Results 31 to 40 of about 41,053 (237)

Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency

Molecular Metabolism, 2021
Objective: Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus are essential regulators of energy balance. Selective loss of POMC production in these cells results in extreme obesity and metabolic comorbidities.
Surbhi, Gábor Wittmann, Malcolm J. Low, Ronald M. Lechan   +3 more
doaj   +1 more source

Gabra5 plays a sexually dimorphic role in POMC neuron activity and glucose balance

Frontiers in Endocrinology, 2022
Pro-opiomelanocortin (POMC) neurons are important for the regulation of body weight and glucose balance. The inhibitory tone to POMC neurons is mediated primarily by the GABA receptors. However, the detailed mechanisms and functions of GABA receptors are
Zhou Pei, Zhou Pei, Yang He, Jonathan C. Bean, Yongjie Yang, Hailan Liu, Meng Yu, Kaifan Yu, Ilirjana Hyseni, Xing Cai, Hesong Liu, Na Qu, Longlong Tu, Kristine M. Conde, Mengjie Wang, Yongxiang Li, Na Yin, Nan Zhang, Junying Han, Camille HS. Potts, Nikolas A. Scarcelli, Zili Yan, Pingwen Xu, Qi Wu, Yanlin He, Yong Xu, Yong Xu, Chunmei Wang   +27 more
doaj   +1 more source

mTOR Signaling Fades POMC Neurons during Aging [PDF]

Neuron, 2012
Hypothalamic POMC neurons contribute to the regulation of energy homeostasis and glucose metabolism. In this issue of Neuron, Yang et al. (2012) show that the mTOR pathway has a pivotal role in deterioration of POMC neurons during age-dependent obesity.
Kim, Jae Geun, Horvath, Tamas L.
openaire   +2 more sources

Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice

Molecular Metabolism, 2020
Objective: Hypothalamic arcuate proopiomelanocortin (Arc-POMC) neurons are involved in different physiological processes such as the regulation of energy balance, glucose homeostasis, and stress-induced analgesia.
Milagros Trotta, Estefanía Pilar Bello, Ramiro Alsina, María Belén Tavella, José Luis Ferrán, Marcelo Rubinstein, Viviana Florencia Bumaschny   +6 more
doaj   +1 more source

Relative number and distribution of murine hypothalamic proopiomelanocortin neurons innervating distinct target sites. [PDF]

PLoS ONE, 2011
Proopiomelanocortin (POMC) neurons send projections widely throughout the brain consistent with their role in regulating numerous homeostatic processes and mediating analgesia and reward.
Connie M King, Shane T Hentges
doaj   +1 more source

Deciphering molecular inputs to CRH neurons from POMC neurons

Fundamental Research
Muhammad Junaid, Eun Jeong Lee, Su Bin Lim   +2 more
openalex   +2 more sources

Defining POMC Neurons Using Transgenic Reagents: Impact of Transient Pomc Expression in Diverse Immature Neuronal Populations [PDF]

Endocrinology, 2012
Melanocortin signaling plays a central role in the regulation of phenotypes related to body weight and energy homeostasis. To specifically target and study the function of proopiomelanocortin (POMC) neurons, Pomc promoter elements have been utilized to generate reporter and Cre recombinase transgenic reagents.
Stephanie L, Padilla, Daniel, Reef, Lori M, Zeltser   +2 more
openaire   +2 more sources

NMDA Receptors in POMC Neurons Connect Exercise With Insulin Sensitivity. [PDF]

Diabetes
Increased arcuate proopiomelanocortin (POMC) neuron activity improves glucose metabolism and reduces appetite, facilitating weight loss. We recently showed that arcuate POMC neurons are activated by exercise. However, the role of excitatory glutamatergic input in these neurons and the metabolic outcomes of exercise
Portillo B, Hwang E, Ajwani J, Grose K, Lieu L, Wallace B, Kabahizi A, Elmquist JK, Williams KW.   +8 more
europepmc   +3 more sources

Mitohormesis in Hypothalamic POMC Neurons Mediates Regular Exercise-Induced High-Turnover Metabolism. [PDF]

Cell Metab, 2021
Kang GM, Min SH, Lee CH, Kim JY, Lim HS, Choi MJ, Jung SB, Park JW, Kim S, Park CB, Dugu H, Choi JH, Jang WH, Park SE, Cho YM, Kim JG, Kim KG, Choi CS, Kim YB, Lee C, Shong M, Kim MS.   +21 more
europepmc   +2 more sources

Nicotine, Food Intake, and Activation of POMC Neurons [PDF]

Neuropsychopharmacology, 2012
The effect of smoking on appetite is well known to smokers. Individuals who quit smoking gain on average 11–15 pounds in the first 2 years of abstinence, and adolescent girls, in particular, may smoke to control their weight (Stice and Shaw, 2003). As we know well from warnings of public health organizations, there is also a growing obesity epidemic in
Marina R, Picciotto, Yann S, Mineur
openaire   +2 more sources