Fear and Foxes: An Educational Primer for Use with "Anterior Pituitary Transcriptome Suggests Differences in ACTH Release in Tame and Aggressive Foxes". [PDF]
, 2020 The way genes contribute to behavior is complicated. Although there are some single genes with large contributions, most behavioral differences are due to small effects from many interacting genes.
Simpson, Julie H
core
Islet-1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood [PDF]
, 2015 Food intake and body weight regulation depend on proper expression of the proopiomelanocortin gene (Pomc) in a group of neurons located in the mediobasal hypothalamus of all vertebrates.
Gonzalez, Laura Elisabeth +6 more
core +2 more sources
Obesity Reviews, EarlyView.ABSTRACT Obesity as a chronic and multifactorial disease requires a multidisciplinary team acting together in a holistic multitarget intervention. Multidisciplinary therapy targeting obesity and its complications includes physical exercise, nutritional, and behavior counseling.
Ana Raimunda Dâmaso +7 more
wiley +1 more source
Cell Reports, 2018 Summary: Mitochondrial oxidative phosphorylation (OXPHOS) and substrate utilization critically regulate the function of hypothalamic proopiomelanocortin (POMC)-expressing neurons.
Katharina Timper +15 more
doaj +1 more source
Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake. [PDF]
PLoS Biology, 2018 Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) respond to numerous hormonal and neural signals, resulting in changes in food intake.
Jae Hoon Jeong +5 more
doaj +1 more source
Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions [PDF]
, 2015 A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes.
Arble, Deanna M +28 more
core +4 more sources
Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases
Obesity Reviews, EarlyView.ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar +4 more
wiley +1 more source
A pró-opiomelanocortina (POMC) e a obesidade: patogenia e perspectivas
Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 2023 Introdução: Embora a obesogênese relacione-se ao estilo de vida moderno, é significativamente influenciada por fatores genéticos. A ativação dos neurônios hipotalâmicos que expressam a POMC (pró-opiomelanocortina) pela ligação com o hormônio leptina é ...
Bianca Ayumi Ogura +3 more
doaj
Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior [PDF]
, 2017 Glucokinase (GK), the hexokinase involved in glucosensing in pancreatic β-cells, is also expressed in arcuate nucleus (AN) neurons and hypothalamic tanycytes, the cells that surround the basal third ventricle (3V).
Barahona, María José +10 more
core +1 more source
Setmelanotide in Bardet‐Biedl Syndrome: A Case Report
Pediatric Dermatology, EarlyView.ABSTRACT Setmelanotide is a melanocortin‐4‐receptor agonist used for the treatment of hyperphagia in the genetic obesity syndrome Bardet‐Biedl. Presented is a case of diffuse hyperpigmentation in a patient treated with setmelanotide, which represents the most common side effect of this medication.
Shelby Smith +2 more
wiley +1 more source