Results 31 to 40 of about 31,735 (160)

mTOR Signaling Fades POMC Neurons during Aging [PDF]

Neuron, 2012
Hypothalamic POMC neurons contribute to the regulation of energy homeostasis and glucose metabolism. In this issue of Neuron, Yang et al. (2012) show that the mTOR pathway has a pivotal role in deterioration of POMC neurons during age-dependent obesity.
Kim, Jae Geun, Horvath, Tamas L.
openaire   +2 more sources

The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight

Molecular Metabolism, 2020
Objective: Regulation of food intake and energy balance depends on a group of hypothalamic neurons that release anorexigenic melanocortins encoded by the Pomc gene.
Clara E. Hael, Daniela Rojo, Daniela P. Orquera, Malcolm J. Low, Marcelo Rubinstein   +4 more
doaj   +1 more source

Whole-brain Mapping of the Direct Inputs and Axonal Projections of Pro-opiomelanocortin(POMC) and Agouti-related peptide(AgRP) Neurons

Frontiers in Neuroanatomy, 2015
Pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) of the hypothalamus and nucleus tractus solitarius (NTS) of the brainstem play important roles in suppressing food intake and maintaining energy homeostasis.
Daqing ewang, Daqing ewang, Xiaobing eHe, Xiaobing eHe, Zhe ezhao, Qiru eFeng, Rui eLin, Yue eSun, Ting eDing, Fuqiang eXu, Fuqiang eXu, Fuqiang eXu, Minmin eLuo, Minmin eLuo, Cheng eZhan   +14 more
doaj   +1 more source

Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo

Molecular Metabolism, 2021
Objective: Long-acting glucagon-like peptide-1 receptor agonists (GLP-1RAs), like liraglutide and semaglutide, are viable treatments for diabetes and obesity. Liraglutide directly activates hypothalamic proopiomelanocortin (POMC) neurons while indirectly
Yanbin Dong, Jamie Carty, Nitsan Goldstein, Zhenyan He, Eunsang Hwang, Dominic Chau, Briana Wallace, Anita Kabahizi, Linh Lieu, Yunqian Peng, Yong Gao, Ling Hu, J. Nicholas Betley, Kevin W. Williams   +13 more
doaj   +1 more source

Unraveling the central proopiomelanocortin neural circuits

Frontiers in Neuroscience, 2013
Central proopiomelanocortin (POMC) neurons form a potent anorexigenic network, but our understanding of the integration of this hypothalamic circuit throughout the central nervous system (CNS) remains incomplete. POMC neurons extend projections along the
Aaron J. Mercer, Shane T. Hentges, Charles K. Meshul, Charles K. Meshul, Malcolm J. Low, Malcolm J. Low   +5 more
doaj   +1 more source

Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression

iScience, 2023
Summary: Hypothalamic pro-opiomelanocortin (POMC) neuron development is considered to play an essential role in the development of obesity. However, the underlying mechanisms remain unclear.
Chenyang Lu, Jinglin Zhang, Bingjie Wang, Qiao Gao, Kezhe Ma, Shaona Pei, Juxue Li, Sheng Cui   +7 more
doaj   +1 more source

Hormone and glucose signalling in POMC and AgRP neurons

The Journal of Physiology, 2009
In the wake of the obesity pandemic, increased research efforts are under way to define how peripheral hormones and metabolites regulate energy homeostasis. The melanocortin system, comprising anorexigenic proopiomelanocortin (POMC) expressing neurons and orexigenic agouti‐related protein (AgRP)/neuropeptide Y (NPY) coexpressing neurons in the arcuate ...
Bengt F, Belgardt, Tomoo, Okamura, Jens C, Brüning   +2 more
openaire   +3 more sources

Role of POMC and AgRP neuronal activities on glycaemia in mice [PDF]

Scientific Reports, 2019
AbstractLeptin regulates both feeding and glycaemia primarily through its receptors expressed on agouti-related peptide (AgRP) and pro-opiomelanocortin-expressing (POMC) neurons; however, it is unknown whether activity of these neuronal populations mediates the regulation of these processes.
Aykut Göktürk Üner, Onur Keçik, Paula G. F. Quaresma, Thiago M. De Araujo, Hyon Lee, Wenjing Li, Hyun Jeong Kim, Michelle Chung, Christian Bjørbæk, Young-Bum Kim   +9 more
openaire   +2 more sources

The role of proopiomelanocortin (POMC) neurones in feeding behaviour [PDF]

Nutrition & Metabolism, 2007
The precursor protein, proopiomelanocortin (POMC), produces many biologically active peptides via a series of enzymatic steps in a tissue-specific manner, yielding the melanocyte-stimulating hormones (MSHs), corticotrophin (ACTH) and beta-endorphin. The MSHs and ACTH bind to the extracellular G-protein coupled melanocortin receptors (MCRs) of which ...
openaire   +3 more sources

NMDA Receptors in POMC Neurons Connect Exercise With Insulin Sensitivity. [PDF]

Diabetes
Increased arcuate proopiomelanocortin (POMC) neuron activity improves glucose metabolism and reduces appetite, facilitating weight loss. We recently showed that arcuate POMC neurons are activated by exercise. However, the role of excitatory glutamatergic input in these neurons and the metabolic outcomes of exercise
Portillo B, Hwang E, Ajwani J, Grose K, Lieu L, Wallace B, Kabahizi A, Elmquist JK, Williams KW.   +8 more
europepmc   +3 more sources