Results 31 to 40 of about 179,797 (233)

Epigenetic Alterations of the Promoter Region of the POMC Gene in Adolescent Depressive Disorder Patients with Nonsuicidal Self-Injury Behaviors [Erratum]

Psychology Research and Behavior Management, 2021
Zheng D, Bi X, Zhang T, et al. Psychol Res Behav Manag. 2020;13:997–1008. The authors have advised that there are several errors in the published paper which were introduced by the Editorial staff during the publication process ...
Zheng D, Bi X, Zhang T, Han C, Ma T, Wang L, Sun M, Cui K, Yang L, Liu L   +9 more
doaj  

The role of insulin receptor substrate 2 in hypothalamic and β cell function [PDF]

, 2005
Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in β cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons ...
Hisadome, Kazunari, Choudhury, Agharul I., Smith, Mark A., Simmgen, M., Diakonov, Ivan, Allison W. Xu, Bedford, D.C., Michael L.J. Ashford, Speakman, J.R., Helen Heffron, Bedford, David C., Selman, Colin, Marc Claret, Xu, Allison W., Kazunari Hisadome, Claret, Marc, MacColl, Gavin, Bell, Jimmy D., Speakman, John R., Heffron, H., Melanie Clements, Barsh, Gregory S., Agharul I. Choudhury, Choudhury, A.I., Heffron, Helen, Hind Al-Qassab, Xu, A.W., Vazira Moosajee, Withers, D.J., Hisadome, K., Barsh, G.S., Clements, Melanie, Mark A. Smith, Ashford, Michael L.J.; id_orcid, Withers, Dominic J., Moosajee, Vazira, Dominic J. Withers, Claret, M., MacColl, G., Selman, C., Ivan Diakonov, Al-Qassab, H., Al-Qassab, Hind, Moosajee, V., Gavin MacColl, Simmgen, Marcus, Bell, J.D., Smith, M.A., Ashford, M.L.J., Gregory S. Barsh, Diakonov, I., Batterham, R.L., David C. Bedford, Batterham, Rachel L., Colin Selman, Jimmy D. Bell, Clements, M., Marcus Simmgen, Rachel L. Batterham, John R. Speakman   +59 more
core   +1 more source

Unraveling the central proopiomelanocortin neural circuits

Frontiers in Neuroscience, 2013
Central proopiomelanocortin (POMC) neurons form a potent anorexigenic network, but our understanding of the integration of this hypothalamic circuit throughout the central nervous system (CNS) remains incomplete. POMC neurons extend projections along the
Aaron J. Mercer, Shane T. Hentges, Charles K. Meshul, Charles K. Meshul, Malcolm J. Low, Malcolm J. Low   +5 more
doaj   +1 more source

SemaGBA: A System Dynamics Model of the Semaglutide-Responsive Gut-Brain Axis A Model of How the Brain and Semaglutide Regulate Appetite and Weight. [PDF]

Diabetes Obes Metab
ABSTRACT Aims Semaglutide is a GLP‐1 receptor agonist for the treatment of type 2 diabetes and obesity. Its clinical effects are well established, but the underlying mechanisms remain unclear. This study aims to use computational modelling to generate hypotheses about semaglutide's long‐term metabolic (body weight, net energy intake, blood glucose ...
Kennis VCW, van Riel NAW.
europepmc   +2 more sources

60 YEARS OF POMC: N-terminal POMC peptides and adrenal growth [PDF]

Journal of Molecular Endocrinology, 2016
The peptide hormones contained within the sequence of proopiomelanocortin (POMC) have diverse roles ranging from pigmentation to regulation of adrenal function to control of our appetite. It is generally acknowledged to be the archetypal hormone precursor, and as its biology has been unravelled, so too have many of the basic principles of hormone ...
openaire   +2 more sources

Central Dicer-miR-103/107 controls developmental switch of POMC progenitors into NPY neurons and impacts glucose homeostasis

eLife, 2018
Proopiomelanocortin (POMC) neurons are major negative regulators of energy balance. A distinct developmental property of POMC neurons is that they can adopt an orexigenic neuropeptide Y (NPY) phenotype.
Sophie Croizier, Soyoung Park, Julien Maillard, Sebastien G Bouret   +3 more
doaj   +1 more source

Whole-brain Mapping of the Direct Inputs and Axonal Projections of Pro-opiomelanocortin(POMC) and Agouti-related peptide(AgRP) Neurons

Frontiers in Neuroanatomy, 2015
Pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) of the hypothalamus and nucleus tractus solitarius (NTS) of the brainstem play important roles in suppressing food intake and maintaining energy homeostasis.
Daqing ewang, Daqing ewang, Xiaobing eHe, Xiaobing eHe, Zhe ezhao, Qiru eFeng, Rui eLin, Yue eSun, Ting eDing, Fuqiang eXu, Fuqiang eXu, Fuqiang eXu, Minmin eLuo, Minmin eLuo, Cheng eZhan   +14 more
doaj   +1 more source

Stocking density affects transcriptome changes in the hypothalamic-pituitary-gonadal axis and reproductive performance in ducks

Italian Journal of Animal Science, 2022
The hypothalamic-pituitary-adrenal (HPA) axis and hypothalamic-pituitary-gonadal (HPG) axis plays a central role in mediating physiological responses related to the reproductive system under any stressful condition.
Hehe Liu, Xia Xiong, Fajun Pu, Jianmei Wang, Yanying Li, Yang Xi, Shengchao Ma, Lili Bai, Rongping Zhang, Li Liang, Chaowu Yang   +10 more
doaj   +1 more source

Epigenetic Alterations of the Promoter Region of the POMC Gene in Adolescent Depressive Disorder Patients with Nonsuicidal Self-injury Behaviors

Psychology Research and Behavior Management, 2020
Doudou Zheng,1,* Xiaojiao Bi,2,* Tianliang Zhang,3 Chao Han,3 Tantan Ma,3 Lina Wang,2 Mengmeng Sun,3 Kaiyan Cui,3 Limin Yang,3 Lanfen Liu3 1Department of Psychiatry, School of Clinical Medicine, Cheeloo College of Medicine, Shandong University, Jinan ...
Zheng D, Bi X, Zhang T, Han C, Ma T, Wang L, Sun M, Cui K, Yang L, Liu L   +9 more
doaj  

Natural History of Obesity Due to POMC, PCSK1, and LEPR Deficiency and the Impact of Setmelanotide.

, 2022
CONTEXT: Rare homozygous or biallelic variants in POMC, PCSK1, and LEPR can disrupt signaling through the melanocortin-4 receptor (MC4R) pathway, resulting in hyperphagia and severe early-onset obesity.
Flück, Christa E., Wabitsch, Martin, Garrison, Jill, Kühnen, Peter, Mallya, Usha G, Flück, Christa E, Stewart, Murray, Mallya, Usha G., Farooqi, Sadaf, van den Akker, Erica, Bratina, Natasa   +10 more
core   +1 more source