Results 101 to 110 of about 189,310 (233)

Mutations in the amino-terminal region of proopiomelanocortin (POMC) in patients with early-onset obesity impair POMC sorting to the regulated secretory pathway

, 2008
Context: Mutations in the proopiomelanocortin (POMC) gene that impair the synthesis or structure of POMC-derived peptides predispose to human obesity.
O'Rahilly, Stephen, Bahceci, Mithat, Herber, Stefan, White, Anne; id_orcid, Keogh, Julia, Farooqi, I. Sadaf, Yung, Seng Lee, Oliver, Robert L., Creemers, John W M, Tuzcu, Alpaslan, Gokalp, Deniz, Creemers, John W. M., Lee, Yung Seng   +12 more
core   +1 more source

Early‐Life Betaine Supplementation Drives Sex‐Specific Metabolic Programming in Rats, Affecting FGF21 Signaling and Energy Balance

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
A maternal western diet (WD) and betaine supplementation during suckling influence metabolic programming. A maternal WD induced adverse metabolic effects in offspring, accompanied by altered FGF21‐related gene expression and decreased Akkermansia muciniphila abundance.
Rocío A. Martín‐Chamorro, Catalina A. Pomar, Andreu Palou, Catalina Picó, Ana M. Rodríguez   +4 more
wiley   +1 more source

Ciliary Membrane Lipid Homeostasis in Health and Disease

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang, Yuan‐yuan Liu, Hanqi Sun, Peiwei Liu   +3 more
wiley   +1 more source

Chromaffin Granule Aspartic Proteinase Processes Recombinant Proopiomelanocortin (POMC)

, 1995
Our search for proteases responsible for proenkephalin (PE) processing in adrenal medulla led to the isolation of a 70 kDa aspartic proteinase that cleaves PE between the basic residues of the Lys-Arg processing site (1).
Hook, Vivian Y., Schiller, Martin R., Azaryan, Anahit V.   +2 more
core   +1 more source

Acute ayahuasca administration attenuates binge‐like eating and anxiety‐related behaviors in mice subjected to intermittent fasting [PDF]

J Neuroendocrinol
Abstract Human binge eating disorder is characterized by recurrent episodes of excessive food consumption accompanied by loss of control and is strongly associated with alterations in reward processing and emotional regulation. Ayahuasca, a psychoactive botanical preparation traditionally used in Amazonian medicine, has been shown to modulate ...
Corona C, Lima F, da Silva Sumensse J, Carvalho K, Grignet P, Confortim H, Gross M, Firmino F, Evangelista F, Nascimento F, Vettorazzi J.   +10 more
europepmc   +2 more sources

Streamlining Diagnosis of Bardet–Biedl Syndrome: New Diagnostic Algorithm With Updated Criteria

American Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2181-2198, October 2026.
ABSTRACT Considerable advances have been made in our understanding of Bardet–Biedl syndrome (BBS), particularly in its core clinical features and molecular genetics, warranting an update to the existing diagnostic criteria framework. Using a rigorous, evidence‐based, and consensus‐driven process, a multidisciplinary group of international experts and ...
Jeremy J. Pomeroy, Jesse Richards, Brooke R. Sweeney, Seema Kumar, Katie E. Queen, Joshua Zaritsky, Carl H. Cramer, Elias I. Traboulsi, Brittni A. Scruggs, Erica E. Davis, Ekaterina Keifer, Emma McGibbon, Timothy Ogden, Bendert De Graaf, Tonia Hymers, Elizabeth Forsythe, Philip Beales   +16 more
wiley   +1 more source

Untersuchungen zur Expression von Proopiomelanocortin (POMC) in den Hautzellinien des Menschen HaCaT, Colo 679 und A 431 [PDF]

, 2005
Ziel dieser Arbeit war es, einen Beitrag zur Klärung der kontroversen Datenlage in Bezug auf die Expression des hypophysären POMC sowie der Bildung und Freisetzung von dessen Derivaten in der Haut des Menschen zu leisten.
Hain, Birgit
core   +1 more source

Effects of chronic high fat diet on mediobasal hypothalamic satiety neuron function in POMC-Cre mice

Molecular Metabolism
Objective: The prevalence of obesity has increased over the past three decades. Proopiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) play a vital role in induction of satiety.
Özge Başer, Yavuz Yavuz, Deniz Öykü Özen, Hüseyin Buğra Özgün, Sami Ağuş, Cihan Civan Civaş, Deniz Atasoy, Bayram Yılmaz   +7 more
doaj   +1 more source

Coat Color‐Associated Transcriptomic Differences of Black and White Hortobágyi Racka Sheep Using the RNA‐Seq Technique

Ecology and Evolution, Volume 16, Issue 10, October 2026.
We compared skin transcriptomes of black‐ and white‐coated Hortobágyi Racka sheep using RNA‐seq to identify coat color‐associated molecular differences. Black‐coated sheep showed coordinated upregulation of melanogenesis and melanosome‐related genes together with pathways linked to redox balance, mitochondrial metabolism, and thermogenesis.
Putri Kusuma Astuti, Zoltán Bagi, Lilla Bodrogi, Szilvia Kusza   +3 more
wiley   +1 more source

POMC及UCP3基因多形性與台灣學童肥胖相關性之研究

, 2012
[[abstract]]Background: Human Uncoupling Protein 3 (UCP3) is a new candidate gene for human obesity. UCPJ has been shown to be regulated by thyroid hormone, 3-adrenergic agonists, leptin, and fat feeding in rodents. Mutations in exon 3 (V1O2I) and exon 4
Chen, Chih-Mei; Liu, Chiu-Shong; Wang, Nancy M. ; Lin, Cheng-Chieh
core