Results 111 to 120 of about 191,601 (231)

Reduced tillage, but not organic matter input, increased nematode diversity and food web stability in European long‐term field experiments [PDF]

, 2019
Soil nematode communities and food web indices can inform about the complexity, nutrient flows and decomposition pathways of soil food webs, reflecting soil quality.
De Caceres M., De Goede R. G. M., Edgar R. C., Ferris H., Ferris H., Köppen W., Mekonen S., Minton N. A., Moura G. S., Neher D. A., Neher D. A., Neher D. A., Niles R. K., Oksanen J., Oostenbrink M., Pan F., Pinheiro J., R Development Core Team, RStudio Team, Toth G., Wang K.‐H., WRB, I. W. G., Yeates G. W.   +22 more
core   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, Volume 183, Issue 9, Page 2139-2165, May 2026.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo. [PDF]

, 1990
Extracts from BSC-40 cells infected with vaccinia recombinants expressing either the yeast KEX2 prohormone endoprotease or a human structural homologue (fur gene product) contained an elevated level of a membrane-associated endoproteolytic activity that ...
Barr, P, Brake, A, Bresnahan, P, Gibson, H, Leduc, R, Thomas, G, Thomas, L, THORNER, Jeremy W.   +7 more
core   +1 more source

Supply and Demand in the Mathematics of Rare Disease Drug Development: Why Choosing the Right Model Is Crucial

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Clinical trials for rare diseases face a fundamental mathematical challenge that conventional randomized controlled trial (RCT) designs cannot overcome. With approximately 95% of the estimated 10,000–16,000 rare diseases lacking approved therapies, and drug development programs failing at rates exceeding 75% in non‐oncology indications, the ...
Marshall L. Summar, Janet Woodcock
wiley   +1 more source

Glucocorticoid receptor action in metabolic and neuronal function [version 1; referees: 3 approved] [PDF]

, 2017
Glucocorticoids via the glucocorticoid receptor (GR) have effects on a variety of cell types, eliciting important physiological responses via changes in gene expression and signaling.
Garabedian, Michael J, Harris, Charles A, Jeanneteau, Freddy   +2 more
core   +4 more sources

Diet-Regulated Anxiety [PDF]

, 2013
Peer reviewedPublisher ...
Mercer, Julian G., Murphy, Michelle
core   +2 more sources

Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation. [PDF]

, 2019
Genome wide association studies (GWAS) in obesity have identified a large number of noncoding loci located near genes expressed in the central nervous system.
Ahituv, Nadav, Eckalbar, Walter L, Inoue, Fumitaka, Matharu, Navneet, Murphy, Karl K, Vaisse, Christian, Wang, Yi   +6 more
core   +1 more source

Six novel mutations in the proopiomelanocortin and melanocortin receptor 4 genes in severely obese adults living in southern Italy. [PDF]

, 2005
BACKGROUND: The genetic characterization of obese individuals could clarify the molecular mechanisms underlying body weight regulation and lead to targeted therapy.
Buono P, Capone S, Contaldo F, Finelli C, Ieno L, Liguori R, Nardelli C, Oriani G, Pasanisi F, Sacchetti L   +9 more
core   +1 more source

Effects of chronic high fat diet on mediobasal hypothalamic satiety neuron function in POMC-Cre mice

Molecular Metabolism
Objective: The prevalence of obesity has increased over the past three decades. Proopiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) play a vital role in induction of satiety.
Özge Başer, Yavuz Yavuz, Deniz Öykü Özen, Hüseyin Buğra Özgün, Sami Ağuş, Cihan Civan Civaş, Deniz Atasoy, Bayram Yılmaz   +7 more
doaj   +1 more source

Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing

Molecular Metabolism, 2017
Objective: Arcuate proopiomelanocortin (POMC) neurons are critical nodes in the control of body weight. Often characterized simply as direct targets for leptin, recent data suggest a more complex architecture.
Brian Y.H. Lam, Irene Cimino, Joseph Polex-Wolf, Sara Nicole Kohnke, Debra Rimmington, Valentine Iyemere, Nicholas Heeley, Chiara Cossetti, Reiner Schulte, Luis R. Saraiva, Darren W. Logan, Clemence Blouet, Stephen O'Rahilly, Anthony P. Coll, Giles S.H. Yeo   +14 more
doaj   +1 more source