Results 71 to 80 of about 189,310 (233)

Autophagic cell death participates in POMC-induced melanoma suppression [PDF]

, 2018
Hypoxia in tumors is known to trigger the pro-survival pathways such as autophagy. Systemic proopiomelanocortin (POMC) gene therapy suppresses melanoma through apoptosis induction and neovascularization blockage.
Wu, JC, Liu, GS, Tai, MH, Wu, CS, Tsai, HE   +4 more
core   +1 more source

A pró-opiomelanocortina (POMC) e a obesidade: patogenia e perspectivas

Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 2023
Introdução: Embora a obesogênese relacione-se ao estilo de vida moderno, é significativamente influenciada por fatores genéticos. A ativação dos neurônios hipotalâmicos que expressam a POMC (pró-opiomelanocortina) pela ligação com o hormônio leptina é ...
Bianca Ayumi Ogura, Geórgia Fernandes de Almeida, Luciano Seraphim Gasques, Ricardo Marcelo Abrão   +3 more
doaj  

Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake. [PDF]

PLoS Biology, 2018
Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) respond to numerous hormonal and neural signals, resulting in changes in food intake.
Jae Hoon Jeong, Dong Kun Lee, Shun-Mei Liu, Streamson C Chua, Gary J Schwartz, Young-Hwan Jo   +5 more
doaj   +1 more source

Rethinking Global Obesity Guidelines: Integrating Evidence, Equity and Precision (2014–2026)

Obesity Reviews, EarlyView.
Challenges and evidence in obesity guidelines. ABSTRACT Obesity remains a global health crisis characterized by substantial heterogeneity in diagnosis, management, and policy implementation. Although numerous national and international clinical practice guidelines have been published over the past decade, their translation into evidence‐based and ...
Rosero‐Revelo Ricardo, Tamayo Mateo, Henao Diana, Juan P. Polanco, Cortés David, Juan C. Alba, Giha Valeria, Camargo Camilo, Hernández Eder, Correa Ricardo, Nassar Ricardo, Cabandugama Peminda, Marcio L. Griebeler, Burguera Bartolome   +13 more
wiley   +1 more source

Metabolic Precision Medicines: Curing POMC Deficiency [PDF]

Cell Metabolism, 2016
Pro-opiomelanocortin deficiency is a rare cause of severe intractable obesity. Two patients have experienced dramatic weight loss in response to setmelanotide, a melanocortin-4 receptor activator. The drug has potential in broader populations, but caution is warranted as it may act at other melanocortin receptors.
Müller, T.D., Tschöp, M.H., O'Rahilly, S.   +2 more
openaire   +3 more sources

Insulin regulates POMC neuronal plasticity to control glucose metabolism

eLife, 2018
Hypothalamic neurons respond to nutritional cues by altering gene expression and neuronal excitability. The mechanisms that control such adaptive processes remain unclear. Here we define populations of POMC neurons in mice that are activated or inhibited
Garron T Dodd, Natalie J Michael, Robert S Lee-Young, Salvatore P Mangiafico, Jack T Pryor, Astrid C Munder, Stephanie E Simonds, Jens Claus Brüning, Zhong-Yin Zhang, Michael A Cowley, Sofianos Andrikopoulos, Tamas L Horvath, David Spanswick, Tony Tiganis   +13 more
doaj   +1 more source

The Skin‐Lightening Efficacy and Mechanisms of Botanical Extracts: A Comprehensive Review [PDF]

J Cosmet Dermatol
ABSTRACT Background Skin pigmentation is regulated by a complex network involving melanogenesis, melanosome transfer, oxidative stress, environmental stimuli, and epidermal turnover. Botanical extracts and phytochemicals have attracted increasing interest as potential skin‐lightening agents. This review evaluates their efficacy, mechanisms, and safety.
Yang S, Ding M, Ye C, Shen J, Zhang L, Yang A, Gu L.   +6 more
europepmc   +2 more sources

Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan

Obesity Reviews, EarlyView.
ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati, David Krongauz, Alice Bosco, Antonio Noto, Cristina Piras, Maria Kafyra, Angelica Dessì, Matteo Mauri, Luigi Atzori, Adina Weinberger, Vassilios Fanos, George V. Dedoussis, on behalf of the BETTER4U consortium   +12 more
wiley   +1 more source

Expression of a hypomorphic Pomc allele alters leptin dynamics during late pregnancy [PDF]

, 2020
Proopiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) are essential for normal energy homeostasis. Maximal ARC Pomc transcription is dependent on neuronal Pomc enhancer 1 (nPE1), located 12 kb upstream from the promoter.
Yu, Hui, Kiran, Sylee, Rubinstein, Marcelo, Low, Malcolm J., Jones, Graham L., Thompson, Zoe, Mundada, Lakshmi   +6 more
core   +1 more source

Duzhong Fang Attenuates the POMC-Derived Neuroinflammation in Parkinsonian Mice

Journal of Inflammation Research, 2021
Lili Li,1,* Shanshan Fan,1,* Wenqi Zhang,1 Dongna Li,1 Zhen Yang,1,2 Pengwei Zhuang,1,2 Juan Han,3 Hong Guo,1 Yanjun Zhang1 1State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin ...
Li L, Fan S, Zhang W, Li D, Yang Z, Zhuang P, Han J, Guo H, Zhang Y   +8 more
doaj