Results 71 to 80 of about 179,797 (233)
Cell Proliferation, EarlyView.By assembling cortical‐hypothalamic circuits, we show that cortical input protects hypothalamic neurons from fatty acid‐induced damage, which activates PGC1α to boost mitochondrial function. This reveals a cortico‐hypothalamic axis that defends against metabolic stress.
Mengdan Tao +10 more
wiley +1 more source
Glucose-excited POMC neurons in the ARC.
, 2014 (A) Hypothalamic sections containing the ARC were prepared from POMC DsRed mice (7 weeks), and POMC neurons were visualized using a fluorescent microscope.
Liangyou Rui (332792) +3 more
core +1 more source
RNA-Seq Mouse Brain Regions Expression Data Analysis: Focus on ApoE Functional Network
Journal of Integrative Bioinformatics, 2017 ApoE expression status was proved to be a highly specific marker of energy metabolism rate in the brain. Along with its neighbor, Translocase of Outer Mitochondrial Membrane 40 kDa (TOMM40) which is involved in mitochondrial metabolism, the corresponding
Babenko Vladimir N. +2 more
doaj +1 more source
Equine Veterinary Education, EarlyView.Summary Background The diagnosis and management of pituitary pars intermedia dysfunction (PPID) in horses includes evaluating abnormal plasma concentrations of adrenocorticotrophic hormone (ACTH). Treatment commonly includes the oral dopamine agonist pergolide mesylate, which suppresses the pathologic overproduction of ACTH.
A. Bracken +5 more
wiley +1 more source
, 2006 Über die Expression des hypophysären POMC-Gens und die Bildung und Freisetzung von hypophysären POMC-Derivaten in der Hypophyse des Menschen liegen viele Informationen vor.
Tschischka, Marcus
core +1 more source
Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases
Obesity Reviews, EarlyView.ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar +4 more
wiley +1 more source
Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake. [PDF]
PLoS Biology, 2018 Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) respond to numerous hormonal and neural signals, resulting in changes in food intake.
Jae Hoon Jeong +5 more
doaj +1 more source
Structure of the rat pro‐opiomelanocortin (POMC) gene [PDF]
FEBS Letters, 1985 The gene encoding pro‐opiomelanocortin (POMC) presents unique regulatory features. In particular, glucocorticoids inhibit transcription of the POMC gene in the anterior pituitary, but not in the intermediate pituitary. In order to study the mechanism leading to transcriptional inhibition of POMC by glucocorticoid and the interaction of the ...
Drouin, Jacques +4 more
openaire +2 more sources
Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity Reviews, EarlyView.Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source
A pró-opiomelanocortina (POMC) e a obesidade: patogenia e perspectivas
Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 2023 Introdução: Embora a obesogênese relacione-se ao estilo de vida moderno, é significativamente influenciada por fatores genéticos. A ativação dos neurônios hipotalâmicos que expressam a POMC (pró-opiomelanocortina) pela ligação com o hormônio leptina é ...
Bianca Ayumi Ogura +3 more
doaj