Results 111 to 120 of about 484,847 (189)

Markers of Systemic Metabolic Dysfunction in Vitiligo and Their Potential Role in Disease Pathogenesis: A Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Vitiligo is a chronic autoimmune disease characterized by the progressive destruction of melanocytes, resulting in depigmented skin macules. While traditionally viewed as a cutaneous disorder driven by a specific CD8+ T cell‐mediated interferon‐γ (IFN‐γ) signature, emerging research suggests that vitiligo may be a systemic condition
Federica Papaccio, Simona Scano, Barbara Bellei   +2 more
wiley   +1 more source

Author response: Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin [PDF]

, 2017
In the arcuate nucleus of the hypothalamus (ARH) satiety signaling (anorexigenic) pro-opiomelanocortin (POMC)-expressing and hunger signaling (orexigenic) agouti-related peptide (AgRP)-expressing neurons are key components of the neuronal circuits that ...
Lars Paeger, Altmueller, J., Altmüller, J., Brüning, J., Kloppenburg, P., Janine Altmüller, Paeger, L., Peter Frommolt, Frommolt, P., Jens Brüning, Peter Kloppenburg, Karakasilioti, I., Frommole, P., Ismene Karakasilioti   +13 more
core   +1 more source

Maternal Vitamin D Deficiency is Associated With Sex‐Dependent Alterations in Neurodevelopment‐Related Gene Expression, Particularly in the Hypothalamus

Molecular Nutrition &Food Research, Volume 70, Issue 20, 28 October 2026.
Maternal vitamin D deficiency (VDD) affects early brain development in a sex‐dependent manner. VDD accelerates neuronal differentiation and synaptogenesis. Male offspring exhibit broader transcriptomic alterations, including dysregulation of melanocortin‐pathway and synaptic signaling genes, indicating greater vulnerability of hypothalamic circuits ...
Lidia Saidi, Emmanuel Snacel‐Fazy, Eva Seipelt, Nicole Haroun, Julien Astier, Charlène Couturier, Mohamed El Soltani, Eric Sérée, Flavie Sicard, Habib Hammou, Michel Puceat, Jean‐François Landrier, Lourdes Mounien   +12 more
wiley   +1 more source

IMPROVE 2025: The 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence

Clinical Obesity, Volume 16, Issue 5, October 2026.
ABSTRACT An international cohort of 161 clinicians and researchers from 19 countries attended the 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence (IMPROVE) in Prague, Czech Republic, on 2–4 July 2025. The aims of the meeting were to advance understanding of hyperphagia and obesity caused by defects in the melanocortin‐4 receptor
Jesús Argente, Erica L. T. van den Akker, Metin Cetiner, Karine Clément, Elizabeth Forsythe, Alastair Garfield, Peter Kühnen, Gabriel Ángel Martos‐Moreno, David Meeker, Hermann L. Müller, Hanneke M. van Santen, Julia von Schnurbein, Bérénice Segrestin, Tomohiro Tanaka, Manuel Tena‐Sempere, Martin Wabitsch, Stefanie Zorn, I. Sadaf Farooqi   +17 more
wiley   +1 more source

Early Weight Regain After GLP‐1 Receptor Agonist Discontinuation: Mechanisms and Implications for Treatment De‐Escalation Strategies

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 8769-8776, October 2026.
ABSTRACT Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have transformed the pharmacological management of obesity, producing substantial and sustained weight loss during active treatment. However, discontinuation of therapy is frequently followed by significant weight regain, raising important questions regarding the durability of treatment ...
M. A. Damhof, F. H. van Bruggen, E. N. van Roon   +2 more
wiley   +1 more source

Activation of TRPV1 receptors in ARC POMC neurons reduces food intake.

, 2018
(A) Schematic drawing of our experimental configuration showing that Cre-inducible AAV-Gi/o-DREADD was injected into the ARC of POMC-Cre mice. (B) Expression of Gi/o-DREADD in POMC neurons in the ARC (top left panel, scale bar: 20 μm).
Streamson C. Chua Jr. (5135990), Shun-Mei Liu (5135993), Dong Kun Lee (387318), Gary J. Schwartz (179665), Young-Hwan Jo (401126), Jae Hoon Jeong (215351)   +5 more
core   +1 more source

Acute ayahuasca administration attenuates binge‐like eating and anxiety‐related behaviors in mice subjected to intermittent fasting

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract Human binge eating disorder is characterized by recurrent episodes of excessive food consumption accompanied by loss of control and is strongly associated with alterations in reward processing and emotional regulation. Ayahuasca, a psychoactive botanical preparation traditionally used in Amazonian medicine, has been shown to modulate ...
Cristian Ferreira Corona, Felipe Alves Alencar Lima, Jessica Sabrina Canedo da Silva Sumensse, Kevin Donansan Carvalho, Pedro Henrique Grignet, Heloisa Deola Confortim, Maria Claudia Gross, Fabiana Aidar Firmino, Fernanda Ferreira Evangelista, Francisney Pinto Nascimento, Jean Franciesco Vettorazzi   +10 more
wiley   +1 more source

TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons

, 2017
The molecular mechanisms underlying acute leptin and serotonin 2C receptor-induced hypophagia remain unclear. Here, we show that neuronal and pro-opiomelanocortin (Pomc)-specific loss of transient receptor potential cation 5 (TrpC5) subunits is ...
Yiru Huang, Rui-tao Wang, Kathryn A. Cunningham, Yongsheng Chang, Yong Gao, Tiemin Liu, Jianqun Yan, Jia Sun, Kevin W. Williams, Kai-jiang Yu, Hongbo Guo, Ting Yao, Xingxing Kong, Jong-Woo Sohn, Hong Chen, Zhuo Deng   +15 more
core   +1 more source

The Skin‐Lightening Efficacy and Mechanisms of Botanical Extracts: A Comprehensive Review

Journal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.
ABSTRACT Background Skin pigmentation is regulated by a complex network involving melanogenesis, melanosome transfer, oxidative stress, environmental stimuli, and epidermal turnover. Botanical extracts and phytochemicals have attracted increasing interest as potential skin‐lightening agents. This review evaluates their efficacy, mechanisms, and safety.
Siting Yang, Mingning Ding, Chenglong Ye, Jingning Shen, Lihua Zhang, Anquan Yang, Lihao Gu   +6 more
wiley   +1 more source

The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis

Molecular Metabolism, 2015
Objective: Hypothalamic agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) expressing neurons play critical roles in control of energy balance.
Aykut Üner, Gabriel H.M. Gonçalves, Wenjing Li, Matheus Porceban, Nicole Caron, Milena Schönke, Eric Delpire, Kenji Sakimura, Christian Bjørbæk   +8 more
doaj   +1 more source