Results 131 to 140 of about 31,735 (160)

Activation of hypothalamic AgRP and POMC neurons evokes disparate sympathetic and cardiovascular responses.

Am J Physiol Heart Circ Physiol, 2020
Jiang J, Morgan DA, Cui H, Rahmouni K.
europepmc   +1 more source

Cav3.1 is a leucine sensor in POMC neurons mediating appetite suppression and weight loss

Tsang AH, Heeley N, Alcaino C, Hwang E, Lam BY, Rahman T, Darwish T, Nuzzaci D, Kay RG, Sarkar A, Wang R, Basha N, Punnoose A, Kirwan P, Ma M, Yeo GS, Merkle FT, Gribble FM, Reimann F, William K, Blouet C.   +20 more
europepmc   +1 more source

Functional heterogeneity of POMC neurons relies on mTORC1 signaling [PDF]

Cell Reports, 2021
Hypothalamic pro-opiomelanocortin (POMC) neurons are known to trigger satiety. However, these neuronal cells encompass heterogeneous subpopulations that release γ-aminobutyric acid (GABA), glutamate, or both neurotransmitters, whose functions are poorly defined. Using conditional mutagenesis and chemogenetics, we show that blockade of the energy sensor
Wilfrid Mazier, Vincent Simon, Luigi Bellocchio   +2 more
exaly   +6 more sources

POMC Neurons: From Birth to Death [PDF]

Annual Review of Physiology, 2017
The hypothalamus is an evolutionarily conserved brain structure that regulates an organism's basic functions, such as homeostasis and reproduction. Several hypothalamic nuclei and neuronal circuits have been the focus of many studies seeking to understand their role in regulating these basic functions. Within the hypothalamic neuronal populations, the
Chitoku Toda, Anna Santoro, Jung Dae Kim   +2 more
exaly   +4 more sources

DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons [PDF]

Cell Metabolism, 2017
Hypothalamic pro-opiomelanocortin (POMC) neurons regulate energy and glucose metabolism. Intracellular mechanisms that enable these neurons to respond to changes in metabolic environment are ill defined. Here we show reduced expression of activated dynamin-related protein (pDRP1), a mitochondrial fission regulator, in POMC neurons of fed mice.
Anna Santoro, Michela Campolo, Chen Liu   +2 more
exaly   +5 more sources

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis [PDF]

EMBO Reports, 2012
Autophagy degrades cytoplasmic contents to achieve cellular homeostasis. We show that selective loss of autophagy in hypothalamic proopiomelanocortin (POMC) neurons decreases α‐melanocyte‐stimulating hormone (MSH) levels, promoting adiposity, impairing lipolysis and altering glucose homeostasis.
Susmita Kaushik, Esperanza Arias, Hyokjoon Kwon   +2 more
exaly   +3 more sources

Hypothalamic POMC neurons promote cannabinoid-induced feeding [PDF]

Nature, 2015
Hypothalamic pro-opiomelanocortin (POMC) neurons promote satiety. Cannabinoid receptor 1 (CB1R) is critical for the central regulation of food intake. Here we test whether CB1R-controlled feeding in sated mice is paralleled by decreased activity of POMC neurons.
Marco Koch, Luis Varela, Jae Geun Kim
exaly   +6 more sources

An ATF4-ATG5 signaling in hypothalamic POMC neurons regulates obesity [PDF]

Autophagy, 2017
ATF4 (activating transcription factor 4) is an important transcription factor that has many biological functions, while its role in hypothalamic POMC (pro-opiomelanocortin-α) neurons in the regulation of energy homeostasis has not been explored. We recently discovered that mice with an Atf4 deletion specific to POMC neurons (PAKO mice) are lean and ...
Yuzhong Xiao, Yalan Deng, Feixiang Yuan   +2 more
exaly   +3 more sources