Results 101 to 110 of about 57,827 (240)

Loss of the C terminus of melanocortin receptor 2 (MC2R) results in impaired cell surface expression and ACTH insensitivity [PDF]

, 2011
Mutations in melanocortin receptor 2 (MC2R) and its related melanocortin receptor accessory protein (MRAP) cause familial glucocorticoid deficiency. We identified a novel MC2R mutation, K289fs. This unique mutation in the C terminus of MC2R is located in
Audi, Laura, Clark, Adrian J L, Adrian J. L. Clark, Andrea Hirsch, Meimaridou, Eirini, Monica Fernandez-Cancio, Fernandez-Cancio, Monica, María Clemente, Amit V. Pandey, Pandey, Amit V, Flück, Christa E, Christa E. Flück, Eirini Meimaridou, Laura Audi, Clemente, María, Hirsch, Andrea   +15 more
core   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Investigation into the immuno-therapeutic potential of melanocortin peptides on activated chondrocytes [PDF]

, 2011
Melanocortin peptides are endogenously produced peptides originating from the posttranslational processing of the pro-opiomelanocortin hormone (POMC), exerting their effect by binding to class A G-protein-coupled 7 transmembrane domain receptors ...
Kyazze, G., Godfrey Kyazze, Tajalli Keshavarz, Keshavarz, T., Oluwaseun Adelaja, Adelaja, O., Kaneva, M.   +6 more
core   +1 more source

Setmelanotide, a Novel, Selective Melanocortin Receptor-4 Agonist Exerts Anti-inflammatory Actions in Astrocytes and Promotes an Anti-inflammatory Macrophage Phenotype

Frontiers in Immunology, 2019
To date, available treatment strategies for multiple sclerosis (MS) are ineffective in preventing or reversing progressive neurologic deterioration, creating a high, and unmet medical need. One potential way to fight MS may be by limiting the detrimental
Alwin Kamermans, Tom Verhoeven, Bert van het Hof, Jasper J. Koning, Lauri Borghuis, Maarten Witte, Jack van Horssen, Helga E. de Vries, Merel Rijnsburger   +8 more
doaj   +1 more source

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3716-3732, November 2026.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source

Pharmacological therapies for monogenic obesity caused by MC4R dysfunction [PDF]

, 2010
PhDMutations in the melanocortin-4 receptor (MC4R) are the most common cause of monogenic obesity. The majority of MC4R mutations are predicted to cause the receptor to aberrantly fold.
Gooljar, Sakina B
core   +2 more sources

SURMOUNT‐REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity

Obesity, Volume 34, Issue 11, Page 2051-2060, November 2026.
ABSTRACT Objective SURMOUNT‐REAL UK will evaluate the effectiveness of tirzepatide when offered in addition to standard‐of‐care (SoC) in adults with Class I obesity (BMI ≥ 30 and ≤ 34.9 kg/m2) and without diabetes in a UK primary care setting. Methods A 5‐year, phase 4, multicenter, open‐label, pragmatic randomized clinical trial is enabled through ...
Martin K. Rutter, Julie Mount, J. Martin Gibson, Joanne Webb, Cheryl Marler, Catherine Reed, Mugdha Gore, Wenyu Ye, Elisa Gomez Valderas, John Wilding, Naveed Sattar, Melanie J. Davies, Kamlesh Khunti, Richard Haynes, Rachel L. Batterham   +14 more
wiley   +1 more source

Leptin is required for hypothalamic regulation of miRNAs targeting POMC 3’UTR

Frontiers in Cellular Neuroscience, 2015
The central nervous system monitors modifications in metabolic parameters or hormone levels and elicits adaptive responses such as food intake regulation. Particularly, within the hypothalamus, leptin modulates the activity of pro-opiomelanocortin (POMC)
Adel eDerghal, Mehdi eDjelloul, Coraline eAirault, Clémént ePierre, Michel eDallaporta, Jean-Denis eTroadec, Vanessa eTillement, Catherine eTardivel, Bruno eBariohay, Jérôme eTrouslard, Lourdes eMounien   +10 more
doaj   +1 more source

A Cilia–Centered Nicotinamide Adenine Dinucleotide (NAD+) Signaling Network Regulates Hypothalamic Lysosomal Homeostasis and Metabolic Aging

Aging Cell, Volume 25, Issue 11, November 2026.
Aging‐associated NAD+ depletion in hypothalamic neurons shortens primary cilia and disrupts CHMP4B trafficking to lysosomes during lysosomal stress, leading to impaired TRPML1–mediated Ca2+ signaling and lysosomal stress responses. Calorie restriction restores hypothalamic NAD+ levels, ciliary structure, and lysosomal homeostasis, thereby improving ...
Se Eun Park, Eun Roh, Jae Woo Park, Seong Jun Kim, So Yeon Jeong, Chae Beom Park, Hyo Sun Lim, Ji Soo Kim, Mun Gyeom Kim, Myeong Ju Kim, Young In Cho, Wontae Jeong, Gil Myoung Kang, Sang‐Yeob Kim, Se Hee Min, Min‐Seon Kim   +15 more
wiley   +1 more source

The Melanocortin-4 Receptor Integrates Circadian Light Cues and Metabolism [PDF]

, 2015
The melanocortin system directs diverse physiological functions from coat color to body weight homoeostasis. A commonality among melanocortin-mediated processes is that many animals modulate similar processes on a circannual basis in response to longer ...
Morano, Rachel, Arble, Deanna M., Sandoval, Darleen A., Perez-Tilve, Diego, Woods, Stephen C., Ottaway, Nickki, Seeley, Randy J., Holland, Jenna, Herman, James P., Sorrell, Joyce, Pressler, Joshua W.   +10 more
core