Results 141 to 150 of about 31,735 (160)

Mitochondrial regulation of obesity by POMC neurons

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Pro-opiomelanocortin (POMC) neurons, nestled in the hypothalamus, play a pivotal role in the intricate coordination of energy homeostasis and metabolic pathways. These neurons' mitochondria, often hailed as the cell's powerhouses, are crucial for maintaining cellular energy equilibrium and metabolic functionality.
Xing-Dan, Luo, Si, Tang, Xiang-Yun, Luo, Luosang, Quzhen, Ruo-Han, Xia, Xian-Wang, Wang   +5 more
openaire   +2 more sources

Hypothalamic proopiomelanocortin (POMC) neurons have a cholinergic phenotype

European Journal of Neuroscience, 2006
AbstractNeuronal networks originating in the hypothalamic arcuate nucleus play fundamental roles in the control of energy balance. Neuropeptide Y (NPY)‐producing neurons in the arcuate nucleus stimulate food intake, whereas arcuate nucleus neurons that release the proopiomelanocortin (POMC)‐derived peptide α‐melanocyte‐stimulating hormone (α‐MSH ...
Björn, Meister, Burçak, Gömüç, Elisabet, Suarez, Yuko, Ishii, Katrin, Dürr, Linda, Gillberg   +5 more
openaire   +2 more sources

Lack of neuronal NOS has consequences for the expression of POMC and POMC-derived peptides in the mouse pituitary

Acta Histochemica, 2001
The relevance of NO in neuroendocrine signalling has been investigated by analysis of cellular expression of pro-opiomelanocortin (POMC) and the POMC-derived peptides beta-endorphin, alpha-melanocyte stimulating hormone and adrenocorticotropin. Expression patterns were studied in the pituitary gland of 150-day old wild-type and neuronal-NOS (nNOS ...
G, Keilhoff, B, Seidel, M, Reiser, A, Stanarius, P L, Huang, B, Bogerts, G, Wolf, H G, Bernstein   +7 more
openaire   +2 more sources

PDK-1/FoxO1 pathway in POMC neurons regulatesPomcexpression and food intake

American Journal of Physiology-Endocrinology and Metabolism, 2010
Both insulin and leptin signaling converge on phosphatidylinositol 3-OH kinase [PI( 3 )K]/3-phosphoinositide-dependent protein kinase-1 (PDK-1)/protein kinase B (PKB, also known as Akt) in proopiomelanocortin (POMC) neurons. Forkhead box-containing protein-O1 (FoxO1) is inactivated in a PI( 3 )K-dependent manner.
Kristy, Iskandar, Yongheng, Cao, Yoshitake, Hayashi, Masanori, Nakata, Eisuke, Takano, Toshihiko, Yada, Changliang, Zhang, Wataru, Ogawa, Miyo, Oki, Streamson, Chua, Hiroshi, Itoh, Tetsuo, Noda, Masato, Kasuga, Jun, Nakae   +13 more
openaire   +2 more sources

POMC Neurons: Feeding, Energy Metabolism, and Beyond

2018
The central melanocortin system is a well-established neuronal pathway involved in regulating energy metabolism. Pro-opiomelanocortin (POMC) neurons, agouti gene-related protein (AgRP) neurons, and their downstream cells expressing the melanocortin-3 (MC3R) and melanocortin-4 receptors (MC4R) are three key components of the central melanocortin pathway.
openaire   +2 more sources

Estrogen Promotes Parvalbumin Expression in Arcuate Nucleus POMC Neurons

Reproductive Sciences, 2010
We have found that estrogen promotes suppression of feeding and a lean body mass while activating the arcuate nucleus proopiomelanocortin (POMC)-expressing neurons. These neurons, when activated, suppress appetite and increase energy expenditure. Because the increased activation of POMC neurons by estradiol was associated with increased glutamate ...
Peter, Sotonyi, Qian, Gao, Ingo, Bechmann, Tamas L, Horvath   +3 more
openaire   +2 more sources

Orexinergic innervation of POMC-containing neurons in the rat arcuate nucleus

Neuroreport, 2001
A pre-embedding double immunostaining technique was used to study the synaptic relationships between orexin-like immunoreactive axon terminals and preopiomelanocortin (POMC)-like immunoreactive neurons in the rat arcuate nucleus. Most of the synapses were axo-dendritic, while some axo-somatic synapses were also found.
J L, Guan, T, Saotome, Q P, Wang, H, Funahashi, T, Hori, S, Tanaka, S, Shioda   +6 more
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Opposing effects of nicotine on hypothalamic arcuate nucleus POMC and NPY neurons

Progress in Neurobiology
The hypothalamic arcuate nucleus (ARC) contains two main populations of neurons essential for energy homeostasis: neuropeptide Y (NPY) neurons, which are orexigenic and stimulate food intake, and proopiomelanocortin (POMC) neurons, which have an anorexigenic effect.
E, Ramírez-Sánchez, A, Mondragón-García, J, Garduño, F, Hernández-Vázquez, S, Ortega-Tinoco, S, Hernández-López   +5 more
exaly   +3 more sources

Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis

Cell Metabolism, 2021
Alicia G Gómez-Valadés, Luis Varela, Sara Ramirez   +2 more
exaly  

Simultaneous targeting of POMC and AgRP neurons

Nature Metabolism
openaire   +2 more sources