Results 111 to 120 of about 179,797 (233)
Genotype–Phenotype Spectrum of Non‐Syndromic Monogenic Obesity in a National Paediatric Cohort
Pediatric Obesity, Volume 21, Issue 6, June 2026.ABSTRACT Objective
Non‐syndromic monogenic obesity, caused by defects in the leptin‐melanocortin pathway, presents with early‐onset severe obesity and hyperphagia, but genotype–phenotype and metabolic correlations across different genetic forms remain unclear.Ahmet Kahveci, Selin Uzun Karauzum, Hayrullah Manyas, Behiye Sarikaya Ozdemir, Zerrin Orbak, Ummahan Tercan, Ruken Yildirim, Nihal Hatipoglu, Fatih Kilci, Hatice Nursoy, Servan Ozalkak, Baris Kolbasi, Semra Cetinkaya, Hazal Canbaz Ozdemir, Mesut Parlak, Filiz Tutunculer Kokenli, Emine Camtosun, Saime Ergen Dibeklioglu, Gonul Buyukyilmaz, Ayse Derya Bulus, Hanife Gul Balki, Ayse Ozden, E. Nazli Gonc, Elif Ozsu, Huseyin Demirbilek, Melek Yildiz, Samim Ozen, Abdullah Bereket, Belma Haliloglu +28 morewiley +1 more sourceLeptin-sensitivity in POMC-LepRb mice on HFD and LFD.
, 2013 A. Acute food intake after leptin (5 mg/kg, i.p.) or vehicle (PBS) in POMC-LepRb and control mice on LFD. B. Body weight change (relative to preinjection weight) after leptin administration in POMC-LepRb and control mice on LFD. C.Christian Bjørbæk (334577), Joyce E. Hairston (334575), Sangdeuk Ha (334574), Sarah Greeley (334576), Lihong Huo (334573), Kevin M. Gamber (334572) +5 morecore +1 more sourceGPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity
Molecular MetabolismObjective: G-protein-signaling modulator 1 (GPSM1) has been proved the potential role in brain tissues, however, whether GPSM1 in hypothalamic nuclei, especially in POMC neurons is essential for the proper regulation of whole-body energy balance remains ...Mengyang Tang, Yi Zhang, Rong Zhang, Yuemei Zhang, Jiangfei Zheng, Daixi Wang, Xinyu Wang, Jing Yan, Cheng Hu +8 moredoaj +1 more sourceThe NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets
Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.ABSTRACT
Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.Bherouz Pourdad, Arash Pourdadwiley +1 more sourceSteroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis.
, 2019 Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, Paternoster, Lavinia, Williamson, Kathleen A., Greenwood, CMT, Pollitt, RC, Ward, Kirsten, Crooks, Lucy, Down, T, Taylor, R, Balasubramanian, Senduran, Xu, P, Liang, J, Xu, J, Smee, C, Cacciottolo, Tessa M, Birney, E, Ciampi, A, Xu, C, Clement, Gail, Smith, BH, Xu, Y, Morris, James, Beales, P, Maslen, John, Foley, AR, Foley, A. Reghan, Edkins, Sarah, Pollitt, Rebecca C., Yan, X, Flicek, Paul, Sharp, SI, Langenberg, C, Bochukova, E, UK10K Consortium, Clapham, Peter, Cocca, Massimiliano, Balasubramanian, S, Wang, Guangbiao, Northstone, K, Liu, R, Spasic-Boskovic, O, Chatterjee, Krishna, Schoenmakers, Nadia, Curtis, D, Payne, SJ, Kennedy, Karen, Perry, John R. B., Dunham, I, Gasparini, P, Danecek, Petr, O’Malley, BW, Metrustry, Sarah, Xu, Jianming, Zhang, W, Inês Barroso,, Zhang, P, Evans, DM, Al Turki, Saeed, Min, JL, Mistry, Vanisha, Stevens, Elizabeth, Antony, Dinu, Tong, Qingchun, Farooqi, IS, Memari, Y, Nordestgaard, Børge G., Banton, MC, Zhang, F, Toniolo, D, Raymond, F. Lucy, Tong, Q, Blackwood, Douglas, Bounds, R, Small, Kerrin S., Lee, I, Collier, DA, Smith, GD, van Duijn, CM, Palotie, A, Day-Williams, Aaron, Wang, Chunmei, MacArthur, DG, Holmans, Peter, Greenwood, Celia M. T., Cosgrove, Catherine, Calissano, M, van der Klaauw, Agatha A, Bounds, Rebecca, Wilson, SG, Barrett, Jeffrey C., Rehnstrom, Karola, Flicek, P, Williamson, KA, Walters, James T. R., Consortium, U, Howie, B, Hysi, Pirro, Lawson, D, Langford, C, Johnson, J, Sun, Jianping, Yang, Jian, Hart, Deborah, Hurles, ME, Vijayarangakannan, P, Klaauw, A.A. (Agatha) van der, Zaza, G, Zhu, Liangru, St Clair, D, Kaye, J, Bolton, PF, Ciampi, Antonio, McQuillin, Andrew, Marchini, J, McKechanie, Andrew G., Paunio, T, McKechanie, AG, Kennedy, K, Morris, Andrew, Tian, J, Roberts, Nicola, Cox, T, Futema, M, Du, Y, Wong, K, Benn, M, Cosgrove, C, Scambler, P, Jackson, David K., Amuzu, A, Bentham, J, Marchini, Jonathan, Cox, Tony, Gambaro, Giovanni, Guo, Xueqin, Brion, M-J, Coates, G, Huang, J, Chen, Lu, Huang, L, Traglia, Michela, Wilson, C, Cacciottolo, T.M., Povey, S, Howie, Bryan, Scott, Robert A., O'Donovan, Michael C., van der Klaauw, Agatha A., Hinton, A, Memari, Yasin, Liao, Lan, van der Klaauw, AA, Chatterjee, K, Farooqi, I. Sadaf, Yang, J, Khawaja, F, O'Rahilly, Stephen, Mathieson, I, Saito, K, O'Donovan, MC, Jamshidi, Y, Liu, Ryan, Marenne, G, Charlton, R, Yang, Y, Wain, Louise V., Lek, Monkol, Edkins, S, Khawaja, Farrah, Danecek, P, Walter, Klaudia, Serra, Eva, St Pourcain, B, Visscher, PM, Keogh, Julia, Casas, Juan Pablo, Antony, D, Kolb-Kokocinski, A, Floyd, James, Brion, Marie-Jo, Shihab, Hashem A., Scambler, Peter, Serra, E, Artigas, Maria Soler, Lopes, M, Whyte, Tamieka, Charlton, Ruth, Oualkacha, Karim, McIntosh, Andrew M., Lek, M, Bhattacharya, Shoumo, Marenne, Gaelle, Vandersteen, Anthony M., Mitchison, Hannah M., Traglia, M, Northstone, Kate, Spasic-Boskovic, Olivera, Lonnqvist, Jouko, Smith, Blair H., Curran, S, Matchan, A, Du, Yuanping, Mistry, V, Hysi, P, Al Turki, S, Casas, JP, Liang, Jieqin, Malerba, Giovanni, Porteous, DJ, Chambers, John C., Joyce, C, Ekong, Rosemary, Savage, DB, Breen, Gerome, Lonnqvist, J, Tybjaerg-Hansen, A, Muntoni, Francesco, Humphries, SE, Semple, Robert K., Robinson, RL, van Duijn, Cornelia M., He, Yanlin, Day-Williams, A, Ellis, P, Lachance, G, Lee, Irene, Quaye, L, Collier, David A., Coates, Guy, Xu, ChangJiang, Zhang, Feng, Marz, W, Zhu, L.R., Cirak, S, Shaw, A, Muntoni, F, Marz, Winfried, Ekong, R, Syrris, Petros, Barroso, Ines, Curran, Sarah, Surdulescu, G, Owen, MJ, Mathieson, Iain, Tachmazidou, Ioanna, Schmidts, Miriam, Timpson, Nicholas J., Kemp, John P., Keogh, JM, Schmidts, M, Vijayarangakannan, Parthiban, Chen, L, Lin, Hong, Sharp, Sally I., Evans, David M., Ayub, M, Kemp, JP, Bochukova, EG, Small, KS, Schiffels, Stephan, Bobrow, Martin, Dunham, Ian, Lopes, Luis R., Visscher, Peter M., Moayyeri, Alireza, Suvisaari, J, Bhattacharya, S, Zaza, Gianluigi, Stalker, Jim, Robinson, Rachel L., Spector, TD, Roberts, N, Stalker, J, Wheeler, Eleanor, Cirak, Sebahattin, Oualkacha, K, Hubbard, Tim, Jamshidi, Yalda, Luan, Jian'an, Vandersteen, AM, Bochukova, Elena G, McIntosh, AM, Henning, Elana, van Kogelenberg, Margriet, Anney, Richard, Gurling, Hugh, Malerba, G, Skuse, David, St Clair, David, Tobin, MD, Wain, LV, Banton, Matthew C, Gaunt, Tom R., Crooks, L, Keogh, Julia M., Ring, S, Isaacs, A, Metrustry, S, Clement, G, Paunio, Tiina, Joyce, Chris, Varbo, A, Benn, Marianne, Matchan, Angela, Scott, Richard H., McGuffin, P, Gambaro, G, Wang, C, Beales, Phil, Langenberg, Claudia, Wang, G, Bobrow, M, Wang, J, Wheeler, E, Bentham, Jamie, Wilson, Scott G., McQuillin, A, Soranzo, N, Quaye, Lydia, Johnson, Jon, Wang, Y, Wang, Yu, Carss, Keren, Craddock, N, Day, Ian N. M., Geschwind, Daniel, Hendricks, Audrey E., Zhang, Pingbo, Palotie, Aarno, Fatemifar, G, Tachmazidou, I, Zeggini, E, Mitchison, HM, Franklin, CS, MacArthur, Daniel G., Owen, Michael J., Bolton, Patrick F., Gaunt, TR, Schiffels, S, Daly, Allan, Zheng, Hou-Feng, Yan, Xiaofeng, Skuse, D, Kleber, ME, Quail, MA, van Kogelenberg, M, St Pourcain, Beate, Lawler, KL, Massimo, Mangino, Zhu, L, Zeggini, Eleftheria, Southam, Lorraine, Valdes, Ana M., Hart, D, Artigas, MS, Stadler, Lukas K J, Kent, A, van, der Klaauw AA, Hubbard, T, Southam, L, Tian, Jing, Blackwood, D, Plagnol, V, Walter, K, Boustred, C, Kleber, Marcus E., Chambers, JC, Dedoussis, George, Whyte, T, Ritchie, Graham R. S., He, Y.L., Syrris, P, Williams, Hywel J., Griffin, Heather, Yang, Yongjie, Saito, Kenji, Pietilainen, Olli, Henning, E, Curtis, David, Moayyeri, A, O’Rahilly, S, Keogh, J, Birney, Ewan, Jackson, DK, Langford, Cordelia, Keane, Thomas, O\u27Malley, Bert W, Dominiczak, A, Farooqi, I Sadaf, Spector, Timothy D., Payne, F, Ridout, CK, Clapham, P, Richards, J. Brent, Lin, H, Huang, Jie, Porteous, David J., Wang, Jun, Savage, David B., Daly, A, Kaye, Jane, Li, Y, Onoufriadis, A, Li, Rui, Banton, Matthew C., Ellis, Peter, Stevens, E, Li, R, Down, Thomas, Franklin, Christopher S., Timpson, NJ, Grozeva, D, Stadler, LKJ, Ward, K, Ayub, Muhammad, Toniolo, Daniela, Stadler, Lukas K. J., He, Y, Plagnol, Vincent, Anderson, CA, Keane, T, Muddyman, Dawn, Payne, Felicity, Cocca, M, Shin, S-Y, Hendricks, AE, Shihab, HA, Fatemifar, Ghazaleh, Lawson, Daniel, Parr, Jeremy R., van Leeuwen, EM, Semple, RK, Griffin, H, Migone, N, Nordestgaard, BG, Gasparini, Paolo, Whincup, P, Smith, George Davey, Williams, HJ, Amuzu, Antoinette, Lopes, Margarida, Futema, Marta, Parr, JR, Inês Barroso, Bochukova, Elena G., Gallagher, L, Floyd, J, Dedoussis, G, Perry, JRB, Grozeva, Detelina, Massimo, M, Geihs, Matthias, Migone, Nicola, Payne, Stewart J., Onoufriadis, Alexandros, Soranzo, Nicole, Muddyman, D, McCarthy, Shane, Maslen, J, Panoutsopoulou, K, van Leeuwen, Elisabeth M., Geihs, M, Quail, Michael A., Anderson, Carl A., Parker, V, Boustred, Chris, Parker, Victoria, Scott, RA, Huang, Liren, Guo, X, Scott, RH, Xu, Pingwen, Shin, So-Youn, Guo, Xiaosen, Li, Yingrui, Raymond, FL, Rehnstrom, K, Geschwind, D, Kooner, Jaspal S., O'Rahilly, S, Kooner, JS, Lopes, LR, Ridout, Cheryl K., Tybjaerg-Hansen, Anne, O\u27Rahilly, Stephen, Luan, J, O'Malley, BW, Gurling, H, Ring, Susan, Gallagher, Louise, Iotchkova, Valentina, Smee, Carol, Barroso, I, Fitzpatrick, David R., Hinton, Antentor, Iotchkova, V, Breen, G, Calissano, Mattia, Zheng, H-F, Anney, R, Schoenmakers, N, Shaw, Adam, McCarthy, S, Bochukova, Elena, Varbo, Anette, Isaacs, Aaron, Zhang, Weihua, Yang, Y.J., Taylor, Rohan, Wong, Kim, Walters, JTR, Holmans, P, Suvisaari, Jaana, Stadler, L.K.J., Fitzpatrick, DR, Hendricks, Audrey E, Hurles, Matthew E., Durbin, R, Lachance, Genevieve, Wilson, Crispian, Pietilainen, O, Durbin, Richard, Cacciottolo, TM, Keogh, Julia M, O'Malley, Bert W., Povey, Sue, Morris, Richard, Kolb-Kokocinski, Anja, Day, INM, Valdes, AM, Barrett, JC, Tobin, Martin D., Whincup, Peter, Xu, Yong, Morris, A, Richards, JB, Ritchie, GRS, Lawler, Katherine L., Morris, J, Kent, Alastair, McGuffin, Peter, Panoutsopoulou, Kalliope, Craddock, Nick, Sun, J, Min, Josine L., Dominiczak, Anna, Morris, R, Surdulescu, Gabriela, Paternoster, L, Lawler, Katherine L, Humphries, Steve E., Liao, L, Cacciottolo, Tessa M., Carss, K +552 morecore +1 more sourceExploring the Potential of Calebin‐A in Targeting Obesity‐Related Genes and Pathways
Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.ABSTRACT
Obesity is a global health crisis affecting millions, associated with metabolic disorders such as type 2 diabetes and cardiovascular disease. Calebin‐A, a bioactive compound derived from Curcuma species, has shown promise in managing obesity and its complications.Ali Mahmoudi, Ali Saeedi‐Boroujeni, Sercan Karav, Prashant Kesharwani, Amirhossein Sahebkar +4 morewiley +1 more sourcePOMC heterogeneity in xenograft tumours after irradiation.
, 2016 DMS 79 cells were established as subcutaneous tumours in nude mice and either left untreated (A-C) or exposed to IR for 10 consecutive days at 2Gy/day (D-G). A central section of the tumour was stained for POMC using our own N1C11 antibody.Philip W. Riddell (2155933), Roya Behrouzi (2155924), Suzanne L. Meredith (2155930), Jennifer L. Bryant (2155927), Kaye J. Williams (692869), Anne White (342719), Muhammad Babur (692864) +6 morecore +1 more sourceKNDy kisspeptin is required for metabolic homeostasis in female mice in an ovarian hormone‐independent manner
Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.Abstract
Disorders of gonadotropin pulsatility contribute to reproductive dysfunction in humans and are often associated with metabolic dysfunction. Hypogonadotropic hypogonadism is characterized by chronically insufficient gonadotropin hormone production, leading to reproductive and metabolic impairments, such as infertility and obesity.Nimisha Nandankar, Ariel L. Negrón, Harshini Ganesh, Natalia Youssef, Saad Farooq, Sarmed Al‐Samerria, Jon E. Levine, Sally Radovick +7 morewiley +1 more source
