorders of gonadotropin pulsatility contribute to reproductive dysfunction in humans and are often associated with metabolic dysfunction. Hypogonadotropic hypogonadism is characterized by chronically insufficient gonadotropin hormone production, leading to reproductive and metabolic impairments, such as infertility and obesity.
Nimisha Nandankar, Ariel L. Negrón, Harshini Ganesh, Natalia Youssef, Saad Farooq, Sarmed Al‐Samerria, Jon E. Levine, Sally Radovick   +7 more
wiley   +1 more source

Effects of chronic high fat diet on mediobasal hypothalamic satiety neuron function in POMC-Cre mice

Molecular Metabolism
Objective: The prevalence of obesity has increased over the past three decades. Proopiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) play a vital role in induction of satiety.
Özge Başer, Yavuz Yavuz, Deniz Öykü Özen, Hüseyin Buğra Özgün, Sami Ağuş, Cihan Civan Civaş, Deniz Atasoy, Bayram Yılmaz   +7 more
doaj   +1 more source

The aging paradox of Cushing's syndrome: Stress without clear senescence?

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Cushing's syndrome (CS), characterized by chronic endogenous hypercortisolism and disruption of the normal circadian cortisol rhythm, represents a unique human model for investigating the interplay between stress endocrinology and biological aging.
Israel Nunes Silveira, Alexandro Guterres   +1 more
wiley   +1 more source

Oleic Acid Directly Regulates POMC Neuron Excitability in the Hypothalamus

Journal of Neurophysiology, 2009
The mammalian CNS relies on a constant supply of external glucose for its undisturbed operation. However, neurons can readily switch to using fatty acids and ketones as alternative fuels. Here, we show that oleic acid (OA) excites pro-opiomelanocortin (POMC) neurons by inhibition of ATP-activated potassium (KATP) channels.
Young-Hwan, Jo, Ya, Su, Roger, Gutierrez-Juarez, Streamson, Chua   +3 more
openaire   +3 more sources

Erg currents support electrical bursting in murine anterior pituitary corticotrophs

The Journal of Physiology, Volume 604, Issue 12, Page 4834-4850, 15 June 2026.
Abstract figure legend Anterior pituitary corticotrophs are a central component of the hypothalamic‐pituitary‐adrenal (HPA) axis that controls the release of glucocorticoids from the adrenal gland in response to stress. The hypothalamic secretagogue corticotrophin releasing hormone (CRH) promotes electrical bursting of mouse anterior pituitary ...
Sooraj V. Nair, Nicola Romanò, Peter J. Duncan, Paul Le Tissier, Richard Bertram, Michael J. Shipston   +5 more
wiley   +1 more source

Chronic attenuation of brain leptin signalling is associated with early metabolic dysfunction in lean rats

The Journal of Physiology, Volume 604, Issue 12, Page 4717-4744, 15 June 2026.
Abstract figure legend Central leptin signalling blockade induces early metabolic dysfunction. Intracerebroventricular infusion of a leptin receptor antagonist (SLA) in rats disrupts hypothalamic leptin signalling, leading to reduced signal transducer and activator of transcription 3 (STAT3) activation, decreased Socs3 and Pomc expression, and ...
Cristina Pintado, Lorena Mazuecos, Óscar Gómez‐Torres, Beatriz Merino, Elena Casanueva‐Álvarez, Blanca Rubio, Emma Burgos‐Ramos, Sara Artigas‐Jerónimo, Eduardo Moltó, Inés María Ramos, Justa María Poveda, Germán Perdomo, Irene Cózar‐Castellano, Carmen Arribas, Ernesto Bernal‐Mizrachi, Antonio Andrés, Nilda Gallardo   +16 more
wiley   +1 more source

OPA1 in MC4R Neurons Regulates Dietary Fat Intake and Body Weight in Mice

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Soybean oil intake induces OPA1 expression in hypothalamic MC4R neurons, contributing to adaptive regulation of appetite. MC4R neuron‐specific OPA1 deficiency increases soybean oil consumption and leads to obesity, with a more pronounced effect in females.
Shigenobu Matsumura, Mizuki Fujiwara, Soyoka Horie, Miona Marutani, Eri Nousou, Nanase Iki, Yuka Yamato, Yui Otonashi, Tsutomu Sasaki, Mina Fujitani, Teppei Fujikawa   +10 more
wiley   +1 more source

The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis

Molecular Metabolism, 2015
Objective: Hypothalamic agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) expressing neurons play critical roles in control of energy balance.
Aykut Üner, Gabriel H.M. Gonçalves, Wenjing Li, Matheus Porceban, Nicole Caron, Milena Schönke, Eric Delpire, Kenji Sakimura, Christian Bjørbæk   +8 more
doaj   +1 more source

The potential role of hypothalamic POMCTRPM2 in interscapular BAT thermogenesis

Experimental and Molecular Medicine
The major function of primary order neurons in the arcuate nucleus of the hypothalamus is control of energy homeostasis. Among these neurons, proopiomelanocortin (POMC) neurons play a significant role in controlling anorexigenic feeding behavior and ...
Ju Hwan Yang, Arbi Bahtiar Boedi Iman Halanobis, Eun-Hye Byeon, Na Hyun Park, Sang Won Park, Hyun Joon Kim, Dawon Kang, Deok-Ryong Kim, Jinsung Yang, Eun Sang Choe, Wanil Kim, Dong Kun Lee   +11 more
doaj   +1 more source