Results 91 to 100 of about 484,847 (189)

Image_1_Upregulation of hypothalamic POMC neurons after biliary diversion in GK rats.png

, 2022
BackgroundBile acids are important signaling molecules that might activate hypothalamic neurons. This study aimed to investigate possible changes in hypothalamic pro-opiomelanocortin (POMC) neurons after biliary diversion in diabetic rats.MethodsTen GK ...
Xuesong Bai (7498218), Weijie Chen (1321836), Liangbo Dong (10767296), Qiang Qu (316561), Xiaodong He (27313), Shengnan Zhou (11153415), Qiang Xu (71522), Jiemin Chen (11856558), Wei Chen (23863)   +8 more
core   +1 more source

Amylin Selectively Signals Onto POMC Neurons in the Arcuate Nucleus of the Hypothalamus [PDF]

Diabetes, 2018
Amylin phosphorylates ERK (p-ERK) in the area postrema to reduce eating and synergizes with leptin to phosphorylate STAT3 in the arcuate (ARC) and ventromedial (VMN) hypothalamic nuclei to reduce food intake and body weight. The current studies assessed potential amylin and amylin-leptin ARC/VMN interactions on ERK signaling and their roles in ...
Lutz, Thomas A, Coester, Bernd, Whiting, Lynda, Dunn-Meynell, Ambrose A, Boyle, Christina N, Bouret, Sebastien G, Levin, Barry E, Le Foll, Christelle   +7 more
openaire   +4 more sources

Increased body weight in mice with fragile X messenger ribonucleoprotein 1 (Fmr1) gene mutation is associated with hypothalamic dysfunction

Scientific Reports, 2023
Mutations in the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene are linked to Fragile X Syndrome, the most common monogenic cause of intellectual disability and autism. People affected with mutations in FMR1 have higher incidence of obesity, but the
Rebecca E. Ruggiero-Ruff, Pedro A. Villa, Sarah Abu Hijleh, Bryant Avalos, Nicholas V. DiPatrizio, Sachiko Haga-Yamanaka, Djurdjica Coss   +6 more
doaj   +1 more source

Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan

Obesity Reviews, EarlyView.
ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati, David Krongauz, Alice Bosco, Antonio Noto, Cristina Piras, Maria Kafyra, Angelica Dessì, Matteo Mauri, Luigi Atzori, Adina Weinberger, Vassilios Fanos, George V. Dedoussis, on behalf of the BETTER4U consortium   +12 more
wiley   +1 more source

Toward “Obesityomics”: Domain‐Specific Omics in Precision Obesity Medicine with a Brief AI Perspective

Obesity Reviews, EarlyView.
ABSTRACT Background Obesity's global rise has outpaced the effectiveness of “one‐size‐fits‐all” prevention and treatment strategies. The promise of precision medicine lies in addressing the etiological and biological diversity of obesity and transforming it into actionable endotypes.
Nadia Abu Samra, Sara G. I. Suliman, Mohammed Al‐Hadad, Dorret I. Boomsma, Fadwa Alhantoobi, Maithah Alsamahi, Haneen Abufarajallah, Alia Al Tikriti, Zeyar Aung, Selena Richards, Abdulrahim Sajini, Mira Mousa, Fatima Sulaiman, Wael Osman   +13 more
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

ARC cholinergic neurons express POMC and Th.

, 2016
A. Images of confocal fluorescence microscopy showing co-labelling of ChAT with POMC (upper panel) or Th (bottom panel). Scale bar: 50 μm. B. Summary plot showing that a subpopulation of cholinergic neurons expressed POMC or Th (21.91±5.5% or 24.34±3.9%;
Streamson Chua Jr. (3112113), Young-Hwan Jo (401126), Jae Hoon Jeong (215351), Young Jae Woo (755285)   +3 more
core   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons

Molecular Metabolism, 2016
Adiponectin receptors (AdipoRs) are located on neurons of the hypothalamus involved in metabolic regulation - including arcuate proopiomelanocortin (Pomc) and Neuropeptide Y/Agouti-related peptide (NPY/AgRP) neurons. AdipoRs play a critical role in regulating glucose and fatty acid metabolism by initiating several signaling cascades overlapping with ...
Sun, Jia, Gao, Yong, Yao, Ting, Huang, Yiru, He, Zhenyan, Yu, Kai-jiang, Wang, Rui-tao, Guo, Hongbo, Yan, Jianqun, Chang, Yongsheng, Chen, Hong, Scherer, Philipp E., Liu, Tiemin, Williams, Kevin W., Kong, Xingxing   +14 more
openaire   +5 more sources

Generation and characterization of POMC-tdTomato reporter human pluripotent stem cell lines

Stem Cell Research
Proopiomelanocortin (POMC) is a precursor polypeptide that undergoes extensive, tissue-specific post-translational processing. It is expressed in several tissues, including pituitary gland, hypothalamus, brain stem, and skin.
Vukasin M. Jovanovic, Rick Rausch, Maria Caterina DeRosa, David Castellano, Cody McKee, Chaitali Sen, Fiona Daly, Claudia A. Doege, Carlos A. Tristan   +8 more
doaj   +1 more source