Results 21 to 30 of about 189,310 (233)

IMPROVE 2025: The 3rd International Meeting on Pathway-Related Obesity: Vision & Evidence. [PDF]

Clin Obes
ABSTRACT An international cohort of 161 clinicians and researchers from 19 countries attended the 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence (IMPROVE) in Prague, Czech Republic, on 2–4 July 2025. The aims of the meeting were to advance understanding of hyperphagia and obesity caused by defects in the melanocortin‐4 receptor
Argente J, van den Akker ELT, Cetiner M, Clément K, Forsythe E, Garfield A, Kühnen P, Martos-Moreno GÁ, Meeker D, Müller HL, van Santen HM, von Schnurbein J, Segrestin B, Tanaka T, Tena-Sempere M, Wabitsch M, Zorn S, Farooqi IS.   +17 more
europepmc   +2 more sources

Sex-Determining Region Y Controls the Effects of Fetal Alcohol Exposure on Proopiomelanocortin Gene Expression

Frontiers in Neuroscience, 2021
Fetal alcohol exposure (FAE) causes various neurodevelopmental deficits in offspring, including reduced expression of the stress regulatory proopiomelanocortin (Pomc) gene and an elevated stress response for multiple generations via the male germline ...
Omkaram Gangisetty, Edward A. Mead, Dipak K. Sarkar   +2 more
doaj   +1 more source

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons [PDF]

, 2007
Hypothalamic AMP-activated protein kinase (AMPK) has been suggested to act as a key sensing mechanism, responding to hormones and nutrients in the regulation of energy homeostasis.
Carling, D., Choudhury, Agharul I., Smith, Mark A., Fryer, L.G.D., Speakman, J.R., Ashford, MLJ, Carling, D, Withers, DJ, Selman, Colin, Xu, Allison W., Al-Qassab, H, Fryer, Lee G.D., Vaulont, Sophie, Choudhury, AI, Fryer, LGD, Vaulont, S., Claret, Marc, Heffron, H, Speakman, John R., Heffron, H., Barsh, Gregory S., Clements, M, Choudhury, A.I., Vaulont, S, Heffron, Helen, Xu, A.W., Withers, D.J., Viollet, B, Smith, MA, Barsh, G.S., Clements, Melanie, Withers, Dominic J., Viollet, B., Ashford, Michael L. J.; id_orcid, Batterham, RL, Selman, C, Claret, M., Barsh, GS, Claret, M, Selman, C., Al-Qassab, H., Xu, AW, Al-Qassab, Hind, Viollet, Benoit, Smith, M.A., Ashford, M.L.J., Batterham, R.L., Batterham, Rachel L., Carling, David, Speakman, JR, Clements, M.   +50 more
core   +1 more source

Dynamic modulation changes of POMC in the arcuate nucleus and neuroendocrine adaptation in response to lifestyle intervention in obese adults [PDF]

مجلة جامعة الانبار للعلوم الصرفة
Obesity occurs as a result of long-term positive energy balance, in which energy intake exceeds energy expenditure. This anabolic condition can lead to impaired hypothalamic neuronal activity involved in nutrient sensing and nutrient-signaling responses.
Nour Rezaieg, Muthanna Awad
doaj   +1 more source

Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances [PDF]

, 2007
The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two of the five melanocortin receptors, MC3R and MC4R are involved in hypothalamic control of energy homeostasis, with the MC4R having the major influence. It is
Hisadome, Kazunari, Michael L. J. Ashford, Smith, Mark A., Helen Heffron, Mark A. Smith, Al-Qassab, Hind, Kazunari Hisadome, Withers, Dominic J., Hind Al‐Qassab, Dominic J. Withers, Ashford, Michael L. J.; id_orcid, Heffron, Helen   +11 more
core   +1 more source

Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.

, 2021
Painful neuropathy is a frequent complication in diabetes. Proopiomelanocortin (POMC) is an endogenous opioid precursor peptide, which plays a protective role against pain. Here, we report dysfunctional POMC-mediated antinociception in sensory neurons in
Klose, C.S.N., Fleming, T., Fleming, Thomas, Deshpande, D., Gaveriaux-Ruff, Claire, Klose, Christophe S. N., Kuner, Roani, Kuner, R., Agarwal, Nitin, Tappe-Theodor, Anke, Deshpande, Divija, Agarwal, N., Nawroth, P.P., Tappe-Theodor, A., Nawroth, Peter, Kuner, R. (Roani), Divija Deshpande, Tappe-Theodor, A. (Anke), Rohini Kuner, Nitin Agarwal, Anke Tappe-Theodor, Christoph S. N. Klose, Agarwal, N. (Nitin), Claire Gaveriaux-Ruff, Deshpande, D. (Divija), Peter Nawroth, Nawroth, P. (Peter), Thomas Fleming, Gaveriaux-Ruff, C. (Claire), Fleming, T. (Thomas)   +29 more
core   +1 more source

Hypothalamic Proopiomelanocortin Is Necessary for Normal Glucose Homeostasis in Female Mice

Frontiers in Endocrinology, 2018
The arcuate nucleus of the hypothalamus is a key regulator of energy balance and glucose homeostasis. In particular, arcuate proopiomelanocortin (POMC) neurons inhibit food intake, stimulate energy expenditure and increase glucose tolerance.
Ramiro Alsina, Milagros Trotta, Viviana Florencia Bumaschny, Viviana Florencia Bumaschny   +3 more
doaj   +1 more source

Epigenetic Alterations of the Promoter Region of the POMC Gene in Adolescent Depressive Disorder Patients with Nonsuicidal Self-Injury Behaviors [Erratum]

Psychology Research and Behavior Management, 2021
Zheng D, Bi X, Zhang T, et al. Psychol Res Behav Manag. 2020;13:997–1008. The authors have advised that there are several errors in the published paper which were introduced by the Editorial staff during the publication process ...
Zheng D, Bi X, Zhang T, Han C, Ma T, Wang L, Sun M, Cui K, Yang L, Liu L   +9 more
doaj  

The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight

Molecular Metabolism, 2020
Objective: Regulation of food intake and energy balance depends on a group of hypothalamic neurons that release anorexigenic melanocortins encoded by the Pomc gene.
Clara E. Hael, Daniela Rojo, Daniela P. Orquera, Malcolm J. Low, Marcelo Rubinstein   +4 more
doaj   +1 more source

Unraveling the central proopiomelanocortin neural circuits

Frontiers in Neuroscience, 2013
Central proopiomelanocortin (POMC) neurons form a potent anorexigenic network, but our understanding of the integration of this hypothalamic circuit throughout the central nervous system (CNS) remains incomplete. POMC neurons extend projections along the
Aaron J. Mercer, Shane T. Hentges, Charles K. Meshul, Charles K. Meshul, Malcolm J. Low, Malcolm J. Low   +5 more
doaj   +1 more source