Results 101 to 110 of about 191,601 (231)
The Journal of Physiology, EarlyView.Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor +4 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Central leptin signalling blockade induces early metabolic dysfunction. Intracerebroventricular infusion of a leptin receptor antagonist (SLA) in rats disrupts hypothalamic leptin signalling, leading to reduced signal transducer and activator of transcription 3 (STAT3) activation, decreased Socs3 and Pomc expression, and ...
Cristina Pintado +16 more
wiley +1 more source
Molecular Metabolism, 2018 Objective: Nutrient availability modulates reactive oxygen species (ROS) production in the hypothalamus. In turn, ROS regulate hypothalamic neuronal activity and feeding behavior.
Magalie Haissaguerre +9 more
doaj +1 more source
5-HT obesity medication efficacy via POMC activation is maintained during aging [PDF]
, 2014 Peer reviewedPublisher ...
Billups, Brian +10 more
core +3 more sources
Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 5184-5194, June 2026.ABSTRACT Aims Semaglutide is a GLP‐1 receptor agonist for the treatment of type 2 diabetes and obesity. Its clinical effects are well established, but the underlying mechanisms remain unclear. This study aims to use computational modelling to generate hypotheses about semaglutide's long‐term metabolic (body weight, net energy intake, blood glucose ...
Vivan C. W. Kennis, Natal A. W. van Riel
wiley +1 more source
Molecular Metabolism, 2018 Objectives: The autonomic nervous system is critically involved in mediating the control by leptin of many physiological processes. Here, we examined the role of the leptin receptor (LepR) in proopiomelanocortin (POMC) and agouti-related peptide (AgRP ...
Balyssa B. Bell +4 more
doaj +1 more source
PTEN: A master regulator of neuronal structure, function, and plasticity. [PDF]
, 2014 PTEN (phosphatase and tensin homolog on chromosome ten) is a dual protein/lipid phosphatase that dephosphorylates PIP3, thereby inhibiting the AKT/mTOR pathway. This inhibition ultimately decreases protein translation, cell proliferation and cell growth.
Garcia-Junco-Clemente, Pablo +1 more
core +1 more source
Methodological Challenges for Ablation of BMPR1A in Hypothalamic Tanycytes—A Cautionary Tale
FASEB BioAdvances, Volume 8, Issue 5, May 2026.Two strategies were used to target BMPR1A in adult hypothalamic tanycytes: (1) inducible Rax‐CreERT2 and (2) AAV‐Dio2‐iCre–mediated recombination. Although robust expression of reporter fluorescence and recombination gel analysis confirmed Cre activity in both models, BMPR1A expression was not reduced in targeted tanycytes.
Tianyi Tao +3 more
wiley +1 more source
Role of PTP1B in POMC neurons during chronic high fat diet: Sex differences in regulation of liver lipids and glucose tolerance [PDF]
, 2018 Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of leptin receptor signalling and may contribute to leptin resistance in diet-induced obesity.
Aberdein, Nicola +6 more
core +1 more source
Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?
Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos +3 more
wiley +1 more source