Results 121 to 130 of about 189,310 (233)
GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity
Molecular MetabolismObjective: G-protein-signaling modulator 1 (GPSM1) has been proved the potential role in brain tissues, however, whether GPSM1 in hypothalamic nuclei, especially in POMC neurons is essential for the proper regulation of whole-body energy balance remains ...
Mengyang Tang +8 more
doaj +1 more source
Magel2-null mice have fewer ARC POMC neurons.
, 2013 A–B) Representative images of GFP (POMC) IHC in A) control and B) Magel2×POMCEGFP mice. Scale bar 100 µm. C) Magel2×POMCEGFP mice have fewer GFP expressing (POMC) cells at all levels of the ARC (Bregma −1.28, 39% reduction ...
Rebecca E. Mercer (288096) +5 more
core +1 more source
Expressions of HDAC4, −5, AcH3, and AcH4s in POMC neurons in the ARH.
, 2013 A, B, C) HDAC4-positive nuclei were found in POMC-positive cells (arrow in B) and POMC-negative cells (arrowhead in B) in the ARH of a high-fat fed mouse.
Masaru Kuroda (353140) +4 more
core +1 more source
The last‐step integrator thesis: Heterarchical control of the mammalian gastrointestinal tract
The Journal of Physiology, Volume 604, Issue 20, Page 8323-8344, 15 October 2026.Abstract figure legend Heterarchy of control of the gastrointestinal tract. The production mechanisms (i.e. epithelial cells and muscles) are shown at the bottom in green. Above them are some of the many mechanisms that provide control inputs to these production mechanisms.
William Bechtel, Leonardo Bich
wiley +1 more source
Early-Life Stress Reduces DNA Methylation of the Pomc Gene in Male Mice
, 2014 Early-life stress (ELS) increases the vulnerability thresholds for stress-related diseases such as major depression and anxiety by inducing alterations in the structure and function of neural circuits and endocrine pathways.
Spengler, D. +4 more
core +1 more source
Differential expression of POMC-processing genes in corticotroph tumors
Endocrine OncologyObjective: Corticotroph tumors (CTs) derive from the TBX19 lineage and are functioning (FCTs) or nonfunctioning (NFCTs). In FCTs, the main pathogenic variants are found in USP8, enhancing proopiomelanocortin (POMC) transcription through epidermal growth ...
Elisa Lamback +7 more
doaj +1 more source
The small GTPase Rap1 in POMC neurons regulates leptin actions and glucose metabolism
Molecular MetabolismThe hypothalamic leptin-proopiomelanocortin (POMC) pathway is critical for regulating metabolism. POMC neurons in the arcuate nucleus respond to leptin and play a pivotal role in mediating energy and glucose balance. However, during diet-induced obesity (
Kentaro Kaneko +4 more
doaj +1 more source
Glucose-excited POMC neurons in the ARC.
, 2014 (A) Hypothalamic sections containing the ARC were prepared from POMC DsRed mice (7 weeks), and POMC neurons were visualized using a fluorescent microscope.
Liangyou Rui (332792) +3 more
core +1 more source
Autophagic cell death participates in POMC-induced melanoma suppression
, 2019 Hypoxia in tumors is known to trigger the pro-survival pathways such as autophagy. Systemic proopiomelanocortin (POMC) gene therapy suppresses melanoma through apoptosis induction and neovascularization blockage.
Wu, C-S (15681587) +4 more
core
FEBS Letters, 1988 In our previous studies, we have purified a unique, paired basic residue‐specific, prohormone‐converting enzyme from pituitary intermediate lobe secretory vesicles. This enzyme, an aspartyl protease, was shown to cleave the intermediate lobe prohormone, pro‐opiomelanocortin (POMC), to adrenocorticotropin, β‐endorphin and a 16 kDa NH2‐terminal ...
openaire +2 more sources