Magel2 knockdown in hypothalamic POMC neurons innervating the medial amygdala reduces susceptibility to diet-induced obesity [PDF]
Life Science Alliance, 2022 Magel2 knockdown in ARC POMC neurons innervating the MeA reduces body weight in mice fed with HFD. This effect is associated with increased locomotor activity that is abolished by central GPER blockade.
Yuna Choi +3 more
doaj +2 more sources
Insulin regulates POMC neuronal plasticity to control glucose metabolism [PDF]
eLife, 2018 Hypothalamic neurons respond to nutritional cues by altering gene expression and neuronal excitability. The mechanisms that control such adaptive processes remain unclear. Here we define populations of POMC neurons in mice that are activated or inhibited
Garron T Dodd +13 more
doaj +5 more sources
AZGP1 in POMC neurons modulates energy homeostasis and metabolism through leptin-mediated STAT3 phosphorylation [PDF]
Nature CommunicationsZinc-alpha2-glycoprotein (AZGP1) has been implicated in peripheral metabolism; however, its role in regulating energy metabolism in the brain, particularly in POMC neurons, remains unknown. Here, we show that AZGP1 in POMC neurons plays a crucial role in
Sheng Qiu +9 more
doaj +2 more sources
Molecular Metabolism, 2020 Objective: Although the hypothalamus is crucial for peripheral metabolism control, the signals in specific neurons involved remain poorly understood.
Feixiang Yuan, Hanrui Yin, Yalan Deng
exaly +3 more sources
InsR/FoxO1 signaling curtails hypothalamic POMC neuron number. [PDF]
PLoS ONE, 2012 Insulin receptor (InsR) signaling through transcription factor FoxO1 is important in the development of hypothalamic neuron feeding circuits, but knowledge about underlying mechanisms is limited.
Leona Plum +4 more
doaj +3 more sources
Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost’ subtypes with atypical identity in a mouse model of obesity [PDF]
Nature CommunicationsThe hypothalamus contains a remarkable diversity of neurons that orchestrate behavioural and metabolic outputs in a highly plastic manner. Neuronal diversity is key to enabling hypothalamic functions and, according to the neuroscience dogma, it is ...
Stéphane Leon +23 more
doaj +2 more sources
PERK in POMC neurons connects celastrol with metabolism. [PDF]
JCI Insight, 2021 ER stress and activation of the unfolded protein response in the periphery as well as the central nervous system have been linked to various metabolic abnormalities. Chemically lowering protein kinase R-like ER kinase (PERK) activity within the hypothalamus leads to decreased food intake and body weight.
He Z +15 more
europepmc +5 more sources
POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons. [PDF]
ElifeAbstract Inactivating mutations in the melanocortin 4 receptor (MC4R) gene cause monogenic obesity. Interestingly, female patients also display various degrees of reproductive disorders, in line with the subfertile phenotype of MC4RKO female mice. However, the cellular mechanisms by which MC4R regulates reproduction are unknown.
Talbi R +11 more
europepmc +5 more sources
UCP2-dependent redox sensing in POMC neurons regulates feeding. [PDF]
Cell Rep, 2022 Paradoxically, glucose, the primary driver of satiety, activates a small population of anorexigenic pro-opiomelanocortin (POMC) neurons. Here, we show that lactate levels in the circulation and in the cerebrospinal fluid are elevated in the fed state and the addition of lactate to glucose activates the majority of POMC neurons while increasing ...
Yoon NA +7 more
europepmc +4 more sources
Deciphering molecular inputs to CRH neurons from POMC neurons. [PDF]
Fundam ResJunaid M +5 more
europepmc +2 more sources