POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons. [PDF]
ElifeAbstract Inactivating mutations in the melanocortin 4 receptor (MC4R) gene cause monogenic obesity. Interestingly, female patients also display various degrees of reproductive disorders, in line with the subfertile phenotype of MC4RKO female mice. However, the cellular mechanisms by which MC4R regulates reproduction are unknown.
Talbi R +11 more
europepmc +6 more sources
Hypothalamic POMC neurons promote cannabinoid-induced feeding [PDF]
Nature, 2015 Hypothalamic pro-opiomelanocortin (POMC) neurons promote satiety. Cannabinoid receptor 1 (CB1R) is critical for the central regulation of food intake. Here we test whether CB1R-controlled feeding in sated mice is paralleled by decreased activity of POMC neurons.
Horváth, Tamás L. +2 more
core +9 more sources
GLP1R agonists activate human POMC neurons
AbstractDrugs like Semaglutide (a.k.a. Ozempic/Wegovy) that activate the glucagon-like peptide-1 receptor (GLP1R) are a promising therapy for obesity and type 2 diabetes (T2D). Animal studies suggest that appetite-suppressing proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus are a likely target of these drugs, but the ...
Mazzaferro S +12 more
europepmc +3 more sources
POMC Neurons: From Birth to Death [PDF]
Annual Review of Physiology, 2017 The hypothalamus is an evolutionarily conserved brain structure that regulates an organism's basic functions, such as homeostasis and reproduction. Several hypothalamic nuclei and neuronal circuits have been the focus of many studies seeking to understand their role in regulating these basic functions. Within the hypothalamic neuronal populations, the
Toda, Chitoku +3 more
openaire +5 more sources
DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons [PDF]
Cell Metabolism, 2017 Hypothalamic pro-opiomelanocortin (POMC) neurons regulate energy and glucose metabolism. Intracellular mechanisms that enable these neurons to respond to changes in metabolic environment are ill defined. Here we show reduced expression of activated dynamin-related protein (pDRP1), a mitochondrial fission regulator, in POMC neurons of fed mice.
SANTORO, ANNA +8 more
openaire +6 more sources
Insulin regulates POMC neuronal plasticity to control glucose metabolism [PDF]
eLife, 2018 Hypothalamic neurons respond to nutritional cues by altering gene expression and neuronal excitability. The mechanisms that control such adaptive processes remain unclear. Here we define populations of POMC neurons in mice that are activated or inhibited
Garron T Dodd +13 more
doaj +5 more sources
InsR/FoxO1 signaling curtails hypothalamic POMC neuron number. [PDF]
PLoS ONE, 2012 Insulin receptor (InsR) signaling through transcription factor FoxO1 is important in the development of hypothalamic neuron feeding circuits, but knowledge about underlying mechanisms is limited.
Leona Plum +4 more
doaj +3 more sources
Somato-dendritic localization and signaling by leptin receptors in hypothalamic POMC and AgRP neurons. [PDF]
PLoS ONE, 2013 Leptin acts via neuronal leptin receptors to control energy balance. Hypothalamic pro-opiomelanocortin (POMC) and agouti-related peptide (AgRP)/Neuropeptide Y (NPY)/GABA neurons produce anorexigenic and orexigenic neuropeptides and neurotransmitters, and
Sangdeuk Ha +11 more
doaj +6 more sources
Magel2 knockdown in hypothalamic POMC neurons innervating the medial amygdala reduces susceptibility to diet-induced obesity [PDF]
Life Science Alliance, 2022 Magel2 knockdown in ARC POMC neurons innervating the MeA reduces body weight in mice fed with HFD. This effect is associated with increased locomotor activity that is abolished by central GPER blockade.
Yuna Choi +3 more
doaj +2 more sources
MANF in POMC Neurons Promotes Brown Adipose Tissue Thermogenesis and Protects Against Diet-Induced Obesity. [PDF]
Diabetes, 2022 Tang Q +9 more
europepmc +3 more sources