Results 121 to 130 of about 41,053 (237)

AMPK in the central nervous system: physiological roles and pathological implications [PDF]

, 2016
5′ AMP-activated protein kinase (AMPK) is considered the master metabolic regulator in all eukaryotes, as it maintains cellular energy homeostasis in a variety of tissues, including the brain.
Fioramonti, Marco, Fracassi, Anna, Marangoni, Martina, Rosso, Pamela, Segatto, Marco, Siteni, Silvia, Taglietti, Valentina   +6 more
core   +1 more source

SemaGBA: A System Dynamics Model of the Semaglutide‐Responsive Gut‐Brain Axis A Model of How the Brain and Semaglutide Regulate Appetite and Weight

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 5184-5194, June 2026.
ABSTRACT Aims Semaglutide is a GLP‐1 receptor agonist for the treatment of type 2 diabetes and obesity. Its clinical effects are well established, but the underlying mechanisms remain unclear. This study aims to use computational modelling to generate hypotheses about semaglutide's long‐term metabolic (body weight, net energy intake, blood glucose ...
Vivan C. W. Kennis, Natal A. W. van Riel
wiley   +1 more source

Pro-opiomelanocortin co-localizes with corticotropin-releasing factor in axon terminals of the noradrenergic nucleus locus coeruleus [PDF]

, 2006
We previously demonstrated that the opioid peptide, enkephalin, and corticotropin-releasing factor (CRF) are occasionally co-localized in individual axon terminals but more frequently converge on common dendrites in the locus coeruleus (LC).
Glaser, Julia D., Magtoto, Ronaldo, Reyes, Beverly A.S., van Bockstaele, Elisabeth K.   +3 more
core   +2 more sources

Methodological Challenges for Ablation of BMPR1A in Hypothalamic Tanycytes—A Cautionary Tale

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
Two strategies were used to target BMPR1A in adult hypothalamic tanycytes: (1) inducible Rax‐CreERT2 and (2) AAV‐Dio2‐iCre–mediated recombination. Although robust expression of reporter fluorescence and recombination gel analysis confirmed Cre activity in both models, BMPR1A expression was not reduced in targeted tanycytes.
Tianyi Tao, Noelle Leon‐Palmer, Sabrina DiPietro, Kristy L. Townsend   +3 more
wiley   +1 more source

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons [PDF]

Neuron, 2011
Leptin acts in the brain to prevent obesity. The underlying neurocircuitry responsible for this is poorly understood, in part because of incomplete knowledge regarding first-order, leptin-responsive neurons. To address this, we and others have been removing leptin receptors from candidate first-order neurons.
Vong, Linh, Ye, Chianping, Yang, Zongfang, Choi, Brian, Chua, Streamson, Lowell, Bradford B.   +5 more
openaire   +2 more sources

Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos, Ana Margarida Araújo, Isabel M. P. L. V. O. Ferreira, Miguel A. Faria   +3 more
wiley   +1 more source

Microglia contribute to cancer cachexia through affecting PVN neurons and POMC neurons

The FASEB Journal, 2020
Background Cancer cachexia is a state of involuntary weight loss, muscle wasting, and severe malnutrition. Browning of adipocytes and anorexia are major contributors to cancer cachexia through thermogenesis‐induced increasing energy consumption and decreasing food intake, respectively.
Soichiro Kashihara, Keisuke Shinohara, Shota Ikeda, Hiroyuki Tsutsui   +3 more
openaire   +1 more source

ERK1/2 mediates glucose-regulated POMC gene expression in hypothalamic neurons [PDF]

Journal of Molecular Endocrinology, 2015
Hypothalamic glucose-sensing neurons regulate the expression of genes encoding feeding-related neuropetidesPOMC,AgRP, andNPY– the key components governing metabolic homeostasis. AMP-activated protein kinase (AMPK) is postulated to be the molecular mediator relaying glucose signals to regulate the expression of these neuropeptides.
Juan, Zhang, Yunting, Zhou, Cheng, Chen, Feiyuan, Yu, Yun, Wang, Jiang, Gu, Lian, Ma, Guyu, Ho   +7 more
openaire   +2 more sources

Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons

eLife, 2017
POMC neurons integrate metabolic signals from the periphery. Here, we show in mice that food deprivation induces a linear current-voltage relationship of AMPAR-mediated excitatory postsynaptic currents (EPSCs) in POMC neurons.
Shigetomo Suyama, Alexandra Ralevski, Zhong-Wu Liu, Marcelo O Dietrich, Toshihiko Yada, Stephanie E Simonds, Michael A Cowley, Xiao-Bing Gao, Sabrina Diano, Tamas L Horvath   +9 more
doaj   +1 more source

Vagal Blocking for Obesity Control : a Possible Mechanism-Of-Action [PDF]

, 2016
14 September 2016 Erratum to: Vagal Blocking for Obesity Control: a Possible Mechanism-Of-Action Helene Johannessen, David Revesz, Yosuke Kodama, Nikki Cassie, Karolina P Skibicka, Perry Barrett, Suzanne Dickson, Jens Holst, Jens Rehfeld, Geoffrey van ...
Adan, Roger, Barrett, Perry, Ben-Menachem, Elinor, Cassie, Nikki, Chen, Duan, Dickson, Suzanne, Holst, Jens, Johannessen, Helene, Kodama, Yosuke, Kulseng, Bård, Rehfeld, Jens, Revesz, David, Skibicka, Karolina P, van der Plasse, Geoffrey, Zhao, Chun-Mei   +14 more
core   +1 more source