Results 61 to 70 of about 179,797 (233)

Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice

Molecular Metabolism, 2022
Objective: The hypothalamus regulates feeding and glucose homeostasis through the balanced action of different neuropeptides, which are cleaved and activated by the proprotein convertases PC1/3 and PC2. However, the recent association of polymorphisms in
Ilaria Coppola, Bas Brouwers, Leanne Walker, Ceyhun Alar, Sandra Meulemans, Anne White, Bruno Ramos-Molina, John W.M. Creemers   +7 more
doaj   +1 more source

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

Local Agouti Signaling Protein/Melanocortin Signaling System that Possibly Regulates Lipid Metabolism in Adipose Tissues of Chickens

The Journal of Poultry Science, 2010
The agouti signaling protein (ASIP)/melanocortin signaling system regulates lipid metabolism in humans but not in mice. To examine whether the system is present in adipose tissues in chickens, we performed reverse transcription-polymerase chain reaction
Masafumi Yabuuchi, Kana Bando, Misato Hiramatsu, Sumio Takahashi, Sakae Takeuchi   +4 more
doaj   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Hypothalamic POMC neurons promote cannabinoid-induced feeding

, 2015
Hypothalamic pro-opiomelanocortin (POMC) neurons promote satiety. Cannabinoid receptor 1 (CB1R) is critical for the central regulation of food intake. Here we test whether CB1R-controlled feeding in sated mice is paralleled by decreased activity of POMC ...
Joel K. Elmquist, Kim, Jung Dae, Cowley, Michael A., Elmquist, Joel K., Claudia R. Vianna, Marcelo O. Dietrich, Dietrich, Marcelo O., Szigeti-Buck, Klara, Koch, Marco, Morozov, Yury M, Jae Geun Kim, Simonds, Stephanie E., Jung Dae Kim, Morozov, Yury M., Horvath, Tamas L., Yury M. Morozov, Francisco Hernández-Nuño, Xiao-Bing Gao, Pasko Rakic, Klara Szigeti-Buck, Hernández-Nuño, Francisco, Cowley, Michael A, Horvath, Tamas L, Vianna, Claudia R, Luis Varela, Stephanie E. Simonds, Vianna, Claudia R., Michael A. Cowley, Tamas L. Horvath, Bechmann, Ingo, Gao, Xiao-Bing, Carlos M. Castorena, Simonds, Stephanie E, Castorena, Carlos M., Diano, Sabrina, Kim, Jae Geun, Castorena, Carlos M, Ingo Bechmann, Rakic, Pasko, Elmquist, Joel K, Dietrich, Marcelo O, Marco Koch, Varela, Luis, Sabrina Diano   +43 more
core   +1 more source

Profiles of pro-opiomelanocortin and encoded peptides, and their processing enzymes in equine pituitary pars intermedia dysfunction. [PDF]

PLoS ONE, 2018
Equine pituitary pars intermedia dysfunction (PPID) is characterized by hyperplasia of the pars intermedia (PI) melanotrophs of the pituitary gland (PG), and increased production of proopiomelanocortin (POMC).
James L Carmalt, Sima Mortazavi, Rebecca C McOnie, Andrew L Allen, Suraj Unniappan   +4 more
doaj   +1 more source

Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo

Molecular Metabolism, 2021
Objective: Long-acting glucagon-like peptide-1 receptor agonists (GLP-1RAs), like liraglutide and semaglutide, are viable treatments for diabetes and obesity. Liraglutide directly activates hypothalamic proopiomelanocortin (POMC) neurons while indirectly
Yanbin Dong, Jamie Carty, Nitsan Goldstein, Zhenyan He, Eunsang Hwang, Dominic Chau, Briana Wallace, Anita Kabahizi, Linh Lieu, Yunqian Peng, Yong Gao, Ling Hu, J. Nicholas Betley, Kevin W. Williams   +13 more
doaj   +1 more source

Metabolic Precision Medicines: Curing POMC Deficiency [PDF]

Cell Metabolism, 2016
Pro-opiomelanocortin deficiency is a rare cause of severe intractable obesity. Two patients have experienced dramatic weight loss in response to setmelanotide, a melanocortin-4 receptor activator. The drug has potential in broader populations, but caution is warranted as it may act at other melanocortin receptors.
Müller, T.D., Tschöp, M.H., O'Rahilly, S.   +2 more
openaire   +3 more sources

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

CTB labels many non-POMC cells and few POMC cells.

, 2013
(A & B) Example images after CTB injection into the SON. (A) Low-power image in the arcuate nucleus shows POMC neurons (red) and CTB-containing neurons (green). The side of the arcuate corresponding to the side of injection (ipsilateral) has more intense
Shane T. Hentges (342798), Connie M. King (342796)   +1 more
core   +1 more source