Results 121 to 130 of about 57,827 (240)

Neuropathic Pain Comorbid Cognitive Impairment and Vitamin D: A Narrative Review From Mechanisms to Clinical Management

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Vitamin D is an essential fat‐soluble nutrient primarily obtained through cutaneous synthesis triggered by ultraviolet exposure and dietary intake. After systemic metabolism and activation, it binds to vitamin D receptors widely distributed in the central and peripheral nervous systems, exerting pleiotropic neuroprotective and regulatory biological ...
Nan Zhao, Yang Yang, Wanqiu Yu, Yuhang Zhu, Zhaoqiong Zhu   +4 more
wiley   +1 more source

Markers of Systemic Metabolic Dysfunction in Vitiligo and Their Potential Role in Disease Pathogenesis: A Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Vitiligo is a chronic autoimmune disease characterized by the progressive destruction of melanocytes, resulting in depigmented skin macules. While traditionally viewed as a cutaneous disorder driven by a specific CD8+ T cell‐mediated interferon‐γ (IFN‐γ) signature, emerging research suggests that vitiligo may be a systemic condition
Federica Papaccio, Simona Scano, Barbara Bellei   +2 more
wiley   +1 more source

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source

Development of novel frog‐skin peptide scaffolds with selectivity towards melanocortin receptor subtypes

, 2020
Melanocortin receptors are pharmaceutically important receptors that are involved in complex physiological functions. They have been associated with various diseases including obesity, erectile dysfunction, acne, and skin cancer.
Lai Yue Chan, Craik, David J., Malik, Uru, Uru Malik, Quentin Kaas, Kaas, Quentin, Norelle L. Daly, David J. Craik, Chan, Lai Yue, Minying Cai, Daly, Norelle L., Cai, Minying, Hruby, Victor J., Victor J. Hruby   +13 more
core   +1 more source

Fish melanocortin system [Oral]

, 2010
6th International Melanocortin meeting, Utrecht (Netherlands), 8 - 11 July 2010Melanocortin signalling is mediated by binding to a family of G protein-coupled receptors that positively couple to adenylyl cyclase.
Cerdá-Reverter, José Miguel, Rotllant, Josep, Guillot, Raúl, Agulleiro Gozalbo, Maria Josep, Sánchez Martínez, Elisa, Ceinos, Rosa M.   +5 more
core  

Early Weight Regain After GLP‐1 Receptor Agonist Discontinuation: Mechanisms and Implications for Treatment De‐Escalation Strategies

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 8769-8776, October 2026.
ABSTRACT Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have transformed the pharmacological management of obesity, producing substantial and sustained weight loss during active treatment. However, discontinuation of therapy is frequently followed by significant weight regain, raising important questions regarding the durability of treatment ...
M. A. Damhof, F. H. van Bruggen, E. N. van Roon   +2 more
wiley   +1 more source

mRNA Therapeutics for Skin Rejuvenation: From Aging Atlases to Clinical Translation

Experimental Dermatology, Volume 35, Issue 10, October 2026.
ABSTRACT Skin aging is a multifactorial process characterized by the progressive decline of tissue structure, function and regenerative capacity. Although numerous interventions have been developed to improve the clinical manifestations of aging, most primarily alleviate downstream consequences rather than directly targeting the molecular mechanisms ...
Fabiana Boncimino, Stefano Sol, Kristina Todorova, Anna Mandinova   +3 more
wiley   +1 more source

Acute ayahuasca administration attenuates binge‐like eating and anxiety‐related behaviors in mice subjected to intermittent fasting

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract Human binge eating disorder is characterized by recurrent episodes of excessive food consumption accompanied by loss of control and is strongly associated with alterations in reward processing and emotional regulation. Ayahuasca, a psychoactive botanical preparation traditionally used in Amazonian medicine, has been shown to modulate ...
Cristian Ferreira Corona, Felipe Alves Alencar Lima, Jessica Sabrina Canedo da Silva Sumensse, Kevin Donansan Carvalho, Pedro Henrique Grignet, Heloisa Deola Confortim, Maria Claudia Gross, Fabiana Aidar Firmino, Fernanda Ferreira Evangelista, Francisney Pinto Nascimento, Jean Franciesco Vettorazzi   +10 more
wiley   +1 more source

Hormonal and Neuroendocrine Regulation of Energy Balance

Frontiers in Physiology, 2016
Maria eMoreno, Antonia eLanni
doaj   +1 more source

The Skin‐Lightening Efficacy and Mechanisms of Botanical Extracts: A Comprehensive Review

Journal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.
ABSTRACT Background Skin pigmentation is regulated by a complex network involving melanogenesis, melanosome transfer, oxidative stress, environmental stimuli, and epidermal turnover. Botanical extracts and phytochemicals have attracted increasing interest as potential skin‐lightening agents. This review evaluates their efficacy, mechanisms, and safety.
Siting Yang, Mingning Ding, Chenglong Ye, Jingning Shen, Lihua Zhang, Anquan Yang, Lihao Gu   +6 more
wiley   +1 more source