Results 51 to 60 of about 189,310 (233)

Chromatin Accessibility Profiling of the Canine Brain Reveals Regulatory Programs Associated With Dog‐Wolf Divergence and Human Psychiatric Risk

Integrative Zoology, EarlyView.
The dog is a valuable model for studying social behavior and neuropsychiatric disease. We generated an ATAC‐seq atlas of 7 brain regions and pituitary from 4 beagles, identifying 251,492 CREs. Integrating dog‐wolf divergence revealed tissue‐specific CREs overlapping divergent loci, including neuronal and neuroendocrine genes.
Biao Deng, Junze Wu, Ye Liu, Xuan Li, Yuanfang Xu, Rongjie Duan, Yibo Tong, Jinsheng Xu, Mengyang Ni, Zijie Scott Zhang, Dan Xue, Bowen Zhou, Yanhu Liu, Rui Cheng, Yuedong Zhang, Ya‐Ping Zhang   +15 more
wiley   +1 more source

Hypothalamic POMC neurons promote cannabinoid-induced feeding

, 2015
Hypothalamic pro-opiomelanocortin (POMC) neurons promote satiety. Cannabinoid receptor 1 (CB1R) is critical for the central regulation of food intake. Here we test whether CB1R-controlled feeding in sated mice is paralleled by decreased activity of POMC ...
Joel K. Elmquist, Kim, Jung Dae, Cowley, Michael A., Elmquist, Joel K., Claudia R. Vianna, Marcelo O. Dietrich, Dietrich, Marcelo O., Szigeti-Buck, Klara, Koch, Marco, Morozov, Yury M, Jae Geun Kim, Simonds, Stephanie E., Jung Dae Kim, Morozov, Yury M., Horvath, Tamas L., Yury M. Morozov, Francisco Hernández-Nuño, Xiao-Bing Gao, Pasko Rakic, Klara Szigeti-Buck, Hernández-Nuño, Francisco, Cowley, Michael A, Horvath, Tamas L, Vianna, Claudia R, Luis Varela, Stephanie E. Simonds, Vianna, Claudia R., Michael A. Cowley, Tamas L. Horvath, Bechmann, Ingo, Gao, Xiao-Bing, Carlos M. Castorena, Simonds, Stephanie E, Castorena, Carlos M., Diano, Sabrina, Kim, Jae Geun, Castorena, Carlos M, Ingo Bechmann, Rakic, Pasko, Elmquist, Joel K, Dietrich, Marcelo O, Marco Koch, Varela, Luis, Sabrina Diano   +43 more
core   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Reduced Pomc and unaltered Npy neuron number in adult Pomc^–Foxo1 mice.

, 2012
Number of Pomc-expressing (A) and Npy-expressing (B) cells per ARC hemisection in Pomc–Foxo1 mice (black bars, n = 7–9) and WT controls (white bars, n = 7–9) at the age of 15 weeks. Exemplary Pomc FISH pictures of two WT and Pomc–Foxo1 mice (C).
Domenico Accili (185429), Yitian Liu (185427), Kumiko S. Aizawa (185425), Leona Plum (27116), Hua V. Lin (185423)   +4 more
core   +1 more source

Age-Dependent Changes in the mRNA Levels of Neuropeptide Y, Proopiomelanocortin, and Corticotropin-Releasing Factor in the Hypothalamus in Growing Broiler Chicks

The Journal of Poultry Science, 2013
Lines of evidence suggest that hypothalamic neuropeptides have a physiological role in the regulation of food intake in mammals. However, little is known about the age-dependent change of hypothalamic neuropeptides in chicks.
Takaoki Saneyasu, Kiwako Nakanishi, Hiroyuki Atsuta, Atsushi Ikura, Hiroshi Kamisoyama, Shin Hasegawa, Kazuhisa Honda   +6 more
doaj   +1 more source

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

UCP2-dependent redox sensing in POMC neurons regulates feeding

, 2022
Paradoxically, glucose, the primary driver of satiety, activates a small population of anorexigenic pro-opiomelanocortin (POMC) neurons. Here, we show that lactate levels in the circulation and in the cerebrospinal fluid are elevated in the fed state and
Jin, Sungho, Kim, Jung Dae, Kibbey, Richard, Sun, Qiushi, Cardone, Rebecca, Yoon, Nal Ae, Liu, Zhong Wu, Diano, Sabrina, Richard Kibbey, Nal Ae Yoon, Sungho Jin, Zhong Wu Liu, Qiushi Sun, Rebecca Cardone, Jung Dae Kim, Sabrina Diano   +15 more
core   +1 more source

Genetic features of hormonal regulation of energy metabolism (literature review)

Актуальні проблеми сучасної медицини, 2019
Summary: Many chronic diseases are associated with impaired human energy metabolism and its hormonal regulation. According to the WHO, there are more than 300 million people with obesity in the world, 24.1% of the population are suffering from obesity in
Taisiia, Olena, Olena
doaj  

Local Agouti Signaling Protein/Melanocortin Signaling System that Possibly Regulates Lipid Metabolism in Adipose Tissues of Chickens

The Journal of Poultry Science, 2010
The agouti signaling protein (ASIP)/melanocortin signaling system regulates lipid metabolism in humans but not in mice. To examine whether the system is present in adipose tissues in chickens, we performed reverse transcription-polymerase chain reaction
Masafumi Yabuuchi, Kana Bando, Misato Hiramatsu, Sumio Takahashi, Sakae Takeuchi   +4 more
doaj   +1 more source

Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice

Molecular Metabolism, 2022
Objective: The hypothalamus regulates feeding and glucose homeostasis through the balanced action of different neuropeptides, which are cleaved and activated by the proprotein convertases PC1/3 and PC2. However, the recent association of polymorphisms in
Ilaria Coppola, Bas Brouwers, Leanne Walker, Ceyhun Alar, Sandra Meulemans, Anne White, Bruno Ramos-Molina, John W.M. Creemers   +7 more
doaj   +1 more source