Results 121 to 130 of about 191,601 (231)

GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity

Molecular Metabolism
Objective: G-protein-signaling modulator 1 (GPSM1) has been proved the potential role in brain tissues, however, whether GPSM1 in hypothalamic nuclei, especially in POMC neurons is essential for the proper regulation of whole-body energy balance remains ...
Mengyang Tang, Yi Zhang, Rong Zhang, Yuemei Zhang, Jiangfei Zheng, Daixi Wang, Xinyu Wang, Jing Yan, Cheng Hu   +8 more
doaj   +1 more source

60 YEARS OF POMC: POMC: the consummate peptide hormone precursor [PDF]

Journal of Molecular Endocrinology, 2016
Adrian J L, Clark, Philip, Lowry
openaire   +2 more sources

Differential expression of POMC-processing genes in corticotroph tumors

Endocrine Oncology
Objective: Corticotroph tumors (CTs) derive from the TBX19 lineage and are functioning (FCTs) or nonfunctioning (NFCTs). In FCTs, the main pathogenic variants are found in USP8, enhancing proopiomelanocortin (POMC) transcription through epidermal growth ...
Elisa Lamback, Renan L Miranda, Laryssa Mendonça, Camila S de Figueiredo, Kaio C R Salum, Rômulo S Dezonne, Luiz Eduardo Wildemberg, Mônica R Gadelha   +7 more
doaj   +1 more source

POMC: An evolutionary perspective

, 2016
Proopiomelanocortin (POMC) is a complex precursor that comprises several peptidic hormones, including melanocyte-stimulating hormones (MSHs), adrenocorticotropic hormone (ACTH), and β-endorphin. POMC belongs to the opioid/orphanin gene family, whose precursors include either opioid (YGGF) or the orphanin/nociceptin core sequences (FGGF).
Navarro, Sandra, Soletto, L., Puchol, Sara, Rotllant, Josep, Soengas, José L., Cerdá-Reverter, José Miguel   +5 more
openaire   +1 more source

The small GTPase Rap1 in POMC neurons regulates leptin actions and glucose metabolism

Molecular Metabolism
The hypothalamic leptin-proopiomelanocortin (POMC) pathway is critical for regulating metabolism. POMC neurons in the arcuate nucleus respond to leptin and play a pivotal role in mediating energy and glucose balance. However, during diet-induced obesity (
Kentaro Kaneko, Weisheng Lu, Yong Xu, Alexei Morozov, Makoto Fukuda   +4 more
doaj   +1 more source

AZGP1 in POMC neurons modulates energy homeostasis and metabolism through leptin-mediated STAT3 phosphorylation

Nature Communications
Zinc-alpha2-glycoprotein (AZGP1) has been implicated in peripheral metabolism; however, its role in regulating energy metabolism in the brain, particularly in POMC neurons, remains unknown. Here, we show that AZGP1 in POMC neurons plays a crucial role in
Sheng Qiu, Qinan Wu, Hao Wang, Dongfang Liu, Chen Chen, Zhiming Zhu, Hongting Zheng, Gangyi Yang, Ling Li, Mengliu Yang   +9 more
doaj   +1 more source

Pro-opiomelanocortin and ACTH–cortisol dissociation during pediatric cardiac surgery

Endocrine Connections
In critically ill adults, high plasma cortisol in the face of low ACTH coincides with high pro-opiomelanocortin (POMC) levels. Glucocorticoids further lower ACTH without affecting POMC.
Arno Téblick, Ilse Vanhorebeek, Inge Derese, An Jacobs, Renata Haghedooren, Sofie Maebe, Gerdien A Zeilmaker-Roest, Enno D Wildschut, Lies Langouche, Greet Van den Berghe   +9 more
doaj   +1 more source

POMC Gene [PDF]

, 2020
openaire   +1 more source

POMC [PDF]

, 2019
openaire   +1 more source

Human Epidermal Proopiomelanocortin (POMC) cDNA Variant is Identical to Mouse POMC cDNA [PDF]

Journal of Investigative Dermatology, 1999
Ancans, Janis, Thody, Anthonny J., Wood, John M., Beazley, Wayne D., Schallreuter, Karin U.   +4 more
openaire   +1 more source