Results 81 to 90 of about 484,847 (189)

Glucose-excited POMC neurons in the ARC.

, 2014
(A) Hypothalamic sections containing the ARC were prepared from POMC DsRed mice (7 weeks), and POMC neurons were visualized using a fluorescent microscope.
Liangyou Rui (332792), Lin Jiang (217766), Malcolm J. Low (616041), Jun Hu (5721)   +3 more
core   +1 more source

Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons – Implications for energy balance and glucose control

Molecular Metabolism, 2019
Objective: The long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist, liraglutide, stimulates insulin secretion and efficiently suppresses food intake to reduce body weight.
Zhenyan He, Yong Gao, Linh Lieu, Sadia Afrin, Jianhong Cao, Natalie J. Michael, Yanbin Dong, Jia Sun, Hongbo Guo, Kevin W. Williams   +9 more
doaj   +1 more source

GLP‐1 receptor activation attenuates chronic migraine‐like behaviour: Sex‐specific modulation of opioid‐ and endocannabinoid‐related pathways

British Journal of Pharmacology, EarlyView.
Background and Purpose Chronic migraine (CM) is a highly disabling condition that remains suboptimally treated. Metabolic disturbances may trigger migraine chronification, whereas impaired endogenous pain inhibition contributes to CM development. Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), used for type 2 diabetes and obesity, show efficacy ...
Katarina Sićović, Katarina Nastić, Miroslav Dinić, Emilija Brdarić, Uroš Pecikoza, Maja Tomić, Ana Micov   +6 more
wiley   +1 more source

Dominant Role of the p110 beta Isoform of PI3K over p110 alpha in Energy Homeostasis Regulation by POMC and AgRP Neurons [PDF]

, 2009
PI3K signaling is thought to mediate leptin and insulin action in hypothalamic pro-opiomelanocortin (POMC) and agouti-related protein (AgRP) neurons, key regulators of energy homeostasis, through largely unknown mechanisms.
Irvine, E.E., Choudhury, Agharul I., Smith, Mark A., Irvine, Elaine E., Choudhury, Agharul I, Ashford, Michael LJ, Vanhaesebroeck, Bart, Selman, Colin, Lingard, Steven, Irvine, Elaine E, Bell, Jimmy D, Claret, Marc, Bell, Jimmy D., Withers, Dominic J, Barsh, Gregory S., Choudhury, A.I., Vanhaesebroeck, B., Piipari, K., Smith, Andrew, Withers, D.J., Smith, Mark A, Chandarana, Keval, Ashford, Michael L. J., Smith, Andrew J. H., Barsh, Gregory S, Chandarana, K., Clements, Melanie, Barsh, G.S., Withers, Dominic J., Guillermet-Guibert, J., Ashford, Michael L. J.; id_orcid, Claret, M., Selman, C., Batterham, Rachel L, Al-Qassab, H., Al-Qassab, Hind, Guillermet-Guibert, Julie, Piipari, Kaisa, Bell, J.D., Smith, M.A., Smith, Andrew JH, Lingard, S., Ashford, M.L.J., Batterham, R.L., Batterham, Rachel L., Clements, M., Smith, A.J.H.   +46 more
core   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

ARC POMC neurons express temperature-sensitive TRPV1 receptors.

, 2018
(A) Single-cell RT-PCR analysis of POMC neurons showing Trpv1 mRNA expression. Images showing POMC-eGFP neurons in hypothalamic slices (left). Right: Transcripts were collected from 20 different POMC neurons (lane, 1–20).
Streamson C. Chua Jr. (5135990), Shun-Mei Liu (5135993), Dong Kun Lee (387318), Gary J. Schwartz (179665), Young-Hwan Jo (401126), Jae Hoon Jeong (215351)   +5 more
core   +1 more source

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons [PDF]

Neuron, 2011
Leptin acts in the brain to prevent obesity. The underlying neurocircuitry responsible for this is poorly understood, in part because of incomplete knowledge regarding first-order, leptin-responsive neurons. To address this, we and others have been removing leptin receptors from candidate first-order neurons.
Vong, Linh, Ye, Chianping, Yang, Zongfang, Choi, Brian, Chua, Streamson, Lowell, Bradford B.   +5 more
openaire   +2 more sources

Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity—Paving the Way for Targeted Clinical Intervention Trials—A Comprehensive Position Paper

Obesity Reviews, EarlyView.
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela e Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat‐Mesquida, Maria Pérez‐Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S. Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn‐Haren, Rikke Andersen, Torsten Bohn   +22 more
wiley   +1 more source

Rethinking Global Obesity Guidelines: Integrating Evidence, Equity and Precision (2014–2026)

Obesity Reviews, EarlyView.
Challenges and evidence in obesity guidelines. ABSTRACT Obesity remains a global health crisis characterized by substantial heterogeneity in diagnosis, management, and policy implementation. Although numerous national and international clinical practice guidelines have been published over the past decade, their translation into evidence‐based and ...
Rosero‐Revelo Ricardo, Tamayo Mateo, Henao Diana, Juan P. Polanco, Cortés David, Juan C. Alba, Giha Valeria, Camargo Camilo, Hernández Eder, Correa Ricardo, Nassar Ricardo, Cabandugama Peminda, Marcio L. Griebeler, Burguera Bartolome   +13 more
wiley   +1 more source

Loss of Leptin Receptors on Hypothalamic POMC Neurons Alters Synaptic Inhibition

, 2010
Adaptive changes in hypothalamic neural circuitry occur in response to alterations in nutritional status. This plasticity at hypothalamic synapses contributes to the control of food intake and body weight.
Sung Kun Chun, Young-Hawn Jo
core   +1 more source