Results 21 to 30 of about 191,601 (231)

Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures [PDF]

, 2019
Primary cilia dysfunction has been associated with hyperphagia and obesity in both ciliopathy patients and mouse models of cilia perturbation. Neurons throughout the brain possess these solitary cellular appendages, including in the feeding centers of ...
Antonellis, Patrick J., Bansal, Ruchi, Baucum, Anthony J., Berbari, Nicolas F., Cummins, Theodore R., Engle, Staci E., Reiter, Jeremy F., Whitehouse, Logan S.   +7 more
core   +1 more source

Metabolic Precision Medicines: Curing POMC Deficiency [PDF]

Cell Metabolism, 2016
Pro-opiomelanocortin deficiency is a rare cause of severe intractable obesity. Two patients have experienced dramatic weight loss in response to setmelanotide, a melanocortin-4 receptor activator. The drug has potential in broader populations, but caution is warranted as it may act at other melanocortin receptors.
Müller, T.D., Tschöp, M.H., O'Rahilly, S.   +2 more
openaire   +3 more sources

Epigenetic Alterations of the Promoter Region of the POMC Gene in Adolescent Depressive Disorder Patients with Nonsuicidal Self-Injury Behaviors [Erratum]

Psychology Research and Behavior Management, 2021
Zheng D, Bi X, Zhang T, et al. Psychol Res Behav Manag. 2020;13:997–1008. The authors have advised that there are several errors in the published paper which were introduced by the Editorial staff during the publication process ...
Zheng D, Bi X, Zhang T, Han C, Ma T, Wang L, Sun M, Cui K, Yang L, Liu L   +9 more
doaj  

Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells - Redundancy or specificity of neuroimmunoendocrine modulators? [PDF]

, 2004
Objective: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Methods: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM.
Auernhammer, Christoph J., Cengic, N., Dorn, F., Engelhardt, D., Isele, N. B., Kopp, F. B., Senaldi, G., Spottl, G., Vlotides, G., Weber, M. M.   +9 more
core   +1 more source

Somatostatin agonist pasireotide inhibits exercise stimulated growth in the male Siberian hamster (Phodopus sungorus) [PDF]

, 2017
R.Dumbell was supported by a University of Aberdeen PhD studentship and a research visit grant awarded by the British Society of Neuroendocrinology. Further support was provided by the Scottish Government Rural and Environment Science and Analytical ...
Barrett, P, Diedrich, V, Dumbell, R, Petri, I, Scherbarth, F, Schmid, H A, Steinlechner, S   +6 more
core   +2 more sources

Unraveling the central proopiomelanocortin neural circuits

Frontiers in Neuroscience, 2013
Central proopiomelanocortin (POMC) neurons form a potent anorexigenic network, but our understanding of the integration of this hypothalamic circuit throughout the central nervous system (CNS) remains incomplete. POMC neurons extend projections along the
Aaron J. Mercer, Shane T. Hentges, Charles K. Meshul, Charles K. Meshul, Malcolm J. Low, Malcolm J. Low   +5 more
doaj   +1 more source

Species Limits and Phylogeography of North American Cricket Frogs (Acris: Hylidae) [PDF]

, 2008
Cricket frogs are widely distributed across the eastern United States and two species, the northern cricket frog (Acris crepitans) and the southern cricket frog (A. gryllus) are currently recognized. We generated a phylogenetic hypothesis for Acris using
Berendzen, Peter B., Gamble, Tony, Shaffer, H. Bradley, Simons, Andrew M., Starkey, David E.   +4 more
core   +2 more sources

Central Dicer-miR-103/107 controls developmental switch of POMC progenitors into NPY neurons and impacts glucose homeostasis

eLife, 2018
Proopiomelanocortin (POMC) neurons are major negative regulators of energy balance. A distinct developmental property of POMC neurons is that they can adopt an orexigenic neuropeptide Y (NPY) phenotype.
Sophie Croizier, Soyoung Park, Julien Maillard, Sebastien G Bouret   +3 more
doaj   +1 more source

Gel chromatographic characterization of immunoreactive adrenocorticotropin in patients with ACTH hypersecretion [PDF]

, 1989
We investigated the molecular size of circulating immunoreactive ACTH by gel chromatography in patients with ACTH hypersecretion due to various disorders of the hypothalamic-pituitary-adrenal axis.
A Chatelain, AC Hale, B Allolio, B. Allolio, H Imura, JL Doppmann, JW Findling, K Nakao, M Reincke, M Reincke, M Thoren, M. Reincke, PJ Fuller, RC Pedersen, RE Mains, RS Yalow, SJ Ratter, U. Deuß, W. Winkelmann, Y Yamada   +19 more
core   +1 more source

Whole-brain Mapping of the Direct Inputs and Axonal Projections of Pro-opiomelanocortin(POMC) and Agouti-related peptide(AgRP) Neurons

Frontiers in Neuroanatomy, 2015
Pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) of the hypothalamus and nucleus tractus solitarius (NTS) of the brainstem play important roles in suppressing food intake and maintaining energy homeostasis.
Daqing ewang, Daqing ewang, Xiaobing eHe, Xiaobing eHe, Zhe ezhao, Qiru eFeng, Rui eLin, Yue eSun, Ting eDing, Fuqiang eXu, Fuqiang eXu, Fuqiang eXu, Minmin eLuo, Minmin eLuo, Cheng eZhan   +14 more
doaj   +1 more source