Results 11 to 20 of about 179,797 (233)

60 YEARS OF POMC: POMC: an evolutionary perspective [PDF]

Journal of Molecular Endocrinology, 2016
Proopiomelanocortin (POMC) is a complex precursor that comprises several peptidic hormones, including melanocyte-stimulating hormones (MSHs), adrenocorticotropic hormone (ACTH), and β-endorphin. POMC belongs to the opioid/orphanin gene family, whose precursors include either opioid (YGGF) or the orphanin/nociceptin core sequences (FGGF).
Sandra, Navarro, Lucia, Soletto, Sara, Puchol, Josep, Rotllant, Jose Luis, Soengas, Jose Miguel, Cerdá-Reverter   +5 more
openaire   +3 more sources

POMC: The Physiological Power of Hormone Processing [PDF]

Physiological Reviews, 2018
Pro-opiomelanocortin (POMC) is the archetypal polypeptide precursor of hormones and neuropeptides. In this review, we examine the variability in the individual peptides produced in different tissues and the impact of the simultaneous presence of their precursors or fragments.
Harno, Erika, Gali Ramamoorthy, Thanuja, Coll, Anthony P, White, Anne   +3 more
openaire   +4 more sources

Insulin regulates POMC neuronal plasticity to control glucose metabolism [PDF]

eLife, 2018
Hypothalamic neurons respond to nutritional cues by altering gene expression and neuronal excitability. The mechanisms that control such adaptive processes remain unclear. Here we define populations of POMC neurons in mice that are activated or inhibited
Garron T Dodd, Natalie J Michael, Robert S Lee-Young, Salvatore P Mangiafico, Jack T Pryor, Astrid C Munder, Stephanie E Simonds, Jens Claus Brüning, Zhong-Yin Zhang, Michael A Cowley, Sofianos Andrikopoulos, Tamas L Horvath, David Spanswick, Tony Tiganis   +13 more
doaj   +2 more sources

The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice

Molecular Metabolism
Objective: Proopiomelanocortin (POMC) neurons release potent anorexigenic neuropeptides, which suppress food intake and enhance energy expenditure via melanocortin receptors.
Hui Yu, Angelika Chiang, Marcelo Rubinstein, Malcolm J. Low   +3 more
doaj   +2 more sources

Pro-Opiomelanocortin (POMC) Expression and Immunolocalization of POMC-Related Peptides in the Ovary of Protopterus annectens, an African Lungfish

Peptides, 1997
Antisera against adrenocorticotropic hormone (ACTH), alpha-melanocyte-stimulating hormone (alpha MSH) and beta-endorphin were used to localize pro-opiomelanocortin (POMC)-derived peptides in the ovary of the African lungfish Protopterus annectens by immunohistochemistry.
MASINI, MARIA ANGELA, M. STURLA, PESTARINO, MARIO, A. GALLINELLI, F. FACCHINETTI, UVA, BIANCA MARIA   +5 more
openaire   +6 more sources

AZGP1 in POMC neurons modulates energy homeostasis and metabolism through leptin-mediated STAT3 phosphorylation

Nature Communications
Zinc-alpha2-glycoprotein (AZGP1) has been implicated in peripheral metabolism; however, its role in regulating energy metabolism in the brain, particularly in POMC neurons, remains unknown. Here, we show that AZGP1 in POMC neurons plays a crucial role in
Sheng Qiu, Qinan Wu, Hao Wang, Dongfang Liu, Chen Chen, Zhiming Zhu, Hongting Zheng, Gangyi Yang, Ling Li, Mengliu Yang   +9 more
doaj   +2 more sources

IL-17A produced by POMC neurons regulates diet-induced obesity

iScience
Summary: Overeating leads to obesity, a low-grade inflammatory condition involving interleukin-17A (IL-17A). While pro-opiomelanocortin (POMC) neurons regulate feeding, their connection with IL-17A is not well understood.
Rosa Gallo, Ana Teijeiro, Mariana Angulo-Aguado, Nabil Djouder   +3 more
doaj   +2 more sources

InsR/FoxO1 signaling curtails hypothalamic POMC neuron number. [PDF]

PLoS ONE, 2012
Insulin receptor (InsR) signaling through transcription factor FoxO1 is important in the development of hypothalamic neuron feeding circuits, but knowledge about underlying mechanisms is limited.
Leona Plum, Hua V Lin, Kumiko S Aizawa, Yitian Liu, Domenico Accili   +4 more
doaj   +2 more sources

Proopiomelanocortin (POMC) mRNA and POMC-derived peptides immunolocalization in the skin of Protopterus annectens, an African lungfish

Peptides, 1999
Antisera against adrenocorticotropic hormone (ACTH), alpha-melanocyte stimulating hormone (alpha-MSH) and beta-endorphin were used to localize, by immunohistochemistry, proopiomelanocortin (POMC)-derived peptides in the skin excised from different regions of the African lungfish Protopterus annectens.
MASINI, MARIA ANGELA, M. STURLA, PESTARINO, MARIO, F. FACCHINETTI, A. GALLINELLI, UVA, BIANCA MARIA   +5 more
openaire   +5 more sources

Proopiomelanocortin (POMC) and Psychodermatology

Skin Health and Disease, 2023
Abstract Psychodermatology is the crossover discipline between Dermatology and Clinical Psychology and/or Psychiatry. It encompasses both Psychiatric diseases that present with cutaneous manifestations (such as delusional infestation) or more commonly, the psychiatric or psychological problems associated with skin disease, such as ...
George W. M. Millington, Hannah E. Palmer   +1 more
openaire   +3 more sources