Results 111 to 120 of about 189,310 (233)

Neuropathic Pain Comorbid Cognitive Impairment and Vitamin D: A Narrative Review From Mechanisms to Clinical Management

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Vitamin D is an essential fat‐soluble nutrient primarily obtained through cutaneous synthesis triggered by ultraviolet exposure and dietary intake. After systemic metabolism and activation, it binds to vitamin D receptors widely distributed in the central and peripheral nervous systems, exerting pleiotropic neuroprotective and regulatory biological ...
Nan Zhao, Yang Yang, Wanqiu Yu, Yuhang Zhu, Zhaoqiong Zhu   +4 more
wiley   +1 more source

Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing

Molecular Metabolism, 2017
Objective: Arcuate proopiomelanocortin (POMC) neurons are critical nodes in the control of body weight. Often characterized simply as direct targets for leptin, recent data suggest a more complex architecture.
Brian Y.H. Lam, Irene Cimino, Joseph Polex-Wolf, Sara Nicole Kohnke, Debra Rimmington, Valentine Iyemere, Nicholas Heeley, Chiara Cossetti, Reiner Schulte, Luis R. Saraiva, Darren W. Logan, Clemence Blouet, Stephen O'Rahilly, Anthony P. Coll, Giles S.H. Yeo   +14 more
doaj   +1 more source

Markers of Systemic Metabolic Dysfunction in Vitiligo and Their Potential Role in Disease Pathogenesis: A Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Vitiligo is a chronic autoimmune disease characterized by the progressive destruction of melanocytes, resulting in depigmented skin macules. While traditionally viewed as a cutaneous disorder driven by a specific CD8+ T cell‐mediated interferon‐γ (IFN‐γ) signature, emerging research suggests that vitiligo may be a systemic condition
Federica Papaccio, Simona Scano, Barbara Bellei   +2 more
wiley   +1 more source

60 YEARS OF POMC: POMC: the consummate peptide hormone precursor [PDF]

Journal of Molecular Endocrinology, 2016
Adrian J L, Clark, Philip, Lowry
openaire   +2 more sources

Generation and characterization of POMC-tdTomato reporter human pluripotent stem cell lines

Stem Cell Research
Proopiomelanocortin (POMC) is a precursor polypeptide that undergoes extensive, tissue-specific post-translational processing. It is expressed in several tissues, including pituitary gland, hypothalamus, brain stem, and skin.
Vukasin M. Jovanovic, Rick Rausch, Maria Caterina DeRosa, David Castellano, Cody McKee, Chaitali Sen, Fiona Daly, Claudia A. Doege, Carlos A. Tristan   +8 more
doaj   +1 more source

Maternal Vitamin D Deficiency is Associated With Sex‐Dependent Alterations in Neurodevelopment‐Related Gene Expression, Particularly in the Hypothalamus

Molecular Nutrition &Food Research, Volume 70, Issue 20, 28 October 2026.
Maternal vitamin D deficiency (VDD) affects early brain development in a sex‐dependent manner. VDD accelerates neuronal differentiation and synaptogenesis. Male offspring exhibit broader transcriptomic alterations, including dysregulation of melanocortin‐pathway and synaptic signaling genes, indicating greater vulnerability of hypothalamic circuits ...
Lidia Saidi, Emmanuel Snacel‐Fazy, Eva Seipelt, Nicole Haroun, Julien Astier, Charlène Couturier, Mohamed El Soltani, Eric Sérée, Flavie Sicard, Habib Hammou, Michel Puceat, Jean‐François Landrier, Lourdes Mounien   +12 more
wiley   +1 more source

Myasthenia Gravis and Thymoma

Muscle &Nerve, Volume 74, Issue 4, Page 1156-1173, October 2026.
ABSTRACT Thymoma is the most common tumor of the anterior mediastinum. Approximately 20%–30% of patients with a thymoma develop myasthenia gravis (MG), and an additional one third may possess positive acetylcholine receptor (AChR) antibodies without MG.
Benjamin Claytor, Lukas Delasos, Daniel P. Raymond, Erik Seroogy, Jason Lempel, Yuebing Li   +5 more
wiley   +1 more source

Physical exercise increases binding of POMC to blood extracellular vesicles

Physical exercise affects multiple physiological processes, including those regulated by hormones, such as energy balance, stress responses, and pain perception.
Vittorio, Serena, Santos, Mark F., Vistoli, Giulio, Lauro, Rita, Fuentes, Geily, Karbanová, Jana, Mosallaei, Sheila, Lorico, Aurelio, Randa, Jacqueline, Tai, Derek, Yokomizo, Alexandra M. K., Schahaf, Nofar Avihen, Hightower, Cheryl E., Karbanov\ue1, Jana, Corbeil, Denis   +14 more
core   +1 more source

Early Weight Regain After GLP‐1 Receptor Agonist Discontinuation: Mechanisms and Implications for Treatment De‐Escalation Strategies

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 8769-8776, October 2026.
ABSTRACT Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have transformed the pharmacological management of obesity, producing substantial and sustained weight loss during active treatment. However, discontinuation of therapy is frequently followed by significant weight regain, raising important questions regarding the durability of treatment ...
M. A. Damhof, F. H. van Bruggen, E. N. van Roon   +2 more
wiley   +1 more source

Loss of Leptin Receptors on Hypothalamic POMC Neurons Alters Synaptic Inhibition

, 2010
Adaptive changes in hypothalamic neural circuitry occur in response to alterations in nutritional status. This plasticity at hypothalamic synapses contributes to the control of food intake and body weight.
Sung Kun Chun, Young-Hawn Jo
core   +1 more source