Results 131 to 140 of about 179,797 (233)

POMC Is Expressed in Pancreatic Alpha Cells

, 2012
Pancreatic alpha cells secrete glucagon to increase blood glucose during hypoglycemia. Currently, the mechanisms that initiate glucagon secretion are not well understood.
Farrara, Samia M.M
core  

POMC polypeptide expression in LFD and HFD C57Bl/6J mice.

, 2013
A. Shown are matched representative images of POMC neurons as detected in situ hybridization. Matched coronal sections from the rostral, medial and caudal mediobasal hypothalamus of a LFD mouse are presented. B.
Christian Bjørbæk (334577), Joyce E. Hairston (334575), Sangdeuk Ha (334574), Sarah Greeley (334576), Lihong Huo (334573), Kevin M. Gamber (334572)   +5 more
core   +1 more source

Mutations in the amino-terminal region of proopiomelanocortin (POMC) in patients with early-onset obesity impair POMC sorting to the regulated secretory pathway

, 2008
Context: Mutations in the proopiomelanocortin (POMC) gene that impair the synthesis or structure of POMC-derived peptides predispose to human obesity.
O'Rahilly, Stephen, Bahceci, Mithat, Herber, Stefan, White, Anne; id_orcid, Keogh, Julia, Farooqi, I. Sadaf, Yung, Seng Lee, Oliver, Robert L., Creemers, John W M, Tuzcu, Alpaslan, Gokalp, Deniz   +10 more
core   +1 more source

The effect of pepstatin A, an inhibitor of the pro‐opiomelanocortin (POMC)‐converting enzyme, on POMC processing in mouse intermediate pituitary

FEBS Letters, 1988
In our previous studies, we have purified a unique, paired basic residue‐specific, prohormone‐converting enzyme from pituitary intermediate lobe secretory vesicles. This enzyme, an aspartyl protease, was shown to cleave the intermediate lobe prohormone, pro‐opiomelanocortin (POMC), to adrenocorticotropin, β‐endorphin and a 16 kDa NH2‐terminal ...
openaire   +2 more sources

Nöron hücrelerinde Ser9Leu proopiomelanokortin (POMC) mutasyonunun hücresel mekanizmalarının incelenmesi.

, 2019
Pro-opiomelanocortin (POMC) is a precursor protein and synthesized in many different tissues of the body. It is proteolytically cleaved into different biologically active peptides which have different physiological functions based on the tissues they are
Vural, Merve
core  

Effects of the Saturated Fatty Acid Palmitate on Neuroinflammation, ER Stress, and Pomc mRNA Expression in Hypothalamic mHypoA-POMC/GFP Neurons

, 2017
Dietary fats can modulate brain function. How free fatty acids (FFAs) alter hypothalamic pro-opiomelanocortin (POMC) neurons remain undefined. The saturated FFA, palmitate, increased neuroinflammatory and ER stress markers, as well as Pomc mRNA levels ...
Tse, Erika Koppert
core   +1 more source

Gene Delivery of POMC for treatment of Intractable Pain

, 2003
The use of gene-based techniques to produce antinociceptive molecules has been actively investigated for treatment of neuropathic pain and trauma of central nervous system. Among the endogenous opioids, b-endorphin (b-EP) is the most potent one, which is
Chuang, Ming-Ju
core  

POMC [PDF]

, 2019
openaire   +1 more source

Human Epidermal Proopiomelanocortin (POMC) cDNA Variant is Identical to Mouse POMC cDNA [PDF]

Journal of Investigative Dermatology, 1999
Ancans, Janis, Thody, Anthonny J., Wood, John M., Beazley, Wayne D., Schallreuter, Karin U.   +4 more
openaire   +1 more source

Membrane-initiated estrogen receptor-α signaling in the hypothalamus regulates trabecular bone in femur in female mice. [PDF]

J Endocrinol
Jiang Y, Horkeby K, Henning P, Nilsson KH, Wu J, Li L, Movérare-Skrtic S, Ohlsson C, Lagerquist MK.   +8 more
europepmc   +1 more source