Results 81 to 90 of about 67,182 (234)

Age‐specific melanoma risk associated with nevi: a pooled analysis from the M‐SKIP project

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Objective This study investigates the association of melanoma risk with total‐body nevus count and the presence of atypical nevi in younger (< 40 years) and older (> 60 years) individuals. Methods A pooled analysis was conducted within the M‐SKIP project, based on multiple melanoma case‐control studies.
Giulia Doi, Aurora Gaeta, Simone Ribero, Nelleke Gruis, Julia Newton‐Bishop, David Polsky, DeAnn Lazovich, Paola Ghiorzo, Gloria Ribas, Chiara Menin, Alexander J. Stratigos, Gabriella Guida, Susana Puig, Maria Concetta Fargnoli, Peter A. Kanetsky, Paola Queirolo, Vincenzo Bagnardi, Veronique Bataille, Sara Raimondi, Sara Gandini, M‐SKIP study group   +20 more
wiley   +1 more source

A mini‐review of chronic suppression of the hypothalamic–pituitary–adrenal axis in animals with P‐glycoprotein deficiency

Journal of Small Animal Practice, EarlyView.
This mini‐review describes the pathophysiology of the disrupted hypothalamic–pituitary–adrenal axis in dogs, and probably cats, with the MDR1 (ABCB1) mutation, ABCB1‐1Δ in dogs and ABCB11930‐1931del TC in cats. Clinical consequences in affected animals are discussed and therapeutic interventions to consider are presented.
K. L. Mealey
wiley   +1 more source

Genetic variation in the SIM1 locus is associated with erectile dysfunction. [PDF]

, 2018
Erectile dysfunction affects millions of men worldwide. Twin studies support the role of genetic risk factors underlying erectile dysfunction, but no specific genetic variants have been identified. We conducted a large-scale genome-wide association study
Ahituv, Nadav, Hoffmann, Thomas J, Hotaling, James M, Jarvik, Gail P, Jorgenson, Eric, Matharu, Navneet, Palmer, Melody R, Shan, Jun, Thai, Khanh K, Van Den Eeden, Stephen K, Wessells, Hunter, Yin, Jie, Zhou, Xujia   +12 more
core  

Distribution of cells responsive to 5-HT6 receptor antagonist-induced hypophagia [PDF]

, 2014
Open Access funded by Medical Research CouncilPeer reviewedPublisher ...
Alastair S. Garfield, Blevins, Fisas, Frassetto, Garfield, Grill, Heal, Heisler, Heisler, Heisler, Hirst, Holenz, Jill Shaw, Lam, Lam, Leibowitz, Li, Lora K. Heisler, Luke K. Burke, Mark L. Evans, Michaud, Monti, Roberts, Wesołowska, Woolley, Woolley, Xu, Xu, Yeo   +28 more
core   +1 more source

The Importance of Melanocortin Receptors and Their Agonists in Pulmonary Disease

Frontiers in Medicine, 2019
Melanocortin agonists are ancient neuropeptides that have steroidogenesis and anti-inflammatory properties. They activate melanocortin receptors (MCR), a family of five seven-transmembrane G-protein coupled receptors. MC1R and MC3R are mainly involved in
Anna Elizabeth Moscowitz, Huda Asif, Laurence Baily Lindenmaier, Andrew Calzadilla, Chongxu Zhang, Mehdi Mirsaeidi, Mehdi Mirsaeidi   +6 more
doaj   +1 more source

Setmelanotide in Bardet‐Biedl Syndrome: A Case Report

Pediatric Dermatology, EarlyView.
ABSTRACT Setmelanotide is a melanocortin‐4‐receptor agonist used for the treatment of hyperphagia in the genetic obesity syndrome Bardet‐Biedl. Presented is a case of diffuse hyperpigmentation in a patient treated with setmelanotide, which represents the most common side effect of this medication.
Shelby Smith, Eric Sanfilippo, Lara Wine Lee   +2 more
wiley   +1 more source

Current evidence for a modulation of low back pain by human genetic variants [PDF]

, 2009
The manifestation of chronic back pain depends on structural, psychosocial, occupational and genetic influences. Heritability estimates for back pain range from 30% to 45%. Genetic influences are caused by genes affecting intervertebral disc degeneration
Aberle, Agarwal, Agrawal, Aladin, Anderson, Andersson, Annunen, Arnold, Ashford, Atkinson, Bandell, Battie, Battie, Bautista, Bejaoui, Berthele, Beyer, Blau, Bond, Brown, Brown, Brown, Campa, Caraco, Carbonell Sala, Carragee, Cascorbi, Cho, Chou, Chou, Cipollone, Collart, Cox, Dalen, Daly, Dawkins, Dayer, Dayer, Diatchenko, Diatchenko, Diatchenko, Dick, Doehring, Eckhardt, Einarsdottir, Fillingim, Foulkes, Fu, Gasche, Goldberg, Grant, Gross, Gursoy, Gutierrez-Roelens, Hamdani, Hartvigsen, Hayashida, Hernandez, Higashino, Hirose, Hoyland, Hummel, Hustmyer, Ikeda, Indo, Irmgard Tegeder, Jayamanne, Jim, Jörn Lötsch, Kales, Kalichman, Karppinen, Karsak, Kawaguchi, Kawaguchi, Kawasaki, Khoromi, Kim, Kim, Kim, Kim, Kirchheiner, Kirchheiner, Klepstad, Knoeringer, Kroslak, Kuisma, Kung, Lafreniere, Landau, Langdahl, Le Maitre, Lee, Lettre, Leyne, Lichtman, Liem, Lorenzo, Lotsch, Lotsch, Lotsch, Lotsch, Lotsch, Lotsch, Lovlie, Lu, Luoma, Lötsch, MacDonald, Macpherson, Madadi, Manning, McNamara, Meeus, Meller, Meller, Mignat, Mio, Miura, Mogil, Mogil, Morrison, Nguyen, Noponen-Hietala, Noponen-Hietala, Oakley, Oertel, Oertel, Oertel, Ofek, Ohtori, Oliveira, Paassilta, Papafili, Pilotto, Pluijm, Poulsen, Racz, Racz, Rakvag, Ralston, Ralston, Reyes-Gibby, Richards, Riviere, Roddier, Romberg, Russo, Sachse, Sakai, Schmidt, Schneider, Seki, Seki, Sindrup, Sipe, Skarke, Skarke, Slade, Slaugenhaupt, Solovieva, Solovieva, Solovieva, Solovieva, Solovieva, Srinivasan, Srinivasan, Stamer, Stamer, Steward, Stohler, Suzuki, Svendsen, Tadic, Takahashi, Tam, Tander, Tegeder, Tegeder, Thieme, Thomas, Trevisani, Uitterlinden, Ujike, van Meurs, Vargas-Alarcon, Verhoeven, Videman, Videman, Virtanen, Voronov, Vree, Wiesinger, Yamada, Yazdanpanah, Zhang, Zhang, Zhang, Zhang, Zubieta, Zuo   +200 more
core   +1 more source

Prolonged exposure to artificial light and carcinogenesis: A systematic review of oncostatic mechanisms associated with melatonin pathways

Photochemistry and Photobiology, EarlyView.
Exposure to artificial light at night (ALAN), particularly at blue wavelengths, disrupts circadian rhythms by suppressing melatonin, thereby increasing cancer susceptibility. This systematic review consolidates evidence linking prolonged ALAN exposure to an elevated risk of breast and prostate tumors.
Gabriel Barboza, Jêmina Oliveira, Antônio Ferreira, Renan Lopes, Marli Cupertino   +4 more
wiley   +1 more source

Hunger and Satiety Mechanisms and Their Potential Exploitation in the Regulation of Food Intake [PDF]

, 2016
Acknowledgments Tehmina Amin is the Project Manager and Julian Mercer is Project Coordinator for Full4Health. Both are funded by the Full4Health project (grant agreement no. 266408) under the EU Seventh Framework Programme (FP7/2007–2013).
Amin, Tehmina, Mercer, Julian G.
core   +2 more sources

Melanocortins, neural plasticity and aging [PDF]

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1986
Peptides derived from ACHT and alpha-MSH are known to exert trophic influences on peripheral and central nervous structures. Age-related brain diseases may in part be related to loss of neural plasticity. Melanocortins improve adaptional abilities of the nervous system. Chronic treatment with melanocortins may counteract age-related brain pathology.
Gispen, W.H., Isaacson, R.L., Spruijt, B.M., Wied, D. de   +3 more
openaire   +3 more sources