Results 81 to 90 of about 189,310 (233)

Toward “Obesityomics”: Domain‐Specific Omics in Precision Obesity Medicine with a Brief AI Perspective

Obesity Reviews, EarlyView.
ABSTRACT Background Obesity's global rise has outpaced the effectiveness of “one‐size‐fits‐all” prevention and treatment strategies. The promise of precision medicine lies in addressing the etiological and biological diversity of obesity and transforming it into actionable endotypes.
Nadia Abu Samra, Sara G. I. Suliman, Mohammed Al‐Hadad, Dorret I. Boomsma, Fadwa Alhantoobi, Maithah Alsamahi, Haneen Abufarajallah, Alia Al Tikriti, Zeyar Aung, Selena Richards, Abdulrahim Sajini, Mira Mousa, Fatima Sulaiman, Wael Osman   +13 more
wiley   +1 more source

Keratinocytes exposed to ultraviolet A and ultraviolet B radiation induce responses in melanocytes

Photochemistry and Photobiology, EarlyView.
Keratinocyte‐derived soluble factors regulate melanocyte responses following UV exposure. Conditioned medium from irradiated keratinocytes enhances melanocyte mitochondrial activity, cell proliferation, and cell cycle progression while improving survival after UVA‐induced damage.
Lais Zortéa, Andressa Mai Matsumoto, Alessandra Costa Lopes, Eduardo Felipe Wagner, Tanira da Silveira Prieto, Andrés Delgado Cañedo, Daza de Moraes Vaz Batista Filgueira, Ana Paula de Souza Votto   +7 more
wiley   +1 more source

In vivo alternative assessment of the chemicals that interfere with anterior pituitary POMC expression and interrenal steroidogenesis in POMC: EGFP transgenic zebrafish

, 2010
Adrenocorticotropin (ACTH) has been considered a classic adrenocorticotropic hormone and the key pituitary-derived peptide controlling steroidogenesis in the adult adrenal.
Yin, Z, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China, He, Jiangyan, Sun, Lingli, Yin, Zhan, Xu, Wei   +4 more
core  

Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin.

, 2007
Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus (ARC) suppress appetite, and lack of POMC-derived peptides or electrical silencing of POMC neurons causes obesity.
Brüning, JC, Burdakov, D, Zubcevic, L, Ma, X, Ashcroft, Frances   +4 more
core   +1 more source

Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons

Molecular Metabolism, 2016
Objective: Obesity is one of the primary healthcare challenges of the 21st century. Signals relaying information regarding energy needs are integrated within the brain to influence body weight.
Luke K. Burke, Barbora Doslikova, Giuseppe D'Agostino, Megan Greenwald-Yarnell, Teodora Georgescu, Raffaella Chianese, Pablo B. Martinez de Morentin, Emmanuel Ogunnowo-Bada, Celine Cansell, Lourdes Valencia-Torres, Alastair S. Garfield, John Apergis-Schoute, Daniel D. Lam, John R. Speakman, Marcelo Rubinstein, Malcolm J. Low, Justin J. Rochford, Martin G. Myers, Mark L. Evans, Lora K. Heisler   +19 more
doaj   +1 more source

Understanding Exosomes in Hair Regeneration

Periodontology 2000, EarlyView.
Abstract Background Alopecia is a prevalent condition correlated with significant psychosocial challenges, while contemporary treatments exhibit variable efficacy, require extended use, and may cause adverse effects. This review aimed to comprehensively assess exosome‐mediated interventions as a novel cell‐free regenerative approach for hair ...
Paras Ahmad, Catherine Davies, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Effects of the Saturated Fatty Acid Palmitate on Neuroinflammation, ER Stress, and Pomc mRNA Expression in Hypothalamic mHypoA-POMC/GFP Neurons [PDF]

, 2017
Dietary fats can modulate brain function. How free fatty acids (FFAs) alter hypothalamic pro-opiomelanocortin (POMC) neurons remain undefined. The saturated FFA, palmitate, increased neuroinflammatory and ER stress markers, as well as Pomc mRNA levels ...
Tse, Erika Koppert
core  

Conditional expression of Pomc in the Lepr-positive subpopulation of POMC neurons is sufficient for normal energy homeostasis and metabolism [PDF]

, 2015
Peptides derived from the proopiomelanocortin (POMC) precursor are critical for the normal regulation of many physiological parameters, and POMC deficiency results in severe obesity and metabolic dysfunction.
Rubinstein, Marcelo, Myers Jr, Martin G., Mercer, Aaron J., Lam, Daniel D., Low, Malcolm J., Attard, Courtney A.   +5 more
core   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

InsR affects Pomc but not Npy neuron numbers in adult L1 mice.

, 2012
Number of Pomc-expressing (A) and Npy-expressing (B) cells per ARC hemisection in L1 mice (grey bars, n = 5) and WT controls (white bars, n = 5) at the age of 15 weeks. Number of Pomc-expressing cells per ARC hemisection in the same mice as in A compared
Domenico Accili (185429), Yitian Liu (185427), Kumiko S. Aizawa (185425), Leona Plum (27116), Hua V. Lin (185423)   +4 more
core   +1 more source