Results 61 to 70 of about 57,827 (240)
The Role of Melanocortin Plasticity in Pain-Related Outcomes After Alcohol Exposure
Frontiers in Psychiatry, 2021 The global COVID-19 pandemic has shone a light on the rates and dangers of alcohol misuse in adults and adolescents in the US and globally. Alcohol exposure during adolescence causes persistent molecular, cellular, and behavioral changes that increase ...
Nathan Sharfman +4 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley +1 more source
Chronic Diseases and Translational Medicine, EarlyView.Kaplan–Meier hypertension‐free survival by baseline body mass index category, primary adult cohort (men aged ≥ 18 years, n = 12,742). Time since baseline in years is plotted on the horizontal axis and the probability of remaining free of treated hypertension is plotted on the vertical axis. Numbers at risk are shown beneath the plot.
Ebenezer Afrifa‐Yamoah
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples +10 more
wiley +1 more source
Ligand Bias and Its Association With Pro-resolving Actions of Melanocortin Drugs
Frontiers in Pharmacology, 2018 Resolution Pharmacology identifies drugs developed on the biology of the resolution phase of inflammation, the complex molecular and cellular network of events that ensure the tight temporal and spatial control on the inflammatory response.
Sara Patruno +9 more
doaj +1 more source
Epilepsia Open, EarlyView.Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira +5 more
wiley +1 more source
, 2015 The melanocortin system regulates many important functions in the body. There are five melanocortin G protein-coupled receptor subtypes known to date.
Aleksandar Todorovic (1374150) +2 more
core +1 more source
Emerging roles of melanocortin receptor accessory proteins (MRAP and MRAP2) in physiology and pathophysiology. [PDF]
, 2020 Melanocortin-2 receptor accessory protein (MRAP) has an unusual dual topology and influences the expression, localisation, signalling and internalisation of the melanocortin receptor 2 (MC ); the adrenocorticotropic hormone (ACTH) receptor.
Smith, C.L., Berruien, N.
core +1 more source
Demonstration of a Common DPhe(7) to DNal(2′)(7) Peptide Ligand Antagonist Switch for Melanocortin-3 and Melanocortin-4 Receptors Identifies the Systematic Mischaracterization of the Pharmacological Properties of Melanocortin Peptides [PDF]
, 2022 [Image: see text] Melanocortin peptides containing a 3-(2-naphthyl)-d-alanine residue in position 7 (DNal(2′)(7)), reported as melanocortin-3 receptor (MC3R) subtype-specific agonists in two separate publications, were found to lack significant MC3R ...
Mullick Bagchi, Satarupa +28 more
core +1 more source
Environmental Toxicology and Chemistry, EarlyView.Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers +10 more
wiley +1 more source