Results 31 to 40 of about 484,847 (189)

Energy imbalance alters Ca2+ handling and excitability of POMC neurons [PDF]

eLife, 2017
Satiety-signaling, pro-opiomelanocortin (POMC)-expressing neurons in the arcuate nucleus of the hypothalamus play a pivotal role in the regulation of energy homeostasis.
Lars Paeger, Paehler, M., Pouzat, C., Pippow, A., Paehler, Moritz, Kloppenburg, P., Brüning, Jens, Klein, A., Peter Kloppenburg, Klein, Andréas, Husch, Andreas, Husch, A., Hess, Simon, Andreas C Klein, Simon Hess, Pouzat, Christophe, Andreas Pippow, Paeger, Lars, Andreas Husch, Pippow, Andreas, Christophe Pouzat, Jens C Brüning, Moritz Paehler, Brüning, J., Paeger, L., Hess, S., Kloppenburg, Peter   +26 more
core   +6 more sources

mTORC1-dependent increase in oxidative metabolism in POMC neurons regulates food intake and action of leptin

Molecular Metabolism, 2018
Objective: Nutrient availability modulates reactive oxygen species (ROS) production in the hypothalamus. In turn, ROS regulate hypothalamic neuronal activity and feeding behavior.
Magalie Haissaguerre, Amandine Ferrière, Vincent Simon, Nicolas Saucisse, Nathalie Dupuy, Caroline André, Samantha Clark, Omar Guzman-Quevedo, Antoine Tabarin, Daniela Cota   +9 more
doaj   +2 more sources

Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake. [PDF]

PLoS Biology, 2018
Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) respond to numerous hormonal and neural signals, resulting in changes in food intake.
Jae Hoon Jeong, Dong Kun Lee, Shun-Mei Liu, Streamson C Chua, Gary J Schwartz, Young-Hwan Jo   +5 more
doaj   +2 more sources

Insulin regulates POMC neuronal plasticity to control glucose metabolism [PDF]

eLife, 2018
Hypothalamic neurons respond to nutritional cues by altering gene expression and neuronal excitability. The mechanisms that control such adaptive processes remain unclear. Here we define populations of POMC neurons in mice that are activated or inhibited
Garron T Dodd, Natalie J Michael, Robert S Lee-Young, Salvatore P Mangiafico, Jack T Pryor, Astrid C Munder, Stephanie E Simonds, Jens Claus Brüning, Zhong-Yin Zhang, Michael A Cowley, Sofianos Andrikopoulos, Tamas L Horvath, David Spanswick, Tony Tiganis   +13 more
doaj   +5 more sources

Magel2 knockdown in hypothalamic POMC neurons innervating the medial amygdala reduces susceptibility to diet-induced obesity [PDF]

Life Science Alliance, 2022
Magel2 knockdown in ARC POMC neurons innervating the MeA reduces body weight in mice fed with HFD. This effect is associated with increased locomotor activity that is abolished by central GPER blockade.
Yuna Choi, Hyeon-Young Min, Jiyeon Hwang, Young-Hwan Jo   +3 more
doaj   +2 more sources

Differential contribution of POMC and AgRP neurons to the regulation of regional autonomic nerve activity by leptin

Molecular Metabolism, 2018
Objectives: The autonomic nervous system is critically involved in mediating the control by leptin of many physiological processes. Here, we examined the role of the leptin receptor (LepR) in proopiomelanocortin (POMC) and agouti-related peptide (AgRP ...
Balyssa B. Bell, Shannon M. Harlan, Donald A. Morgan, Deng-Fu Guo, Kamal Rahmouni   +4 more
doaj   +2 more sources

InsR/FoxO1 signaling curtails hypothalamic POMC neuron number. [PDF]

PLoS ONE, 2012
Insulin receptor (InsR) signaling through transcription factor FoxO1 is important in the development of hypothalamic neuron feeding circuits, but knowledge about underlying mechanisms is limited.
Leona Plum, Hua V Lin, Kumiko S Aizawa, Yitian Liu, Domenico Accili   +4 more
doaj   +3 more sources

Overexpression of Smad7 in hypothalamic POMC neurons disrupts glucose balance by attenuating central insulin signaling

Molecular Metabolism, 2020
Objective: Although the hypothalamus is crucial for peripheral metabolism control, the signals in specific neurons involved remain poorly understood.
Feifan Guo, Shanghai Chen, Fuxin Jiao
exaly   +3 more sources

Effects of chronic high fat diet on mediobasal hypothalamic satiety neuron function in POMC-Cre mice

Molecular Metabolism
Objective: The prevalence of obesity has increased over the past three decades. Proopiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) play a vital role in induction of satiety.
Yavuz Yavuz, Bayram Yilmaz, Deniz Atasoy
exaly   +3 more sources

Conditional expression of Pomc in the Lepr-positive subpopulation of POMC neurons is sufficient for normal energy homeostasis and metabolism [PDF]

Endocrinology, 2015
Peptides derived from the proopiomelanocortin (POMC) precursor are critical for the normal regulation of many physiological parameters, and POMC deficiency results in severe obesity and metabolic dysfunction.
Rubinstein, Marcelo, Myers Jr, Martin G., Mercer, Aaron J., Lam, Daniel D., Low, Malcolm J., Attard, Courtney A.   +5 more
core   +5 more sources