Results 81 to 90 of about 57,827 (240)

Melanocortins and feeding behavior

Biomedicine & Pharmacotherapy, 2000
The melanocortin (ACTH/MSH) peptides exert a number of central effects. In the eighties, we described for the first time a role for melanocortins in the central control of appetite. We showed that the injection of ACTH-(1-24) into a brain lateral ventricle reduced food intake up to 76.6% in starved rats.
A V, Vergoni, H B, Schiöth, A, Bertolini   +2 more
openaire   +2 more sources

Melanocortin Pathways: Suppressed and Stimulated Melanocortin-4 Receptor (MC4R)

Physiological Research, 2020
Leptin-melanocortin pathway plays an essential role in the body weight regulation. Enhanced melanocortin signaling in the hypothalamus results in both decreased food intake and increased energy expenditure. The discovery of monogenic obesities with dysfunction of melanocortin-4 receptor (MC4R) greatly contributed to understanding of energy balance ...
V, Hainer, I, Aldhoon Hainerová, M, Kunešová, R, Taxová Braunerová, H, Zamrazilová, B, Bendlová   +5 more
openaire   +2 more sources

Table_1_Pharmacological Evaluation of Melanocortin 2 Receptor Accessory Protein 2 on Axolotl Neural Melanocortin Signaling.docx

, 2022
The Melanocortin-3 receptor (MC3R) and Melanocortin-4 receptor (MC4R), two members of the key hypothalamic neuropeptide signaling, function as complex mediators to control the central appetitive and energy homeostasis.
Jing Guo (102972), Lei Li (29537), Xuan Li (137217), Hailin Zhang (48017), Yao Luo (1636354), Song Xue (316115), Gufa Lin (12097421), Xiaowei Lei (12097418), Wenqi Song (503416), Meng Wang (124646), Yanbin Fu (5784551), Chao Zhang (51048), Xiaozhu Wang (5497964), Cong Zhang (582922)   +13 more
core   +1 more source

Modulation of sebocyte function in acne: A pathway‐inclusive review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Acne is multifactorial, with the sebocyte acting as a central immunometabolic hub linking lipogenic, inflammatory, hormonal and barrier pathways. Mapping established and investigational therapies onto this sebocyte‐centred model offers a mechanism‐based framework that complements existing treatment paradigms and may guide more targeted, antibiotic ...
Christos C. Zouboulis, Apostolos Pappas, Katja Martin, Mauro Picardo   +3 more
wiley   +1 more source

Table_2_Pharmacological Evaluation of Melanocortin 2 Receptor Accessory Protein 2 on Axolotl Neural Melanocortin Signaling.xlsx

, 2022
The Melanocortin-3 receptor (MC3R) and Melanocortin-4 receptor (MC4R), two members of the key hypothalamic neuropeptide signaling, function as complex mediators to control the central appetitive and energy homeostasis.
Jing Guo (102972), Lei Li (29537), Xuan Li (137217), Hailin Zhang (48017), Yao Luo (1636354), Song Xue (316115), Gufa Lin (12097421), Xiaowei Lei (12097418), Wenqi Song (503416), Meng Wang (124646), Yanbin Fu (5784551), Chao Zhang (51048), Xiaozhu Wang (5497964), Cong Zhang (582922)   +13 more
core   +1 more source

Development of a genetically encoded melanocortin sensor for high sensitivity in vivo imaging

Molecular Metabolism
Objective: The central melanocortin system, composed of peptides derived from pro-opiomelanocortin (POMC) such as the melanocyte-stimulating hormones (α-, β-, γ-MSH) and melanocortin 4 receptors (MC4R), along with the agouti-related protein (AgRP), plays
Yoon Namkung, Tal Slutzki, Joao Pedroso, Xiaohong Liu, Paul V. Sabatini, Maia V. Kokoeva, Stéphane A. Laporte   +6 more
doaj   +1 more source

Nature and timing of dysregulation associated with pseudoalbinism in California Halibut, Paralichthys californicus

Journal of Fish Biology, EarlyView.
Abstract Pseudoalbinism in flatfishes, the absence of melanophores or melanin over most of the ocular side of the body, is often observed in hatcheries. The prevalence of pseudoalbinism can be very high, sometimes exceeding 90% of individuals in California Halibut, Paralichthys californicus.
Lee A. Fuiman, Cynthia K. Faulk, Ruairi MacNamara   +2 more
wiley   +1 more source

Synaptic changes induced by melanocortin signalling

, 2014
The melanocortin system has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its involvement in memory, nociception, mood disorders and addiction. In this Review, we focus on the role of the melanocortin 4
Vanni Caruso, Helgi B. Schiöth, Schiöth, Helgi B.,, Malin C. Lagerström, Pawel K. Olszewski, Fredriksson, Robert,, Robert Fredriksson, Olszewski, Pawel K.,, Lagerström, Malin C.,, Caruso, Vanni,   +9 more
core   +1 more source

Melanocortin 1 Receptor: Structure, Function and Regulation

Frontiers in Genetics, 2016
The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic gene, and loss of function correlates with a fair, UV-sensitive, and melanoma ...
Erin Marissa Wolf Horrell, Mary Catherine Boulanger, John August D'orazio   +2 more
doaj   +1 more source

Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors

Molecular Metabolism, 2020
Objective: Histaminergic neurons of the tuberomammillary nucleus (TMN) are wake-promoting and contribute to the regulation of energy homeostasis. Evidence indicates that melanocortin 4 receptors (MC4R) are expressed within the TMN.
Natalie J. Michael, Alexandre Caron, Charlotte E. Lee, Carlos M. Castorena, Syann Lee, Jeffrey M. Zigman, Kevin W. Williams, Joel K. Elmquist   +7 more
doaj   +1 more source