Results 121 to 130 of about 179,797 (233)
Erg currents support electrical bursting in murine anterior pituitary corticotrophs
The Journal of Physiology, Volume 604, Issue 12, Page 4834-4850, 15 June 2026.Abstract figure legend Anterior pituitary corticotrophs are a central component of the hypothalamic‐pituitary‐adrenal (HPA) axis that controls the release of glucocorticoids from the adrenal gland in response to stress. The hypothalamic secretagogue corticotrophin releasing hormone (CRH) promotes electrical bursting of mouse anterior pituitary ...
Sooraj V. Nair +5 more
wiley +1 more source
Chromaffin Granule Aspartic Proteinase Processes Recombinant Proopiomelanocortin (POMC)
, 1995 Our search for proteases responsible for proenkephalin (PE) processing in adrenal medulla led to the isolation of a 70 kDa aspartic proteinase that cleaves PE between the basic residues of the Lys-Arg processing site (1).
Hook, Vivian Y. +2 more
core +1 more source
The Journal of Physiology, Volume 604, Issue 12, Page 4717-4744, 15 June 2026.Abstract figure legend Central leptin signalling blockade induces early metabolic dysfunction. Intracerebroventricular infusion of a leptin receptor antagonist (SLA) in rats disrupts hypothalamic leptin signalling, leading to reduced signal transducer and activator of transcription 3 (STAT3) activation, decreased Socs3 and Pomc expression, and ...
Cristina Pintado +16 more
wiley +1 more source
Weaning stress induced alterations to the hypothalamic‐pituitary‐thyroid and ‐adrenal axes in swine
Physiological Reports, Volume 14, Issue 12, June 2026.Abstract Combined modulation of the hypothalamic–pituitary–thyroid (HPT) and hypothalamic–pituitary–adrenal (HPA) axes is known to play a critical role in maintaining physiological stability in response to stress. In this study, stress induced modulation of these axes was examined using 20 pigs/treatment either weaned (WN), weaned with feed/water ...
Isabel B. Walpole +5 more
wiley +1 more source
ARC cholinergic neurons express POMC and Th.
, 2016 A. Images of confocal fluorescence microscopy showing co-labelling of ChAT with POMC (upper panel) or Th (bottom panel). Scale bar: 50 μm. B. Summary plot showing that a subpopulation of cholinergic neurons expressed POMC or Th (21.91±5.5% or 24.34±3.9%;
Streamson Chua Jr. (3112113) +3 more
core +1 more source
OPA1 in MC4R Neurons Regulates Dietary Fat Intake and Body Weight in Mice
The FASEB Journal, Volume 40, Issue 10, 31 May 2026.Soybean oil intake induces OPA1 expression in hypothalamic MC4R neurons, contributing to adaptive regulation of appetite. MC4R neuron‐specific OPA1 deficiency increases soybean oil consumption and leads to obesity, with a more pronounced effect in females.
Shigenobu Matsumura +10 more
wiley +1 more source
Systemic POMC Overexpression Increases Visceral Fat Accumulation in Mice
, 2011 Proopiomelanocortin (POMC) is a polypeptide precursor with 241 amino acid residues which undergoes extensive post-translational modification to yield a range of smaller, biological active peptides including \uce\ub1-, \uce\ub2 -, \uce\ub3-melanocyte ...
Tang, Chia-Hua
core
Growing Up POMC: Pro-opiomelanocortin in the Developing Brain
, 2011 Neurons in the arcuate nucleus of the hypothalamus (ARH) play a central role in the regulation of body weight and energy homeostasis. ARH neurons directly sense nutrient and hormonal signals of energy availability from the periphery and relay this ...
Padilla, Stephanie Louise
core +1 more source
The small GTPase Rap1 in POMC neurons regulates leptin actions and glucose metabolism
Molecular MetabolismThe hypothalamic leptin-proopiomelanocortin (POMC) pathway is critical for regulating metabolism. POMC neurons in the arcuate nucleus respond to leptin and play a pivotal role in mediating energy and glucose balance. However, during diet-induced obesity (
Kentaro Kaneko +4 more
doaj +1 more source