Results 121 to 130 of about 484,847 (189)

Proopiomelanocortin (POMC)–β‐Endorphin System in the Rat Colon: Expression, Up Regulation by Stress, and Correlation With Stress‐Induced Visceral Analgesia

Neurogastroenterology &Motility, Volume 38, Issue 10, October 2026.
This study identified a functional proopiomelanocortin–β‐endorphin system in the rat colon. Peripheral CRF and repeated water avoidance stress increased colonic POMC expression, which was associated with reduced visceral pain. These findings suggest that, outside the pituitary, a CRF‐ and stress‐sensitive enteric POMC–β‐endorphin system may help ...
Pu‐Qing Yuan, Muriel Larauche, Vincent Wu, Yvette Taché   +3 more
wiley   +1 more source

The potential role of hypothalamic POMCTRPM2 in interscapular BAT thermogenesis

Experimental and Molecular Medicine
The major function of primary order neurons in the arcuate nucleus of the hypothalamus is control of energy homeostasis. Among these neurons, proopiomelanocortin (POMC) neurons play a significant role in controlling anorexigenic feeding behavior and ...
Ju Hwan Yang, Arbi Bahtiar Boedi Iman Halanobis, Eun-Hye Byeon, Na Hyun Park, Sang Won Park, Hyun Joon Kim, Dawon Kang, Deok-Ryong Kim, Jinsung Yang, Eun Sang Choe, Wanil Kim, Dong Kun Lee   +11 more
doaj   +1 more source

The last‐step integrator thesis: Heterarchical control of the mammalian gastrointestinal tract

The Journal of Physiology, Volume 604, Issue 20, Page 8323-8344, 15 October 2026.
Abstract figure legend Heterarchy of control of the gastrointestinal tract. The production mechanisms (i.e. epithelial cells and muscles) are shown at the bottom in green. Above them are some of the many mechanisms that provide control inputs to these production mechanisms.
William Bechtel, Leonardo Bich
wiley   +1 more source

Effects of the Saturated Fatty Acid Palmitate on Neuroinflammation, ER Stress, and Pomc mRNA Expression in Hypothalamic mHypoA-POMC/GFP Neurons [PDF]

, 2017
Dietary fats can modulate brain function. How free fatty acids (FFAs) alter hypothalamic pro-opiomelanocortin (POMC) neurons remain undefined. The saturated FFA, palmitate, increased neuroinflammatory and ER stress markers, as well as Pomc mRNA levels ...
Tse, Erika Koppert
core  

Knockdown of the Trpv1 gene in ARC POMC neurons blocks the anorexigenic effect of capsaicin.

, 2018
(A) Images of fluorescence confocal microscopy showing GFP-positive POMC neurons in the ARC of POMC-Cre::CRISPR-Cas-9-eGFP mice. Scale bar: 50 μm. (B) Images of fluorescence confocal microscopy showing that local injection of capsaicin induced expression
Streamson C. Chua Jr. (5135990), Shun-Mei Liu (5135993), Dong Kun Lee (387318), Gary J. Schwartz (179665), Young-Hwan Jo (401126), Jae Hoon Jeong (215351)   +5 more
core   +1 more source

MicroRNAs are involved in the hypothalamic leptin sensitivity

Epigenetics, 2018
The central nervous system monitors modifications in metabolic parameters or hormone levels (leptin) and elicits adaptive responses such as food intake and glucose homeostasis regulation. Particularly, within the hypothalamus, pro-opiomelanocortin (POMC)
Adel Derghal, Mehdi Djelloul, Myriam Azzarelli, Sébastien Degonon, Franck Tourniaire, Jean-François Landrier, Lourdes Mounien   +6 more
doaj   +1 more source

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

, 2006
Leptin and insulin have been identified as fuel sensors acting in part through their hypothalamic receptors to inhibit food intake and stimulate energy expenditure. As their intracellular signaling converges at the PI3K pathway, we directly addressed the
Burdakov, D, Shanabrough, Marya, Belgardt, Bengt F., Shanaborough, M, Hampel, Brigitte, Coppari, R, Rother, E, Mak, TW, Ashcroft, FM, Rother, Eva, Fekete, Csaba, Seibler, Jost, Janoschek, R, Horvath, TL, Suzuki, A, Ashcroft, Frances M., Alber, Jens, Krone, W, Balthasar, N, Plum, Leona, Belgardt, BF, Schwenk, F, Hampel, B, Mak, Tak W, Burdakov, Denis, Brüning, Jens C, Janoschek, Ruth, Suzuki, Akira, Alber, J, Plum, L, Ma, Xiaosong, Koch, L, Coppari, Roberto, Belgardt, Bengt F, Horvath, Tamas L., Mak, Tak W., Fekete, C, Horvath, Tamas L, Schwenk, Frieder, Koch, Linda, Brüning, Jens C., Krone, Wilhelm, Münzberg, Heike, Ashcroft, Frances M, Ma, XS, Balthasar, Nina, Munzberg, H, Bruning, JC   +47 more
core   +1 more source

Single-cell mapping of POMC neurons in obesity

, 2023
The hypothalamus contains heterogeneous neurons with different functional identities, a critical feature for brain-mediated control of body weight and energy metabolism. Alterations in the synaptic activity and neuropeptide production capacity of neurons
Leon, Stéphane
core  

Opposing Effects of Nicotine on Hypothalamic Arcuate Nucleus Pomc and Npy Neurons

Progress in Neurobiology
The hypothalamic arcuate nucleus (ARC) contains two main populations of neurons essential for energy homeostasis: neuropeptide Y (NPY) neurons, which are orexigenic and stimulate food intake, and proopiomelanocortin (POMC) neurons, which have an anorexigenic effect.
E, Ramírez-Sánchez, A, Mondragón-García, J, Garduño, F, Hernández-Vázquez, S, Ortega-Tinoco, S, Hernández-López   +5 more
openaire   +2 more sources

Involvement of POMC neurons in LEAP2 regulation of food intake and body weight. [PDF]

Front Endocrinol (Lausanne), 2022
Chu G, Peng H, Yu N, Zhang Y, Lin X, Lu Y.   +5 more
europepmc   +1 more source