SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis [PDF]
Cell & Bioscience, 2022 Background Pro-opiomelanocortin (POMC) neurons play a sexually dimorphic role in body weight and glucose balance. However, the mechanisms for the sex differences in POMC neuron functions are not fully understood.
Meng Yu +20 more
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Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes [PDF]
eLife, 2022 Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus are essential to regulate food intake and energy balance. However, the ontogenetic transcriptional programs that specify the identity and functioning of these neurons are poorly ...
Hui Yu +2 more
doaj +4 more sources
IL-17A produced by POMC neurons regulates diet-induced obesity [PDF]
iScienceSummary: Overeating leads to obesity, a low-grade inflammatory condition involving interleukin-17A (IL-17A). While pro-opiomelanocortin (POMC) neurons regulate feeding, their connection with IL-17A is not well understood.
Rosa Gallo +3 more
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Cell Reports, 2018 Summary: Mitochondrial oxidative phosphorylation (OXPHOS) and substrate utilization critically regulate the function of hypothalamic proopiomelanocortin (POMC)-expressing neurons.
Luis Varela +2 more
exaly +4 more sources
The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice [PDF]
Molecular MetabolismObjective: Proopiomelanocortin (POMC) neurons release potent anorexigenic neuropeptides, which suppress food intake and enhance energy expenditure via melanocortin receptors.
Hui Yu +3 more
doaj +3 more sources
Lactate activates hypothalamic POMC neurons by intercellular signaling [PDF]
Scientific Reports, 2021 Previous studies indicate that the activity of hypothalamic POMC neurons can be regulated by glucose via intracellular mechanisms, but its regulation by lactate is poorly understood. In addition to its energetic role, lactate acts as a signaling molecule.
P. Órdenes +6 more
doaj +5 more sources
The small GTPase Rap1 in POMC neurons regulates leptin actions and glucose metabolism [PDF]
Molecular MetabolismThe hypothalamic leptin-proopiomelanocortin (POMC) pathway is critical for regulating metabolism. POMC neurons in the arcuate nucleus respond to leptin and play a pivotal role in mediating energy and glucose balance. However, during diet-induced obesity (
Weisheng Lu +2 more
exaly +4 more sources
AZGP1 in POMC neurons modulates energy homeostasis and metabolism through leptin-mediated STAT3 phosphorylation [PDF]
Nature CommunicationsZinc-alpha2-glycoprotein (AZGP1) has been implicated in peripheral metabolism; however, its role in regulating energy metabolism in the brain, particularly in POMC neurons, remains unknown. Here, we show that AZGP1 in POMC neurons plays a crucial role in
Sheng Qiu +9 more
doaj +3 more sources
Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost’ subtypes with atypical identity in a mouse model of obesity [PDF]
Nature CommunicationsThe hypothalamus contains a remarkable diversity of neurons that orchestrate behavioural and metabolic outputs in a highly plastic manner. Neuronal diversity is key to enabling hypothalamic functions and, according to the neuroscience dogma, it is ...
Stéphane Leon +23 more
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UCP2-dependent redox sensing in POMC neurons regulates feeding. [PDF]
Cell Rep, 2022 Paradoxically, glucose, the primary driver of satiety, activates a small population of anorexigenic pro-opiomelanocortin (POMC) neurons. Here, we show that lactate levels in the circulation and in the cerebrospinal fluid are elevated in the fed state and
Yoon NA +7 more
europepmc +5 more sources