Results 71 to 80 of about 191,601 (231)
A Patient with Proopiomelanocortin Deficiency: An Increasingly Important Diagnosis to Make [PDF]
, 2017 Proopiomelanocortin (POMC) deficiency is a rare monogenic disorder with early-onset obesity. Investigation of this entity have increased our insight into the important role of the leptin-melanocortin pathway in energy balance. Here, we present a patient
Achermann, JC +9 more
core +2 more sources
Cell Proliferation, EarlyView.By assembling cortical‐hypothalamic circuits, we show that cortical input protects hypothalamic neurons from fatty acid‐induced damage, which activates PGC1α to boost mitochondrial function. This reveals a cortico‐hypothalamic axis that defends against metabolic stress.
Mengdan Tao +10 more
wiley +1 more source
Profiles of pro-opiomelanocortin and encoded peptides, and their processing enzymes in equine pituitary pars intermedia dysfunction. [PDF]
PLoS ONE, 2018 Equine pituitary pars intermedia dysfunction (PPID) is characterized by hyperplasia of the pars intermedia (PI) melanotrophs of the pituitary gland (PG), and increased production of proopiomelanocortin (POMC).
James L Carmalt +4 more
doaj +1 more source
CNS Control of Glucose Metabolism: Response to Environmental Challenges [PDF]
, 2013 Over the last 15 years, considerable work has accumulated to support the role of the CNS in regulating postprandial glucose levels. As discussed in the first section of this review, the CNS receives and integrates information from afferent neurons ...
Arble, Deanna M., Sandoval, Darleen A.
core +1 more source
Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice [PDF]
, 2009 Development and maintenance of the male phenotype and establishment of fertility are all dependent upon the activity of the Sertoli cells and Leydig cells of the testis.
Abel, M.H. +4 more
core +1 more source
mTOR Signaling Fades POMC Neurons during Aging [PDF]
Neuron, 2012 Hypothalamic POMC neurons contribute to the regulation of energy homeostasis and glucose metabolism. In this issue of Neuron, Yang et al. (2012) show that the mTOR pathway has a pivotal role in deterioration of POMC neurons during age-dependent obesity.
Kim, Jae Geun, Horvath, Tamas L.
openaire +2 more sources
Cell Proliferation, EarlyView.Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang +8 more
wiley +1 more source
RNA-Seq Mouse Brain Regions Expression Data Analysis: Focus on ApoE Functional Network
Journal of Integrative Bioinformatics, 2017 ApoE expression status was proved to be a highly specific marker of energy metabolism rate in the brain. Along with its neighbor, Translocase of Outer Mitochondrial Membrane 40 kDa (TOMM40) which is involved in mitochondrial metabolism, the corresponding
Babenko Vladimir N. +2 more
doaj +1 more source
Steady-state energy balance in animal models of obesity and weight loss [PDF]
, 2016 Supported by European Union Seventh Framework Programme (FP7/2007-2013, n°266408 (Full4Health)), the Joint Programme of the Medical Faculty of Norwegian University of Science and Technology (NTNU) and St. Olav’s University Hospital, the Liaison Committee
Barrett, Perry +7 more
core +2 more sources
Equine Veterinary Education, EarlyView.Summary Background The diagnosis and management of pituitary pars intermedia dysfunction (PPID) in horses includes evaluating abnormal plasma concentrations of adrenocorticotrophic hormone (ACTH). Treatment commonly includes the oral dopamine agonist pergolide mesylate, which suppresses the pathologic overproduction of ACTH.
A. Bracken +5 more
wiley +1 more source