Results 11 to 20 of about 189,310 (233)

POMC: the physiological power of hormone processing [PDF]

Physiological Reviews, 2018
Pro-opiomelanocortin (POMC) is the archetypal polypeptide precursor of hormones and neuropeptides. In this review, we examine the variability in the individual peptides produced in different tissues and the impact of the simultaneous presence of their ...
Anthony P. Coll, Coll, Anthony P, Thanuja Gali Ramamoorthy, White, Anne; id_orcid, Anne White, Gali Ramamoorthy, Thanuja, Harno, Erika, Erika Harno   +7 more
core   +5 more sources

InsR/FoxO1 signaling curtails hypothalamic POMC neuron number. [PDF]

PLoS ONE, 2012
Insulin receptor (InsR) signaling through transcription factor FoxO1 is important in the development of hypothalamic neuron feeding circuits, but knowledge about underlying mechanisms is limited.
Leona Plum, Hua V Lin, Kumiko S Aizawa, Yitian Liu, Domenico Accili   +4 more
doaj   +2 more sources

Pro-opiomelanocortin (POMC) expression and immunolocalization of POMC-related peptides in the ovary of Protopterus annectens, an African lungfish

Peptides, 1997
Antisera against adrenocorticotropic hormone (ACTH), alpha-melanocyte-stimulating hormone (alpha MSH) and beta-endorphin were used to localize pro-opiomelanocortin (POMC)-derived peptides in the ovary of the African lungfish Protopterus annectens by ...
Masini MA, A. GALLINELLI, Sturla M, Pestarino M, MASINI, MARIA ANGELA, F. FACCHINETTI, Gallinelli A, FACCHINETTI, Fabio, B. M. UVA, M. PESTARINO, Uva BM, M. STURLA, B.M Uva, A Gallinelli, M Pestarino, M.A Masini, M Sturla, F Facchinetti   +17 more
core   +6 more sources

Gabra5 plays a sexually dimorphic role in POMC neuron activity and glucose balance [PDF]

Frontiers in Endocrinology, 2022
Pro-opiomelanocortin (POMC) neurons are important for the regulation of body weight and glucose balance. The inhibitory tone to POMC neurons is mediated primarily by the GABA receptors. However, the detailed mechanisms and functions of GABA receptors are
Zhou Pei, Zhou Pei, Yang He, Jonathan C. Bean, Yongjie Yang, Hailan Liu, Meng Yu, Kaifan Yu, Ilirjana Hyseni, Xing Cai, Hesong Liu, Na Qu, Longlong Tu, Kristine M. Conde, Mengjie Wang, Yongxiang Li, Na Yin, Nan Zhang, Junying Han, Camille HS. Potts, Nikolas A. Scarcelli, Zili Yan, Pingwen Xu, Qi Wu, Yanlin He, Yong Xu, Yong Xu, Chunmei Wang   +27 more
doaj   +2 more sources

IL-17A produced by POMC neurons regulates diet-induced obesity

iScience
Summary: Overeating leads to obesity, a low-grade inflammatory condition involving interleukin-17A (IL-17A). While pro-opiomelanocortin (POMC) neurons regulate feeding, their connection with IL-17A is not well understood.
Rosa Gallo, Ana Teijeiro, Mariana Angulo-Aguado, Nabil Djouder   +3 more
doaj   +2 more sources

Proopiomelanocortin (POMC) mRNA and POMC-derived peptides immunolocalization in the skin of Protopterus annectens, an African lungfish

Peptides, 1999
Antisera against adrenocorticotropic hormone (ACTH), alpha-melanocyte stimulating hormone (alpha-MSH) and beta-endorphin were used to localize, by immunohistochemistry, proopiomelanocortin (POMC)-derived peptides in the skin excised from different ...
F. Facchinetti, B.M. Uva, Pestarino M, MASINI, MARIA ANGELA, Gallinelli A, B. M. UVA, A. Gallinelli, Masini MA, Sturla M, FACCHINETTI, Fabio, Uva BM, M.A. Masini, M. Sturla, M. Pestarino   +13 more
core   +6 more sources

The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice

Molecular Metabolism
Objective: Proopiomelanocortin (POMC) neurons release potent anorexigenic neuropeptides, which suppress food intake and enhance energy expenditure via melanocortin receptors.
Hui Yu, Angelika Chiang, Marcelo Rubinstein, Malcolm J. Low   +3 more
doaj   +2 more sources

Proopiomelanocortin (POMC) and Psychodermatology

Skin Health and Disease, 2023
Abstract Psychodermatology is the crossover discipline between Dermatology and Clinical Psychology and/or Psychiatry. It encompasses both Psychiatric diseases that present with cutaneous manifestations (such as delusional infestation) or more commonly, the psychiatric or psychological problems associated with skin disease, such as ...
George W. M. Millington, Hannah E. Palmer   +1 more
openaire   +3 more sources

60 YEARS OF POMC: POMC: an evolutionary perspective [PDF]

Journal of Molecular Endocrinology, 2016
Proopiomelanocortin (POMC) is a complex precursor that comprises several peptidic hormones, including melanocyte-stimulating hormones (MSHs), adrenocorticotropic hormone (ACTH), and β-endorphin. POMC belongs to the opioid/orphanin gene family, whose precursors include either opioid (YGGF) or the orphanin/nociceptin core sequences (FGGF).
Sandra, Navarro, Lucia, Soletto, Sara, Puchol, Josep, Rotllant, Jose Luis, Soengas, Jose Miguel, Cerdá-Reverter   +5 more
openaire   +2 more sources

Natural History of Obesity Due to POMC, PCSK1, and LEPR Deficiency and the Impact of Setmelanotide. [PDF]

, 2022
CONTEXT: Rare homozygous or biallelic variants in POMC, PCSK1, and LEPR can disrupt signaling through the melanocortin-4 receptor (MC4R) pathway, resulting in hyperphagia and severe early-onset obesity.
Flück, Christa E., Wabitsch, Martin, Garrison, Jill, Kühnen, Peter, Mallya, Usha G, Flück, Christa E, Stewart, Murray, Mallya, Usha G., Farooqi, Sadaf, van den Akker, Erica, Bratina, Natasa, Erica van den Akker, Natasa Bratina, Peter Kühnen, Murray Stewart, Christa E Flück, Jill Garrison, Sadaf Farooqi, Usha G Mallya, Martin Wabitsch   +19 more
core   +3 more sources