Results 61 to 70 of about 484,847 (189)
POMC neuronal heterogeneity in energy balance and beyond: an integrated view
Nature Metabolism, 2021 Hypothalamic AgRP and POMC neurons are conventionally viewed as the yin and yang of the body's energy status, since they act in an opposite manner to modulate appetite and systemic energy metabolism. However, although AgRP neurons' functions are comparatively well understood, a unifying theory of how POMC neuronal cells operate has remained elusive ...Carmelo Quarta, Marc Claret, Lori M. Zeltser, Kevin W. Williams, Giles S. H. Yeo, Matthias H. Tschöp, Sabrina Diano, Jens C. Brüning, Daniela Cota +8 moreopenaire +6 more sourcesNicotine Decreases Food Intake Through Activation of POMC Neurons [PDF]
Science, 2011 Nicotine decreases weight gain by targeting a brain pathway involved in the regulation of energy balance and food intake.Mineur, Yann S, Abizaid, Alfonso, Rao, Yan, Salas, Ramiro, DiLeone, Ralph J, Gündisch, Daniela, Diano, Sabrina, De Biasi, Mariella, Horvath, Tamas L, Gao, Xiao-Bing, Picciotto, Marina R +10 moreopenaire +3 more sources5-ht inhibition of rat insulin 2 promoter cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus [PDF]
, 2009 A number of anti-obesity agents have been developed that enhance hypothalamic 5-HT transmission. Various studies have demonstrated that arcuate neurons, which express proopiomelanocortin peptides (POMC neurons), and neuropeptide Y with agouti-related ...Smith, M. A., Ashford, M. L. J.; id_orcid, Hisadome, K., Withers, D. J., Claret, M., Choudhury, A. I. +5 morecore +1 more sourceSelective Restoration ofPomcExpression in Glutamatergic POMC Neurons: Evidence for a Dynamic Hypothalamic Neurotransmitter Network [PDF]
eneuro, 2019 AbstractHypothalamic POMC deficiency leads to obesity and metabolic deficiencies, largely due to the loss of melanocortin peptides. However, POMC neurons in the arcuate nucleus (ARC) are comprised of glutamatergic and GABAergic subpopulations. The developmental program, relative proportion and function of these two subpopulations are unresolved.Graham L. Jones, Gábor Wittmann, Eva B. Yokosawa, Hui Yu, Aaron J. Mercer, Ronald M. Lechan, Malcolm J. Low +6 moreopenaire +2 more sourcesUnveiling the transcriptome alteration of POMC neuron in diet-induced obesity [PDF]
Experimental Cell Research, 2019 Abstract Background: Loss of neuron homeostasis in the Arcuate nucleus (ARC) is suggested to be responsible for the development diet-induced-obesity (DIO). We previously reported that loss of Rb1 gene compromised the homeostasis of anorexigenic POMC neurons in ARC and induced obesity in mice.Method: To shed light on how DIO develops, we propose Peng Lyu, Zhishun Huang, Qingjun Feng, Yongfu Su, Mengying Zheng, Yannv Hong, Xiang Cai, Zhonglei LU +7 moreopenaire +2 more sourcesSteroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis. [PDF]
, 2019 Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, Paternoster, Lavinia, Williamson, Kathleen A., Greenwood, CMT, Pollitt, RC, Ward, Kirsten, Crooks, Lucy, Down, T, Taylor, R, Balasubramanian, Senduran, Xu, P, Liang, J, Xu, J, Smee, C, Cacciottolo, Tessa M, Birney, E, Ciampi, A, Xu, C, Clement, Gail, Smith, BH, Xu, Y, Morris, James, Beales, P, Maslen, John, Foley, AR, Foley, A. Reghan, Edkins, Sarah, Pollitt, Rebecca C., Yan, X, Flicek, Paul, Sharp, SI, Langenberg, C, Bochukova, E, UK10K Consortium, Clapham, Peter, Cocca, Massimiliano, Balasubramanian, S, Wang, Guangbiao, Northstone, K, Liu, R, Spasic-Boskovic, O, Chatterjee, Krishna, Schoenmakers, Nadia, Curtis, D, Payne, SJ, Kennedy, Karen, Perry, John R. B., Dunham, I, Gasparini, P, Danecek, Petr, O’Malley, BW, Metrustry, Sarah, Xu, Jianming, Zhang, W, Inês Barroso,, Zhang, P, Evans, DM, Al Turki, Saeed, Min, JL, Mistry, Vanisha, Stevens, Elizabeth, Antony, Dinu, Tong, Qingchun, Farooqi, IS, Memari, Y, Nordestgaard, Børge G., Banton, MC, Zhang, F, Toniolo, D, Raymond, F. Lucy, Tong, Q, Blackwood, Douglas, Bounds, R, Small, Kerrin S., Lee, I, Collier, DA, Smith, GD, van Duijn, CM, Palotie, A, Day-Williams, Aaron, Wang, Chunmei, MacArthur, DG, Holmans, Peter, Greenwood, Celia M. T., Cosgrove, Catherine, Calissano, M, van der Klaauw, Agatha A, Bounds, Rebecca, Wilson, SG, Barrett, Jeffrey C., Rehnstrom, Karola, Flicek, P, Williamson, KA, Walters, James T. R., Consortium, U, Howie, B, Hysi, Pirro, Lawson, D, Langford, C, Johnson, J, Sun, Jianping, Yang, Jian, Hart, Deborah, Hurles, ME, Vijayarangakannan, P, Klaauw, A.A. (Agatha) van der, Zaza, G, Zhu, Liangru, St Clair, D, Kaye, J, Bolton, PF, Ciampi, Antonio, McQuillin, Andrew, Marchini, J, McKechanie, Andrew G., Paunio, T, McKechanie, AG, Kennedy, K, Morris, Andrew, Tian, J, Roberts, Nicola, Cox, T, Futema, M, Du, Y, Wong, K, Benn, M, Cosgrove, C, Scambler, P, Jackson, David K., Amuzu, A, Bentham, J, Marchini, Jonathan, Cox, Tony, Gambaro, Giovanni, Guo, Xueqin, Brion, M-J, Coates, G, Huang, J, Chen, Lu, Huang, L, Traglia, Michela, Wilson, C, Cacciottolo, T.M., Povey, S, Howie, Bryan, Scott, Robert A., O'Donovan, Michael C., van der Klaauw, Agatha A., Hinton, A, Memari, Yasin, Liao, Lan, van der Klaauw, AA, Chatterjee, K, Farooqi, I. Sadaf, Yang, J, Khawaja, F, O'Rahilly, Stephen, Mathieson, I, Saito, K, O'Donovan, MC, Jamshidi, Y, Liu, Ryan, Marenne, G, Charlton, R, Yang, Y, Wain, Louise V., Lek, Monkol, Edkins, S, Khawaja, Farrah, Danecek, P, Walter, Klaudia, Serra, Eva, St Pourcain, B, Visscher, PM, Keogh, Julia, Casas, Juan Pablo, Antony, D, Kolb-Kokocinski, A, Floyd, James, Brion, Marie-Jo, Shihab, Hashem A., Scambler, Peter, Serra, E, Artigas, Maria Soler, Lopes, M, Whyte, Tamieka, Charlton, Ruth, Oualkacha, Karim, McIntosh, Andrew M., Lek, M, Bhattacharya, Shoumo, Marenne, Gaelle, Vandersteen, Anthony M., Mitchison, Hannah M., Traglia, M, Northstone, Kate, Spasic-Boskovic, Olivera, Lonnqvist, Jouko, Smith, Blair H., Curran, S, Matchan, A, Du, Yuanping, Mistry, V, Hysi, P, Al Turki, S, Casas, JP, Liang, Jieqin, Malerba, Giovanni, Porteous, DJ, Chambers, John C., Joyce, C, Ekong, Rosemary, Savage, DB, Breen, Gerome, Lonnqvist, J, Tybjaerg-Hansen, A, Muntoni, Francesco, Humphries, SE, Semple, Robert K., Robinson, RL, van Duijn, Cornelia M., He, Yanlin, Day-Williams, A, Ellis, P, Lachance, G, Lee, Irene, Quaye, L, Collier, David A., Coates, Guy, Xu, ChangJiang, Zhang, Feng, Marz, W, Zhu, L.R., Cirak, S, Shaw, A, Muntoni, F, Marz, Winfried, Ekong, R, Syrris, Petros, Barroso, Ines, Curran, Sarah, Surdulescu, G, Owen, MJ, Mathieson, Iain, Tachmazidou, Ioanna, Schmidts, Miriam, Timpson, Nicholas J., Kemp, John P., Keogh, JM, Schmidts, M, Vijayarangakannan, Parthiban, Chen, L, Lin, Hong, Sharp, Sally I., Evans, David M., Ayub, M, Kemp, JP, Bochukova, EG, Small, KS, Schiffels, Stephan, Bobrow, Martin, Dunham, Ian, Lopes, Luis R., Visscher, Peter M., Moayyeri, Alireza, Suvisaari, J, Bhattacharya, S, Zaza, Gianluigi, Stalker, Jim, Robinson, Rachel L., Spector, TD, Roberts, N, Stalker, J, Wheeler, Eleanor, Cirak, Sebahattin, Oualkacha, K, Hubbard, Tim, Jamshidi, Yalda, Luan, Jian'an, Vandersteen, AM, Bochukova, Elena G, McIntosh, AM, Henning, Elana, van Kogelenberg, Margriet, Anney, Richard, Gurling, Hugh, Malerba, G, Skuse, David, St Clair, David, Tobin, MD, Wain, LV, Banton, Matthew C, Gaunt, Tom R., Crooks, L, Keogh, Julia M., Ring, S, Isaacs, A, Metrustry, S, Clement, G, Paunio, Tiina, Joyce, Chris, Varbo, A, Benn, Marianne, Matchan, Angela, Scott, Richard H., McGuffin, P, Gambaro, G, Wang, C, Beales, Phil, Langenberg, Claudia, Wang, G, Bobrow, M, Wang, J, Wheeler, E, Bentham, Jamie, Wilson, Scott G., McQuillin, A, Soranzo, N, Quaye, Lydia, Johnson, Jon, Wang, Y, Wang, Yu, Carss, Keren, Craddock, N, Day, Ian N. M., Geschwind, Daniel, Hendricks, Audrey E., Zhang, Pingbo, Palotie, Aarno, Fatemifar, G, Tachmazidou, I, Zeggini, E, Mitchison, HM, Franklin, CS, MacArthur, Daniel G., Owen, Michael J., Bolton, Patrick F., Gaunt, TR, Schiffels, S, Daly, Allan, Zheng, Hou-Feng, Yan, Xiaofeng, Skuse, D, Kleber, ME, Quail, MA, van Kogelenberg, M, St Pourcain, Beate, Lawler, KL, Massimo, Mangino, Zhu, L, Zeggini, Eleftheria, Southam, Lorraine, Valdes, Ana M., Hart, D, Artigas, MS, Stadler, Lukas K J, Kent, A, van, der Klaauw AA, Hubbard, T, Southam, L, Tian, Jing, Blackwood, D, Plagnol, V, Walter, K, Boustred, C, Kleber, Marcus E., Chambers, JC, Dedoussis, George, Whyte, T, Ritchie, Graham R. S., He, Y.L., Syrris, P, Williams, Hywel J., Griffin, Heather, Yang, Yongjie, Saito, Kenji, Pietilainen, Olli, Henning, E, Curtis, David, Moayyeri, A, O’Rahilly, S, Keogh, J, Birney, Ewan, Jackson, DK, Langford, Cordelia, Keane, Thomas, O\u27Malley, Bert W, Dominiczak, A, Farooqi, I Sadaf, Spector, Timothy D., Payne, F, Ridout, CK, Clapham, P, Richards, J. Brent, Lin, H, Huang, Jie, Porteous, David J., Wang, Jun, Savage, David B., Daly, A, Kaye, Jane, Li, Y, Onoufriadis, A, Li, Rui, Banton, Matthew C., Ellis, Peter, Stevens, E, Li, R, Down, Thomas, Franklin, Christopher S., Timpson, NJ, Grozeva, D, Stadler, LKJ, Ward, K, Ayub, Muhammad, Toniolo, Daniela, Stadler, Lukas K. J., He, Y, Plagnol, Vincent, Anderson, CA, Keane, T, Muddyman, Dawn, Payne, Felicity, Cocca, M, Shin, S-Y, Hendricks, AE, Shihab, HA, Fatemifar, Ghazaleh, Lawson, Daniel, Parr, Jeremy R., van Leeuwen, EM, Semple, RK, Griffin, H, Migone, N, Nordestgaard, BG, Gasparini, Paolo, Whincup, P, Smith, George Davey, Williams, HJ, Amuzu, Antoinette, Lopes, Margarida, Futema, Marta, Parr, JR, Inês Barroso, Bochukova, Elena G., Gallagher, L, Floyd, J, Dedoussis, G, Perry, JRB, Grozeva, Detelina, Massimo, M, Geihs, Matthias, Migone, Nicola, Payne, Stewart J., Onoufriadis, Alexandros, Soranzo, Nicole, Muddyman, D, McCarthy, Shane, Maslen, J, Panoutsopoulou, K, van Leeuwen, Elisabeth M., Geihs, M, Quail, Michael A., Anderson, Carl A., Parker, V, Boustred, Chris, Parker, Victoria, Scott, RA, Huang, Liren, Guo, X, Scott, RH, Xu, Pingwen, Shin, So-Youn, Guo, Xiaosen, Li, Yingrui, Raymond, FL, Rehnstrom, K, Geschwind, D, Kooner, Jaspal S., O'Rahilly, S, Kooner, JS, Lopes, LR, Ridout, Cheryl K., Tybjaerg-Hansen, Anne, O\u27Rahilly, Stephen, Luan, J, O'Malley, BW, Gurling, H, Ring, Susan, Gallagher, Louise, Iotchkova, Valentina, Smee, Carol, Barroso, I, Fitzpatrick, David R., Hinton, Antentor, Iotchkova, V, Breen, G, Calissano, Mattia, Zheng, H-F, Anney, R, Schoenmakers, N, Shaw, Adam, McCarthy, S, Bochukova, Elena, Varbo, Anette, Isaacs, Aaron, Zhang, Weihua, Yang, Y.J., Taylor, Rohan, Wong, Kim, Walters, JTR, Holmans, P, Suvisaari, Jaana, Stadler, L.K.J., Fitzpatrick, DR, Hendricks, Audrey E, Hurles, Matthew E., Durbin, R, Lachance, Genevieve, Wilson, Crispian, Pietilainen, O, Durbin, Richard, Cacciottolo, TM, Keogh, Julia M, O'Malley, Bert W., Povey, Sue, Morris, Richard, Kolb-Kokocinski, Anja, Day, INM, Valdes, AM, Barrett, JC, Tobin, Martin D., Whincup, Peter, Xu, Yong, Morris, A, Richards, JB, Ritchie, GRS, Lawler, Katherine L., Morris, J, Kent, Alastair, McGuffin, Peter, Panoutsopoulou, Kalliope, Craddock, Nick, Sun, J, Min, Josine L., Dominiczak, Anna, Morris, R, Surdulescu, Gabriela, Paternoster, L, Lawler, Katherine L, Humphries, Steve E., Liao, L, Cacciottolo, Tessa M., Carss, K, Qingchun Tong, Yang, YJ, Matthew C. Banton, Xiaofeng Yan, Liangru Zhu, Duijn, Cornelia, Pingwen Xu, Chunmei Wang, I. Sadaf Farooqi, Agatha A. van der Klaauw, Zhang, WH, Julia M. Keogh, Zhu, LR, Antentor Hinton, Lukas K. J. Stadler, Kenji Saito, Leeuwen, Elisa, Elana Henning, Elena G. Bochukova, He, YL, Stephen O’Rahilly, Yongjie Yang, Yong Xu, Audrey E. Hendricks, Jianming Xu, Katherine L. Lawler, Lan Liao, Nordestgaard, Borge G., Yanlin He, Tessa M. Cacciottolo, Vanisha Mistry, Bert W. O’Malley +584 morecore +4 more sourcesPretreatment Cachexia Index Is Associated With Severe Treatment Toxicity and Overall Survival in HPV‐Negative Head and Neck Squamous Cell Carcinoma
Head &Neck, EarlyView.ABSTRACT Introduction
Cancer cachexia is characterized by skeletal muscle loss, poor nutrition, and systemic inflammation and is common in head and neck cancer. We evaluated whether the Cachexia Index (CXI) predicts treatment toxicity and survival in HPV‐negative HNSCC.Gianluca Savoia, Michael P. Hier, Nader Sadeghi, Alex Mlynarek, Keith Richardson, Sabrina Daniela Silva Wurzba, Christina Tsien, George Shenouda, Khalil Sultanem, Nathaniel Bouganim, Khashayar Esfahani, Marco A. Mascarella +11 morewiley +1 more source
