Results 141 to 150 of about 41,053 (237)

Effects of chronic high fat diet on mediobasal hypothalamic satiety neuron function in POMC-Cre mice

Molecular Metabolism
Objective: The prevalence of obesity has increased over the past three decades. Proopiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) play a vital role in induction of satiety.
Özge Başer, Yavuz Yavuz, Deniz Öykü Özen, Hüseyin Buğra Özgün, Sami Ağuş, Cihan Civan Civaş, Deniz Atasoy, Bayram Yılmaz   +7 more
doaj   +1 more source

Enhancer turnover and conserved regulatory function in vertebrate evolution [PDF]

, 2013
Mutations in regulatory regions including enhancers are an important source of variation and innovation during evolution. Enhancers can evolve by changes in the sequence, arrangement and repertoire of transcription factor binding sites, but whole ...
Bumaschny, Viviana Florencia, Domene, Sabina, Franchini, Lucia Florencia, Low, Malcolm J., Nasif, Sofia, Rubinstein, Marcelo, Silva Junqueira de Souza, Flavio   +6 more
core   +2 more sources

PGC-1α expression in murine AgRP neurons regulates food intake and energy balance [PDF]

, 2016
Food intake and whole-body energy homeostasis are controlled by agouti-related protein (AgRP) and pro-opiomelanocortin (POMC) neurons located in the arcuate nucleus of the hypothalamus.
Delezie, Julien, Gill, Jonathan F., Handschin, Christoph, Santos, Gesa   +3 more
core   +3 more sources

The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis

Molecular Metabolism, 2015
Objective: Hypothalamic agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) expressing neurons play critical roles in control of energy balance.
Aykut Üner, Gabriel H.M. Gonçalves, Wenjing Li, Matheus Porceban, Nicole Caron, Milena Schönke, Eric Delpire, Kenji Sakimura, Christian Bjørbæk   +8 more
doaj   +1 more source

Reduced alfa-MSH underlies hypothalamic ER-stress-induced hepatic gluconeogenesis [PDF]

, 2016
Alterations in ER homeostasis have been implicated in the pathophysiology of obesity and type-2 diabetes (T2D). Acute ER stress induction in the hypothalamus produces glucose metabolism perturbations.
Altirriba Gutiérrez, Jordi, Bortolozzi Biasoni, Analía, Claret i Carles, Marc, Drougard, Anne, Esteban, Yaiza, Ferrés Coy, Albert, Garcia, Ainhoa, García-Roves, Pablo M. (Pablo Miguel), Gomis, Ramon, 1946-, Gómez Valadés, Alicia G., Jones, John G., Manadas, Bruno, Ramírez, Sara, Schneeberger, Marc, Sebastián Muñoz, David, Zorzano Olarte, Antonio   +15 more
core   +1 more source

Metformin ameliorates olanzapine-induced disturbances in POMC neuron number, axonal projection, and hypothalamic leptin resistance

, 2022
Jaedeok Kim, Nayoung Lee, Sang Bum Suh, Sooyeon Jang, Saeha Kim, Dong-Gyu Kim, Jong Kook Park, Keunwook Lee, Soo Young Choi, Chan Hee Lee   +9 more
openalex   +2 more sources

Appropriate Inhibition of Orexigenic Hypothalamic Arcuate Nucleus Neurons Independently of Leptin Receptor/STAT3 Signaling [PDF]

, 2007
Leptin directly suppresses the activity of orexigenic neurons in the hypothalamic arcuate nucleus (ARC). We examined c-Fos-like immunoreactivity (CFLIR) as a marker of ARC neuronal activity in db/db mice devoid of the signaling form of the leptin ...
Bates, Sarah H., Björnholm, Marie, Cowley, Michael A., Elmquist, Joel, Jobst, Erin E., Jones, Justin, Leshan, Rebecca, Myers, Martin G., Jr., Münzberg, Heiki, Sleeman, Mark, Villanueva, Eneida   +10 more
core   +2 more sources

EphrinB1 modulates glutamatergic inputs into POMC neurons and controls glucose homeostasis [PDF]

, 2020
Manon Gervais, Alexandre Picard, Bernard Thorens, Sophie Croizier   +3 more
openalex   +1 more source

Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation [PDF]

, 2011
Background The arcuate nucleus of the hypothalamus regulates food intake. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) is expressed in neuropeptide Y and proopiomelanocortin (POMC) neurons in the arcuate nucleus, target neurons in
Biaoxin Chai, Cam Patterson, Chao Zhang, Danielle Fritze, Ji-Yao Li, Michael W Mulholland, Weizhen Zhang, Xiaobin Wu, Zefeng Xia   +8 more
core   +2 more sources

The potential role of hypothalamic POMCTRPM2 in interscapular BAT thermogenesis

Experimental and Molecular Medicine
The major function of primary order neurons in the arcuate nucleus of the hypothalamus is control of energy homeostasis. Among these neurons, proopiomelanocortin (POMC) neurons play a significant role in controlling anorexigenic feeding behavior and ...
Ju Hwan Yang, Arbi Bahtiar Boedi Iman Halanobis, Eun-Hye Byeon, Na Hyun Park, Sang Won Park, Hyun Joon Kim, Dawon Kang, Deok-Ryong Kim, Jinsung Yang, Eun Sang Choe, Wanil Kim, Dong Kun Lee   +11 more
doaj   +1 more source