Results 81 to 90 of about 31,735 (160)

Cilia in Nervous System Development, Function, and Disease

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Cilia are evolutionarily conserved organelles that function as essential sensory and motility platforms in the nervous system. This review outlines key cilia‐dependent signaling pathways and their roles in neural development and function. Furthermore, it highlights how ciliary dysfunction can lead to a variety of neurological disorders, known as ...
Qingchao Li, Anqi Zhang, Ting Song
wiley   +1 more source

Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons

Molecular Metabolism, 2016
Adiponectin receptors (AdipoRs) are located on neurons of the hypothalamus involved in metabolic regulation - including arcuate proopiomelanocortin (Pomc) and Neuropeptide Y/Agouti-related peptide (NPY/AgRP) neurons. AdipoRs play a critical role in regulating glucose and fatty acid metabolism by initiating several signaling cascades overlapping with ...
Sun, Jia, Gao, Yong, Yao, Ting, Huang, Yiru, He, Zhenyan, Yu, Kai-jiang, Wang, Rui-tao, Guo, Hongbo, Yan, Jianqun, Chang, Yongsheng, Chen, Hong, Scherer, Philipp E., Liu, Tiemin, Williams, Kevin W., Kong, Xingxing   +14 more
openaire   +5 more sources

Somato-dendritic localization and signaling by leptin receptors in hypothalamic POMC and AgRP neurons. [PDF]

PLoS ONE, 2013
Leptin acts via neuronal leptin receptors to control energy balance. Hypothalamic pro-opiomelanocortin (POMC) and agouti-related peptide (AgRP)/Neuropeptide Y (NPY)/GABA neurons produce anorexigenic and orexigenic neuropeptides and neurotransmitters, and
Sangdeuk Ha, Scott Baver, Lihong Huo, Adriana Gata, Joyce Hairston, Nicholas Huntoon, Wenjing Li, Thompson Zhang, Elizabeth J Benecchi, Maria Ericsson, Shane T Hentges, Christian Bjørbæk   +11 more
doaj   +1 more source

G Protein‐Coupled Receptor 17 (Gpr17) Enhances Leptin and Insulin Sensitivity in Lean and Obese Mouse Models

Obesity, Volume 34, Issue S1, Page 77-87, June 2026.
This study identifies G protein‐coupled receptor 17 (Gpr17) as a novel regulator of leptin and insulin sensitivity. Using complementary knockout models, we demonstrate that Gpr17 deletion enhances energy expenditure, restores leptin responsiveness, and improves insulin sensitivity, revealing Gpr17 as a potential therapeutic GPCR target for obesity and ...
Xun Sun, Connor Mahler, Natalie D. Stull, Ali Nasiri, Baohua Zhou, Varman Samuel, Gerald Shulman, Jonathan N. Flak, Hongxia Ren   +8 more
wiley   +1 more source

Next‐Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS

Cell Proliferation, Volume 59, Issue 6, June 2026.
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang, Jinrui Li, Xingjia Mao, Wanyu Wang, Yansong Li, Xuefei Hu, Jinjie Zhong, Fengdong Zhao, Linlin Wang   +8 more
wiley   +1 more source

Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons

eLife, 2017
POMC neurons integrate metabolic signals from the periphery. Here, we show in mice that food deprivation induces a linear current-voltage relationship of AMPAR-mediated excitatory postsynaptic currents (EPSCs) in POMC neurons.
Shigetomo Suyama, Alexandra Ralevski, Zhong-Wu Liu, Marcelo O Dietrich, Toshihiko Yada, Stephanie E Simonds, Michael A Cowley, Xiao-Bing Gao, Sabrina Diano, Tamas L Horvath   +9 more
doaj   +1 more source

SemaGBA: A System Dynamics Model of the Semaglutide‐Responsive Gut‐Brain Axis A Model of How the Brain and Semaglutide Regulate Appetite and Weight

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 5184-5194, June 2026.
ABSTRACT Aims Semaglutide is a GLP‐1 receptor agonist for the treatment of type 2 diabetes and obesity. Its clinical effects are well established, but the underlying mechanisms remain unclear. This study aims to use computational modelling to generate hypotheses about semaglutide's long‐term metabolic (body weight, net energy intake, blood glucose ...
Vivan C. W. Kennis, Natal A. W. van Riel
wiley   +1 more source

Generation and characterization of POMC-tdTomato reporter human pluripotent stem cell lines

Stem Cell Research
Proopiomelanocortin (POMC) is a precursor polypeptide that undergoes extensive, tissue-specific post-translational processing. It is expressed in several tissues, including pituitary gland, hypothalamus, brain stem, and skin.
Vukasin M. Jovanovic, Rick Rausch, Maria Caterina DeRosa, David Castellano, Cody McKee, Chaitali Sen, Fiona Daly, Claudia A. Doege, Carlos A. Tristan   +8 more
doaj   +1 more source

The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley   +1 more source

Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons

Molecular Metabolism, 2016
Objective: Obesity is one of the primary healthcare challenges of the 21st century. Signals relaying information regarding energy needs are integrated within the brain to influence body weight.
Luke K. Burke, Barbora Doslikova, Giuseppe D'Agostino, Megan Greenwald-Yarnell, Teodora Georgescu, Raffaella Chianese, Pablo B. Martinez de Morentin, Emmanuel Ogunnowo-Bada, Celine Cansell, Lourdes Valencia-Torres, Alastair S. Garfield, John Apergis-Schoute, Daniel D. Lam, John R. Speakman, Marcelo Rubinstein, Malcolm J. Low, Justin J. Rochford, Martin G. Myers, Mark L. Evans, Lora K. Heisler   +19 more
doaj   +1 more source