Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling
Molecular Metabolism, 2020 Objective: Sirt6 is an essential regulator of energy metabolism in multiple peripheral tissues. However, the direct role of Sirt6 in the hypothalamus, specifically pro-opiomelanocortin (POMC) neurons, controlling energy balance has not been established ...
Qin Tang +18 more
doaj +1 more source
Glucose rapidly induces different forms of excitatory synaptic plasticity in hypothalamic POMC neurons. [PDF]
PLoS ONE, 2014 Hypothalamic POMC neurons are required for glucose and energy homeostasis. POMC neurons have a wide synaptic connection with neurons both within and outside the hypothalamus, and their activity is controlled by a balance between excitatory and inhibitory
Jun Hu +3 more
doaj +1 more source
Trilogy Development of Proopiomelanocortin Neurons From Embryonic to Adult Stages in the Mice Retina
Frontiers in Cell and Developmental Biology, 2021 Proopiomelanocortin-positive amacrine cells (POMC ACs) were first discovered in adult mouse retinas in 2010; however, the development of POMC-ACs has not been studied.
Xuhong Zhang +10 more
doaj +1 more source
The role of insulin receptor substrate 2 in hypothalamic and beta cell function [PDF]
, 2005 Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in beta cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons ...
Al-Qassab, H +19 more
core
PTEN: A master regulator of neuronal structure, function, and plasticity. [PDF]
, 2014 PTEN (phosphatase and tensin homolog on chromosome ten) is a dual protein/lipid phosphatase that dephosphorylates PIP3, thereby inhibiting the AKT/mTOR pathway. This inhibition ultimately decreases protein translation, cell proliferation and cell growth.
Garcia-Junco-Clemente, Pablo +1 more
core +1 more source
The Sodium Channel B4-Subunits are Dysregulated in Temporal Lobe Epilepsy Drug-Resistant Patients [PDF]
, 2020 Temporal lobe epilepsy (TLE) is the most common type of partial epilepsy referred for surgery due to antiepileptic drug (AED) resistance. A common molecular target for many of these drugs is the voltage-gated sodium channel (VGSC).
Falciani, Francesco +4 more
core +1 more source
Amylin analogues as a novel perspective in anti‐obesity therapy
British Journal of Pharmacology, EarlyView.Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley +1 more source
An ATF4-ATG5 signaling in hypothalamic POMC neurons regulates obesity [PDF]
Autophagy, 2017 ATF4 (activating transcription factor 4) is an important transcription factor that has many biological functions, while its role in hypothalamic POMC (pro-opiomelanocortin-α) neurons in the regulation of energy homeostasis has not been explored. We recently discovered that mice with an Atf4 deletion specific to POMC neurons (PAKO mice) are lean and ...
Yuzhong Xiao +11 more
openaire +2 more sources
5-HT obesity medication efficacy via POMC activation is maintained during aging [PDF]
, 2014 Peer reviewedPublisher ...
Billups, Brian +10 more
core +3 more sources
Cell Proliferation, EarlyView.By assembling cortical‐hypothalamic circuits, we show that cortical input protects hypothalamic neurons from fatty acid‐induced damage, which activates PGC1α to boost mitochondrial function. This reveals a cortico‐hypothalamic axis that defends against metabolic stress.
Mengdan Tao +10 more
wiley +1 more source