Results 131 to 140 of about 41,053 (237)

Amylin/Calcitonin Receptor–Mediated Signaling in POMC Neurons Influences Energy Balance and Locomotor Activity in Chow-Fed Male Mice [PDF]

, 2020
Bernd Coester, Christina Koester-Hegmann, Thomas A. Lutz, Christelle Le Foll   +3 more
openalex   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, Volume 183, Issue 9, Page 2139-2165, May 2026.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

Oleic Acid Directly Regulates POMC Neuron Excitability in the Hypothalamus

Journal of Neurophysiology, 2009
The mammalian CNS relies on a constant supply of external glucose for its undisturbed operation. However, neurons can readily switch to using fatty acids and ketones as alternative fuels. Here, we show that oleic acid (OA) excites pro-opiomelanocortin (POMC) neurons by inhibition of ATP-activated potassium (KATP) channels.
Young-Hwan, Jo, Ya, Su, Roger, Gutierrez-Juarez, Streamson, Chua   +3 more
openaire   +3 more sources

Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice. [PDF]

, 1975
SummaryHypothalamic ribosomal S6K1 has been suggested as a point of convergence for hormonal and nutrient signals in the regulation of feeding behavior, bodyweight, and glucose metabolism.
Smith, MA, Katsouri, L, Irvine, EE, Hankir, MK, Pedroni, SM, Voshol, PJ, Gordon, MW, Choudhury, AI, Woods, A, Vidal-Puig, A, Carling, D, Withers, DJ   +11 more
core   +3 more sources

Melanocortin 3 Receptors Do Not Specifically Localize to Primary Cilia in Cultured Human and Rodent Neurons

Cell Biochemistry and Function, Volume 44, Issue 4, April 2026.
ABSTRACT The melanocortin‐3 receptor (MC3R) and the melanocortin‐4 receptor (MC4R), both expressed in hypothalamic nuclei, are key downstream effectors of leptin signaling and play important roles in energy homeostasis. While pathogenic variants in the MC4R gene represent the most common cause of monogenic obesity, the clinical significance of MC3R ...
Niels Vos, Alessandro Moro, Wim Van Hul, Lotte Kleinendorst, Ralph J. Florijn, Susanne E. la Fleur, Matthijs Verhage, Mieke M. van Haelst, Ruud F. Toonen   +8 more
wiley   +1 more source

Generation and characterization of POMC-tdTomato reporter human pluripotent stem cell lines

Stem Cell Research
Proopiomelanocortin (POMC) is a precursor polypeptide that undergoes extensive, tissue-specific post-translational processing. It is expressed in several tissues, including pituitary gland, hypothalamus, brain stem, and skin.
Vukasin M. Jovanovic, Rick Rausch, Maria Caterina DeRosa, David Castellano, Cody McKee, Chaitali Sen, Fiona Daly, Claudia A. Doege, Carlos A. Tristan   +8 more
doaj   +1 more source

Leptin is required for hypothalamic regulation of miRNAs targeting POMC 3 ′ UTR [PDF]

, 2015
International audienceThe central nervous system (CNS) monitors modifications in metabolic parameters or hormone levels and elicits adaptive responses such as food intake regulation. Particularly, within the hypothalamus, leptin modulates the activity of
Adel Derghal, Bagga, Benoit, Berglund, Bruno Bariohay, Catherine Tardivel, Ceddia, Chen, Chiang, Clément Pierre, Coraline Airault, Cowley, Crépin, Gao, Girardet, Greenman, Herzer, Hill, Huszar, Ibrahim, Jean-Denis Troadec, Jérôme Trouslard, Lee, Li, Lourdes Mounien, Lovis, Margetic, Mehdi Djelloul, Michel Dallaporta, Mizuno, Morton, Mounien, Mounien, Mounien, Mounien, Mounien, Nakanishi, Nilaweera, Ollmann, Parton, Pinto, Plum, Porte, Poy, Sangiao-Alvarellos, Schneeberger, Smith, Tattikota, Thompson, Vanessa Tillement, Williams, Xie, Yaswen   +52 more
core   +4 more sources

Time‐Restricted Feeding Alters Behavior in a Sex‐Specific Manner in Mice With Neuropathic Pain

Molecular Nutrition &Food Research, Volume 70, Issue 8, 27 April 2026.
Time‐restricted feeding (TRF) alleviates anxiety‐like behavior in male mice with neuropathic pain (NP), but not in females. Upon nerve injury, TRF altered the diurnal expression of transcripts in the hypothalamus. These findings suggest that TRF should be explored as a new therapeutic approach to alleviate the comorbid anxiety in NP.
Manqing Wen, Wenjing Dai, Eija Kalso, Vinko Palada   +3 more
wiley   +1 more source

Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons

Molecular Metabolism, 2016
Objective: Obesity is one of the primary healthcare challenges of the 21st century. Signals relaying information regarding energy needs are integrated within the brain to influence body weight.
Luke K. Burke, Barbora Doslikova, Giuseppe D'Agostino, Megan Greenwald-Yarnell, Teodora Georgescu, Raffaella Chianese, Pablo B. Martinez de Morentin, Emmanuel Ogunnowo-Bada, Celine Cansell, Lourdes Valencia-Torres, Alastair S. Garfield, John Apergis-Schoute, Daniel D. Lam, John R. Speakman, Marcelo Rubinstein, Malcolm J. Low, Justin J. Rochford, Martin G. Myers, Mark L. Evans, Lora K. Heisler   +19 more
doaj   +1 more source

Joint TOS/OMA/OAC Expert Guidance Statement on the Pharmacological Management of United States Adults With Overweight or Obesity Using the GRADE Approach

Obesity, Volume 34, Issue 4, Page 851-870, April 2026.
Guidance recommendations by TOS/OMA/OAC for the use of obesity medications to treat obesity and its complications. ABSTRACT Background Obesity affects over 40% of US adults, with severe obesity on the rise. Despite recognition of obesity as a chronic disease, it remains underdiagnosed and undertreated.
Lydia Alexander, Jonathan Q. Purnell, Karlijn Burridge, Marc‐André Cornier, Angela Golden, Deborah Bade Horn, Michelle Look, Joe Nadglowski, Camila Ávila‐Oliver, Francisco Novillo, Ana María Rojas‐Gómez, Brad Hussey, Ximena Ramos Salas   +12 more
wiley   +1 more source